scholarly journals Predicting the Future Distribution of Ara rubrogenys, an Endemic Endangered Bird Species of the Andes, Taking into Account Trophic Interactions

Diversity ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 94
Author(s):  
Alain Hambuckers ◽  
Simon de Harenne ◽  
Eberth Rocha Ledezma ◽  
Lilian Zúñiga Zeballos ◽  
Louis François
Keyword(s):  
Food Resource ◽  
Bird Species ◽  
Co2 Concentration ◽  
Distribution Models ◽  
Plant Resources ◽  
Term Survival ◽  
The Andes ◽  
Vegetation Models ◽  
Fertilizing Effect ◽  
The Impact

Species distribution models (SDMs) are commonly used with climate only to predict animal distribution changes. This approach however neglects the evolution of other components of the niche, like food resource availability. SDMs are also commonly used with plants. This also suffers limitations, notably an inability to capture the fertilizing effect of the rising CO2 concentration strengthening resilience to water stress. Alternatively, process-based dynamic vegetation models (DVMs) respond to CO2 concentration. To test the impact of the plant modelling method to model plant resources of animals, we studied the distribution of a Bolivian macaw, assuming that, under future climate, DVMs produce more conservative results than SDMs. We modelled the bird with an SDM driven by climate. For the plant, we used SDMs or a DVM. Under future climates, the macaw SDM showed increased probabilities of presence over the area of distribution and connected range extensions. For plants, SDMs did not forecast overall response. By contrast, the DVM produced increases of productivity, occupancy and diversity, also towards higher altitudes. The results offered positive perspectives for the macaw, more optimistic with the DVM than with the SDMs, than initially assumed. Nevertheless, major common threats remain, challenging the short-term survival of the macaw.

Agriculture in Southern Mediterranean areas under climate change: Impacts on irrigated wheat grain yield and irrigation requirements

2020 ◽  
Author(s):  
Bouras EL houssaine ◽  
Jarlan Lionel ◽  
Khabba Said ◽  
Er-Raki Salah ◽  
Dezetter Alain ◽  
...  
Keyword(s):  
Arable Land ◽  
Temporal Patterns ◽  
Co2 Concentration ◽  
Sowing Date ◽  
Phenological Stages ◽  
Water Requirements ◽  
Aquacrop Model ◽  
Southern Mediterranean ◽  
Fertilizing Effect ◽  
The Impact

<p>The southern Mediterranean regions are likely to face drastic climate changes (CC). Agricultural yields, particularly of cereals, could be severely affected, especially if significant changes occur at the key phenological stages. In addition, while agriculture is expected to meet around 83% of North African food demand by 2050, the increase in agricultural water requirements due to the intensification of practices, the extension of arable land and the expected warming could jeopardize the water supply of other key economic sectors. In this context, the present work aims to quantify the impact of CC on the grain yields of irrigated cereals and their water requirements in the Tensift-Haouz region of Morocco. The Med-CORDEX ensemble runs under scenarios RCP4.5 and RCP8.5 are first evaluated and disaggregated using the quantile-quantile approach. The impact of CC on the duration of the main wheat phenological stages based on the degree-day approach is then analysed by considering three typical sowing dates (early, around November 15th; intermediate, around December 15th; and late, around January, 15th). The results show that the rise in air temperature causes a shortening of the development cycle of up to 50 days (around 30%). The impacts of rising temperature, increasing atmospheric CO2 concentration and changes in precipitation on wheat yields are next evaluated, based on the AquaCrop model (previously calibrated on several plots of winter wheat in the region of study), both with and without taking into account the fertilizing effect of CO2. As expected, optimal wheat yields for all climate scenarios and time horizons will decrease on the order of 7 to 30% depending on the sowing date, if CO2 concentration rise is not considered. The results also show that the fertilizing effect of CO2 can counterbalance yield losses, since optimal yields could increase by 7% and 13% respectively at mid-century for the RCP4.5 and RCP8.5 scenarios. Finally, water requirements are expected to decrease by 13 to 42% depending on sowing date, scenario and horizon, mainly in response to the shortening of the cycle. This decrease is associated with a change in temporal patterns, with the requirement peak coming two months earlier than under current conditions. This study provides some quantitative elements for agricultural practices adaptation, in particular concerning the sowing date and also for water management in the south mediterranean region related to the temporal patterns of the crop water needs</p>

scholarly journals Endemic Juniperus Montane Species Facing Extinction Risk under Climate Change in Southwest China: Integrative Approach for Conservation Assessment and Prioritization

Biology ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 63
Author(s):  
Mohammed A. Dakhil ◽  
Marwa Waseem A. Halmy ◽  
Walaa A. Hassan ◽  
Ali El-Keblawy ◽  
Kaiwen Pan ◽  
...  
Keyword(s):  
Climate Change ◽  
Potential Distribution ◽  
Extinction Risk ◽  
In Situ Conservation ◽  
Integrative Approach ◽  
Conservation Assessment ◽  
Distribution Models ◽  
Area Of Occupancy ◽  
Annual Range ◽  
The Impact

Climate change is an important driver of biodiversity loss and extinction of endemic montane species. In China, three endemic Juniperus spp. (Juniperuspingii var. pingii, J.tibetica, and J.komarovii) are threatened and subjected to the risk of extinction. This study aimed to predict the potential distribution of these three Juniperus species under climate change and dispersal scenarios, to identify critical drivers explaining their potential distributions, to assess the extinction risk by estimating the loss percentage in their area of occupancy (AOO), and to identify priority areas for their conservation in China. We used ensemble modeling to evaluate the impact of climate change and project AOO. Our results revealed that the projected AOOs followed a similar trend in the three Juniperus species, which predicted an entire loss of their suitable habitats under both climate and dispersal scenarios. Temperature annual range and isothermality were the most critical key variables explaining the potential distribution of these three Juniperus species; they contribute by 16–56.1% and 20.4–38.3%, respectively. Accounting for the use of different thresholds provides a balanced approach for species distribution models’ applications in conservation assessment when the goal is to assess potential climatic suitability in new geographical areas. Therefore, south Sichuan and north Yunnan could be considered important priority conservation areas for in situ conservation and search for unknown populations of these three Juniperus species.

scholarly journals Chemotherapy Delays Are Associated with Inferior Outcome in Acute Lymphoblastic Leukemia: A Retrospective Study from a Tertiary Cancer Center in South India

2021 ◽  
Vol 42 (01) ◽  
pp. 051-060
Author(s):  
Vineet Agrawal ◽  
Smita Kayal ◽  
Prasanth Ganesan ◽  
Biswajit Dubashi
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Univariate Analysis ◽  
Cancer Center ◽  
Survival Outcomes ◽  
Separate Analysis ◽  
Term Survival ◽  
Free Survival ◽  
Intensive Phase ◽  
The Impact

Abstract Background Treatment protocols for acute lymphoblastic leukemia (ALL) have evolved over time to give excellent cure rates in children and moderate outcomes in adults; however, little is known how delays in chemotherapy affect long-term survival. Objectives To find the association of delays during different treatment phases on the survival outcomes. Materials and Methods Data from 149 ALL cases treated between 2009 and 2015 were retrospectively analyzed. Treatment course in commonly used protocols was divided into three phases—induction, consolidation (postremission), maintenance, and also a combined intensive phase (induction plus consolidation) for the purpose of analysis, and delay in each phase was defined based on clinically acceptable breaks. Analysis was done to find the impact of treatment delay in each phase on the survival outcomes. Results The median age was 12 years (range, 1–57). Multi-center Protocol-841 (MCP-841) was used for 72%, German Multicenter Study Group for Adult ALL (GMALL) for 19%, and Berlin, Frankfurt, Muenster, 95 protocol (BFM-95) for 9% of patients. Delay in induction was seen in 52%, consolidation in 66%, and during maintenance in 42% of patients. The median follow-up was 41 months, and 3-year survival outcomes for the entire cohort were event-free survival (EFS)—60%, relapse-free survival (RFS)—72%, and overall survival (OS)—68%. On univariate analysis, delay in induction adversely affected EFS (hazard ratio [HR] = 1.78, p = 0.04), while delay in intensive phase had significantly worse EFS and RFS (HR = 2.41 [p = 0.03] and HR = 2.57 [p = 0.03], respectively). On separate analysis of MCP-841 cohort, delay in intensive phase affected both EFS (HR = 3.85, p = 0.02) and RFS (HR = 3.42, p = 0.04), whereas delay in consolidation significantly affected OS with (HR = 4.74, p = 0.04) independently. Conclusion Treatment delays mostly in intensive phase are associated with worse survival in ALL; attempts should be made to maintain protocol-defined treatment intensity while adequately managing toxicities.

scholarly journals Effects of Climatic Conditions, Season and Environmental Factors on CO2 Concentrations in Naturally Ventilated Primary Schools in Chile

2021 ◽  
Vol 13 (8) ◽  
pp. 4139
Author(s):  
Muriel Diaz ◽  
Mario Cools ◽  
Maureen Trebilcock ◽  
Beatriz Piderit-Moreno ◽  
Shady Attia
Keyword(s):  
Air Quality ◽  
Indoor Air Quality ◽  
Indoor Air ◽  
Primary Schools ◽  
Co2 Concentration ◽  
Building Design ◽  
Climatic Conditions ◽  
Indoor Environmental Quality ◽  
Co2 Concentrations ◽  
The Impact

Between the ages of 6 and 18, children spend between 30 and 42 h a week at school, mostly indoors, where indoor environmental quality is usually deficient and does not favor learning. The difficulty of delivering indoor air quality (IAQ) in learning facilities is related to high occupancy rates and low interaction levels with windows. In non-industrialized countries, as in the cases presented, most classrooms have no mechanical ventilation, due to energy poverty and lack of normative requirements. This fact heavily impacts the indoor air quality and students’ learning outcomes. The aim of the paper is to identify the factors that determine acceptable CO2 concentrations. Therefore, it studies air quality in free-running and naturally ventilated primary schools in Chile, aiming to identify the impact of contextual, occupant, and building design factors, using CO2 concentration as a proxy for IAQ. The monitoring of CO2, temperature, and humidity revealed that indoor air CO2 concentration is above 1400 ppm most of the time, with peaks of 5000 ppm during the day, especially in winter. The statistical analysis indicates that CO2 is dependent on climate, seasonality, and indoor temperature, while it is independent of outside temperature in heated classrooms. The odds of having acceptable concentrations of CO2 are bigger when indoor temperatures are high, and there is a need to ventilate for cooling.

scholarly journals Alpha-Fetoprotein- and CD40Ligand-Expressing Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3375
Author(s):  
Annabelle Vogt ◽  
Farsaneh Sadeghlar ◽  
Tiyasha H. Ayub ◽  
Carlo Schneider ◽  
Christian Möhring ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cells ◽  
Dendritic Cells ◽  
Tumor Regression ◽  
Combined Therapy ◽  
Term Survival ◽  
Effector Cells ◽  
Tumor Environment ◽  
The Impact

Dendritic cells (DC) as professional antigen presenting cells are able to prime T-cells against the tumor-associated antigen α-fetoprotein (AFP) for immunotherapy of hepatocellular carcinoma (HCC). However, a strong immunosuppressive tumor environment limits their efficacy in patients. The co-stimulation with CD40Ligand (CD40L) is critical in the maturation of DC and T-cell priming. In this study, the impact of intratumoral (i.t.) CD40L-expressing DC to improve vaccination with murine (m)AFP-transduced DC (Ad-mAFP-DC) was analyzed in subcutaneous (s.c.) and orthotopic murine HCC. Murine DC were adenovirally transduced with Ad-mAFP or Ad-CD40L. Hepa129-mAFP-cells were injected into the right flank or the liver of C3H-mice to induce subcutaneous (s.c.) and orthotopic HCC. For treatments, 106 Ad-mAFP-transduced DC were inoculated s.c. followed by 106 CD40L-expressing DC injected intratumorally (i.t.). S.c. inoculation with Ad-mAFP-transduced DC, as vaccine, induced a delay of tumor-growth of AFP-positive HCC compared to controls. When s.c.-inoculation of Ad-mAFP-DC was combined with i.t.-application of Ad-CD40L-DC synergistic antitumoral effects were observed and complete remissions and long-term survival in 62% of tumor-bearing animals were achieved. Analysis of the tumor environment at different time points revealed that s.c.-vaccination with Ad-mAFP-DC seems to stimulate tumor-specific effector cells, allowing an earlier recruitment of effector T-cells and a Th1 shift within the tumors. After i.t. co-stimulation with Ad-CD40L-DC, production of Th1-cytokines was strongly increased and accompanied by a robust tumor infiltration of mature DC, activated CD4+-, CD8+-T-cells as well as reduction of regulatory T-cells. Moreover, Ad-CD40L-DC induced tumor cell apoptosis. Intratumoral co-stimulation with CD40L-expressing DC significantly improves vaccination with Ad-mAFP-DC in pre-established HCC in vivo. Combined therapy caused an early and strong Th1-shift in the tumor environment as well as higher tumor apoptosis, leading to synergistic tumor regression of HCC. Thus, CD40L co-stimulation represents a promising tool for improving DC-based immunotherapy of HCC.

scholarly journals Efficacy of Surgery for the Treatment of Gastric Cancer Liver Metastases: A Systematic Review of the Literature and Meta-Analysis of Prognostic Factors

2021 ◽  
Vol 10 (5) ◽  
pp. 1141
Author(s):  
Gianpaolo Marte ◽  
Andrea Tufo ◽  
Francesca Steccanella ◽  
Ester Marra ◽  
Piera Federico ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Prognostic Factors ◽  
Liver Metastases ◽  
Meta Analysis ◽  
Multidisciplinary Treatment ◽  
Review Of The Literature ◽  
Term Survival ◽  
The Impact

Background: In the last 10 years, the management of patients with gastric cancer liver metastases (GCLM) has changed from chemotherapy alone, towards a multidisciplinary treatment with liver surgery playing a leading role. The aim of this systematic review and meta-analysis is to assess the efficacy of hepatectomy for GCLM and to analyze the impact of related prognostic factors on long-term outcomes. Methods: The databases PubMed (Medline), EMBASE, and Google Scholar were searched for relevant articles from January 2010 to September 2020. We included prospective and retrospective studies that reported the outcomes after hepatectomy for GCLM. A systematic review of the literature and meta-analysis of prognostic factors was performed. Results: We included 40 studies, including 1573 participants who underwent hepatic resection for GCLM. Post-operative morbidity and 30-day mortality rates were 24.7% and 1.6%, respectively. One-year, 3-years, and 5-years overall survival (OS) were 72%, 37%, and 26%, respectively. The 1-year, 3-years, and 5-years disease-free survival (DFS) were 44%, 24%, and 22%, respectively. Well-moderately differentiated tumors, pT1–2 and pN0–1 adenocarcinoma, R0 resection, the presence of solitary metastasis, unilobar metastases, metachronous metastasis, and chemotherapy were all strongly positively associated to better OS and DFS. Conclusion: In the present study, we demonstrated that hepatectomy for GCLM is feasible and provides benefits in terms of long-term survival. Identification of patient subgroups that could benefit from surgical treatment is mandatory in a multidisciplinary setting.

scholarly journals How decisive is the number of distal arterial anastomoses in coronary bypass surgery?

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Olivier J. L. Jegaden ◽  
Fadi Farhat ◽  
Margaux P. O. Jegaden ◽  
Amar O. Hassan ◽  
Joel Lapeze ◽  
...  
Keyword(s):  
Arterial Graft ◽  
Complete Revascularization ◽  
Prognosis Factor ◽  
Arterial Grafts ◽  
Term Survival ◽  
Late Mortality ◽  
Vessel Disease ◽  
Diabetes Status ◽  
The Impact ◽  
Late Survival

Abstract Background The benefit of arterial revascularization in coronary surgery remains controversial. The incremental value of additional grafts to the left internal thoracic artery (ITA) has been mainly assessed according to the number of arterial grafts, possibly limiting the detection of its actual impact. We analyzed the influence of the number of distal arterial anastomoses (DAA) performed on late mortality in patients having received from one to three arterial grafts. Methods Retrospective review of 3685 primary isolated coronary artery bypass grafting (CABG) performed from 1989 to 2014 was conducted with a 13-year mean follow-up. One arterial graft (SITA) was used in 969 patients, two arterial grafts, ITA or gastroepiploic artery (GEA), in 1883 patients (BITA: 1644; SITA+GEA: 239), and three arterial grafts in 833 patients (BITA+GEA). Totally, 795 patients (22%) received one DAA, 1142 patients (31%) two, 1337 patients (36%) three, and 411 patients (11%) four or more. A sub-group analysis was done in the 2104 patients with 3-vessel disease who received at least 2 arterial grafts. Results In this series the early mortality was 1.6% and it was not influenced by the surgical technique. Late mortality was significantly influenced by age, gender, heart failure, LV ejection fraction, diabetes status, complete revascularization, number of arterial grafts, number of DAA, both ITA, sequential ITA graft, GEA graft. In multivariable analysis with Cox regression model, the number of DAA was the only technical significant independent prognosis factor of late survival (p < 0.0001), predominant over both ITA, complete revascularization and number of arterial grafts. The impact of the number of DAA on survival was found discriminant from 1 to 3; after 3 there was no more additional effect. In 3-vessel disease patients who received at least 2 arterial grafts, the number of DAA remained a significant independent prognosis factor of late survival (p < 0.0001). Conclusions The number of distal arterial anastomoses is an independent predictor of long-term survival, predominant over the number of arterial grafts and the completeness of the revascularization; higher the number, better the late survival. It is a strong support of the extensive use of arterial grafting in CABG.

scholarly journals Prey, management and landscape requirements of an endangered population of the Woodlark Lullula arborea in Southwest Germany

2021 ◽  
Author(s):  
Verena Rösch ◽  
Pascal Aloisio ◽  
Martin H. Entling
Keyword(s):  
Food Resource ◽  
Bird Species ◽  
Ground Cover ◽  
Main Food ◽  
Vegetation Height ◽  
Endangered Population ◽  
Rhine Valley ◽  
Territory Selection ◽  
Main Food Source ◽  
Upper Rhine

AbstractVineyards can be valuable habitats for biodiversity conservation. For example, in Rhineland-Palatinate (Germany) over a third of the state’s critically endangered Woodlark (Lullula arborea) population breeds in vineyards along the western margin of the Upper Rhine Valley. We here aim to elucidate how local ground cover management, food availability and the proximity to settlements affect territory selection by this bird species in the region. As climate, site conditions and management differ greatly from more continental or Mediterranean wine-growing areas, conditions for Woodlark conservation may differ as well.We compared 26 Woodlark territories in vineyards with 26 nearby reference areas from which Woodlarks were absent. We recorded vineyard ground cover in the inter-rows (% cover) as well as vegetation height and composition (forbs vs. grasses). Arthropods were sampled using pitfall traps, since they are the main food resource of Woodlarks during the breeding season. In addition, the distance to built-up areas was measured. The vegetation in Woodlark territories was shorter (mean 14.2 vs. 19.6 cm) and more dominated by forbs (39% vs. 27% cover) than in absence areas. The vegetation cover in the inter-rows had no effect on Woodlark territory presence or absence. Woodlarks also favoured areas with a higher abundance of arthropods (mean abundance 69.1 vs. 57.5) and a greater distance to built-up areas (mean distance 554 vs. 373 m). We conclude that to promote the Woodlark in wine-growing areas, short, forb-rich swards should be created, facilitating arthropod detectability. This is likely to require low levels of nitrogen fertilization since fertilizers favour tall-growing grasses that outcompete forbs. Pesticide applications should be kept at a minimum to enhance arthropods as the main food source for Woodlarks and their chicks. In addition, the expansion of settlements into breeding areas of Woodlarks should be avoided.

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