scholarly journals Risk Factors and Prediction of Leptospiral Seropositivity Among Dogs and Dog Handlers in Malaysia

2019 ◽  
Vol 16 (9) ◽  
pp. 1499 ◽  
Author(s):  
Soon Heng Goh ◽  
Rosnah Ismail ◽  
Seng Fong Lau ◽  
Puteri Azaziah Megat Abdul Rani ◽  
Taznim Begam Mohd Mohidin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Small Mammal ◽  
Potential Risk ◽  
Contact Time ◽  
Agglutination Test ◽  
Housing Area ◽  
Common Area ◽  
Potential Risk Factors

This study determined the potential risk factors that may contribute to seropositivity among dogs and dog handlers from working dog and dog shelter institutions. Data was collected from dogs (n = 266) and dog handlers (n = 161) using a standardised guided questionnaire. Serum obtained from the dogs and dog handlers was tested using the microscopic agglutination test (MAT). A logistic regression analysis was used to predict leptospiral seropositivity of dogs and dog handlers based on potential risk factors. A total of 22.2% of dogs and 21.7% of dog handlers were seropositive. The significant predictors for the dogs’ seropositivity were presence of rats (OR = 4.61 (95% CI: 1.05, 20.33), p = 0.043) and shared common area (OR = 5.12 (95% CI: 1.94, 13.46), p = 0.001) within the organisation. Significant predictor for dog handler seropositivity was contact time with the dogs of more than six hours/day (OR = 3.28 (95% CI: 1.28, 8.40), p = 0.013) after controlling for the effect of other risk factors such as small mammal contact, rat infestation at home, flooding at housing area (within three months) and urban locality. The exposure to various disease sources identified poses risk to dogs and dog handlers. Risk could be reduced with adequate application of protection at work while handling dogs and thus limiting contact with these sources and reducing exposure to infection.

scholarly journals 1650. Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S812-S813
Author(s):  
Yaxu Liu ◽  
Lifan Zhang ◽  
Ziyue Zhou ◽  
Luxi Sun ◽  
Baotong Zhou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Weight Loss ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Potential Risk ◽  
Behcet’S Disease ◽  
Active Tuberculosis ◽  
Unexplained Weight Loss ◽  
Potential Risk Factors

Abstract Background Understanding the clinical characteristics and risk factors of active tuberculosis (ATB) in Behçet’s disease (BD) is of great significance to improve the treatment efficacy and guide the preventive treatment. However, the relevant studies are very limited. Methods We retrospectively reviewed medical records of BD patients admitted to our institute from 2010 to 2019. BD patients with ATB were enrolled as the case group, and the control group was selected by random number sampling from the remaining BD patients. Multivariate logistic regression analysis was performed to explore the potential risk factors of ATB in BD patients. Figure 1. Flowchart of the study Results Twenty-one ATB cases were identified from 386 BD patients, including four (19.0%) microbiologically confirmed and 17 (81.0%) clinically diagnosed. ATB patients can present with systemic symptoms (fever, night sweating, unexplained weight loss) and/or symptoms related to the infection site. Logistic regression analysis revealed that ESR>60mm/h (OR=13.710, 95%CI (1.101, 170.702)), increased IgG (OR=1.226, 95%CI (1.001, 1.502)), and positive T-SPOT.TB (OR=7.793, 95%CI (1.312, 48.464), for 24-200 SFC/106PBMC; OR=17.705 (2.503, 125.260), for >200 SFC/106PBMC) were potential risk factors for ATB in BD patients. Table 1. Past medical history and medication of BD patients with and without ATB Table 2. Clinical presentation and laboratory results of BD patients with and without ATB Table 3. Potential risk factors for ATB in BD patients Conclusion When BD patients have fever, night sweating, unexplained weight loss, or manifestations rarely occurred in BD, the diagnosis of ATB should be considered. Significantly elevated T-SPOT.TB indicates a high risk of ATB in BD patients. Disclosures All Authors: No reported disclosures

Clinical features of and risk factors for intracranial aneurysms associated with moyamoya disease

2020 ◽  
pp. 174749302096722
Author(s):  
Hecheng Yang ◽  
Limin Zhang ◽  
Menghan Wang ◽  
Jingtao Wang ◽  
Lijie Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Clinical Features ◽  
Moyamoya Disease ◽  
Logistic Regression Analysis ◽  
Potential Risk ◽  
Intracranial Aneurysms ◽  
Age Of Onset ◽  
Potential Risk Factors

Background The clinical features of aneurysms associated with moyamoya disease (MMD) and risk factors for the formation and rupture of aneurysms are not well defined. Aims In this study, we retrospectively analyzed clinical data of MMD patients and examined the potential risk factors for the formation and rupture of aneurysms in these patients. Methods The medical records of all MMD patients in our hospital from April 2012 to May 2019 were reviewed. The logistic regression analysis was used to determine the independent association between various potential risk factors and the presence or rupture of intracranial aneurysms in MMD patients. Results Of 2230 MMD patients, 182 (8.2%) cases had intracranial aneurysms. The mean age of onset in patients with aneurysms was 47.2 years, which was significantly higher when compared with those without aneurysms ( p < 0.001). In logistic regression analysis, age of onset remained significantly associated with the presence of intracranial aneurysms, while female gender, hypertension, diabetes mellitus, and coronary artery disease were not. Besides, intracranial aneurysms were significantly associated with intracranial hemorrhage in MMD patients (odds ratio [OR] = 5.19; 95% confidence interval [CI], 3.80–7.09). About 60% aneurysms >5 mm in size, and 62.1% aneurysms with irregularly shaped morphology were ruptured. Aneurysms located in basilar tip, collateral or moyamoya vessels were more likely to present with rupture. Conclusions Age was an important risk factor for intracranial aneurysms formation in MMD patients. Aneurysms increased the risk of intracerebral hemorrhage in MMD patients, and their ruptures were correlated with aneurysms size, location, and morphology.

scholarly journals Association of Adiponectin Gene Variations with Risk of Incident Myocardial Infarction and Ischemic Stroke: A Nested Case-Control Study

2006 ◽  
Vol 52 (11) ◽  
pp. 2021-2027 ◽  
Author(s):  
Hillary H Hegener ◽  
I-Min Lee ◽  
Nancy R Cook ◽  
Paul M Ridker ◽  
Robert YL Zee
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Ischemic Stroke ◽  
Conditional Logistic Regression ◽  
Adiponectin Gene ◽  
Conditional Logistic Regression Analysis ◽  
Caucasian Men ◽  
Potential Risk Factors

Abstract Background: Adiponectin (ADIPOQ) gene variations are associated with risk of cardiovascular disease in patients with diabetes. No prospective data are available, however, on the risk of atherothrombotic disorders in persons with ADIPOQ variations who do not have diabetes. Methods: From a group of DNA samples collected at baseline in a prospective cohort of 14 916 initially healthy American men, we assessed the presence of 5 ADIPOQ genetic variants (rs266729, rs182052, rs822396, rs2241766, and rs1501299) in samples from 600 Caucasian men who subsequently suffered an atherothrombotic event (incident myocardial infarction or ischemic stroke) and from 600 age- and smoking-matched Caucasian men who remained free of reported vascular disease during follow-up (controls). Results: Genotype distributions for the variations tested were in Hardy-Weinberg equilibrium. Marker-by-marker conditional logistic regression analysis, adjusted for potential risk factors, showed an association of rs266729 [recessive: odds ratio (OR), 0.26; 95% confidence interval (CI), 0.10–0.64; P = 0.004] and rs182052 (recessive: OR, 0.40; 95% CI, 0.21–0.76; P = 0.006) with decreased risk of ischemic stroke. These findings remained significant after Bonferroni correction. Haplotype-based (constituted by rs266729, rs182052, and rs822396) conditional logistic regression analysis, adjusted for the same potential risk factors, showed an association of haplotype G-A-G (OR, 0.28; 95% CI, 0.09–0.87; P = 0.03) with decreased risk of ischemic stroke. Prespecified analysis limited to participants without baseline diabetes showed similar significant findings. Conclusions: The present prospective investigation provides further evidence for a protective role of adiponectin gene variation in the risk of ischemic stroke that was independent of the presence of diabetes.

scholarly journals Risk Factors for In-Hospital Complications of Fall-Related Fractures among Older Chinese: A Retrospective Study

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Hong-Ying Pi ◽  
Yuan Gao ◽  
Jing Wang ◽  
Meng-Meng Hu ◽  
Dan Nie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Potential Risk ◽  
Preventive Measures ◽  
Chinese Patients ◽  
Potential Risk Factors ◽  
Older Chinese ◽  
Individual Complication ◽  
The Impact ◽  
Univariate Analyses

Purpose. The aim of this study was to investigate the risk factors and the efficacy of the preventive measurements for the in-hospital complications of fall-related fractures. Methods. The data on older Chinese patients with fall-related fractures were collected, including information on the patients, diseases, and preventive measurements. The potential risk factors for the in-hospital complications included health status on admission, comorbidity, fractures, preventive measures of the complications, and drugs use for the comorbidity. After univariate analyses, multivariate logistic regression analyses were applied to investigate the impact of the potential risk factors on the number of the complications and each individual complication, respectively, and the efficacy of the preventive measurements. Results. A total of 525 male and 1367 female were included in this study. After univariate analyses, multiple logistic regression showed that dementia, pneumonia, antidepressant, postural hypotension, and cerebral infarction could increase the incidence and number of comorbidities. Meanwhile, dementia has shown the strongest association with each individual complication. Conclusions. Different combinations of comorbidity, medication use, and preventive measurements were related to the in-hospital complications of fall-related fractures. Dementia emerged as the most important risk factor for these complications, while most of the preventive measurements could not reduce their incidences.

scholarly journals Retrospective Analyses of Potential Risk Factors for Posterior Capsule Opacification after Cataract Surgery

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Shuang Wu ◽  
Nianting Tong ◽  
Lin Pan ◽  
Xiaohui Jiang ◽  
Yanan Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Cataract Surgery ◽  
Potential Risk ◽  
Posterior Capsule Opacification ◽  
Posterior Capsule ◽  
Factors Associated ◽  
Time Of Surgery ◽  
Department Of Ophthalmology ◽  
Potential Risk Factors

Purpose. To evaluate the potential risk factors of posterior capsule opacification (PCO) after cataract surgery. Methods. Data on PCO patients diagnosed from September 2015 to May 2017 were obtained from the Department of Ophthalmology at Qingdao Municipal Hospital, Qingdao, China. The factors associated with PCO were assessed using Pearson's χ2 test for univariate analyses and logistic regression for multivariate analyses. Results. Eyes (652) from 550 patients were enrolled in this study. All patients were diagnosed with PCO/non-PCO and had <3 years of follow-up after surgery. The numbers of PCO and non-PCO were 108 eyes and 544 eyes, respectively. Statistically significant associations with PCO were found for age at the time of surgery (χ2 = 78.504; p<0.001), diabetes (χ2 = 4.829; p=0.028), immune diseases (χ2 = 4.234; p=0.004), high myopia (χ2 = 5.753; p=0.016), lens nucleus hardness (χ2 = 11.046; p=0.026), surgery type (χ2 = 11.354; p=0.001), a history of vitrectomy (χ2 = 4.212; p=0.004), ocular inflammation (χ2 = 6.01; p=0.009), and the intraocular lens (IOL) type (χ2 = 8.696; p=0.003). Multivariable data analyses using logistic regression analyses of the variables showed that age at the time of surgery <60 years, diabetes, lens nucleus hardness of III–V, extracapsular cataract extraction (ECCE), postvitrectomy, and hydrophilic IOLs were significant independent risk factors associated with PCO. Conclusions. Age <60 years, diabetes, lens nucleus hardness of III–V, ECCE, postvitrectomy, and a hydrophilic IOL were significantly associated with the formation of PCO. Estimation of the incidence of and risk factors for PCO should help in patients counseling and in the design of treatment protocols to reduce or prevent its development.

scholarly journals A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Qiang Tang ◽  
Yanwei Liu ◽  
Yingfeng Fu ◽  
Ziyang Di ◽  
Kailiang Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Serum Ferritin ◽  
Potential Risk ◽  
Comprehensive Evaluation ◽  
Organ Damage ◽  
Kaplan Meier ◽  
Public Crisis ◽  
Potential Risk Factors ◽  
Multivariable Regression

AbstractThe 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25.9%) and diabetes (20.8%), and presented with dyspnoea (23.4%), neutrophilia (31.5%), and lymphocytopenia (46.7%). These patients were more prone to develop organ damage in liver, kidney, and heart (P < 0.05). A multivariable regression analysis showed that advanced age, comorbidities, dyspnea, lymphopenia, and elevated levels of Fbg, CTnI, IL-6, and serum ferritin were significant predictors of disease aggravation. Further, we performed a Kaplan–Meier analysis to evaluate the prognosis of COVID-19 patients, which suggested that 64.9% of the patients had not experienced ICU transfers and survival from the hospital.

Tricuspid valve replacement: an appraisal of 45 years of experience

2020 ◽  
Vol 30 (6) ◽  
pp. 896-903 ◽  
Author(s):  
Kevin M Veen ◽  
Thijs J M Quanjel ◽  
Mostafa M Mokhles ◽  
Ad J J C Bogers ◽  
Johanna J M Takkenberg
Keyword(s):  
Risk Factors ◽  
Patient Outcome ◽  
Regression Analysis ◽  
Valve Replacement ◽  
Tricuspid Valve ◽  
Potential Risk ◽  
Carcinoid Heart Disease ◽  
Tricuspid Valve Replacement ◽  
Potential Risk Factors ◽  
Over Time

Abstract OBJECTIVES This study provides an overview of the change over a 45-year time period in the characteristics and outcome of patients with tricuspid valve disease undergoing surgical tricuspid valve replacement (TVR). METHODS The characteristics and outcomes of all consecutive TVRs from November 1972 to November 2017 at Erasmus MC were collected retrospectively. A logistic regression analysis was conducted to identify the significant predictors of 30-day mortality. Multivariable Cox regression analysis was used to identify the potential risk factors of patient outcome and the effect of time on these factors. RESULTS Ninety-eight patients with tricuspid valve dysfunction underwent 114 consecutive TVRs at a mean age of 50.1 ± 17.2 years (68.5% female). Aetiology changed over time from predominantly functional regurgitation (42.9% in 1972-1985) to predominantly carcinoid heart disease (47.7% in 2001-2017). Early mortality declined significantly from 35% in 1972–1985 to 6.7% in 2001–2017 (P &lt; 0.001). Over time, the hazard ratio of late mortality decreased for higher New York Heart Association class, lower preoperative haemoglobin, and high central venous pressure and increased for the presence of preoperative leg oedema, higher creatinine and alkaline phosphatase. The late survival was 43.8% ± 5.89% at 10 years and was comparable among eras (P = 0.44). The cumulative incidence of reoperation at 10 years was 14.1% (2.3–26.0) in biological valves and 4.9% (0.1–10.3) in mechanical valves (P = 0.25). CONCLUSIONS Patient characteristics, potential risk factors and patient outcome changed considerably over time in patients undergoing TVR. Notably, there was a shift in aetiology, completely altering the patient population and their characteristics.

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