scholarly journals Relationship of Cardiorespiratory Fitness and Body Mass Index with the Incidence of Dyslipidemia among Japanese Women: A Cohort Study

2019 ◽  
Vol 16 (23) ◽  
pp. 4647 ◽  
Author(s):  
Takahisa Ohta ◽  
Junzo Nagashima ◽  
Hiroyuki Sasai ◽  
Naokata Ishii
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cardiorespiratory Fitness ◽  
Synergistic Effects ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Japanese Women ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Cox Proportional Hazard Regression

Low cardiorespiratory fitness (CRF) and obesity are independent risk factors for dyslipidemia. We investigated the synergistic effects of CRF and obesity on the incidence of dyslipidemia among Japanese women. Of 7627 participants, 927 normolipidemic Japanese women completed a submaximal exercise test, medical examination, and a questionnaire on smoking and alcohol drinking. The incidence of dyslipidemia was defined as having at least one of the following: high-density lipoprotein cholesterol < 40 mg/dL, low-density lipoprotein cholesterol ≥ 140 mg/dL, fasting triglyceride ≥ 150 mg/dL, or physician-diagnosed dyslipidemia. Multivariable hazard ratios (HRs) and 95% confidence intervals (CI) were calculated using a Cox proportional hazard regression model. During the follow-up period of ≤16 years (median 1 year), 196 (21.1%) women developed dyslipidemia. Compared with those in the body mass index (BMI)-specific (< or ≥25.0 kg/m2) lowest CRF tertile, the multivariable HRs for dyslipidemia in the highest CRF tertile were 1.36 (95% CI, 0.75–2.48) for women with BMI ≥ 25 kg/m2 and 0.70 (95% CI, 0.45–1.09) for those with BMI < 25 kg/m2 (p < 0.01 for interaction). These results suggest that CRF and BMI are interdependent and, together, they affect the incidence of dyslipidemia among Japanese women. CRF is inversely related to a lower incidence of dyslipidemia with low BMI.

scholarly journals FEATURES OF LIPID METABOLISM IN OVERWEIGHT AND OBESE ADOLESCENTS DEPENDING ON THE VARIOUS LEVELS OF VITAMIN D

2019 ◽  
pp. 37-43
Author(s):  
A-M. A. Shulhai ◽  
H. A. Pavlyshyn
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Lipid Metabolism ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Low Density Lipoprotein Cholesterol

Vitamin D deficiency and overweight have now become an important global problem in the field of health care as well as public health. A substantial hypovitaminosis D in children with obesity is often accompanied by metabolic disorders. The aim of the study was to determine the relationship between the levels of vitamin D and lipid metabolism markers in adolescents with overweight and obesity. Material and methods. 139 adolescents were examined (63 (45.4 %) girls and 76 (54.7 %) boys). Depending on the body mass index (BMI) 65 children were overweight and 74 were obese children. The mean age of teenagers was (15,4±2,3) years. To establish vitamin D status using the immune-enzyme method, blood serum levels of 25(OH)D were determined. Lipid metabolism markers were determined using the Roche Diagnostics Cholesterol reagent kit using and automatic Cobas c111 analyzer. Results. The study established a direct relationship between the level of vitamin D and high-density lipoprotein cholesterol and indirect with total cholesterol, triglycerides, low-density lipoprotein cholesterol, atherogenic index, body mass index and waist circumference. Using a simple linear regression analysis, it was determined that total cholesterol, low-density lipoprotein cholesterol and atherogenic index have the greatest correlation with vitamin D. Conclusions: Vitamin D deficiency in overweight and obese adolescents is associated with an increase in the body mass index, blood pressure, and atherogenic dyslipidemia.

scholarly journals Association of Body Mass Index in Youth With Adult Cardiometabolic Risk

2020 ◽  
Vol 9 (14) ◽  
Author(s):  
Feitong Wu ◽  
Markus Juonala ◽  
Matthew A. Sabin ◽  
Marie‐Jeanne Buscot ◽  
Katja Pahkala ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Lipoprotein Cholesterol ◽  
Stiffness Index ◽  
Overweight Or Obesity

Background Whether long‐term exposure to overweight or obesity from early life to adulthood has a detrimental influence on health outcomes is unknown. We aimed to investigate whether duration of overweight or obesity from youth to adulthood is associated with adult cardiometabolic risk. Methods and Results A population‐based cohort study was performed of 1268 youths, aged 3 to 18 years, with follow‐ups at 3, 6, 9, 12, 21, 27, and 31 years. Duration of overweight or obesity over 31‐year follow‐up was calculated. Adulthood outcomes included type 2 diabetes mellitus, impaired fasting glucose, high insulin levels, high carotid intima‐media thickness, hypertension, low high‐density lipoprotein cholesterol, high low‐density lipoprotein cholesterol and triglycerides, arterial pulse wave velocity, carotid artery compliance, Young elastic modulus, and stiffness index. Rates of overweight/obesity were 7.9% at baseline and 55.9% after 31 years. After adjustment for confounders, longer duration of overweight or obesity was associated with increased risk of all outcomes (relative risk ranged from 1.45–9.06 for type 2 diabetes mellitus, impaired fasting glucose, carotid intima‐media thickness, hypertension, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, and triglycerides; β from 0.370–0.543 m/s for pulse wave velocity; –0.193 to –0.237 %/10 mm Hg for carotid artery compliance; 52.1–136.8 mm Hg·mm for Young elastic modulus; and 0.554–0.882 for stiffness index). When body mass index was further adjusted, these associations disappeared or were substantially reduced. Detrimental associations of adult body mass index with all outcomes were robust to adjustment for confounders and duration of overweight or obesity. Conclusions Overweight or obesity in adulthood rather than childhood appears to be more important for adult cardiometabolic health.

scholarly journals Association between eating habits, body mass index, cardiorespiratory fitness, and cardiometabolic risk factors in children

2021 ◽  
Vol 34 ◽  
Author(s):  
Miguel Angelo dos Santos DUARTE JUNIOR ◽  
Adroaldo Cezar Araujo GAYA ◽  
Vanilson Batista LEMES ◽  
Camila Felin FOCHESATTO ◽  
Caroline BRAND ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Cardiorespiratory Fitness ◽  
Cardiometabolic Risk ◽  
Eating Habits ◽  
Density Lipoprotein ◽  
The Body ◽  
Cardiometabolic Risk Factors

ABSTRACT Objective To verify the multivariate relationships between eating habits, cardiorespiratory fitness, body mass index, and cardiometabolic risk factors in children. Methods This is a cross-sectional study developed in a public elementary school with 60 first- to sixth-graders. Their eating habits were assessed using the Food Frequency Survey, weight, height, and cardiorespiratory fitness, assessed according to the Projeto Esporte Brasil protocol. Moreover, the variables, high-density lipoprotein, low-density lipoprotein, glucose, insulin, C-reactive protein, adiponectin, leptin, diastolic and systolic blood pressure were evaluated. Descriptive statistics were used for data analysis and generalized estimation equations were used for the analysis of direct and indirect relations, in a multivariate analysis model with several simultaneous outcomes. Results It appears that the eating habits and cardiorespiratory fitness explain 20% of the body mass index. Cardiometabolic risk factors are explained by the relationship between eating habits, cardiorespiratory fitness, and body mass index, according to the following percentages: 29% (systolic blood pressure), 18% (diastolic blood pressure), 63% (leptin), 4% (adiponectin), 14% (C-reactive protein), 17% (insulin), 10% (high-density lipoprotein), 1% (low-density lipoprotein), 4% (glucose). It is also observed that the effects of the eating habits on cardiometabolic risk factors are indirect, that is, they are dependent on changes in the body mass index and cardiorespiratory fitness levels. Conclusions The relationship between eating habits and cardiometabolic risk factors in children is dependent on cardiorespiratory fitness and body mass index. Thus, our findings suggest a multivariate relationship between these factors.

scholarly journals Association of Lipid Profile with Body Mass Index in Public Employees in Halabja City, Kurdistan Region of Iraq

2020 ◽  
Vol 10 (2) ◽  
pp. 71-80
Author(s):  
Tareq H. Abdullah ◽  
Hardi R. Baqi ◽  
Salar H. Karim ◽  
Dashti A. Ghafor
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Renal Diseases ◽  
Public Employees ◽  
Kurdistan Region ◽  
Males And Females ◽  
The Mean

Obesity and overweight are extensive phenomena that reached epidemics extent worldwide, including the Kurdistan region of Iraq. The aim of this study is to evaluate the values of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), body mass index (BMI), and the state of physical activity in Halabja’s public employees. Overall 355 adults aged from 19 to 63 including 246 males and 109 females contributed to the study. The lipid profiles were tested in all subjects after over-night fasting. In addition, anthropometry measurements were taken; the mean height for males is 1.7129 m and 1.5732 m for females. The mean weights of males and females are 80.4813 and 69.9459 kg, respectively. The mean BMI value for males and females is 27.4258 and 28.3274, respectively. Some of the cases were diagnosed with diabetes, renal diseases, hypertension, and other relevant diseases. 246 of participants adopted sedentary lifestyles while 109 of them lived an active lifestyle. 65, 162, 98, and 206 of participants had TC, TG, LDL-C, and HDL-C off-limits, respectively. Pearson’s correlation between BMI with TC, TG, and LDL-C showed a significant relationship at 0.01 level as 0.156**, 0.140**, and 0.144**, respectively. HDL-C was negatively correlated to BMI at −0.062 level. The analysis of variance showed statistically significant p-values between TC, TG, and HDL-C according to BMI at 0.027, 0.000, and 0.000, respectively. The sedentary group of participants showed a higher Mean range of TC, TG, LDL-C, and HDL-C than an active group of participants.

Insulin-like growth factor-binding protein-1 is correlated with low density lipoprotein cholesterol in normal subjects

1994 ◽  
Vol 140 (3) ◽  
pp. 521-524 ◽  
Author(s):  
K D Hopkins ◽  
E D Lehmann ◽  
J R Parker ◽  
R G Gosling
Keyword(s):  
Body Mass Index ◽  
Growth Factor ◽  
Body Mass ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
The Body ◽  
Low Density ◽  
Insulin Like Growth Factor ◽  
Igf I

Abstract Insulin-like growth factor-I (IGF-I) has been inversely associated with low-density lipoprotein (LDL) cholesterol in normal women with slightly elevated cholesterol levels and hypothyroid women. More than 95% of IGF-I circulates bound to binding proteins (IGFBPs); of these IGFBP-1 is of particular interest as it is inversely regulated by insulin and is thought to inhibit the action of IGF-I and IGF-II. We examined the relationship between IGFBP-1 and LDL cholesterol in 41 healthy adult subjects. LDL cholesterol correlated with the body mass index (r=0·40, P<0·01), sex (r=0·51, P<0·001) and IGFBP-1 levels (r=0·36, P<0·02). LDL cholesterol did not correlate with age (r=0·25, P=not significant) or IGF-I (r=0·06, P=not significant). Upon multivariate regression analysis, sex, body mass index and IGFBP-1 were all independent predictors of LDL cholesterol (all P<0·05). Elevated IGFBP-1 levels have been associated with an inhibition of serum IGF-I bioactivity in children with insulin-dependent diabetes. IGFBP-1 also appears to inhibit IGF-I hexose-stimulated uptake. IGFBP-1 may also be inhibiting the effect of IGFs on the cellular metabolism of LDL cholesterol. Journal of Endocrinology (1994) 140, 521–524

scholarly journals Effects of Hypothetical Interventions on Ischemic Stroke Using Parametric G-Formula

Stroke ◽  
2019 ◽  
Vol 50 (11) ◽  
pp. 3286-3288 ◽  
Author(s):  
Yaser Mokhayeri ◽  
Seyed Saeed Hashemi-Nazari ◽  
Soheila Khodakarim ◽  
Saeid Safiri ◽  
Nasrin Mansournia ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Ischemic Stroke ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Time Dependent ◽  
Lipoprotein Cholesterol ◽  
Men And Women ◽  
Quitting Smoking ◽  
Using Data

Background and Purpose— Standard analytic approaches (eg, logistic regression) fail to adequately control for time-dependent confounding and, therefore, may yield biased estimates of the total effect of the exposure on the outcome. In the present study, we estimate the effect of body mass index, intentional physical activity, HDL (high-density lipoprotein) cholesterol, LDL (low-density lipoprotein) cholesterol, hypertension, and cigarette smoking on the 11-year risk of ischemic stroke by sex using the parametric g-formula to control time-dependent confounders. Methods— Using data from the MESA (Multi-Ethnic Study of Atherosclerosis), we followed 6809 men and women aged 45 to 84 years. We estimated the risk of stroke under 6 hypothetical interventions: maintaining body mass index <25 kg/m 2 , maintaining normotension (systolic blood pressure <140 and diastolic <90 mm Hg), quitting smoking, maintaining HDL >1.55 mmol/L, maintaining LDL <3.11 mmol/L, and exercising at least 210 minutes per week. The effects of joint hypothetical interventions were also simulated. Results— In men, the 11-year risk of ischemic stroke would be reduced by 85% (95% CI, 66–96) for all 6 hypothetical interventions. In women, this same effect was estimated as 55% (95% CI, 6–82). Conclusions— The hypothetical interventions explored in our study resulted in risk reduction in both men and women.

scholarly journals Association of body mass index with non-achievement of target low-density lipoprotein level in older patients at very high cardiovascular risk: a multicentre study

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
H T Nguyen ◽  
A H Nguyen ◽  
H M Lam ◽  
T T Nguyen
Keyword(s):  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Body Mass ◽  
Older Patients ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
High Cardiovascular Risk ◽  
Very High

Abstract Introduction Low-density lipoprotein cholesterol (LDL-c) is a well-established risk factor for atherosclerotic cardiovascular disease. Nonetheless, the association of body mass index (BMI) with non-achievement of target LDL-c level in older patients with type 2 diabetes (T2D) at very high cardiovascular risk is unknown. Purpose To investigate whether BMI is associated with non-achievement of target LDL-c level in older patients with T2D at very high cardiovascular risk. Methods From December 2019 to June 2020, in this multicentre prospective cross-sectional study, we enrolled 733 consecutive outpatients aged ≥60 years with T2D at very high cardiovascular risk in whom LDL-c levels could be measured after any stable lipid-lowering therapy for ≥6 months. Achievement of target lipid level was assessed based on the 2019 guidelines of the European Society of Cardiology for dyslipidaemia. Factors associated with non-achievement of target LDL-c level were determined using logistic regression analysis. Results Of the total cases (age, 68.6±7.2 years; men, 51.3%), 654 patients (89.2%) did not achieve an aggressive target LDL-c level of &lt;1.4 mmol/L. Target non-high-density lipoprotein cholesterol level of &lt;2.2 mmol/L and triglyceride level of &lt;1.7 mmol/L were not achieved in 87.9% and 56.2% of the patients, respectively. In the multivariate model, BMI was the only factor associated with failure to achieve target LDL-c level, but not other factors such as age, sex, education level, smoking, and comorbidities. The adjusted odds ratio were 0.88 (95% confidence interval [95% CI], 0.24–3.21; P=0.84) for underweight, 1.57 (95% CI, 0.87–2.81; P=0.13) for overweight, and 2.63 (95% CI, 1.43–4.83; P=0.002) for obesity (normal weight was set as reference) status. Conclusions Non-achievement of target LDL-c level is highly prevalent in older patients with T2D at very high cardiovascular risk. Obesity, defined by BMI, can be a factor associated with non-achievement of the target. The findings highlight the importance of management of lipid levels in older patients with T2D. FUNDunding Acknowledgement Type of funding sources: None. Figure 1

Sign in / Sign up

Export Citation Format

Share Document