scholarly journals Plasmonic Biosensors for the Detection of Lung Cancer Biomarkers: A Review

Chemosensors ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 326
Author(s):  
Fahad Usman ◽  
John Ojur Dennis ◽  
A.I. Aljameel ◽  
M.K.M. Ali ◽  
O. Aldaghri ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Electromagnetic Interference ◽  
Dynamic Range ◽  
Cancer Biomarkers ◽  
Cancer Type ◽  
Phenotypic Properties ◽  
Plasmonic Sensors

Lung cancer is the most common and deadliest cancer type globally. Its early diagnosis can guarantee a five-year survival rate. Unfortunately, application of the available diagnosis methods such as computed tomography, chest radiograph, magnetic resonance imaging (MRI), ultrasound, low-dose CT scan, bone scans, positron emission tomography (PET), and biopsy is hindered due to one or more problems, such as phenotypic properties of tumours that prevent early detection, invasiveness, expensiveness, and time consumption. Detection of lung cancer biomarkers using a biosensor is reported to solve the problems. Among biosensors, optical biosensors attract greater attention due to being ultra-sensitive, free from electromagnetic interference, capable of wide dynamic range detection, free from the requirement of a reference electrode, free from electrical hazards, highly stable, capable of multiplexing detection, and having the potential for more information content than electrical transducers. Inspired by promising features of plasmonic sensors, including surface plasmon resonance (SPR), localised surface plasmon resonance (LSPR), and surface enhanced Raman scattering (SERS) such as ultra-sensitivity, single particle/molecular level detection capability, multiplexing capability, photostability, real-time measurement, label-free measurement, room temperature operation, naked-eye readability, and the ease of miniaturisation without sophisticated sensor chip fabrication and instrumentation, numerous plasmonic sensors for the detection of lung cancer biomarkers have been investigated. In this review, the principle plasmonic sensor is explained. In addition, novel strategies and modifications adopted for the detection of lung cancer biomarkers such as miRNA, carcinoembryonic antigen (CEA), cytokeratins, and volatile organic compounds (VOCs) using plasmonic sensors are also reported. Furthermore, the challenges and prospects of the plasmonic biosensors for the detection of lung cancer biomarkers are highlighted.

A Surface Plasmon Resonance Based Inhibition Immunoassay for Sensitive and Selective Detection of 17β-Estradiol

2018 ◽  
Author(s):  
Yong Cao ◽  
Mark T. McDermott
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Quantitative Measurement ◽  
Dynamic Range ◽  
Indirect Detection ◽  
Negative Slope ◽  
Chip Surface ◽  
Detection Mechanism ◽  
17Β Estradiol

<div> <div> <div> <p>Quantitative measurement of small-molecule metabolites is now emerging as an effective way to link the metabolite profile to disease state. Surface plasmon resonance (SPR) is a sensing platform that has demonstrated applicability for a large range of biomolecules. However, direct detection of small molecules with SPR challenges the refractive index based detection mechanism. Herein, we utilized an indirect detection format and developed an inhibition immunoassay for the quantitative measurement of 17β-estradiol (E2) using SPR. One competitor, BSA-E2 conjugate, was immobilized to the SPR chip via the reaction between the primary amino group of the conjugate and the succinimide group (NHS) introduced by the formation of a thiol-NHS monolayer on gold surface. Free E2 molecules compete with BSA-E2 on chip surface for binding sites provided by a monoclonal anti-E2 antibody. It was found the binding affinity of the antibody to BSA-E2 conjugate increases with decreasing surface coverage of BSA-E2 conjugate. Under optimal conditions, a sigmoidal calibration curve with a negative slope and a dynamic range from 10 pM to 2 nM was generated. The detection limit of the immunoassay is estimated to be 0.3 pM. Moreover, the immunoassay exhibits high specificity for E2 detection using estrone (E1) as a potential interference.</p></div></div></div>

scholarly journals Surface Plasmonic Sensors: Sensing Mechanism and Recent Applications

Sensors ◽  
2021 ◽  
Vol 21 (16) ◽  
pp. 5262
Author(s):  
Qilin Duan ◽  
Yineng Liu ◽  
Shanshan Chang ◽  
Huanyang Chen ◽  
Jin-hui Chen
Keyword(s):  
Surface Plasmon Resonance ◽  
Optical Fiber ◽  
Surface Plasmon ◽  
Optical Sensors ◽  
Plasmon Resonance ◽  
2D Materials ◽  
Localized Surface Plasmon ◽  
Plasmonic Sensors ◽  
Hyperbolic Dispersion ◽  
Challenges And Opportunities

Surface plasmonic sensors have been widely used in biology, chemistry, and environment monitoring. These sensors exhibit extraordinary sensitivity based on surface plasmon resonance (SPR) or localized surface plasmon resonance (LSPR) effects, and they have found commercial applications. In this review, we present recent progress in the field of surface plasmonic sensors, mainly in the configurations of planar metastructures and optical-fiber waveguides. In the metastructure platform, the optical sensors based on LSPR, hyperbolic dispersion, Fano resonance, and two-dimensional (2D) materials integration are introduced. The optical-fiber sensors integrated with LSPR/SPR structures and 2D materials are summarized. We also introduce the recent advances in quantum plasmonic sensing beyond the classical shot noise limit. The challenges and opportunities in this field are discussed.

Wide dynamic range phase-sensitive surface plasmon resonance biosensor based on measuring the modulation harmonics

2007 ◽  
Vol 23 (5) ◽  
pp. 627-632 ◽  
Author(s):  
Wing-Cheung Law ◽  
Przemyslaw Markowicz ◽  
Ken-Tye Yong ◽  
Indrajit Roy ◽  
Alexander Baev ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Dynamic Range ◽  
Wide Dynamic Range ◽  
Surface Plasmon Resonance Biosensor ◽  
Phase Sensitive

Highly sensitive and wide-dynamic-range liquid-prism surface plasmon resonance refractive index sensor based on the phase and angular interrogations

2016 ◽  
Vol 14 (2) ◽  
pp. 022401-22405 ◽  
Author(s):  
Guoqiang Lan Guoqiang Lan ◽  
Shugang Liu Shugang Liu ◽  
Xueru Zhang Xueru Zhang ◽  
Yuxiao Wang Yuxiao Wang ◽  
and Yinglin Song and Yinglin Song
Keyword(s):  
Refractive Index ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Dynamic Range ◽  
Refractive Index Sensor ◽  
Wide Dynamic Range ◽  
Highly Sensitive

Nano-film aluminum-gold for ultra-high dynamic-range surface plasmon resonance chemical sensor

2019 ◽  
Vol 12 (3) ◽  
pp. 286-295
Author(s):  
Briliant Adhi Prabowo ◽  
I Dewa Putu Hermida ◽  
Robeth Viktoria Manurung ◽  
Agnes Purwidyantri ◽  
Kou-Chen Liu
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Chemical Sensor ◽  
Dynamic Range ◽  
High Dynamic Range ◽  
High Dynamic

Surface plasmon resonance sensors using molecularly imprinted polymers for sorbent assay of theophylline, caffeine, and xanthine

1998 ◽  
Vol 76 (3) ◽  
pp. 265-273 ◽  
Author(s):  
Edward PC Lai ◽  
Ania Fafara ◽  
Victoria A VanderNoot ◽  
Mari Kono ◽  
Brandee Polsky
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Dynamic Range ◽  
Soxhlet Extraction ◽  
Cross Reactivity ◽  
Sensing Element ◽  
Standard Drug ◽  
Molecularly Imprinted ◽  
Optical Phenomenon

A sensor system based on the optical phenomenon of surface plasmon resonance (SPR), which employs either photothermal deflection spectroscopy (PDS) or a photodiode array (PDA) for detection, was developed to use molecularly imprinted (MI) polymethacrylic acid - ethylene glycol dimethacrylates (PMAA-EDMA) as the sensing element. The MI polymers were first processed by Soxhlet extraction to remove the print molecules (theophylline, caffeine, and xanthine), yielding the specific anti-polymers. Each anti-polymer was layered over a silver film to serve as the analysis surface for the molecularly imprinted sorbent assay (MIA) of one target drug. This surface was exposed for 60 min to an aqueous standard drug solution, dried in air, and the uptake of the print molecule into the anti-polymer was monitored by shifts in the SPR angle θ r (and hence the SPR-PDS signal measured at constant θ ). The linear dynamic range of the MIA was found to extend up to 6 mg/mL, with a concentration detection limit estimated at 0.4 mg/mL for theophylline in aqueous solution. A cross-reactivity study of the anti-theophylline and anti-caffeine polymers, using eight other drugs structurally similar to theophylline and caffeine, showed none or very slight shifts in θ r. This implies that the anti-polymers were selective only for their original print molecules and had no affinity for the other drug molecules. Similar molecular recognition characteristics were observed for the anti-xanthine polymer.Key words: surface plasmon resonance, molecular imprinting, theophylline, caffeine, xanthine, sensor.

scholarly journals Monitoring Biomaterials with Light: Review of Surface Plasmon Resonance Biosensing Using two Dimensional Materials

2021 ◽  
Author(s):  
Parsa Yari ◽  
Homa Farmani ◽  
Ali Farmani ◽  
Amir Mosavi
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
High Sensitivity ◽  
Optical Biosensors ◽  
Two Dimensional ◽  
Plasmonic Sensors ◽  
Analysis Instrument ◽  
Two Dimensional Materials ◽  
Fiber Optical

The purpose of this paper is to present advanced techniques in optical biodevices. Moreover different configurations involving the generation of fiber optical biosensors are described. To overcome some limitations of fiber optical biosensors, plasmonic phenomena proposed. In addition novel plasmonic phenomena have broaden researcher&rsquo;s horizons in new discovering in terms of technology and application. As regards there are many challenges to detect ultra-low concentration samples with high sensitivity in real time. Researchers have always made great efforts to discover more effective methods. Throughout the paper SPR and LSPR as a powerful analysis instrument are introduced. Finally surveys the current practical performances of plasmonic sensors in detection of bio target are provided. As a result these devices demonstrate great potential in identifying target analytic due to their unique optical biosensors.

scholarly journals Rapid and Sensitive Detection of Lung Cancer Biomarker Using Nanoporous Biosensor Based on Localized Surface Plasmon Resonance Coupled with Interferometry

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Jae-Sung Lee ◽  
Sae-Wan Kim ◽  
Eun-Yoon Jang ◽  
Byoung-Ho Kang ◽  
Sang-Won Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Localized Surface Plasmon Resonance ◽  
Limit Of Detection ◽  
Surrounding Medium ◽  
Electrochemical Anodization ◽  
Localized Surface Plasmon ◽  
Label Free Detection

We propose a nanobiosensor to evaluate a lung cancer-specific biomarker. The nanobiosensor is based on an anodic aluminum oxide (AAO) chip and functions on the principles of localized surface plasmon resonance (LSPR) and interferometry. The pore-depth of the fabricated nanoporous AAO chip was 1 µm and was obtained using a two-step electrochemical anodization process. The sensor chip is sensitive to the refractive index (RI) changes of the surrounding medium and also provides simple and label-free detection when specific antibodies are immobilized on the gold-deposited surface of the AAO chip. In order to confirm the effectiveness of the sensor, the antibodies were immobilized on the surface of the AAO chip, and the lung cancer-specific biomarker was applied atop of the immobilized-antibody layer using the self-assembled monolayer method. The nanoporous AAO chip was used as a sensor system to detect serum amyloid A1, which is a lung cancer-specific biomarker. The specific reaction of the antigen-antibody contributes to the change in the RI. This in turn causes a shift in the resonance spectrum in the refractive interference pattern. The limit of detection (LOD) was found to be 100 ag/mL and the biosensor had high sensitivity over a wide concentration range.

Biochemical Sensing with Nanoplasmonic Architectures: We Know How but Do We Know Why?

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Andreas Dahlin
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Interaction Analysis ◽  
Research Field ◽  
Annual Review ◽  
Publication Date ◽  
Instrumental Performance ◽  
Complex Samples ◽  
Plasmonic Sensors

Here, the research field of nanoplasmonic sensors is placed under scrutiny, with focus on affinity-based detection using refractive index changes. This review describes how nanostructured plasmonic sensors can deliver unique advantages compared to the established surface plasmon resonance technique, where a planar metal surface is used. At the same time, it shows that these features are actually only useful in quite specific situations. Recent trends in the field are also discussed and some devices that claim extraordinary performance are questioned. It is argued that the most important challenges are related to limited receptor affinity and nonspecific binding rather than instrumental performance. Although some nanoplasmonic sensors may be useful in certain situations, it seems likely that conventional surface plasmon resonance will continue to dominate biomolecular interaction analysis. For detection of analytes in complex samples, plasmonics may be an important tool, but probably not in the form of direct refractometric detection. Expected final online publication date for the Annual Review of Analytical Chemistry, Volume 14 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Sign in / Sign up

Export Citation Format

Share Document