Layer-by-Layer Self-Assembly Composite Coatings for Improved Corrosion and Wear Resistance of Mg Alloy for Biomedical Applications

Mg alloys are promising biomedical metal due to their natural degradability, good processability, and favorable mechanical properties. However, the poor corrosion resistance limits their further clinical applications. In this study, the combined strategies of surface chemical treatment and layer-by-layer self-assembly were used to prepare composite coatings on Mg alloys to improve the biocorrosion resistance. Specially, alkalized AZ91 Mg alloy generated chemical linkage with silane via Si–O–Mg covalent bond at the interface. Subsequently, Si–OH group from silane formed a crosslinked silane layer by Si–O–Si network. Further chemical assembly with graphene oxide (GO), lengthened the diffusion pathway of corrosive medium. The chemically assembled composite coatings could firmly bond to Mg alloy substrate, which persistently and effectively acted as compact barriers against corrosion propagation. Improved biocorrosion resistance of AZ91 Mg alloy with self-assembly composite coatings of silane/GO was subsequently confirmed by immersion tests. Besides, the Mg alloy exhibited good wear resistance due to outside layer of GO with a lubricant effect. Cell viability of higher than 75% had also been found for the alloy with self-assembly composite coatings, which showed good cytocompatibility.

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Molecular Composite Coatings on Nafion Using Layer-by-Layer Self-Assembly

ACS Applied Materials & Interfaces ◽

10.1021/acsami.5b01371 ◽

2015 ◽

Vol 7 (19) ◽

pp. 10365-10373 ◽

Cited By ~ 8

Author(s):

Christophe J. Lefaux ◽

Byoung-Suhk Kim ◽

Narayanan Venkat ◽

Patrick T. Mather

Keyword(s):

Self Assembly ◽

Composite Coatings ◽

Layer By Layer

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Phospholipid-based multifunctional coating via layer-by-layer self-assembly for biomedical applications

Materials Science and Engineering C ◽

10.1016/j.msec.2020.111237 ◽

2020 ◽

Vol 116 ◽

pp. 111237 ◽

Cited By ~ 1

Author(s):

Peichuang Li ◽

Xiaojing Li ◽

Wanhao Cai ◽

Huiqing Chen ◽

Hang Chen ◽

...

Keyword(s):

Self Assembly ◽

Biomedical Applications ◽

Layer By Layer

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Synthesis and characterization of innovative poly(lactide-co-glycolide)-(poly-l-ornithine/fucoidan) core–shell nanocarriers by layer-by-layer self-assembly

RSC Advances ◽

10.1039/c7ra04908k ◽

2017 ◽

Vol 7 (52) ◽

pp. 32786-32794 ◽

Cited By ~ 7

Author(s):

Jingqian Fan ◽

Yuangang Liu ◽

Shibin Wang ◽

Yulu Liu ◽

Siming Li ◽

...

Keyword(s):

Self Assembly ◽

Biomedical Applications ◽

Synthesis And Characterization ◽

Core Shell ◽

Layer By Layer

Layer-by-Layer (LbL) self-assembly of nanocarriers has garnered the interest of researchers for a wide variety of biomedical applications.

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A Micro Arc Oxidation Composite Coating Developed on a Biocompatible Magnesium Alloy for Bone Implant Applications

Volume 1: Additive Manufacturing; Advanced Materials Manufacturing; Biomanufacturing; Life Cycle Engineering; Manufacturing Equipment and Automation ◽

10.1115/msec2020-8492 ◽

2020 ◽

Author(s):

Hamdy Ibrahim

Keyword(s):

Composite Coating ◽

Biomedical Applications ◽

The Body ◽

Mg Alloys ◽

Mg Alloy ◽

Patient Specific ◽

Coating Process ◽

Bone Implant ◽

Corrosion Rates ◽

Micro Arc Oxidation

Abstract The biocompatibility, mechanical properties and biodegradable nature of Mg alloys have made them attractive for biomedical applications, especially as bone implants. However, one of the main problems that limit the use of Mg alloy for several biomedical applications is their fast corrosion rates inside the body. Coating Mg-based implants is one of the most extensively studied approaches to address the fast corrosion rates of Mg alloys in the physiological environment. Micro arc oxidation (MAO) coating process has shown very promising results towards reducing the corrosion rates of Mg alloys due to the formation of a protective dense, well-adhered and wear-resistant oxide layer on the surface of the Mg alloy. In this study, the feasibility of coating an Mg-Zn-Ca-based alloy with a composite coating made using a micro-arc oxidation coating process and an immersion (dipping process) was investigated. The corrosion properties and surface characteristics of the coated alloy samples are assessed. The created protective composite coating is used to slow the corrosion rates of an Mg-Zn-Ca-based alloy. The developed composite coating resulted in a significant reduction in the corrosion rates. The results of this study show that it is possible to achieve more controlled corrosion rates of Mg-based implants towards patient-specific bone implant applications.

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Covalent-driven Layer-by-layer Self-assembly of Clindamycin-loaded PPLA nanoparticles/chitosan membrane on titanium sheet for long-acting anti-infection

Current Nanoscience ◽

10.2174/1573413716999200917120155 ◽

2020 ◽

Vol 16 ◽

Author(s):

Shuangya Yang ◽

Yan Yin ◽

Yajuan Xu ◽

Tanglin Zhang ◽

Youbin Li ◽

...

Keyword(s):

Polyethylene Glycol ◽

Polylactic Acid ◽

Self Assembly ◽

Covalent Bond ◽

Amide Bond ◽

Secondary Amines ◽

Layer By Layer ◽

Sustained Drug Release ◽

Titanium Sheet ◽

Chitosan Membrane

Background: Post-arthroplasty implant-related infection is one of the most feared complications with adverse consequences for patients and public health systems, especially in terms of the huge financial cost of treatment. This is compounded by the potential risks of continuous metamorphosis and emergence of new resistant bacterial strains. Constructing an antibacterial surface therefore on the implant represents an approach to reduce the incidence of implant-related infections. Methods: In this study, a covalent-driven layer-by-layer self-assembly of clindamycin-loaded polyethylene glycol grafted polylactic acid nanoparticles/chitosan membrane has been successfully fabricated on the titanium sheet and evaluated for drug releasing potential and antibiotic activity. Results: Attenuated total reflectance spectrum of the layer-by-layer self-assembly membrane showed three absorption peaks around 1680, 1520 and 1240 cm-1, which are the characteristic absorption peaks of secondary amines. The results indicated the formation of an amide bond between the carboxyl groups of clindamycin-loaded polyethylene glycol grafted polylactic acid nanoparticles and the amino groups of chitosan. The covalent bond stabilized the membrane construct. The membrane exhibited a sustained drug release behavior whereby less than 50% of clindamycin was released after 160 hr. The membrane persistently inhibited the growth of staphylococcus aureus with the inhibition ratio exceeding 60%. Conclusion: The membrane construct holds a great potential for managing anti-implant-related infections.

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Layer by layer assembled chitosan (TiO2)-heparin composite coatings on MAO-coated Mg alloys

Materials Letters ◽

10.1016/j.matlet.2020.128640 ◽

2020 ◽

Vol 281 ◽

pp. 128640

Author(s):

Yang Chen ◽

Jing Wang ◽

Jinhe Dou ◽

Huijun Yu ◽

Chuanzhong Chen

Keyword(s):

Composite Coatings ◽

Mg Alloys ◽

Layer By Layer

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Flame-Retardant Wood Composites Based on Immobilizing with Chitosan/Sodium Phytate/Nano-TiO2-ZnO Coatings via Layer-by-Layer Self-Assembly

Coatings ◽

10.3390/coatings10030296 ◽

2020 ◽

Vol 10 (3) ◽

pp. 296 ◽

Cited By ~ 3

Author(s):

Lin Zhou ◽

Yanchun Fu

Keyword(s):

Flame Retardant ◽

Flame Retardancy ◽

Self Assembly ◽

Composite Coatings ◽

Wood Products ◽

Layer By Layer ◽

Zno Nanoparticle ◽

Nano Tio2 ◽

Limiting Oxygen Index ◽

Sodium Phytate

Composite coatings of inorganic nanomaterials with polyelectrolytes are promising materials for wood modification. Endowing wood with flame retardancy behavior can not only broaden the range of applications of wood, but also improve the safety of wood products. In this work, chitosan/sodium phytate/TiO2-ZnO nanoparticle (CH/SP/nano-TiO2-ZnO) composite coatings were coated on wood surface through layer-by-layer self-assembly. The morphology and chemical composition of the modified wood samples were analyzed using scanning electron microscopy and energy dispersive spectrometry. The thermal degradation properties and flame retardancy of the samples treated with different assembly structures were observed by thermogravimetric analysis, limiting oxygen test, and combustion test. Due to the presence of an effective intumescent flame retardant system and a physical barrier, the CH/SP/nano-TiO2-ZnO coatings exhibited the best flame retardant performance and required only approximately six seconds for self-extinguishing. The coated samples had a limiting oxygen index of 8.4% greater than the original wood.

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Biomedical Applications of Layer-by-Layer Self-Assembly for Cell Encapsulation: Current Status and Future Perspectives

Advanced Healthcare Materials ◽

10.1002/adhm.201800939 ◽

2018 ◽

Vol 8 (1) ◽

pp. 1800939 ◽

Cited By ~ 23

Author(s):

Tengfei Liu ◽

Ying Wang ◽

Wen Zhong ◽

Bingyun Li ◽

Kibret Mequanint ◽

...

Keyword(s):

Self Assembly ◽

Biomedical Applications ◽

Cell Encapsulation ◽

Current Status ◽

Layer By Layer ◽

Future Perspectives

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Self-Assembly Technique for Biomedical Applications

Nano LIFE ◽

10.1142/s1793984415420027 ◽

2015 ◽

Vol 05 (02) ◽

pp. 1542002 ◽

Cited By ~ 5

Author(s):

Xiao Gong

Keyword(s):

Drug Delivery ◽

Self Assembly ◽

Biomedical Applications ◽

Recent Progress ◽

Layer By Layer ◽

Biomedical Materials ◽

Biomedical Material ◽

Potential Applications ◽

Assembly Technique

Layer-by-layer (LbL) self-assembly has attracted extensive attention for its simplicity and versatility. Self-assembly has many potential applications, among which biomedical applications is especially important because it can be used as a means of generating drug delivery and biomedical materials. Based on this, most recent progress in the field of self-assembly technique for drug delivery and biomedical material applications are summarized in this mini review. The remaining challenges are also mentioned.

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Dry Sliding Wear Characteristics of Severely Deformed 6061 Aluminum and AZ61 Magnesium Alloys

Materials Science Forum ◽

10.4028/www.scientific.net/msf.449-452.597 ◽

2004 ◽

Vol 449-452 ◽

pp. 597-600 ◽

Cited By ~ 16

Author(s):

Yong Suk Kim ◽

J.S. Ha ◽

Woo Jin Kim

Keyword(s):

Wear Resistance ◽

Sliding Wear ◽

Mg Alloys ◽

Mg Alloy ◽

Dry Sliding Wear ◽

Dry Sliding ◽

Al Alloy ◽

Fine Grained ◽

6061 Al Alloy ◽

Az61 Mg Alloy

Dry-sliding-wear behavior of ultra-fine grained 6061 Al alloy and AZ61 Mg alloy was investigated. The accumulative roll bonding (ARB) and the equal channel angular pressing (ECAP) processes were employed to obtain refined microstructures in the Al and Mg alloys, respectively. Pin-on-disk wear tests of the processed alloys were carried out with various applied load against a 304 stainless steel counterpart. In spite of the increased hardness and strength, wear resistance of the ultra-fine grained 6061 Al alloy was lower than that of the coarse-grained starting alloy. The strength and wear resistance of the ECAP processed AZ61 Mg alloy did not change appreciably despite the refined microstructure. Recrystallization was found to occur during the ECAP process of the Mg alloy. Worn surfaces and cross-sections of the wear-tested specimens were examined to investigate the wear mechanism of the ultra-fine grained Al and Mg alloys.

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