Circulating miR-122-5p and miR-375 as Potential Biomarkers for Bone Mass Recovery after Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Proof-of-Concept Study

Primary hyperparathyroidism (PHPT) is the leading cause of secondary osteoporosis. Although bone mineral density (BMD) tends to recover after parathyroidectomy in PHPT patients, the degree of recovery varies. Circulating microRNAs (miRNAs) profiles are known to be correlated with osteoporosis and fracture. We aimed to investigate whether osteoporotic fracture-related miRNAs are associated with postoperative BMD recovery in PHPT. Here, 16 previously identified osteoporotic fracture-related miRNAs were selected. We analyzed the association between the preoperative level of each miRNA and total hip (TH) BMD change. All 12 patients (among the 18 patients enrolled) were cured of PHPT after parathyroidectomy as parathyroid hormone (PTH) and calcium levels were restored to the normal range. Preoperative miR-19b-3p, miR-122-5p, and miR-375 showed a negative association with the percent changes in TH BMD from baseline. The association remained robust for miR-122-5p and miR-375 even after adjusting for sex, age, PTH, and procollagen type 1 N-terminal propeptide levels in a multivariable model. In conclusion, preoperative circulating miR-122-5p and miR-375 levels were negatively associated with TH BMD changes after parathyroidectomy in PHPT patients. miRNAs have the potential to serve as predictive biomarkers of treatment response in PHPT patients, which merits further investigation.

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Anhuienoside C Ameliorates Osteoclast Differentiation in Ovariectomy-Induced Osteoporosis by Regulating RANKL/Wnt Signaling Pathways

Current Topics in Nutraceutical Research ◽

10.37290/ctnr2641-452x.20:51-55 ◽

2020 ◽

Vol 20 (1) ◽

pp. 51-55

Author(s):

Bo Sun ◽

Tian Su ◽

Zhibin Meng ◽

Songjie Tang

Keyword(s):

Side Effects ◽

Wnt Pathway ◽

Osteoclast Differentiation ◽

Mineral Density ◽

Beneficial Effects ◽

Procollagen Type ◽

Proinflammatory Mediators ◽

Mediators Of Inflammation ◽

Dose Dependent

Postmenopausal and ovariectomy-induced osteoporosis is the most common bone disorder. While pharmacotherapy has been valuable in the management of osteoporosis, it has been associated with undesired side effects. Plant bioactives with minimal side effects have been seen as adjunct to classical therapy. Herein, we have evaluated the protective effect of anhuienoside C (AC) in a rat model of ovariectomy-induced osteoporosis. The treatment of osteoporotic rats with AC caused dose-dependent favorable changes in biochemical markers of bone formation and metabolism (osteocalcin, C-telopeptide of type 1 collagen, and procollagen type 1 N-terminal propeptide), enhanced bone mineral density, and decrease in proinflammatory mediators of inflammation and RANKL/Wnt pathway proteins. Furthermore, histopathologic changes in the tibia support beneficial effects of AC. In conclusion, our result reveals that treatment with AC shows beneficial effect against ovariectomy-induced osteoporosis by regulating the RANKL/Wnt pathway.

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Bone mineral density analysis in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 after total parathyroidectomy

Clinical Endocrinology ◽

10.1111/j.1365-2265.2009.03672.x ◽

2010 ◽

Vol 72 (4) ◽

pp. 462-468 ◽

Cited By ~ 14

Author(s):

Flavia L. Coutinho ◽

Delmar M. Lourenço Jr ◽

Rodrigo A. Toledo ◽

Fabio L. M. Montenegro ◽

Joya E. M. Correia-Deur ◽

...

Keyword(s):

Bone Mineral Density ◽

Primary Hyperparathyroidism ◽

Bone Mineral ◽

Multiple Endocrine Neoplasia ◽

Multiple Endocrine Neoplasia Type ◽

Total Parathyroidectomy ◽

Mineral Density ◽

Endocrine Neoplasia ◽

Density Analysis

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Dietary calcium intake and rate of bone loss in men

British Journal Of Nutrition ◽

10.1017/s0007114517001301 ◽

2017 ◽

Vol 117 (10) ◽

pp. 1432-1438 ◽

Cited By ~ 10

Author(s):

Sarah M. Bristow ◽

Gregory D. Gamble ◽

Anne M. Horne ◽

Ian R. Reid

Keyword(s):

Bone Loss ◽

Bone Turnover ◽

Dietary Calcium Intake ◽

Osteoporosis Prevention ◽

Mineral Density ◽

Procollagen Type ◽

Markers Of Bone Turnover ◽

Total Body ◽

The Relationship

AbstractA high Ca intake has been recommended for osteoporosis prevention; however, little research has examined the relationship between dietary Ca and bone health in men. We examined associations between dietary Ca intake, bone mineral density (BMD) and change in BMD at the total body, hip and spine over 2 years in a cohort of men (mean age 57 years, BMI 26 kg/m2) from a trial. Data from the total cohort (n 323) were used in the analysis of Ca intake and BMD at baseline, and data from the placebo group (n 99) were used in the longitudinal analysis of Ca intake and change in BMD. Parathyroid hormone (PTH) and the markers of bone turnover serum total alkaline phosphatase activity, serum C-telopeptide and serum procollagen type-1 N-terminal propeptide were measured in a subset of participants at baseline (n 150), and associations with dietary Ca at baseline were examined. Mean Ca intake was 870 mg/d. Baseline BMD was not related to dietary Ca intake at any site, before or after adjustment for covariables. Similarly, bone loss over 2 years was not related to Ca intake at any site, before or after adjustment. Dietary Ca intake was inversely correlated with PTH at baseline (r −0·19, P=0·02), but was not associated with the markers of bone turnover. BMD and rates of bone loss were unrelated to Ca intake in these men. This suggests that strategies to increase Ca intake are unlikely to impact on the prevalence of and morbidity from male osteoporosis.

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Exploring the Relationship of Bone Turnover Markers and Bone Mineral Density in Community-Dwelling Postmenopausal Women

Disease Markers ◽

10.1155/2021/6690095 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Xu Wei ◽

Yili Zhang ◽

Xinghua Xiang ◽

Menghua Sun ◽

Kai Sun ◽

...

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Area Under The Curve ◽

Community Dwelling ◽

Mineral Density ◽

Procollagen Type ◽

Turnover Markers ◽

High Level

Aims. To explore the relationships of procollagen type 1 N-terminal propeptide (P1NP) and β cross-linked C-telopeptide of type 1 collagen (β-CTX) with bone mineral density (BMD) in postmenopausal women. Methods. All postmenopausal women were selected from a community-based case-control study. The anteroposterior L1-L4 and left proximal femur BMD were measured. P1NP and β-CTX were also collected and tested. The main correlation analysis was applied to explore the relationships of BMD, P1NP, and β-CTX. Results. The total 1055 postmenopausal women were enrolled. The BMD at all sites kept a decrease continually with age ( P < 0.01 ). In addition, the level of β-CTX increased significantly from 45 to 50 years old and remained at a high level in the later stage, while the level of P1NP changed little or even decreased with age. Logistic regression model showed that β-CTX has better ability to predict BMD than P1NP, as demonstrated by an area under the curve (AUC) of 0.63. Conclusion. P1NP and β-CTX are important markers to monitor bone metabolism. This trial is registered with ChiCTR-SOC-17013090. The date of registration is Oct. 23, 2017.

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Postoperative Zoledronic Acid for Osteoporosis in Primary Hyperparathyroidism: a Randomized Placebo-controlled Study

Acta Endocrinologica ◽

10.1530/eje-21-0322 ◽

2021 ◽

Author(s):

E M Ryhänen ◽

A M Koski ◽

Eliisa Löyttyniemi ◽

M J Valimaki ◽

Ulla Kiviniemi ◽

...

Keyword(s):

Lumbar Spine ◽

Zoledronic Acid ◽

Femoral Neck ◽

Primary Hyperparathyroidism ◽

Bone Turnover ◽

Bone Turnover Markers ◽

Controlled Study ◽

Mineral Density ◽

Turnover Markers

Objective: In primary hyperparathyroidism (PHPT) with osteoporosis, bone mineral density (BMD) improves after parathyroidectomy. It is unclear whether combining surgery with postoperative bisphosphonate treatment can further improve bone health. Design: This randomized, placebo-controlled study compared the effects of surgery alone and surgery combined with zoledronic acid on bone metabolism in PHPT with osteoporosis. Methods: Fifty-six patients (f/m 47/9, mean age 68.4 years) with PHPT and osteoporosis were randomized 1–3 months after parathyroidectomy to receive a two-year treatment of zoledronic acid or placebo. Dual-energy X-ray absorptiometry (DXA) and bone turnover markers (N-terminal propeptide of type 1 procollagen, C-terminal telopeptide of type 1 collagen, and alkaline phosphatase) were measured annually during the 2-year follow-up. Results: Two years after parathyroidectomy, BMD was significantly higher in the zoledronic acid (ZOL) group compared with the placebo (PBO) group at the femoral neck (P = 0.045 for Z-score) and lumbar spine (P = 0.039 and 0.017 for T- and Z-scores, respectively). Bone turnover markers were significantly lower in the ZOL group (P < 0.001 for all markers). Of the 18 patients who had received bisphosphonates for >1 year before surgery, BMD improved significantly in the ZOL group both in the femoral neck and lumbar spine (N = 10; all P < 0.001–0.01) but in the PBO group only in the lumbar spine (N = 8, P = 0.03), (P= 0.08-0.95 for between-group changes). Conclusion: BMD increases after parathyroidectomy both with and without zoledronic acid but the increase is significantly higher with postoperative zoledronic acid.

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