scholarly journals Shear at Fluid-Fluid Interfaces Affects the Surface Topologies of Alginate Microfibers

2019 ◽  
Vol 1 (1) ◽  
pp. 265-272 ◽  
Author(s):  
Marilyn C. McNamara ◽  
Ryan J. Pretzer ◽  
Reza Montazami ◽  
Nicole N. Hashemi
Keyword(s):  
Microfluidic Device ◽  
Shear Force ◽  
Three Dimensional ◽  
Surface Topology ◽  
Fluid Interfaces ◽  
Animal Testing ◽  
Simple Modification ◽  
Core Solution ◽  
Tunable Mechanical Properties ◽  
Alginate Microfibers

Hydrogel microfibers have great potential for applications such as tissue engineering or three-dimensional cell culturing. Their favorable attributes can lead to tissue models that can help to reduce or eliminate animal testing, thereby providing an eco-friendly alternative to this unsustainable process. In addition to their highly tunable mechanical properties, this study shows that varying the viscosity and flow rates of the prepolymer core solution and gellator sheath solution within a microfluidic device can affect the surface topology of the resulting microfibers. Higher viscosity core solutions are more resistant to deformation from shear force within the microfluidic device, thereby yielding smoother fibers. Similarly, maintaining a smaller velocity gradient between the fluids within the microfluidic device minimizes shear force and smooths fiber surfaces. This simple modification provides insight into manufacturing microfibers with highly tunable properties.

scholarly journals Development of a human neuromuscular tissue-on-a-chip model on a 24-well-plate-format compartmentalized microfluidic device

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Kazuki Yamamoto ◽  
Nao Yamaoka ◽  
Yu Imaizumi ◽  
Takunori Nagashima ◽  
Taiki Furutani ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Microfluidic Device ◽  
Motor Neurons ◽  
Muscle Fibers ◽  
Three Dimensional ◽  
Tissue Model ◽  
Skeletal Muscle Fibers

A three-dimensional human neuromuscular tissue model that mimics the physically separated structures of motor neurons and skeletal muscle fibers is presented.

scholarly journals 3D Printing of High Viscosity Reinforced Silicone Elastomers

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2239
Author(s):  
Nicholas Rodriguez ◽  
Samantha Ruelas ◽  
Jean-Baptiste Forien ◽  
Nikola Dudukovic ◽  
Josh DeOtte ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
High Performance ◽  
New Technologies ◽  
Three Dimensional ◽  
High Viscosity ◽  
Layer By Layer ◽  
Silicone Elastomers ◽  
Uv Curable ◽  
Octet Truss ◽  
Tunable Mechanical Properties

Recent advances in additive manufacturing, specifically direct ink writing (DIW) and ink-jetting, have enabled the production of elastomeric silicone parts with deterministic control over the structure, shape, and mechanical properties. These new technologies offer rapid prototyping advantages and find applications in various fields, including biomedical devices, prosthetics, metamaterials, and soft robotics. Stereolithography (SLA) is a complementary approach with the ability to print with finer features and potentially higher throughput. However, all high-performance silicone elastomers are composites of polysiloxane networks reinforced with particulate filler, and consequently, silicone resins tend to have high viscosities (gel- or paste-like), which complicates or completely inhibits the layer-by-layer recoating process central to most SLA technologies. Herein, the design and build of a digital light projection SLA printer suitable for handling high-viscosity resins is demonstrated. Further, a series of UV-curable silicone resins with thiol-ene crosslinking and reinforced by a combination of fumed silica and MQ resins are also described. The resulting silicone elastomers are shown to have tunable mechanical properties, with 100–350% elongation and ultimate tensile strength from 1 to 2.5 MPa. Three-dimensional printed features of 0.4 mm were achieved, and complexity is demonstrated by octet-truss lattices that display negative stiffness.

scholarly journals A Three-Dimensional Microfluidic Device for Monitoring Cancer and Chemotherapy-Associated Platelet Activation

ACS Omega ◽  
2021 ◽  
Vol 6 (4) ◽  
pp. 3164-3172
Author(s):  
Zhujing Hao ◽  
Haichen Lv ◽  
Ruopeng Tan ◽  
Xiaolei Yang ◽  
Yang Liu ◽  
...  
Keyword(s):  
Platelet Activation ◽  
Microfluidic Device ◽  
Three Dimensional

scholarly journals Optocapillarity-driven assembly and reconfiguration of liquid crystal polymer actuators

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhiming Hu ◽  
Wei Fang ◽  
Qunyang Li ◽  
Xi-Qiao Feng ◽  
Jiu-an Lv
Keyword(s):  
Liquid Crystal ◽  
Liquid Surface ◽  
Three Dimensional ◽  
Liquid Crystal Polymer ◽  
Fluid Interfaces ◽  
Ordered Structures ◽  
Polymer Actuators ◽  
Crystal Polymer ◽  
Wide Range ◽  
Micromechanical Systems

AbstractRealizing programmable assembly and reconfiguration of small objects holds promise for technologically-significant applications in such fields as micromechanical systems, biomedical devices, and metamaterials. Although capillary forces have been successfully explored to assemble objects with specific shapes into ordered structures on the liquid surface, reconfiguring these assembled structures on demand remains a challenge. Here we report a strategy, bioinspired by Anurida maritima, to actively reconfigure assembled structures with well-defined selectivity, directionality, robustness, and restorability. This approach, taking advantage of optocapillarity induced by photodeformation of floating liquid crystal polymer actuators, not only achieves programmable and reconfigurable two-dimensional assembly, but also uniquely enables the formation of three-dimensional structures with tunable architectures and topologies across multiple fluid interfaces. This work demonstrates a versatile approach to tailor capillary interaction by optics, as well as a straightforward bottom-up fabrication platform for a wide range of applications.

Formation of Copolymer-Ag Nanoparticles Composite Micelles in Three-dimensional Co-flow Focusing Microfluidic Device

2019 ◽  
Vol 34 (6) ◽  
pp. 1259-1265
Author(s):  
Mengran Feng ◽  
Guangyao He ◽  
Si Yi ◽  
Weizheng Song ◽  
Yanjun Chen ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Ag Nanoparticles ◽  
Three Dimensional ◽  
Flow Focusing

scholarly journals Melamine promotes calcium crystal formation in three-dimensional microfluidic device

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Farai Gombedza ◽  
Sade Evans ◽  
Samuel Shin ◽  
Eugenia Awuah Boadi ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Three Dimensional ◽  
Crystal Formation

scholarly journals Three-dimensional (3D) extra-cellular matrix coating of a microfluidic device

2006 ◽  
Vol 34 ◽  
pp. 747-751 ◽  
Author(s):  
K C Chaw ◽  
M Manimaran ◽  
Francis E H Tay ◽  
S Swaminathan
Keyword(s):  
Microfluidic Device ◽  
Three Dimensional ◽  
Extra Cellular Matrix ◽  
Cellular Matrix

A Microfluidic-Based Tactile Sensor for 3-DOF Force/Torque Detection

2015 ◽  
Author(s):  
Yichao Yang ◽  
Zhili Hao
Keyword(s):  
Soft Lithography ◽  
Shear Force ◽  
Normal Force ◽  
Three Dimensional ◽  
Tactile Sensor ◽  
Degree Of Freedom ◽  
Experimental Results ◽  
Torque Sensor ◽  
Resistance Increase ◽  
3D Microstructure

This paper reports on a microfluidic-based tactile sensor capable of detecting forces along two directions and torque about one direction. The 3-Degree-Of-Freedom (3-DOF) force/torque sensor encompasses a symmetric three-dimensional (3D) microstructure embedded with two sets of electrolyte-enabled distributed resistive transducers underneath. The 3D microstructure is built into a rectangular block with a loading-bump on its top and two microchannels at its bottom. Together with electrode pairs distributed along the microchannel length, electrolyte in each microchannel functions as a set of three resistive transducers. While a normal force results in a resistance increase in the two sets of transducers, a shear force causes opposite resistance changes in the two sets of transducers. Conversely, a torque leads to the opposite resistance changes in the two side transducers in each set. Soft lithography and CNC molding are combined to fabricate a prototype tactile sensor. The experimental results validate the feasibility of using this microfluidic-based tactile sensor for 3-DOF force/torque detection.

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