scholarly journals Acoustic Location of Bragg Peak for Hadrontherapy Monitoring

Proceedings ◽  
2018 ◽  
Vol 4 (1) ◽  
pp. 6
Author(s):  
Jorge Otero ◽  
Miguel Ardid ◽  
Ivan Felis ◽  
Alicia Herrero
Keyword(s):  
Energy Deposition ◽  
Bragg Peak ◽  
Heavy Particle ◽  
Patient Positioning ◽  
Spot Size ◽  
Simulation Studies ◽  
Acoustic Localization ◽  
Acoustic Technologies ◽  
High Doses ◽  
Anatomical Parameters

Hadrontherapy makes it possible to deliver high doses of energy to cancerous tumors by using the large energy deposition in the Bragg-peak. However, uncertainties in the patient positioning and or in the anatomical parameters can cause distortions in the calculation of the dose distribution. In order to maximize the effectiveness of heavy particle treatments, an accurate monitoring system of the deposited dose depending on the energy, the beam time, and the spot size is necessary. The localized deposition of this energy leads to the generation of a thermoacoustic pulse that can be detected using acoustic technologies. This article presents different experimental and simulation studies of the acoustic localization of thermoacoustic pulses by generating similar signals that have been captured with a set of sensors around the samples. In addition, numerical simulations have been done where thermoacoustic pulses are emitted for the specific case of a proton beam of 100 MeV.

scholarly journals Acoustic Localization of Bragg Peak Proton Beams for Hadrontherapy Monitoring

Sensors ◽  
2019 ◽  
Vol 19 (9) ◽  
pp. 1971 ◽  
Author(s):  
Otero ◽  
Felis ◽  
Ardid ◽  
Herrero
Keyword(s):  
Bragg Peak ◽  
Heavy Particle ◽  
Patient Positioning ◽  
Spot Size ◽  
Simulation Studies ◽  
Acoustic Localization ◽  
Energy Beam ◽  
Acoustic Technologies ◽  
High Doses ◽  
Anatomical Parameters

Hadrontherapy makes it possible to deliver high doses of energy to cancerous tumors by using the large energy deposition in the Bragg-peak. However, uncertainties in the patient positioning and/or in the anatomical parameters can cause distortions in the calculation of the dose distribution. In order to maximize the effectiveness of heavy particle treatments, an accurate monitoring system of the deposited dose depending on the energy, beam time, and spot size is necessary. The localized deposition of this energy leads to the generation of a thermoacoustic pulse that can be detected using acoustic technologies. This article presents different experimental and simulation studies of the acoustic localization of thermoacoustic pulses captured with a set of sensors around the sample. In addition, numerical simulations have been done where thermo-acoustic pulses are emitted for the specific case of a proton beam of 100 MeV.

scholarly journals Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment

Sensors ◽  
2020 ◽  
Vol 20 (10) ◽  
pp. 2987
Author(s):  
Jorge Otero ◽  
Ivan Felis ◽  
Alicia Herrero ◽  
José A. Merchán ◽  
Miguel Ardid
Keyword(s):  
Energy Deposition ◽  
Sound Pressure ◽  
Bragg Peak ◽  
Local Heating ◽  
Piezoelectric Sensors ◽  
Thermal Source ◽  
Acoustic Beam ◽  
Beam Monitoring ◽  
The Brain ◽  
Therapy Treatment

A full chain simulation of the acoustic hadrontherapy monitoring for brain tumours is presented in this work. For the study, a proton beam of 100 MeV is considered. In the first stage, Geant4 is used to simulate the energy deposition and to study the behaviour of the Bragg peak. The energy deposition in the medium produces local heating that can be considered instantaneous with respect to the hydrodynamic time scale producing a sound pressure wave. The resulting thermoacoustic signal has been subsequently obtained by solving the thermoacoustic equation. The acoustic propagation has been simulated by FEM methods in the brain and the skull, where a set of piezoelectric sensors are placed. Last, the final received signals in the sensors have been processed in order to reconstruct the position of the thermal source and, thus, to determine the feasibility and accuracy of acoustic beam monitoring in hadrontherapy.

scholarly journals Geometrical Parametrization of Piezoelectric Sensors for Acoustical Monitoring in Hadrontherapy

Proceedings ◽  
2019 ◽  
Vol 42 (1) ◽  
pp. 73
Author(s):  
Jorge Otero ◽  
Ivan Felis
Keyword(s):  
Gamma Rays ◽  
Energy Deposition ◽  
Piezoelectric Sensors ◽  
Surrounding Tissue ◽  
Signal Frequency ◽  
Heavy Particles ◽  
Numerical Studies ◽  
Acoustic Technologies ◽  
Acoustical Monitoring ◽  
Hadron Beam

Hadrontherapy has been constantly evolving in leaps and bounds since the 1950s, when the use of heavy particles was proposed as an alternative treatment to radiotherapy with gamma rays or electrons. The main objective of this treatment is to maximize the dose applied to the tumour, avoiding damage to the surrounding tissue. One of the keys to the success of hadrontherapy is to achieve instantaneous monitoring of the energy deposition in the environment. Since energy deposition leads to the generation of a thermoacoustic pulse, acoustic technologies have been tested with successful results. However, for this purpose, it is essential to increase the sensitivity of the sensors for the acoustical signal and, therefore, to optimize their geometry as a function of the beam that would be used. We have studied a PTZ material in volumetric and surface volumes through experimental measures and FEM methods. In this text, we start with numerical studies which determine the dependence of the thermoacoustic signal frequency with the energy and duration of the hadron beam.

Monte Carlo simulation and analysis of proton energy-deposition patterns in the Bragg peak

2008 ◽  
Vol 53 (11) ◽  
pp. 2857-2875 ◽  
Author(s):  
Gloria González-Muñoz ◽  
Nina Tilly ◽  
José M Fernández-Varea ◽  
Anders Ahnesjö
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Proton Energy ◽  
Energy Deposition ◽  
Bragg Peak ◽  
Deposition Patterns

scholarly journals Robotic Systems in Radiotherapy and Radiosurgery

2022 ◽  
Author(s):  
Stefan Gerlach ◽  
Alexander Schlaefer
Keyword(s):  
Medical Devices ◽  
Patient Positioning ◽  
Target Motion ◽  
Robotic Systems ◽  
Beam Source ◽  
Target Region ◽  
Safe Delivery ◽  
Research Context ◽  
Research Systems ◽  
High Doses

Abstract Purpose of Review This review provides an overview of robotic systems in radiotherapy and radiosurgery, with a focus on medical devices and recently proposed research systems. We summarize the key motivation for using robotic systems and illustrate the potential advantages. Recent Findings. Robotic systems have been proposed for a variety of tasks in radiotherapy, including the positioning of beam source, patients, and imaging devices. A number of systems are cleared for use in patients, and some are widely used, particularly for beam and patient positioning. Summary The need for precise and safe delivery of focused high doses to the target region motivates the use of robots in radiotherapy. Flexibility in the arrangement of beams and the ability to compensate for target motion are key advantages of robotic systems. While robotic patient couches are widely used and robotic beam positioning is well established, brachytherapy robots are mostly considered in a research context.

scholarly journals On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Taisuke Takayanagi ◽  
Tomoki Uesaka ◽  
Yuta Nakamura ◽  
Mehmet Burcin Unlu ◽  
Yasutoshi Kuriyama ◽  
...  
Keyword(s):  
Resonant Frequency ◽  
Proton Beam ◽  
Patient Positioning ◽  
Proton Beam Therapy ◽  
Simulation Studies ◽  
Clinical Dose ◽  
On Line ◽  
Verification Methodology ◽  
Beam Range ◽  
Range Verification

AbstractIn contrast to conventional X-ray therapy, proton beam therapy (PBT) can confine radiation doses to tumours because of the presence of the Bragg peak. However, the precision of the treatment is currently limited by the uncertainty in the beam range. Recently, a unique range verification methodology has been proposed based on simulation studies that exploit spherical ionoacoustic waves with resonant frequency (SPIREs). SPIREs are emitted from spherical gold markers in tumours initially introduced for accurate patient positioning when the proton beam is injected. These waves have a remarkable property: their amplitude is linearly correlated with the residual beam range at the marker position. Here, we present proof-of-principle experiments using short-pulsed proton beams at the clinical dose to demonstrate the feasibility of using SPIREs for beam-range verification with submillimetre accuracy. These results should substantially contribute to reducing the range uncertainty in future PBT applications.

Ionoacoustics: A new direct method for range verification

2015 ◽  
Vol 30 (17) ◽  
pp. 1540025 ◽  
Author(s):  
Katia Parodi ◽  
Walter Assmann
Keyword(s):  
Bragg Peak ◽  
Direct Method ◽  
Organs At Risk ◽  
Ion Beam ◽  
Patient Positioning ◽  
Nuclear Interaction ◽  
Ion Beams ◽  
Verification Techniques ◽  
Range Verification

The superior ballistic properties of ion beams may offer improved tumor-dose conformality and unprecedented sparing of organs at risk in comparison to other radiation modalities in external radiotherapy. However, these advantages come at the expense of increased sensitivity to uncertainties in the actual treatment delivery, resulting from inaccuracies of patient positioning, physiological motion and uncertainties in the knowledge of the ion range in living tissue. In particular, the dosimetric selectivity of ion beams depends on the longitudinal location of the Bragg peak, making in vivo knowledge of the actual beam range the greatest challenge to full clinical exploitation of ion therapy. Nowadays, in vivo range verification techniques, which are already, or close to, being investigated in the clinical practice, rely on the detection of the secondary annihilation photons or prompt gammas, resulting from nuclear interaction of the primary ion beam with the irradiated tissue. Despite the initial promising results, these methods utilize a not straightforward correlation between nuclear and electromagnetic processes, and typically require massive and costly instrumentation. On the contrary, the long-term known, yet only recently revisited process of "ionoacoustics", which is generated by local tissue heating especially at the Bragg peak, may offer a more direct approach to in vivo range verification, as reviewed here.

scholarly journals Acoustic Bragg Peak Localization in Proton Therapy Treatment: Simulation Studies

Proceedings ◽  
2019 ◽  
Vol 42 (1) ◽  
pp. 71
Author(s):  
Jorge Otero ◽  
Ivan Felis ◽  
Miguel Ardid ◽  
Alicia Herrero ◽  
José A. Merchán
Keyword(s):  
Energy Deposition ◽  
Bragg Peak ◽  
Local Heating ◽  
Therapy Monitoring ◽  
Thermal Source ◽  
The Finite Element Method ◽  
Hadron Therapy ◽  
Beam Monitoring ◽  
The Brain ◽  
Therapy Treatment

A full chain simulation of the acoustic hadron therapy monitoring for brain tumors is presented in this work. For the study, a proton beam of 100 MeV was considered. In the first stage, Geant4 was used to simulate the energy deposition and to study the behavior of the Bragg peak. The energy deposition in the medium produced local heating that can be considered instantaneous with respect to the hydrodynamic time scale producing a sound pressure wave. The resulting thermoacoustic signal was subsequently obtained by solving the thermoacoustic equation. The acoustic propagation was simulated by the Finite Element Method (FEM) in the brain and the skull, where a set of piezoelectric sensors were placed. Lastly, the final received signals in the sensors were processed in order to reconstruct the position of the thermal source and, thus, to determine the feasibility and accuracy of acoustic beam monitoring in hadron therapy.

Sign in / Sign up

Export Citation Format

Share Document