scholarly journals Multienzymatic Processes Involving Baeyer–Villiger Monooxygenases

Catalysts ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 605
Author(s):  
Gonzalo de Gonzalo ◽  
Andrés R. Alcántara

Baeyer–Villiger monooxygenases (BVMOs) are flavin-dependent oxidative enzymes capable of catalyzing the insertion of an oxygen atom between a carbonylic Csp2 and the Csp3 at the alpha position, therefore transforming linear and cyclic ketones into esters and lactones. These enzymes are dependent on nicotinamides (NAD(P)H) for the flavin reduction and subsequent reaction with molecular oxygen. BVMOs can be included in cascade reactions, coupled to other redox enzymes, such as alcohol dehydrogenases (ADHs) or ene-reductases (EREDs), so that the direct conversion of alcohols or α,β-unsaturated carbonylic compounds to the corresponding esters can be achieved. In the present review, the different synthetic methodologies that have been performed by employing multienzymatic strategies with BVMOs combining whole cells or isolated enzymes, through sequential or parallel methods, are described, with the aim of highlighting the advantages of performing multienzymatic systems, and show the recent advances for overcoming the drawbacks of using BVMOs in these techniques.

2018 ◽  
Vol 57 (41) ◽  
pp. 13444-13448 ◽  
Author(s):  
Uttam Kumar Das ◽  
Subrata Chakraborty ◽  
Yael Diskin-Posner ◽  
David Milstein

ChemInform ◽  
2007 ◽  
Vol 38 (52) ◽  
Author(s):  
Mohammad Navid Soltani Rad ◽  
Ali Khalafi-Nezhad ◽  
Somayeh Behrouz ◽  
Mohammad Ali Faghihi

2021 ◽  
Author(s):  
Diana Ainembabazi ◽  
Jonathan Horlyck ◽  
Darren Dolan ◽  
Adam Lee ◽  
Karen Wilson ◽  
...  

<p>Design of active and selective supported catalysts is critical for developing new tandem processes for upgrading biomass-derived alcohols. Hydrogen-free upgrading alcohols to liquid hydrocarbons is desirable for producing drop-in fuel substitutes, but direct and atom-economical processes are yet to be reported. Here we report a novel alcohol upgrading and<b> </b>deoxygenation cascade that meets these criteria. This hydrogen-free cascade is catalyzed by multifunctional Pd catalysts, whose supports feature a range of acid-base properties: primarily basic MgO, acidic Al<sub>2</sub>O<sub>3</sub> and Mg-Al hydrotalcite (HT) with a combination of Lewis acidic and basic sites. The impact of support selection on selectivity offers insights into the design principles for next-generation catalysts for this process and related transformations.</p>


2007 ◽  
Vol 48 (38) ◽  
pp. 6779-6784 ◽  
Author(s):  
Mohammad Navid Soltani Rad ◽  
Ali Khalafi-Nezhad ◽  
Somayeh Behrouz ◽  
Mohammad Ali Faghihi

ChemBioChem ◽  
2018 ◽  
Vol 19 (17) ◽  
pp. 1845-1848 ◽  
Author(s):  
László Nagy‐Győr ◽  
Emese Abaházi ◽  
Viktória Bódai ◽  
Péter Sátorhelyi ◽  
Balázs Erdélyi ◽  
...  

2014 ◽  
Vol 43 (46) ◽  
pp. 17248-17254 ◽  
Author(s):  
Jong-Hoo Choi ◽  
Leo E. Heim ◽  
Mike Ahrens ◽  
Martin H. G. Prechtl

In this work, we present a mild method for direct conversion of primary alcohols into carboxylic acids with the use of water as an oxygen source.


Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 91
Author(s):  
Pedro Soares-Castro ◽  
Filipa Soares ◽  
Pedro M. Santos

Monoterpenes are plant secondary metabolites, widely used in industrial processes as precursors of important aroma compounds, such as vanillin and (−)-menthol. However, the physicochemical properties of monoterpenes make difficult their conventional conversion into value-added aromas. Biocatalysis, either by using whole cells or enzymes, may overcome such drawbacks in terms of purity of the final product, ecological and economic constraints of the current catalysis processes or extraction from plant material. In particular, the ability of oxidative enzymes (e.g., oxygenases) to modify the monoterpene backbone, with high regio- and stereo-selectivity, is attractive for the production of “natural” aromas for the flavor and fragrances industries. We review the research efforts carried out in the molecular analysis of bacterial monoterpene catabolic pathways and biochemical characterization of the respective key oxidative enzymes, with particular focus on the most relevant precursors, β-pinene, limonene and β-myrcene. The presented overview of the current state of art demonstrates that the specialized enzymatic repertoires of monoterpene-catabolizing bacteria are expanding the toolbox towards the tailored and sustainable biotechnological production of values-added aroma compounds (e.g., isonovalal, α-terpineol, and carvone isomers) whose implementation must be supported by the current advances in systems biology and metabolic engineering approaches.


1995 ◽  
Vol 36 (4) ◽  
pp. 609-612 ◽  
Author(s):  
Reni Joseph ◽  
Pradeep S. Pallan ◽  
A. Sudalai ◽  
T. Ravindranathan

Sign in / Sign up

Export Citation Format

Share Document