scholarly journals Antihistamines Increase Body Mass Index Percentiles and Z-Scores in Hispanic Children

Children ◽  
2020 ◽  
Vol 7 (12) ◽  
pp. 305
Author(s):  
Michelle Saad ◽  
Sabeen Syed ◽  
Maheen Ilyas ◽  
Anatoliy A. Gashev
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Animal Studies ◽  
Liver Enzymes ◽  
Comparison Group ◽  
The United States ◽  
Alcoholic Fatty Liver ◽  
Z Scores ◽  
Alcoholic Fatty Liver Disease

The prevalence of childhood obesity has increased over the years in the United States and contributed to a rise in metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Animal studies suggested the role of histamine blockade on mesenteric lymphatics tone, contributing to weight gain and hepatic steatosis. This study aimed to investigate an association between antihistamines (AH) use in children and obesity. A single-center retrospective cohort study on children with a diagnosis of NAFLD, followed in the gastroenterology clinic, was performed between January 2018 and April 2019. The demographics, medications, and body mass index (BMI) were assessed. Participants were divided into an AH group with documented use and comparison group, antihistamine naïve. Of the 32 participants in the study, 13 used AH, and 19 did not. Antihistamine users had a mean increase in BMI percentile per year of 1.17 compared to a decrease of 0.06 in comparison group (p = 0.0008). AH usage correlated with a mean increase in BMI z-score of 0.23 per year, as opposed to a decrease by 0.012 in comparison group (p = 0.0016). No difference was found in triglycerides (TG), glucose, and liver enzymes. AH use increases BMI percentiles and z-scores over time and is associated with obesity in children.

scholarly journals Clinical characteristics and longitudinal changes of patients with non-alcoholic fatty liver disease in 2 decades: the NAGALA study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Takuro Okamura ◽  
Yoshitaka Hashimoto ◽  
Masahide Hamaguchi ◽  
Akihiro Obora ◽  
Takao Kojima ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Body Mass ◽  
Fatty Liver Disease ◽  
Abdominal Ultrasonography ◽  
Alcoholic Fatty Liver ◽  
The Past ◽  
Significant Difference ◽  
Alcoholic Fatty Liver Disease

Abstract Background In this study, to clarify the evolving background of people with non-alcoholic fatty liver disease (NAFLD), we compared the current prevalence of NAFLD with that of 2 decades ago. Methods We included two cohorts. The past cohort was from 1994 to 1997 and included 4279 men and 2502 women. The current cohort was from 2014 to 2017 and included 8918 men and 7361 women. NAFLD was diagnosed by abdominal ultrasonography. Results The prevalence of NAFLD increased in both genders throughout these 2 decades (18.5% in the past cohort and 27.1% in the current cohort for men; and 8.0% in the past cohort and 9.4% in the current cohort for women). The prevalence of hyperglycemia increased, whereas the prevalence of low high-density lipoprotein cholesterol levels and hypertriglyceridemia significantly decreased. There was no significant difference in the mean body mass index. Multivariate analysis revealed that the prevalence of obesity and body mass index were significantly associated with the prevalence of NAFLD in both the past and current cohorts. Conclusions The incidence of NAFLD significantly increased throughout these 2 decades, and obesity is the most prevalent factor. Thus, body weight management is an essential treatment option for NAFLD.

852 NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) MAY DEVELOP IN PATIENTS WITH NORMAL BODY MASS INDEX (BMI)

2011 ◽  
Vol 54 ◽  
pp. S340 ◽  
Author(s):  
E. Margariti ◽  
M. Deutsch ◽  
S. Manolakopoulos ◽  
G. Kaflri ◽  
D. Tiniakos ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Body Mass ◽  
Fatty Liver Disease ◽  
Normal Body Mass Index ◽  
Alcoholic Fatty Liver ◽  
Normal Body ◽  
Alcoholic Fatty Liver Disease

Body Mass Index as a Predictor of Mortality for Severe Non-alcoholic Fatty Liver Disease

2015 ◽  
Vol 110 ◽  
pp. S855-S856
Author(s):  
Ashley H. Davis-Yadley ◽  
Seth Lipka ◽  
Ghulamullah Shahzad ◽  
Steven B. Clayton ◽  
Ambuj Kumar ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Body Mass ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals CLINICAL FEATURES AND LABORATORY PARAMETERS IN PREGNANT WOMEN WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND OBESITY

2021 ◽  
pp. 5-13
Author(s):  
L. V. BAHNIY ◽  
S. N. HERYAK ◽  
N. I. BAHNIY
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Pregnant Women ◽  
Body Mass ◽  
Fatty Liver Disease ◽  
The Body ◽  
Alcoholic Fatty Liver ◽  
Group I ◽  
Alcoholic Fatty Liver Disease

Today, non-alcoholic fatty liver disease (NAFLD) is a common pathology and pressing problem in pregnant women, especially among overweight, as the incidence of obese women of childbearing age is rapidly increasing. Disorders of lipid metabolism, which is an integral part of this disease, lead to pathological changes in the functional state of the liver, which in turn have a negative impact on pregnancy and lead to the formation of obstetric and perinatal complications. THE AIM OF OUR STUDY was to evaluate the clinical and laboratory markers of liver disorders in pregnant women with NAFLD depending on body mass index. MATERIALS AND METHODS. We’ve examined 98 pregnant women with NAFLD at the stage of non-alcoholic steatohepatitis (NASH) in combination with obesity. The age of the examined women ranged from 21 to 35 years (mean age 30.5 ± 1.5 years). The control group consisted of 30 almost healthy pregnant women. Depending on the body mass index (BMI), all surveyed women are divided into three groups: Group I - overweight pregnant women, Group II - pregnant women with grade I obesity, Group III - pregnant women with grade II obesity. We evaluated the incidence of major clinical complaints and changes in blood biochemical parameters in pregnant women depending on the increasing of BMI. RESULTS. When comparing the clinical manifestations of NAFLD on the stage of NASH in pregnant, the highest frequency is observed in the group of examined women with severe obesity compared with the group of patients with moderate obesity and overweight: symptoms of asthenic syndrome (increased fatigue, sleep disturbances, emotional lability, decreased and increased appetite) in 91.6.0%, 79.1% and 61.5% of patients (p<0.05), manifestations of dyspepsia  (constipation, nausea, flatulence) - in 87.5%, 54% and 34.6% patients (p <0.05), feeling of heaviness or moderate pain in the right hypochondrium - in 62.5% 50% and 30.7% of patients, respectively (p <0.05). CONCLUSIONS. It has been established that pregnant women with non-alcoholic fatty liver disease on the stage of nonalcoholic steatohepatitits have pronounced clinical picture of the disease, which depends on the increase in BMI. It was found that in pregnant women with NAFLD liver dysfunction occurs on the background of grade I obesity, which can be considered as an early marker of steatohepatitis and risk of obstetric complications.

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