Prevalence of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs) among Italian Women Referred for a Colposcopy

Sexually transmitted infections (STIs) represent a major cause of morbidity in women and men worldwide. Human Papillomavirus (HPV) infections are among the most prevalent STIs and persistent infections with high-risk HPV (hrHPV) genotypes can cause cervical dysplasia and invasive cervical cancer. The association of other STIs with HPV cervical infection and/or dysplasia has however not yet been fully elucidated. The aim of this study was to assess the prevalence of HPV and other STIs among women presenting with an abnormal cervical cytology. Cervical infections with 28 HPV genotypes and seven other sexually transmitted pathogens were evaluated in 177 women referred for a colposcopy after an abnormal Pap smear. Positivity for at least one hrHPV genotype was shown in 87% of women; HPV 16 was the most prevalent (25.0%), followed by HPV 31 and HPV 51. The overall positivity for other STIs was 49.2%, with Ureaplasma parvum being the most prevalent microrganism (39.0%). Co-infections between hrHPV and other STIs were demonstrated in 17.5% of women; no significant association was demonstrated between multiple infections and the colposcopy findings. This study provides new epidemiological data on the prevalence of cervical infections associated with HPV and seven other common sexually transmitted pathogens in a population of women presenting with an abnormal cervical cytology.

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Relationships of Sexually Transmitted Infections, Bacterial (STI) with High-Risk Human Papillomavirus (HR-HPV) and Abnormal Cervical Cytology in Gynecological Outpatients

Journal of the American Society of Cytopathology ◽

10.1016/j.jasc.2015.09.080 ◽

2015 ◽

Vol 4 (6) ◽

pp. S34

Author(s):

Sung Ran Hong ◽

Tae Jin Kim ◽

In Ho Lee ◽

Hye Sun Kim

Keyword(s):

Human Papillomavirus ◽

High Risk ◽

Sexually Transmitted Infections ◽

Cervical Cytology ◽

Sexually Transmitted ◽

Abnormal Cervical Cytology

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Association of sexually transmitted infections and human papillomavirus co-infection with abnormal cervical cytology among women in Saudi Arabia

Saudi Journal of Biological Sciences ◽

10.1016/j.sjbs.2020.03.021 ◽

2020 ◽

Vol 27 (6) ◽

pp. 1587-1595

Author(s):

H.J. Alotaibi ◽

F.N. Almajhdi ◽

A.N. Alsaleh ◽

D.A Obeid ◽

H.H Khayat ◽

...

Keyword(s):

Saudi Arabia ◽

Human Papillomavirus ◽

Sexually Transmitted Infections ◽

Cervical Cytology ◽

Sexually Transmitted ◽

Abnormal Cervical Cytology

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Risk Factors for Human Papillomavirus Infection and Abnormal Cervical Cytology Among Perinatally Human Immunodeficiency Virus-Infected and Uninfected Asian Youth

Clinical Infectious Diseases ◽

10.1093/cid/ciy144 ◽

2018 ◽

Vol 67 (4) ◽

pp. 606-613 ◽

Cited By ~ 8

Author(s):

Annette H Sohn ◽

Stephen J Kerr ◽

Rawiwan Hansudewechakul ◽

Sivaporn Gatechompol ◽

Kulkanya Chokephaibulkit ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

Hpv Vaccination ◽

Cervical Cytology ◽

Low Grade ◽

Sexually Transmitted ◽

Screening Programs ◽

Perinatal Hiv ◽

Abnormal Cervical Cytology ◽

Immunodeficiency Virus

AbstractBackgroundInfection with high-risk human papillomavirus (HR-HPV) may be higher in perinatally human immunodeficiency virus (HIV)–infected (PHIV) than HIV-uninfected (HU) adolescents because of long-standing immune deficiency.MethodsPHIV and HU females aged 12–24 years in Thailand and Vietnam were matched by age group and lifetime sexual partners. At enrollment, blood, cervical, vaginal, anal, and oral samples were obtained for HPV-related testing. The Wilcoxon and Fisher exact tests were used for univariate and logistic regression for multivariate analyses.ResultsNinety-three PHIV and 99 HU adolescents (median age 19 [18–20] years) were enrolled (June 2013–July 2015). Among PHIV, 94% were currently receiving antiretroviral therapy, median CD4 count was 593 (392–808) cells/mm3, and 62% had a viral load <40 copies/mL. Across anogenital compartments, PHIV had higher rates of any HPV detected (80% vs 60%; P = .003) and any HR-HPV (60% vs 43%, P = .02). Higher proportions of PHIV had abnormal Pap smears (eg, atypical squamous cells of unknown significance [ASC-US], 12% vs 14%; low-grade squamous intraepithelial neoplastic lesions, 19% vs 1%). After adjusting for ever being pregnant and asymptomatic sexually transmitted infections (STI) at enrollment, PHIV were more likely to have HR-HPV than HU (odds ratio, 2.02; 95% confidence interval, 1.09–3.77; P = .03).ConclusionsPerinatal HIV infection was associated with a higher risk of HR-HPV and abnormal cervical cytology. Our results underscore the need for HPV vaccination for PHIV adolescents and for prevention and screening programs for HPV and other STIs.

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Correction: Associations of sexually transmitted infections and bacterial vaginosis with abnormal cervical cytology: A cross-sectional survey with 9090 community women in China

PLoS ONE ◽

10.1371/journal.pone.0238272 ◽

2020 ◽

Vol 15 (8) ◽

pp. e0238272

Author(s):

Wu Li ◽

Lan-lan Liu ◽

Zhen-zhou Luo ◽

Chun-yan Han ◽

Qiu-hong Wu ◽

...

Keyword(s):

Bacterial Vaginosis ◽

Sexually Transmitted Infections ◽

Cervical Cytology ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Sexually Transmitted ◽

Abnormal Cervical Cytology

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Human Papillomavirus Types Associated with Cervical Dysplasia among HIV- and Non-HIV-Infected Women Attending Reproductive Health Clinics in Eastern Kenya

BioMed Research International ◽

10.1155/2021/2250690 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

James Kinoti Njue ◽

Margaret Muturi ◽

Lucy Kamau ◽

Raphael Lwembe

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Reproductive Health ◽

Single Case ◽

Invasive Cervical Cancer ◽

Cervical Dysplasia ◽

Epidemiological Data ◽

Chi Square ◽

Hpv Genotypes ◽

Endocervical Canal

Background. Human papillomavirus (HPV) causes over 99% of all cervical cancer globally. In 2019, it was responsible for 3286 deaths in Kenya. Data on the epidemiological distribution of HPV genotypes by cervical dysplasia and HIV-infected women which is important in designing prevention strategy monitoring treatment and management of cervical cancer is lacking in Eastern Kenya. Objective. To determine HPV genotype prevalence and their association with cervical dysplasia among HIV-infected (cases) and noninfected (control) women aged 18-48 years seeking reproductive healthcare. Methods. A cervical broom was softly rotated 360 degrees five times to exfoliate cells from the region of the transformation zone, squamocolumnar junction, and endocervical canal for HPV genotyping. Social-demographic and risk factors responsible for HPV acquisition were collected using a questionnaire. Laboratory outcome and questionnaire data statistical relationships were computed using Pearson chi-square test. Results. 317 women (cases: 161 (50.8%), control 156 (49.2%), mean age: 34.3, SD ± 10.4 , range 18-46 years) were recruited from Embu (85/317 (26.8%)), Isiolo (64/317 (20.2%)), Kirinyaga (56/317 (17.7%)), Meru (81/317 (25.6%)), and Tharaka-Nithi (31/317 (9.8%)). The frequency HPV genotypes detected by cervical dysplasia were CIN1 (cases: HPV81 (12/317 (3.8%)), HPV11 (2/317 (0.6%)); control: HPV53 and 66 coinfection (1/317 (0.3%)), CIN2 (cases: HPV11, HPV16, HPV66 ((1/317 (0.3%) each), HPV81 (6/317 (1.9%)), and single case (1/317 (0.3%)) of HPV11 and 66, HPV81 and 44, HPV81 and 88, HPV9 and 53, and HPV16 and 58 coinfection; control: HPV81 (2/317 (0.6%)) and invasive cervical cancer (cases: HPV16 (1/317 (0.3%)) and HPV81 (3/317 (0.9%)); control: HPV16 and 66 (1/317 (0.3%))).Conclusions. There was a higher frequency of both high-risk and low-risk HPV genotypes associated with cervical dysplasia among HIV-infected than HIV-uninfected women seeking reproductive health care. This study provides epidemiological data on the existence of nonvaccine HPV types associated with cervical dysplasia in the region.

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