scholarly journals Simultaneously Monitoring Whole Corneal Injury with Corneal Optical Density and Thickness in Patients Undergoing Cataract Surgery

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1639
Author(s):  
Tzu-Han Hsieh ◽  
Hun-Ju Yu ◽  
I-Hui Yang ◽  
Ren-Wen Ho ◽  
Yu-Ting Hsiao ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cataract Surgery ◽  
Optical Density ◽  
Corneal Thickness ◽  
Average Density ◽  
Corneal Injury ◽  
Corneal Wound ◽  
Post Operation ◽  
Corneal Damage ◽  
Novel Method

To pursue the least corneal implication during cataract surgery, this study aimed to monitor corneal wound injury after cataract surgery with a novel method. The prospective cohort study involved thirty-two patients, who were assessed by a Scheimpflug tomography AxL® (Oculus GmbH, Wetzlar, Germany) via the following two kinds of indices: whole corneal optical density (COD) and corneal thickness (CT), two weeks before and one month after cataract surgery. The results of the COD revealed that corneal annuli 0.0–2.0 mm and 2.0–6.0 mm, and the average and maximal values at the incisional site significantly increased postoperatively. Also, the anterior and central stroma of 0.0–2.0 mm, and all three depths of 2.0–6.0 mm, increased remarkably after the operation. For the CT, all ranges of diameters plus incisional sites showed significant increases postoperatively. Furthermore, we analyzed the differences (delta) of COD and CT between pre- and post-operation, and found significant correlations between the delta of COD and the delta of CT, regarding annuli 0.0–2.0 mm, 2.0–6.0 mm, and 6.0–10.0 mm, but no correlation at the incisional site, with either average density or maximal density, was detected. We concluded that whole COD and CT, especially at the central zones of the cornea (annulus < 6 mm), are both valuable parameters in the assessment of corneal damage post-cataract surgery, and are independent indices at the incisional site.

scholarly journals Serp-1 change globally Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis

2021 ◽  
Vol 8 ◽  
Author(s):  
Brent Ju ◽  
Owen Guo ◽  
Dathe Z. Benissan-Messan ◽  
McKinley H. Shawver ◽  
Peng Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Cell ◽  
Serine Protease Inhibitor ◽  
High Morbidity ◽  
Cross Sectional ◽  
Corneal Wound Healing ◽  
Corneal Injury ◽  
Corneal Wound ◽  
Corneal Damage

Purpose: Chemical corneal injuries carry a high morbidity and commonly lead to visual impairment. Here, we investigate the role of Serp-1, a serine protease inhibitor, in corneal wound healing.Methods: An alkaline-induced corneal injury was induced in 14 mice. Following injury, five mice received daily topical saline application while nine mice received Serp-1 100 μL topically combined with a daily subcutaneous injection of 100 ng/gram body weight of Serp-1. Corneal damage was monitored daily through fluorescein staining and imaging. Cross sectional corneal H&amp;E staining were obtained. CD31 was used as marker for neovascularization.Results: Serp-1 facilitates corneal wound healing by reducing fibrosis and neovascularization while mitigating inflammatory cell infiltration with no noticeable harm related to its application.Conclusions: Serp-1 effectively mitigates inflammation, decreases fibrosis, and reduce neovascularization in a murine model of corneal injury without affecting other organs.Translational Relavence: Our study provides preclinical data for topical application of Serp-1 to treat corneal wounds.

Comparison of changes in blood pressure in phacoemulsification cataract surgery performed via topical and peribulbar anaesthesia: A cohort study

2021 ◽  
Author(s):  
Bhupinderpal Singh ◽  
Poninder Kumar ◽  
P.S. Moulick ◽  
Sandeep Shankar ◽  
Jaya Kaushik ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Cataract Surgery ◽  
Peribulbar Anaesthesia ◽  
Phacoemulsification Cataract Surgery

scholarly journals Time to recovery from cataract and its predictors among eye cataract patients treated with cataract surgery: A retrospective cohort study in Ethiopia

2021 ◽  
pp. 102275
Author(s):  
Asmare Mihret Beyene ◽  
Aragaw Eshetie ◽  
Yohannes Tadesse ◽  
Moges Gashaw Getnet
Keyword(s):  
Cohort Study ◽  
Cataract Surgery ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Cataract Patients

Gestational diabetes and the long-term risk of cataract surgery: A longitudinal cohort study

2017 ◽  
Vol 31 (11) ◽  
pp. 1565-1570 ◽  
Author(s):  
Nathalie Auger ◽  
Tina Tang ◽  
Jessica Healy-Profitós ◽  
Gilles Paradis
Keyword(s):  
Cohort Study ◽  
Gestational Diabetes ◽  
Cataract Surgery ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

Endophthalmitis Incidence of Cancer Patients After Cataract Surgery: A Nationwide Matched Cohort Study in Taiwan

2019 ◽  
Vol 199 ◽  
pp. 246-254 ◽  
Author(s):  
Chiun-Ho Hou ◽  
Jiahn-Shing Lee ◽  
Ken-Kuo Lin ◽  
Shu-Hao Chang ◽  
Wen-Kuan Huang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cataract Surgery ◽  
Cancer Patients ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Incidence Of Cancer

scholarly journals Fuchs endothelial corneal dystrophy and small eyes

2020 ◽  
Vol 17 (1) ◽  
pp. 35-40
Author(s):  
Nicole Shao-Yuen Lim ◽  
John Males
Keyword(s):  
Cohort Study ◽  
Outcome Measures ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Strong Association ◽  
Corneal Thickness ◽  
Anterior Chamber Depth ◽  
Corneal Dystrophy ◽  
T Test ◽  
Corneal Decompensation

Aim: To determine whether there is an association between Fuchs endothelial corneal dystrophy (FECD) and shorter axial length (AL), shallower anterior chamber depth (ACD) and higher spherical equivalent (SE). In addition, to evaluate whether there is a correlation between AL and severity of corneal decompensation in FECD, using corneal thickness as a proxy. Design: Retrospective cohort study. Methods: This was a single-centre study conducted in a cornea clinic in Sydney, Australia. Detailed clinical measurements of 91 eyes of 50 FECD patients were compared with 110 eyes of 55 controls. Main outcome measures included AL, ACD and SE. Other outcome measures included central corneal thickness, visual acuity, intraocular pressure and keratometry. Results: Mean AL of FECD patients was 23.6 mm (standard deviation [SD] ±0.9 mm), compared with 24.7 mm (SD ±1.8 mm) for controls (1.1 mm difference [95% confidence interval [CI] 0.5-1.6], p < 0.001, independent sample t-test); corresponding means for ACD were 3.0 and 3.3 mm (0.32 mm difference [95%CI 0.2-0.5], p < 0.001, independent t-test). Eleven out of the 22 FECD patients with available refraction data had hypermetropic refraction compared with 16 out of 36 controls (p = 0.68, chi-squared test). The mean SE of FECD patients (+0.10D) was higher than controls (−1.33D) (1.4D difference [0.1-2.8], p = 0.04, independent t-test). No statistically significant correlation was found between AL and corneal thickness (p = 0.28, linear regression). Conclusion: In this retrospective cohort study, a strong association was established between FECD and small eyes, with shorter AL and shallower ACD, compared with controls. These results have important implications for surgical planning, as shorter AL and ACD in FECD patients likely contribute to their high risk of corneal decompensation following cataract surgery.

scholarly journals Evaluation of Anterior Chamber Depth in 28,709 Adult Cataract Patients in China using Swept-Source Optical Biometry

2021 ◽  
Author(s):  
Qiong Lei ◽  
Haixia Tu ◽  
Xi Feng ◽  
Yong Wang
Keyword(s):  
Cataract Surgery ◽  
Anterior Chamber ◽  
Axial Length ◽  
Corneal Thickness ◽  
Anterior Chamber Depth ◽  
Multivariate Regression Analysis ◽  
Swept Source ◽  
Mean Values ◽  
The Mean ◽  
Cataract Patients

Abstract Background: To create an anterior chamber depth (ACD) regression model for adult cataract surgery candidates from China, and to evaluate the distribution of their ocular biometric parameters.Methods: The ocular biometric records of 28,709 right eyes of cataract surgery candidates who were treated at Aier Eye Hospitals in nine cities from 2018 to 2019 were retrospectively analyzed. All measurements were taken with IOLMaster 700. We included patients who were at least 40 years old and were diagnosed with cataract.Results: The mean age of the patients was 68.6 ± 11.0 years. The mean values recorded were as follows: axial length (AL), 24.17 ± 2.47 mm; mean keratometry (Km) value, 44.09 ± 3.25 D; corneal astigmatism (CA), 1.06 ± 0.98 D; ACD, 3.02 ± 0.45 mm; lens thickness (LT), 4.52 ± 0.45 mm; central corneal thickness (CCT), 0.534 ± 0.04 mm; and white to white (WTW) corneal diameter, 11.64 ± 0.46 mm. The proportion of patients with long axial length (AL >25 mm) decreased with age. ACD, LT, AL, Km, WTW, and age were correlated. In the multivariate regression analysis of ACD, which included LT, AL, WTW, sex, Km, CCT, and age, there was a reasonable prediction with adjusted R2 = 0.629.Conclusions: The results show that high myopes are inclined to schedule cataract surgery at a younger age. LT and AL were found to be important factors that affect ACD. This study provides reference data for cataract patients from China.

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