scholarly journals Molecular Functions of WWOX Potentially Involved in Cancer Development

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1051
Author(s):  
Karim Taouis ◽  
Keltouma Driouch ◽  
Rosette Lidereau ◽  
François Lallemand
Keyword(s):  
Tumor Suppressor ◽  
Gene Mapping ◽  
Tumor Suppressor Gene ◽  
Chromosomal Region ◽  
Fragile Site ◽  
Suppressor Gene ◽  
Cancer Development ◽  
Suppressive Activity ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor

The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific.

Developmental defects in gorlin syndrome related to a putative tumor suppressor gene on chromosome 9

Cell ◽  
1992 ◽  
Vol 69 (1) ◽  
pp. 111-117 ◽  
Author(s):  
Mae R. Gailani ◽  
Sherri J. Bale ◽  
David J. Leffell ◽  
John J. DiGiovanna ◽  
Gary L. Peck ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Chromosome 9 ◽  
Gorlin Syndrome ◽  
Developmental Defects ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor

scholarly journals Analysis of the putative tumor suppressor gene cdkn2ab in pigment cells and melanoma of Xiphophorus and medaka

2018 ◽  
Vol 32 (2) ◽  
pp. 248-258 ◽  
Author(s):  
Janine Regneri ◽  
Barbara Klotz ◽  
Brigitta Wilde ◽  
Verena A. Kottler ◽  
Michael Hausmann ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Pigment Cells ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor

scholarly journals Loss of heterozygosity in the chromosomal region 12p12-13 is very common in childhood acute lymphoblastic leukemia and permits the precise localization of a tumor-suppressor gene distinct from p27KIP1

Blood ◽  
1995 ◽  
Vol 86 (10) ◽  
pp. 3869-3875 ◽  
Author(s):  
H Cave ◽  
B Gerard ◽  
E Martin ◽  
C Guidal ◽  
I Devaux ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Chromosomal Region ◽  
Lymphoblastic Leukemia ◽  
Chromosome Analysis ◽  
Hematologic Malignancies ◽  
Suppressor Gene ◽  
Gene Encoding ◽  
Putative Tumor Suppressor Gene

Abnormalities of the short arm of chromosome 12 are relatively common in hematologic malignancies and deletions of the region. 12p12–13 are found in approximately 5% of the patients with acute lymphoblastic leukemia (ALL). As a potent inhibitor of cyclin-dependent kinases, p27KIP1 prevents the progression of the cell cycle and the gene encoding p27KIP1 represents a potential tumor-suppressor gene. Its recent assignment to the chromosomal region (12p12.3) prompted us to study the p27KIP1 gene in a series of 61 children with ALL. Microsatellite polymorphic markers flanking the p27KIP1 gene were analyzed to detect losses of heterozygosity (LOH). Eleven patients displayed LOH for at least one of the markers. The deleted are encompassed the p27KIP1 gene locus in 10 cases, but inactivation of the remaining allele by deletion, translocation, or mutation was never observed. In addition, in 1 patient, the p27KIP1 gene was situated outside of the region of LOH. Thus, p27KIP1 does not seem to be the target gene of 12p12–13 alterations. However, this study indicates that 12p12–13 alterations at the molecular level, which are present in about 27% of the children with B-lineage ALL, are much more common than had previously been reported by usual chromosome analysis. Moreover, LOH mapping allowed us to better define the location of a putative tumor- suppressor gene implicated in these malignancies and should therefore help in identifying this gene.

Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma

1999 ◽  
Vol 26 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Marco Theobald ◽  
Holger Christiansen ◽  
Anke Schmidt ◽  
Badrig Melekian ◽  
Nicole Wolkewitz ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor ◽  
Chromosome Arm
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