scholarly journals Conventional Machine Learning versus Deep Learning for Magnification Dependent Histopathological Breast Cancer Image Classification: A Comparative Study with Visual Explanation

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 528
Author(s):  
Said Boumaraf ◽  
Xiabi Liu ◽  
Yuchai Wan ◽  
Zhongshu Zheng ◽  
Chokri Ferkous ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Deep Learning ◽  
Large Scale ◽  
Binary Classification ◽  
Breast Cancer Diagnosis ◽  
Visual Interpretation ◽  
Support Tool ◽  
Histopathological Images ◽  
Conventional Machine

Breast cancer is a serious threat to women. Many machine learning-based computer-aided diagnosis (CAD) methods have been proposed for the early diagnosis of breast cancer based on histopathological images. Even though many such classification methods achieved high accuracy, many of them lack the explanation of the classification process. In this paper, we compare the performance of conventional machine learning (CML) against deep learning (DL)-based methods. We also provide a visual interpretation for the task of classifying breast cancer in histopathological images. For CML-based methods, we extract a set of handcrafted features using three feature extractors and fuse them to get image representation that would act as an input to train five classical classifiers. For DL-based methods, we adopt the transfer learning approach to the well-known VGG-19 deep learning architecture, where its pre-trained version on the large scale ImageNet, is block-wise fine-tuned on histopathological images. The evaluation of the proposed methods is carried out on the publicly available BreaKHis dataset for the magnification dependent classification of benign and malignant breast cancer and their eight sub-classes, and a further validation on KIMIA Path960, a magnification-free histopathological dataset with 20 image classes, is also performed. After providing the classification results of CML and DL methods, and to better explain the difference in the classification performance, we visualize the learned features. For the DL-based method, we intuitively visualize the areas of interest of the best fine-tuned deep neural networks using attention maps to explain the decision-making process and improve the clinical interpretability of the proposed models. The visual explanation can inherently improve the pathologist’s trust in automated DL methods as a credible and trustworthy support tool for breast cancer diagnosis. The achieved results show that DL methods outperform CML approaches where we reached an accuracy between 94.05% and 98.13% for the binary classification and between 76.77% and 88.95% for the eight-class classification, while for DL approaches, the accuracies range from 85.65% to 89.32% for the binary classification and from 63.55% to 69.69% for the eight-class classification.

scholarly journals Comparison of Deep-Learning and Conventional Machine-Learning Methods for the Automatic Recognition of the Hepatocellular Carcinoma Areas from Ultrasound Images

Sensors ◽  
2020 ◽  
Vol 20 (11) ◽  
pp. 3085 ◽  
Author(s):  
Raluca Brehar ◽  
Delia-Alexandrina Mitrea ◽  
Flaviu Vancea ◽  
Tiberiu Marita ◽  
Sergiu Nedevschi ◽  
...  
Keyword(s):  
Machine Learning ◽  
Hepatocellular Carcinoma ◽  
Deep Learning ◽  
Binary Classification ◽  
Classification Performance ◽  
Ultrasound Images ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Segmentation Accuracy ◽  
Conventional Machine

The emergence of deep-learning methods in different computer vision tasks has proved to offer increased detection, recognition or segmentation accuracy when large annotated image datasets are available. In the case of medical image processing and computer-aided diagnosis within ultrasound images, where the amount of available annotated data is smaller, a natural question arises: are deep-learning methods better than conventional machine-learning methods? How do the conventional machine-learning methods behave in comparison with deep-learning methods on the same dataset? Based on the study of various deep-learning architectures, a lightweight multi-resolution Convolutional Neural Network (CNN) architecture is proposed. It is suitable for differentiating, within ultrasound images, between the Hepatocellular Carcinoma (HCC), respectively the cirrhotic parenchyma (PAR) on which HCC had evolved. The proposed deep-learning model is compared with other CNN architectures that have been adapted by transfer learning for the ultrasound binary classification task, but also with conventional machine-learning (ML) solutions trained on textural features. The achieved results show that the deep-learning approach overcomes classical machine-learning solutions, by providing a higher classification performance.

Classification of Invasive Ductal Carcinoma from histopathology breast cancer images using Stacked Generalized Ensemble

2020 ◽  
pp. 1-16
Author(s):  
Deepika Kumar ◽  
Usha Batra
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Deep Learning ◽  
Invasive Ductal Carcinoma ◽  
Cancer Detection ◽  
Ductal Carcinoma ◽  
Machine Learning Algorithms ◽  
Diagnostic Methods ◽  
Learner Model ◽  
Histopathological Images

Breast cancer positions as the most well-known threat and the main source of malignant growth-related morbidity and mortality throughout the world. It is apical of all new cancer incidences analyzed among females. However, Machine learning algorithms have given rise to progress across different domains. There are various diagnostic methods available for cancer detection. However, cancer detection through histopathological images is considered to be more accurate. In this research, we have proposed the Stacked Generalized Ensemble (SGE) approach for breast cancer classification into Invasive Ductal Carcinoma+ and Invasive Ductal Carcinoma-. SGE is inspired by the stacking model which utilizes output predictions. Here, SGE uses six deep learning models as level-0 learner models or sub-models and Logistic regression is used as Level – 1 learner or meta – learner model. Invasive Ductal Carcinoma dataset for histopathology images is used for experimentation. The results of the proposed methodology have been compared and analyzed with existing machine learning and deep learning methods. The results demonstrate that the proposed methodology performed exponentially good in image classification in terms of accuracy, precision, recall, and F1 measure.

Design Model of Deep Stacking Network for Breast Cancer Prediction Using Microarray

2018 ◽  
Vol 24 (8) ◽  
pp. 6095-6096
Author(s):  
Nurul Hanifah ◽  
Ito Wasito ◽  
Boy Subiroso Sabarguna
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Deep Learning ◽  
Cancer Patients ◽  
Cancer Diagnosis ◽  
Microarray Dataset ◽  
Breast Cancer Diagnosis ◽  
Design Model ◽  
Complex Data ◽  
Microarray Technology

Breast cancer diagnosis currently relies on clinical information, image radiology and histopathology. However molecular biology aspect needs to be considered for accurate diagnoses. Microarray technology allows the analysis of thousands of gene expression to be used as additional information for breast cancer diagnosis. This study aims to use microarray for breast cancer diagnosis by using machine learning. Machine learning is widely used for pattern analysis and can be used for microarray dataset, such as deep stacking network (DSN). Design of DSN is stacked each of base module which using a simple form of the multilayer perceptron. Using DSN is suitable for complex data like microarray dataset because it has a deep architecture (deep learning). Furthermore, DSN model does not use stochastic gradient descent which is difficult to be implemented on large scale of machine learning. In Indonesia, microarray technology is still not well known, therefore the current studies only use secondary data from cancer patients overseas. DSN which is a deep learning model is suitable to be used for microarray dataset that has a complex structure. Suggested for subsequent study using primary data from patient cancer in Indonesia so that the design model will be more suitable to be implemented for cancer patients in Indonesia.

scholarly journals A Deep Learning Algorithm to Predict Hazardous Drinkers and the Severity of Alcohol-Related Problems Using K-NHANES

2021 ◽  
Vol 12 ◽  
Author(s):  
Suk-Young Kim ◽  
Taesung Park ◽  
Kwonyoung Kim ◽  
Jihoon Oh ◽  
Yoonjae Park ◽  
...  
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Large Scale ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Deep Learning Algorithm ◽  
Conventional Machine ◽  
Large Scale Survey ◽  
Alcohol Related Problems

Purpose: The number of patients with alcohol-related problems is steadily increasing. A large-scale survey of alcohol-related problems has been conducted. However, studies that predict hazardous drinkers and identify which factors contribute to the prediction are limited. Thus, the purpose of this study was to predict hazardous drinkers and the severity of alcohol-related problems of patients using a deep learning algorithm based on a large-scale survey data.Materials and Methods: Datasets of National Health and Nutrition Examination Survey of South Korea (K-NHANES), a nationally representative survey for the entire South Korean population, were used to train deep learning and conventional machine learning algorithms. Datasets from 69,187 and 45,672 participants were used to predict hazardous drinkers and the severity of alcohol-related problems, respectively. Based on the degree of contribution of each variable to deep learning, it was possible to determine which variable contributed significantly to the prediction of hazardous drinkers.Results: Deep learning showed the higher performance than conventional machine learning algorithms. It predicted hazardous drinkers with an AUC (Area under the receiver operating characteristic curve) of 0.870 (Logistic regression: 0.858, Linear SVM: 0.849, Random forest classifier: 0.810, K-nearest neighbors: 0.740). Among 325 variables for predicting hazardous drinkers, energy intake was a factor showing the greatest contribution to the prediction, followed by carbohydrate intake. Participants were classified into Zone I, Zone II, Zone III, and Zone IV based on the degree of alcohol-related problems, showing AUCs of 0.881, 0.774, 0.853, and 0.879, respectively.Conclusion: Hazardous drinking groups could be effectively predicted and individuals could be classified according to the degree of alcohol-related problems using a deep learning algorithm. This algorithm could be used to screen people who need treatment for alcohol-related problems among the general population or hospital visitors.

scholarly journals Histo-CADx: duo cascaded fusion stages for breast cancer diagnosis from histopathological images

2021 ◽  
Vol 7 ◽  
pp. e493
Author(s):  
Omneya Attallah ◽  
Fatma Anwar ◽  
Nagia M. Ghanem ◽  
Mohamed A. Ismail
Keyword(s):  
Breast Cancer ◽  
Deep Learning ◽  
Early Stage ◽  
Breast Cancer Diagnosis ◽  
Extraction Methods ◽  
Automatic Diagnosis ◽  
Multiple Classifier ◽  
Histopathological Images ◽  
Public Datasets ◽  
The Impact

Breast cancer (BC) is one of the most common types of cancer that affects females worldwide. It may lead to irreversible complications and even death due to late diagnosis and treatment. The pathological analysis is considered the gold standard for BC detection, but it is a challenging task. Automatic diagnosis of BC could reduce death rates, by creating a computer aided diagnosis (CADx) system capable of accurately identifying BC at an early stage and decreasing the time consumed by pathologists during examinations. This paper proposes a novel CADx system named Histo-CADx for the automatic diagnosis of BC. Most related studies were based on individual deep learning methods. Also, studies did not examine the influence of fusing features from multiple CNNs and handcrafted features. In addition, related studies did not investigate the best combination of fused features that influence the performance of the CADx. Therefore, Histo-CADx is based on two stages of fusion. The first fusion stage involves the investigation of the impact of fusing several deep learning (DL) techniques with handcrafted feature extraction methods using the auto-encoder DL method. This stage also examines and searches for a suitable set of fused features that could improve the performance of Histo-CADx. The second fusion stage constructs a multiple classifier system (MCS) for fusing outputs from three classifiers, to further improve the accuracy of the proposed Histo-CADx. The performance of Histo-CADx is evaluated using two public datasets; specifically, the BreakHis and the ICIAR 2018 datasets. The results from the analysis of both datasets verified that the two fusion stages of Histo-CADx successfully improved the accuracy of the CADx compared to CADx constructed with individual features. Furthermore, using the auto-encoder for the fusion process has reduced the computation cost of the system. Moreover, the results after the two fusion stages confirmed that Histo-CADx is reliable and has the capacity of classifying BC more accurately compared to other latest studies. Consequently, it can be used by pathologists to help them in the accurate diagnosis of BC. In addition, it can decrease the time and effort needed by medical experts during the examination.

scholarly journals Automatic freezing-tolerant rapeseed material recognition using UAV images and deep learning

Plant Methods ◽  
2022 ◽  
Vol 18 (1) ◽  
Author(s):  
Lili Li ◽  
Jiangwei Qiao ◽  
Jian Yao ◽  
Jie Li ◽  
Li Li
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Large Scale ◽  
Binary Classification ◽  
Field Investigation ◽  
Freezing Injury ◽  
Learning Networks ◽  
Material Recognition ◽  
Comparison Results ◽  
Uav Images

Abstract Background Freezing injury is a devastating yet common damage that occurs to winter rapeseed during the overwintering period which directly reduces the yield and causes heavy economic loss. Thus, it is an important and urgent task for crop breeders to find the freezing-tolerant rapeseed materials in the process of breeding. Existing large-scale freezing-tolerant rapeseed material recognition methods mainly rely on the field investigation conducted by the agricultural experts using some professional equipments. These methods are time-consuming, inefficient and laborious. In addition, the accuracy of these traditional methods depends heavily on the knowledge and experience of the experts. Methods To solve these problems of existing methods, we propose a low-cost freezing-tolerant rapeseed material recognition approach using deep learning and unmanned aerial vehicle (UAV) images captured by a consumer UAV. We formulate the problem of freezing-tolerant material recognition as a binary classification problem, which can be solved well using deep learning. The proposed method can automatically and efficiently recognize the freezing-tolerant rapeseed materials from a large number of crop candidates. To train the deep learning network, we first manually construct the real dataset using the UAV images of rapeseed materials captured by the DJI Phantom 4 Pro V2.0. Then, five classic deep learning networks (AlexNet, VGGNet16, ResNet18, ResNet50 and GoogLeNet) are selected to perform the freezing-tolerant rapeseed material recognition. Result and conclusion The accuracy of the five deep learning networks used in our work is all over 92%. Especially, ResNet50 provides the best accuracy (93.33$$\%$$ % ) in this task. In addition, we also compare deep learning networks with traditional machine learning methods. The comparison results show that the deep learning-based methods significantly outperform the traditional machine learning-based methods in our task. The experimental results show that it is feasible to recognize the freezing-tolerant rapeseed using UAV images and deep learning.

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