scholarly journals Formula Development of Red Palm (Elaeis guineensis) Fruit Extract Loaded with Solid Lipid Nanoparticles Containing Creams and Its Anti-Aging Efficacy in Healthy Volunteers

Cosmetics ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 3
Author(s):  
Thipapun Plyduang ◽  
Apichart Atipairin ◽  
Attawadee Sae Yoon ◽  
Namfa Sermkaew ◽  
Pajaree Sakdiset ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Elaeis Guineensis ◽  
Lipid Nanoparticles ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Skin Texture ◽  
Fruit Extract ◽  
Solid Lipid ◽  
Melanin Index ◽  
Palm Fruits

Palm fruits (Elaeis guineensis) comprise antioxidants that can be used as skin care agents. This study developed a cosmeceutical cream containing E. guineensis extract, loaded with solid lipid nanoparticles (SLNs), and assessed its efficacy on female volunteers. The E. guineensis extract exhibited a good antioxidant activity with high levels of vitamin E, β-carotene, and palmitic acid. Day and night creams containing E. guineensis fruit extract, loaded with SLNs, were formulated and exhibited acceptable physical characteristics and good stability. Subsequently, their clinical efficacy and safety were evaluated on female volunteers. Both creams were non-irritating and had good cutaneous compatibility. Skin hydration, transepidermal water loss (TEWL), skin elasticity, melanin index, and skin texture were measured before and 30 min after the first application, as well as after 7, 14, and 30 days of daily application. A satisfactory survey was implemented using a questionnaire, and volunteer satisfaction scores were high for the product’s performance. Overall, the results showed that skin hydration, TEWL, cutaneous elasticity, and melanin index were improved, compared to the baseline data, after 30 days. Thus, the formulated facial day and night creams made the skin moist, reduced wrinkles, increased elasticity, and cleared the skin to the consumers’ satisfaction.

scholarly journals Preparation, characterization and evaluation of moisturizing and UV protecting effects of topical solid lipid nanoparticles

2012 ◽  
Vol 48 (4) ◽  
pp. 683-690 ◽  
Author(s):  
Shiva Golmohammadzadeh ◽  
Mohsen Mokhtari ◽  
Mahmoud Reza Jaafari
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Morphological Characteristics ◽  
Lipid Nanoparticles ◽  
Uv Protection ◽  
Skin Hydration ◽  
Full Potential ◽  
Solid Lipid ◽  
Significant Difference

Solid lipid nanoparticles (SLN) were recently proposed as carriers for various pharmaceutical and cosmetic actives. These lipid nanoparticles can act as moisturizers and physical sunscreens on their own. Therefore, the full potential of these carriers has yet to be determined. The present study was aimed to determine and compare moisturizing and UV-protecting effects of different solid lipid nanoparticles (SLN) prepared by different solid lipids including Glyceryl monostearate (GMS), Precirol® (P) and cetyl palmitate (CP) as carrier systems of moisturizers and sunscreens. The influence of the size and matrix crystallinity of the solid lipids on the occlusive factor, skin hydration and UV-protection were evaluated by in vitro and in vivo methods. The SLN were prepared by high-shear homogenization and ultrasound methods. Size, zeta potential and morphological characteristics of the samples were assessed by transmission electron microscopy (TEM) and thermotropic properties with differential scanning calorimetry (DSC) technique. Results of the assessments showed that SLN-CP significantly increases skin hydration and UV-protection, compared to SLN-GMS and SLN-P. It was demonstrated that the size of SLN, crystallinity index of solid lipid in SLN and probably other mechanisms besides the occlusive factor can influence skin hydration and UV-protection indices. Furthermore, findings of the assessments demonstrated significant difference between in vitro and in vivo assessments regarding occlusive factor and moisturizing effects. Findings of the present study indicate that the SLN-CP could be a promising carrier for sunscreens and moisturizers.

scholarly journals NANOSTRUCTURED LIPID CARRIERS: A PROMISING APPROACH FOR TOPICAL DRUG DELIVERY SYSTEM

2021 ◽  
Vol 6 (7) ◽  
pp. 81-101
Author(s):  
Nikam Supriya S. ◽  
Phadatare Priya P. ◽  
Watode Ankita B. ◽  
Kalyani Kayande
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Lipid Nanoparticles ◽  
Drug Loading ◽  
Lipid Nanoparticles ◽  
Local Effect ◽  
Nanostructured Lipid Carriers ◽  
Skin Hydration ◽  
Solid Lipid

Nanostructured lipid carriers (NLCs) are innovative pharmaceutical formulations made up of physiological and biocompatible lipids, as well as surfactants and co-surfactant. The initial generation of lipid nanoparticles was Solid Lipid Nanoparticles (SLN), which had a longer-lasting activity and was better, suited to drug penetration. The NLC is a second-generation lipid nanoparticle designed to alleviate the limitations of SLN, such as limited drug loading capacity and solid lipid polymorphism. Many benefits of topical medication delivery include avoiding first-pass metabolism, focusing active components for a local effect, and patient compliance. When compared to typical topical dose forms, nanoparticles have a greater effect in transporting medications through the skin. The structure, composition, many formulation methods, and characterization of NLCs are all important aspects in formulating a stable drug delivery system, as discussed in this review paper. A variety of approaches are used to make solid lipid nanoparticles and nanostructured lipid carriers, which are discussed in this paper. Lipid nanoparticles have a variety of features that make them suitable for topical usage in cosmetics and medicinal formulations. Because of extensive positive benefits such as skin hydration, skin occlusion, and skin targeting, NLCs have a significant potential in the pharmaceutical market. Skin hydration is important for API topical distribution because it hydrates the skin, which causes the pores to open. Trans epidermal water loss decreases due to the occlusion nature of lipid nanoparticles, softening the skin. It is more suited since it uses biodegradable grade lipid, which does not cause toxicity like polymeric Nano formulations. Actually, because of their biodegradable composition, NLCs are a “Nano safe” carrier that has a lot of potential for overcoming the obstacles of topical distribution.

Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles

2009 ◽  
Vol 00 (00) ◽  
pp. 090820062440031-9 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Mohsen Minayian ◽  
Elaheh Moazen
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Development and optimization of solid lipid nanoparticles of amikacin by central composite design

2009 ◽  
Vol 00 (00) ◽  
pp. 090721051030036-8
Author(s):  
Jaleh Varshosaz ◽  
Solmaz Ghaffari ◽  
Mohammad Reza Khoshayand ◽  
Fatemeh Atyabi ◽  
Shirzad Azarmi ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Central Composite

Solid lipid nanoparticles for oral delivery of curcumin

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
C Righeschi ◽  
M Bergonzi ◽  
B Isacchi ◽  
A Bilia
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

2009 ◽  
Vol 1 (1) ◽  
Author(s):  
Pravin Patil ◽  
Anil Sharma ◽  
Subhash Dadarwal ◽  
Vijay Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Solid Lipid Nanoparticles ◽  
Rotation Speed ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Brain Penetration ◽  
Solid Lipid ◽  
Diffusion Technique

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

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