scholarly journals Efficacy and Safety of Topical Dexpanthenol-Containing Spray and Cream in the Recovery of the Skin Integrity Compared with Petroleum Jelly after Dermatologic Aesthetic Procedures

Cosmetics ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 87
Author(s):  
Flávia Alvim Sant’Anna Addor ◽  
Maurício Cândido de Souza ◽  
Sonja Trapp ◽  
Erwan Peltier ◽  
Juliana Machado Canosa
Keyword(s):  
Transepidermal Water Loss ◽  
Positive Control ◽  
Adverse Event Reporting ◽  
Petroleum Jelly ◽  
Efficacy And Safety ◽  
Laser Resurfacing ◽  
Aesthetic Dermatology ◽  
Skin Integrity ◽  
Aesthetic Procedures ◽  
Control Skin

Moisturizers are commonly prescribed after laser and chemical peel aesthetic procedures, but the evidence regarding their efficacy and safety of such use is scarce. We conducted four single-blind, three-week, controlled studies to evaluate the efficacy and safety of topical Dexpanthenol-containing products (Bepantol® spray and Bepantol® cream) using petroleum jelly as a positive control. Skin recovery was assessed after four aesthetic procedures: (1) non-ablative facial laser resurfacing, (2) laser depilation on the external genital and inguinal regions, (3) chemical peel on the external genital and inguinal regions, and (4) ablative facial laser resurfacing. Efficacy was assessed through transepidermal water loss (TEWL) combined with clinical assessment of the skin by the investigators and the participants. In studies (1) and (4), the erythema intensity was evaluated by measuring dermal temperature with a thermal imaging camera. Safety was assessed through adverse event reporting and acceptability through a questionnaire. Dexpanthenol-containing products significantly decreased TEWL and dermal temperature, therefore maintaining skin integrity, promoting its recovery, and reducing erythema. No statistical differences with the positive control were observed. In addition, Dexpanthenol-containing products were well appreciated by the participants from a sensory perspective. These findings suggest that these Dexpanthenol-containing products are adequate for post-procedural care in aesthetic dermatology.

Expedited Resolution of 5-Fluorouracil-Induced Erythema and Barrier Dysfunction with White Petrolatum

2019 ◽  
Vol 3 (4) ◽  
pp. 279-282
Author(s):  
Melody Maarouf ◽  
Bryan Kromenacker ◽  
Eric Brucks ◽  
Vivian Shi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Wound Healing ◽  
Recovery Time ◽  
Patient Adherence ◽  
Precancerous Lesions ◽  
Transepidermal Water Loss ◽  
Petroleum Jelly ◽  
Barrier Dysfunction ◽  
Exposed Skin ◽  
Risk Of Progression

Actinic keratoses (AK) are precancerous lesions that develop on chronically sun-exposed skin. They frequently require prophylactic field treatment due to the risk of progression to squamous cell carcinoma. Topical treatment with 5-fluorouracil (5-FU) yields near complete AK resolution, yet leaves a patient with an exuberant erythematous treatment site, which may be embarrassing and/or uncomfortable. We report a case of a patient with diffuse facial AK who was treated with 5-FU twice daily for 2 weeks, resulting in fiery-red erythema and disrupted barrier indices. Application of pure ultra white petroleum jelly, an emollient preferred by dermatologists for post-operative wound healing, resulted in drastic decreased erythema and recovery time of post-treatment transepidermal water loss and hydration, compared to the contralateral, non-petrolatum-treated side. Additionally, petrolatum use did not disrupt the AK resolution endpoint. We suggest that petroleum jelly be used for the repair of 5-FU-induced barrier disruption and erythema to promote greater patient adherence. 

Efficacy and Safety of a Topically Applied Avène Spring Water Spray in the Healing of Facial Skin after Laser Resurfacing

2002 ◽  
Vol 28 (5) ◽  
pp. 415-418 ◽  
Author(s):  
L. SULIMOVIC ◽  
D. LICU ◽  
E. LEDO ◽  
J. M. NAEYAERT ◽  
P. PIGATTO ◽  
...  
Keyword(s):  
Spring Water ◽  
Water Spray ◽  
Efficacy And Safety ◽  
Facial Skin ◽  
Laser Resurfacing

scholarly journals Adverse event reporting in the recent study by Imanaka et al. describing the efficacy and safety of tapentadol extended release for tumor-related pain

2014 ◽  
Vol 30 (9) ◽  
pp. 1909-1910 ◽  
Author(s):  
Keiichiro Imanaka ◽  
Yushin Tominaga ◽  
Mila Etropolski ◽  
Ilse Van Hove ◽  
Masaki Ohsaka ◽  
...  
Keyword(s):  
Adverse Event ◽  
Extended Release ◽  
Adverse Event Reporting ◽  
Efficacy And Safety ◽  
Event Reporting

An evaluation of the suitability of benzocaine as a positive control skin sensitizer

1995 ◽  
Vol 33 (1) ◽  
pp. 28-32 ◽  
Author(s):  
D. A. Basketter ◽  
E. W. Scholes ◽  
H. Wahlkvist ◽  
J. Montelius
Keyword(s):  
Positive Control ◽  
Control Skin ◽  
Skin Sensitizer

Efficacy and Safety of a Topically Applied Avène Spring Water Spray in the Healing of Facial Skin after Laser Resurfacing

2002 ◽  
Vol 28 (5) ◽  
pp. 415-418 ◽  
Author(s):  
L. SULIMOVIC ◽  
D. LICU ◽  
E. LEDO ◽  
J. M. NAEYAERT ◽  
P. PIGATTO ◽  
...  
Keyword(s):  
Spring Water ◽  
Water Spray ◽  
Efficacy And Safety ◽  
Facial Skin ◽  
Laser Resurfacing

scholarly journals A Nonimmunosuppressant Approach on Asia Psoriasis Subjects: 5-Year Followup and 11-Year Data Analysis

2012 ◽  
Vol 2012 ◽  
pp. 1-11
Author(s):  
Tony Yuqi Tang
Keyword(s):  
Severity Index ◽  
Adverse Event Reporting ◽  
Efficacy And Safety ◽  
Psoriasis Area Severity Index ◽  
Telephone Interviews ◽  
Liver Function Testing ◽  
Pasi Score ◽  
Psoriasis Lesion ◽  
Function Testing ◽  
Monthly Visit

Mono- or combine immunosuppressants are commonly used for psoriasis; however the side effect caused by potent systemic immunosuppressants frequently incurred; moreover the inflammation flares up shortly after immunosuppressants are discontinued. An alternative nonimmunosuppressive therapy was introduced to psoriasis subjects. A retrospective observational study consisted of 1583 psoriasis patients who were treated with Herose Psoria capsule 1440 mg three times daily at two clinical centres, one in China, the other in Singapore, from 1 January 2000 to 1 January 2011. Psoriasis lesion evolution was photographed at monthly visit, and efficacy and safety were assessed using psoriasis area severity index PASI score grading, renal and liver function testing, and adverse event reporting and supplemented by information obtained during targeted telephone interviews. The effectiveness of Herose on psoriasis was inversely associated to prior immunosuppressants exposure (r=0.9154), significant improvements occurred in non-immunosuppressants subjects, and complete clearance was achieved in 8 months (87.5%, 14 of 16); the wavelike evolution of psoriatic lesion appeared in prior immunosuppressants subjects.

scholarly journals Picosecond laser applications in aesthetic dermatology

2017 ◽  
Vol 2 (t1) ◽  
Author(s):  
Nasrin Saki
Keyword(s):  
Clinical Trials ◽  
Picosecond Laser ◽  
Efficacy And Safety ◽  
Laser Applications ◽  
Aesthetic Dermatology

<span lang="EN-US">Clinical trials have reported the efficacy and safety of PS lasers in the treatment of multicolored and recalcitrant tattoos.</span>

scholarly journals The Efficacy and Safety of Fecal Microbiota Transplant for Recurrent Clostridiumdifficile Infection: Current Understanding and Gap Analysis

2020 ◽  
Vol 7 (5) ◽  
Author(s):  
Mark H Wilcox ◽  
Barbara H McGovern ◽  
Gail A Hecht
Keyword(s):  
Gap Analysis ◽  
Treatment Guidelines ◽  
Current Knowledge ◽  
Fecal Microbiota ◽  
Adverse Event Reporting ◽  
Efficacy And Safety ◽  
Fecal Microbiota Transplant ◽  
Symptomatic Disease ◽  
Wide Range ◽  
Suppressive Antibiotic Therapy

Abstract The leading risk factor for Clostridioides (Clostridium) difficile infection (CDI) is broad-spectrum antibiotics, which lead to low microbial diversity, or dysbiosis. Current therapeutic strategies for CDI are insufficient, as they do not address the key role of the microbiome in preventing C. difficile spore germination into toxin-producing vegetative bacteria, which leads to symptomatic disease. Fecal microbiota transplant (FMT) appears to reduce the risk of recurrent CDI through microbiome restoration. However, a wide range of efficacy rates have been reported, and few placebo-controlled trials have been conducted, limiting our understanding of FMT efficacy and safety. We discuss the current knowledge gaps driven by questions around the quality and consistency of clinical trial results, patient selection, diagnostic methodologies, use of suppressive antibiotic therapy, and methods for adverse event reporting. We provide specific recommendations for future trial designs of FMT to provide improved quality of the clinical evidence to better inform treatment guidelines.

scholarly journals THE EFFICACY OF FRACTIONAL CO2 LASER WHEN COMBINED WITH PLATELET-RICH FIBRIN MEMBRANE FOR FACIAL REJUVENATION

2021 ◽  
pp. 1-3
Author(s):  
Vasim F Chauhan ◽  
Krina B Patel ◽  
Nitin S Vora
Keyword(s):  
Co2 Laser ◽  
Topical Application ◽  
Autologous Blood ◽  
Facial Rejuvenation ◽  
Efficacy And Safety ◽  
Platelet Rich Fibrin ◽  
Fractional Co2 Laser ◽  
Combined Use ◽  
Aesthetic Procedures ◽  
Fibrin Membrane

Background: Facial rejuvenation is different from other aesthetic procedures in that it directly restores a younger appearance in patients. Demand for a youthful and attractive appearance has increased recently and mass media have promoted the desire for beauty. Fractional-CO2 laser one of the most utilised modality for this purpose nowadays but there are few drawbacks of this method which can be reduced and efficacy can be increased by the addition of autologous blood components. Objectives: We evaluated the synergistic efficacy and safety of combined use of fractional-CO2 laser and topical application platelet-rich fibrin membrane for facial rejuvenation. Methodology: Total of 12 patients (M:5, F:7) was included in the study. All patients were treated once with fractional-CO2 laser followed by topical application of platelet-rich fibrin membrane application over face for 30 minutes. Patients were evaluated at baseline, one, four, and eight weeks after the session. Result: PRF when applied after fractional-CO2 laser showed additive effects on facial rejuvenation with lesser downtime.

scholarly journals Microalgae as a Sustainable, Natural-Oriented and Vegan Dermocosmetic Bioactive Ingredient: The Case of Neochloris oleoabundans

Cosmetics ◽  
2022 ◽  
Vol 9 (1) ◽  
pp. 9
Author(s):  
Ana Lucía Morocho-Jácome ◽  
Bruna Bertoloni dos Santos ◽  
João Carlos Monteiro de Carvalho ◽  
Tânia Santos de Almeida ◽  
Patrícia Rijo ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Natural Compound ◽  
Transepidermal Water Loss ◽  
Positive Control ◽  
Neochloris Oleoabundans ◽  
Healthy Male ◽  
In Vivo Experiments ◽  
Copolymer 1 ◽  
Strong Claim

“Vegan” and “sustainable” characteristics are strong claim trends behind the development of innovative skincare, fragrances, and makeup products. This created a need in the market for compliant ingredients. To date, there have been no records evidencing the use of the microalgae Neochloris oleoabundans (NA) in dermocosmetics. Therefore, we studied the applicability of such a natural compound in this context. NA was cultivated, and the scavenging activity (SA) of the NA extracts was evaluated. The highest SA was from the aqueous extract (54.8% ± 2.1%), being higher than that of the positive control. Two hydrogels were prepared with 1.0% ammonium acryloyldimethyltaurate/VP copolymer: (1) control gel; and (2) gel with a 1.0% NA aqueous extract. In vivo experiments were performed in healthy male and female volunteers with skin phototypes of II–IV. The stratum corneum (SC) hydration and the transepidermal water loss (TEWL) were measured in the forearm of participants to determine their biocompatibility. This parameter was determined by skin bioengineering measurements, confirming that SC hydration and TEWL were not affected by the samples. The laser Doppler measurements results showed a delayed erythema onset in the sites, where the NA hydrogel was applied. The results confirmed the biocompatibility and the anti-inflammatory activity of an innovative ingredient derived from microalgae suitable for a natural and vegan lifestyle.

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