scholarly journals Predict Treatment Response by Magnetic Resonance Diffusion Weighted Imaging: A Preliminary Study on 46 Meningiomas Treated with Proton-Therapy

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1684
Author(s):  
Paola Feraco ◽  
Daniele Scartoni ◽  
Giulia Porretti ◽  
Riccardo Pertile ◽  
Davide Donner ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Treatment Response ◽  
Proton Therapy ◽  
Diffusion Weighted Imaging ◽  
Post Treatment ◽  
Wilcoxon Test ◽  
Growth Strategies ◽  
Diffusion Weighted ◽  
Pre Treatment ◽  
Predict Treatment Response

Objective: a considerable subgroup of meningiomas (MN) exhibit indolent and insidious growth. Strategies to detect earlier treatment responses based on tumour biology rather than on size can be useful. We aimed to characterize therapy-induced changes in the apparent diffusion coefficient (ADC) of MN treated with proton-therapy (PT), determining whether the pre- and early post-treatment ADC values may predict tumour response. Methods: Forty-four subjects with MN treated with PT were retrospectively enrolled. All patients underwent conventional magnetic resonance imaging (MRI) including diffusion-weighted imaging (DWI) at baseline and each 3 months for a follow-up period up to 36 months after the beginning of PT. Mean relative ADC (rADCm) values of 46 MN were measured at each exam. The volume variation percentage (VV) for each MN was calculated. The Wilcoxon test was used to assess the differences in rADCm values between pre-treatment and post-treatment exams. Patients were grouped in terms of VV (threshold −20%). A p < 0.05 was considered statistically significant for all the tests. Results: A significant progressive increase of rADCm values was detected at each time point when compared to baseline rADCm (p < 0.05). Subjects that showed higher pre-treatment rADCm values had no significant volume changes or showed volume increase, while subjects that showed a VV < −20% had significantly lower pre-treatment rADCm values. Higher and earlier rADCm increases (3 months) are related to greater volume reduction. Conclusion: In MN treated with PT, pre-treatment rADCm values and longitudinal rADCm changes may predict treatment response.

scholarly journals Potentialities of multi-b-values diffusion-weighted imaging for predicting efficacy of concurrent chemoradiotherapy in cervical cancer patients

2020 ◽  
Author(s):  
Bing Liu ◽  
Wan-Ling Ma ◽  
Guang-Wen Zhang ◽  
Zhen Sun ◽  
Meng-Qi Wei ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Diffusion Coefficient ◽  
Treatment Response ◽  
Cancer Patients ◽  
Diffusion Weighted Imaging ◽  
Concurrent Chemoradiotherapy ◽  
Poor Responders ◽  
B Values ◽  
Diffusion Weighted ◽  
Predict Treatment Response

Abstract Background: To testify whether multi-b-values diffusion-weighted imaging (DWI) can be used to ultra-early predict treatment response of concurrent chemoradiotherapy (CCRT) in cervical cancer patients and to assess the predictive ability of concerning parameters.Methods: Fifty-three patients with biopsy proved cervical cancer were retrospectively recruited in this study. All patients underwent pelvic multi-b-values DWI before and at the 3rd day during treatment. The apparent diffusion coefficient (ADC), true diffusion coefficient (Dslow), perfusion-related pseudo-diffusion coefficient (Dfast), perfusion fraction (f), distributed diffusion coefficient(DDC) and intravoxel diffusion heterogeneity index(α) were generated by mono-exponential, bi-exponential and stretched exponential models. Treatment response was assessed based on Response Evaluation Criteria in Solid Tumors (RECIST v1.1) at 1 month after the completion of whole CCRT. Parameters were compared using independent t test or Mann-Whitney U test as appropriate. Receiver operating characteristic (ROC) curves was used for statistical evaluations.Results: ADC-T0 (p=0.02), Dslow-T0 (p<0.01), DDC-T0 (p=0.03), ADC-T1 (p<0.01), Dslow-T1 (p<0.01), ΔADC (p=0.04) and Δα (p<0.01) were significant lower in non-CR group patients. ROC analyses showed that ADC-T1 and Δα exhibited high prediction value, with area under the curves of 0.880 and 0.869, respectively. Conclusions: Multi-b-values DWI can be used as a noninvasive technique to assess and predict treatment response in cervical cancer patients at the 3rd day of CCRT. ADC-T1 and Δα can be used to differentiate good responders from poor responders.

scholarly journals The role of magnetic resonance cholangiopancreatography and diffusion-weighted imaging for the differential diagnosis of obstructive biliary disorders

2017 ◽  
Vol 21 (1) ◽  
Author(s):  
Zeynep Cetiner-Alpay ◽  
Fatma Kulali ◽  
Aslihan Semiz-Oysu ◽  
Yasar Bukte ◽  
Kamil Ozdil
Keyword(s):  
Magnetic Resonance ◽  
Sensitivity And Specificity ◽  
Gold Standard ◽  
Diffusion Weighted Imaging ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Malignant Tumours ◽  
Diagnostic Efficacy ◽  
Diffusion Weighted ◽  
Sensitivity Specificity ◽  
And Diffusion

Background: Although endoscopic retrograde cholangiopancreatography (ERCP) is accepted as the gold standard, there is a place for magnetic resonance cholangiopancreatography (MRCP) and diffusion-weighted imaging (DWI) in the diagnosis of obstructive biliary disorders.Aim: To compare the findings of MRCP with ERCP in patients with obstructive biliary disorders and to investigate the diagnostic efficacy of MRCP combined with DWI.Study design: Retrospective, analytic, cross-sectional study.Methods: The MRCP images of 126 patients who underwent both MRCP and ERCP owing to biliary obstruction were reviewed. Nine patients were excluded because of incomplete diagnostic workup or a long period (>3 months) between MRCP and ERCP. Ninety-two patients underwent DWI, which was also evaluated. The sensitivity, specificity and accuracy of MRCP and DWI were analysed.Results: The sensitivity, specificity and accuracy of MRCP according to ERCP results as the gold standard was 97%, 71% and 93% for assessment of biliary dilatation; 100%, 94.7% and 97.5% for the diagnosis of choledocholithiasis; 93.7%, 100% and 99% for the identification of benign strictures; 100%, 100% and 100% for the diagnosis of malignant tumours; and 100%, 100% and 100% for the detection of complicated hydatid cysts; respectively. The sensitivity and specificity of DWI for the diagnosis of malignant tumour was 100%. In the detection of choledocholithiasis, the sensitivity and specificity of DWI was 70.8% and 100%.Conclusions: MRCP is an alternative, non-invasive, diagnostic modality, comparable with ERCP for the evaluation of pancreaticobiliary diseases. DWI can be helpful for diagnosis of choledocholithiasis and tumours.

Diffusion-weighted imaging and magnetic resonance proton spectroscopy following preterm birth

2014 ◽  
Vol 69 (8) ◽  
pp. 870-879 ◽  
Author(s):  
A.R. Hart ◽  
M.F. Smith ◽  
E.H. Whitby ◽  
S. Alladi ◽  
S. Wilkinson ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Magnetic Resonance ◽  
Diffusion Weighted Imaging ◽  
Proton Spectroscopy ◽  
Diffusion Weighted
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