scholarly journals The Development of a WTC Environmental Health Center Pan-Cancer Database

2021 ◽  
Vol 18 (4) ◽  
pp. 1646
Author(s):  
Yongzhao Shao ◽  
Nedim Durmus ◽  
Yian Zhang ◽  
Sultan Pehlivan ◽  
Maria-Elena Fernandez-Beros ◽  
...  
Keyword(s):  
Environmental Health ◽  
Health Center ◽  
World Trade Center ◽  
Cancer Registries ◽  
Future Research ◽  
Environment Interaction ◽  
Community Members ◽  
Pathology Reports ◽  
Clinical Records ◽  
Pan Cancer

(1) Background: Recent studies have reported elevated risks of multiple cancers in the World Trade Center (WTC) affected community members (also called WTC “Survivors”). The large variety of WTC-cancers created a need to develop a comprehensive cancer database. This paper describes the development of a pan-cancer database at the WTC Environmental Health Center (EHC) Data Center. (2) Methods: A new REDCap-based pan-cancer database was created using the pathology reports and available biomarker data of confirmed cancer cases after review by a cancer epidemiologist, a pathologist, physicians and biostatisticians. (3) Results: The WTC EHC pan-cancer database contains cancer characteristics and emerging biomarker information for cancers of individuals enrolled in the WTC EHC and diagnosed after 11 September 2001 and up to 31 December 2019 obtained from WTC EHC clinical records, pathological reports and state cancer registries. As of 31 December 2019, the database included 3440 cancer cases with cancer characteristics and biomarker information. (4) Conclusions: This evolving database represents an important resource for the scientific community facilitating future research about the etiology, heterogeneity, characteristics and outcomes of cancers and comorbid mental health conditions, cancer economics and gene–environment interaction in the unique population of WTC survivors.

scholarly journals Lung Cancer Characteristics in the World Trade Center Environmental Health Center

2021 ◽  
Vol 18 (5) ◽  
pp. 2689
Author(s):  
Nedim Durmus ◽  
Sultan Pehlivan ◽  
Yian Zhang ◽  
Yongzhao Shao ◽  
Alan A. Arslan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Environmental Health ◽  
Health Center ◽  
World Trade ◽  
World Trade Center ◽  
Smoking History ◽  
Community Members ◽  
The World ◽  
Trade Center ◽  
Never Smokers

The destruction of the World Trade Center (WTC) towers on 11 September 2001 resulted in acute and chronic dust and fume exposures to community members, including local workers and residents, with well-described aerodigestive adverse health effects. This study aimed to characterize lung cancer in the WTC Environmental Health Center (WTC EHC) focusing on gender and smoking history. WTC EHC patients undergo an initial evaluation that includes WTC exposure information, demographics, and tobacco use. Detailed cancer characteristics are recorded from pathology reports. As of 31 December 2019, 248 WTC EHC patients had a diagnosis of lung cancer. More patients with lung cancer were women (57%) compared to men (43%). Many cases (47% women, 51% men) reported acute dust cloud exposure. Thirty-seven percent of lung cancer cases with available smoking history were never-smokers (≤1 pack-years) and 42% had a ≤5 pack-year history. The median age of cancer diagnosis in never-smoking women was 61 years compared to 66 years in men. Adenocarcinoma was more common in never-smokers compared to ever-smokers (72% vs. 65%) and in women compared to men (70% vs. 65%). We provide an initial description of lung cancers in local community members with documented exposure to the WTC dust and fumes.

scholarly journals Characteristics of Cancer Patients in the World Trade Center Environmental Health Center

2020 ◽  
Vol 17 (19) ◽  
pp. 7190
Author(s):  
Nedim Durmus ◽  
Yongzhao Shao ◽  
Alan A. Arslan ◽  
Yian Zhang ◽  
Sultan Pehlivan ◽  
...  
Keyword(s):  
Environmental Health ◽  
Health Center ◽  
Cancer Patients ◽  
World Trade ◽  
World Trade Center ◽  
Cancer Site ◽  
Community Members ◽  
The World ◽  
Cancer Types ◽  
Trade Center

The destruction of the World Trade Center (WTC) towers on 11 September 2001 released many tons of aerosolized dust and smoke with potential for carcinogenic exposures to community members as well as responders. The WTC Environmental Health Center (WTC EHC) is a surveillance and treatment program for a diverse population of community members (“Survivors”), including local residents and workers, present in the NYC disaster area on 9/11 or in the days or weeks following. We report a case series of cancers identified in the WTC EHC as of 31 December 2019. Descriptive characteristics are presented for 2561 cancer patients (excluding non-melanoma skin cancer) and 5377 non-cancer WTC-EHC participants who signed informed consent. We identified a total of 2999 cancer diagnoses in 2561 patients: 2534 solid tumors (84.5%) and 465 lymphoid and hematopoietic tissue cancers (15.5%) with forty-one different cancer types. We describe the distribution, frequency, median age of cancer diagnosis and median latency from 9/11 by cancer site. In addition to common cancer types, rare cancers, including male breast cancers and mesotheliomas have been identified. The current study is the first report on cancer characteristics of enrollees at WTC EHC, a federally designated treatment and surveillance program for local community members affected by the 9/11 terrorist attack on the WTC.

scholarly journals Combining Three Cohorts of WTC Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality

2021 ◽  
Author(s):  
Robert Brackbill ◽  
Amy Kahn ◽  
Jiehui LI ◽  
Rachel Zeig-Owens ◽  
David Goldfarb ◽  
...  
Keyword(s):  
New York ◽  
World Trade ◽  
World Trade Center ◽  
Fire Department ◽  
Analysis Data ◽  
Cancer Registries ◽  
Future Research ◽  
Incidence And Mortality ◽  
The World ◽  
Trade Center

Three cohorts including the Fire Department of the City of New York (FDNY), the World Trade Center Health Registry (WTCHR), and the General Responder Cohort (GRC), each funded by the World Trade Center Health Program have reported associations between WTC-exposures and cancer. Results have generally been consistent with effect estimates for excess incidence for all cancers ranging from 6 to 14% above background rates. Pooling would increase sample size and de-duplicate cases between the cohorts. Pooling required time consuming steps: obtaining IRB approvals and legal agreements from entities involved; establishing an honest broker for managing the data; de-duplicating the pooled cohort files; applying to State Cancer Registries (SCRs) for matched cancer cases; and finalizing analysis data files. Obtaining SCR data use agreements ranged from 6.5 to 114.5 weeks with six states requiring >20 weeks. Records from FDNY (n=16,221), WTCHR (n=29,372), and GRC (n=33,427) were combined de-duplicated resulting in 69,102 unique individuals. Overall, 7,894 cancer tumors were matched to the pooled cohort, increasing the number cancers by as much as 58% compared to previous analyses. Pooling resulted in a coherent resource for future research for studies on rare cancers and mortality, with more representative of occupations and WTC- exposure.

scholarly journals Breast Cancer Characteristics in the Population of Survivors Participating in the World Trade Center Environmental Health Center Program 2002–2019

2021 ◽  
Vol 18 (14) ◽  
pp. 7555
Author(s):  
Alan A. Arslan ◽  
Yian Zhang ◽  
Nedim Durmus ◽  
Sultan Pehlivan ◽  
Adrienne Addessi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Environmental Health ◽  
Health Center ◽  
World Trade ◽  
World Trade Center ◽  
Complex Mixture ◽  
Breast Cancers ◽  
Cancer Data ◽  
Female Breast ◽  
Trade Center

The destruction of World Trade Center on 11 September 2001 exposed local community members to a complex mixture of known carcinogens and potentially carcinogenic substances. To date, breast cancer has not been characterized in detail in the WTC-exposed civilian populations. The cancer characteristics of breast cancer patients were derived from the newly developed Pan-Cancer Database at the WTC Environmental Health Center (WTC EHC). We used the Surveillance, Epidemiology, and End Results (SEER) Program breast cancer data as a reference source. Between May 2002 and 31 December 2019, 2840 persons were diagnosed with any type of cancer at the WTC EHC, including 601 patients with a primary breast cancer diagnosis (592 women and 9 men). There was a higher proportion of grade 3 (poorly differentiated) tumors (34%) among the WTC EHC female breast cancers compared to that of the SEER-18 data (25%). Compared to that of the SEER data, female breast cancers in the WTC EHC had a lower proportion of luminal A (88% and 65%, respectively), higher proportion of luminal B (13% and 15%, respectively), and HER-2-enriched (5.5% and 7%, respectively) subtypes. These findings suggest considerable differences in the breast cancer characteristics and distribution of breast cancer intrinsic subtypes in the WTC-exposed civilian population compared to that of the general population. This is important because of the known effect of molecular subtypes on breast cancer prognosis.

scholarly journals Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality

2021 ◽  
Vol 18 (4) ◽  
pp. 1386
Author(s):  
Robert M. Brackbill ◽  
Amy R. Kahn ◽  
Jiehui Li ◽  
Rachel Zeig-Owens ◽  
David G. Goldfarb ◽  
...  
Keyword(s):  
New York ◽  
World Trade ◽  
World Trade Center ◽  
Fire Department ◽  
Analysis Data ◽  
Cancer Registries ◽  
Future Research ◽  
Incidence And Mortality ◽  
The World ◽  
Trade Center

Three cohorts including the Fire Department of the City of New York (FDNY), the World Trade Center Health Registry (WTCHR), and the General Responder Cohort (GRC), each funded by the World Trade Center Health Program have reported associations between WTC-exposures and cancer. Results have generally been consistent with effect estimates for excess incidence for all cancers ranging from 6 to 14% above background rates. Pooling would increase sample size and de-duplicate cases between the cohorts. However, pooling required time consuming steps: obtaining Institutional Review Board (IRB) approvals and legal agreements from entities involved; establishing an honest broker for managing the data; de-duplicating the pooled cohort files; applying to State Cancer Registries (SCRs) for matched cancer cases; and finalizing analysis data files. Obtaining SCR data use agreements ranged from 6.5 to 114.5 weeks with six states requiring >20 weeks. Records from FDNY (n = 16,221), WTCHR (n = 29,372), and GRC (n = 33,427) were combined de-duplicated resulting in 69,102 unique individuals. Overall, 7894 cancer tumors were matched to the pooled cohort, increasing the number cancers by as much as 58% compared to previous analyses. Pooling resulted in a coherent resource for future research for studies on rare cancers and mortality, with more representative of occupations and WTC- exposure.

scholarly journals Impact of World Trade Center-Related Health Research: An Application of the NIEHS Translational Framework

2021 ◽  
Vol 18 (5) ◽  
pp. 2659
Author(s):  
Jaime Madrigano ◽  
Thomas W. Concannon ◽  
Sean Mann ◽  
Sameer M. Siddiqi ◽  
Ramya Chari ◽  
...  
Keyword(s):  
World Trade ◽  
Grey Literature ◽  
World Trade Center ◽  
Diagnostic Procedures ◽  
Health Conditions ◽  
Future Research ◽  
Physical And Mental Health ◽  
Post Traumatic Stress ◽  
Related Research ◽  
Trade Center

The World Trade Center Health Program (WTCHP) has a research mission to identify physical and mental health conditions that may be related to the 9/11 terrorist attacks as well as effective diagnostic procedures and treatments for WTC-related health conditions. The ability of the WTCHP to serve its members and realize positive impacts on all of its stakeholders depends on effective translation of research findings. As part of an ongoing assessment of the translational impact of World Trade Center (WTC)-related research, we applied the National Institute of Environmental Health Sciences (NIEHS) translational framework to two case studies: WTC-related research on post-traumatic stress disorder (PTSD) and cancer. We conducted a review of 9/11 health-related research in the peer-reviewed literature through October 2017, grey literature, and WTCHP program documentation. We mapped peer-reviewed studies in the literature to the NIEHS framework and used WTCHP program documentation and grey literature to find evidence of translation of research into clinical practice and policy. Using the NIEHS framework, we identified numerous translational milestones and bridges, as well as areas of opportunity, within each case study. This application demonstrates the utility of the NIEHS framework for documenting progress toward public health impact and for setting future research goals.

scholarly journals Wastewater Surveillance for SARS-CoV-2 on College Campuses: Initial Efforts, Lessons Learned, and Research Needs

2021 ◽  
Vol 18 (9) ◽  
pp. 4455
Author(s):  
Sasha Harris-Lovett ◽  
Kara L. Nelson ◽  
Paloma Beamer ◽  
Heather N. Bischel ◽  
Aaron Bivins ◽  
...  
Keyword(s):  
Information Needs ◽  
Community Dynamics ◽  
The United States ◽  
Lessons Learned ◽  
Future Research ◽  
Private Institutions ◽  
Community Members ◽  
Public And Private ◽  
College And University ◽  
University Systems

Wastewater surveillance for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging approach to help identify the risk of a coronavirus disease (COVID-19) outbreak. This tool can contribute to public health surveillance at both community (wastewater treatment system) and institutional (e.g., colleges, prisons, and nursing homes) scales. This paper explores the successes, challenges, and lessons learned from initial wastewater surveillance efforts at colleges and university systems to inform future research, development and implementation. We present the experiences of 25 college and university systems in the United States that monitored campus wastewater for SARS-CoV-2 during the fall 2020 academic period. We describe the broad range of approaches, findings, resources, and impacts from these initial efforts. These institutions range in size, social and political geographies, and include both public and private institutions. Our analysis suggests that wastewater monitoring at colleges requires consideration of local information needs, sewage infrastructure, resources for sampling and analysis, college and community dynamics, approaches to interpretation and communication of results, and follow-up actions. Most colleges reported that a learning process of experimentation, evaluation, and adaptation was key to progress. This process requires ongoing collaboration among diverse stakeholders including decision-makers, researchers, faculty, facilities staff, students, and community members.

EFFECTS OF GROWTH INHIBITION BY HYDROCORTISONE ACETATE ON VARIANCE IN CHICKENS

1970 ◽  
Vol 12 (3) ◽  
pp. 627-634
Author(s):  
J. S. Gavora ◽  
G. C. Hodgson
Keyword(s):  
Body Weight ◽  
External Environment ◽  
Hormonal Treatment ◽  
Genotype By Environment Interaction ◽  
Future Research ◽  
Environment Interaction ◽  
Internal Environment ◽  
Hydrocortisone Acetate ◽  
Genotype By Environment ◽  
Treatment Interaction

Traditionally genotype by environment interaction studies have dealt with changes in external environment. In this experiment an attempt was made to alter internal environment and keep external environment constant. Cockerels from each of six different commercial stocks were injected with 0,1,2 and 4 mgs hydrocortisone acetate per 100 gms body weight at 14 days of age. This type of hormonal treatment was shown to release additional variability in growth without producing any stock-treatment interaction at the level of means. The results indicate a possible new avenue for future research.

scholarly journals Nonprofits and the Promotion of Civic Engagement: A Conceptual Framework for Understanding the "Civic Footprint" of Nonprofits within Local Communities

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Micheal L. Shier ◽  
Lindsey McDougle ◽  
Femida Handy
Keyword(s):  
United States ◽  
Civic Engagement ◽  
Nonprofit Organizations ◽  
Rural Community ◽  
Community Education ◽  
The United States ◽  
Local Communities ◽  
Future Research ◽  
Community Members ◽  
Education And Awareness

ABSTRACT   The literature suggests that nonprofit organizations provide civic benefits by promoting engagement within local communities. However, there exists minimal empirical evidence describing the ways in which nonprofits actually undertake this role. In order to address this omission, we conducted interviews with personnel of nonprofit organizations in one rural community in the United States. Our preliminary findings indicate that nonprofit organizations promote civic engagement through programs and activities that: 1) engage volunteers and donors; 2) bring community members together; 3) collaborate with organizations within and beyond the community; and 4) promote community education and awareness. Together, these findings help to develop a working model to understand the civic footprint of nonprofit organizations with methodological implications for future research that would seek to measure the extent to which nonprofits promote civic engagement. Il est normal de supposer que les associations à but non lucratif favorisent l’engagement du citoyen dans les communautés locales. Cependant, il existe peu de données empiriques sur la manière dont ces associations assument véritablement ce rôle. Pour combler ce manque, nous avons mené des entretiens semi-directifs approfondis auprès du personnel d’associations à but non lucratif dans une petite communauté rurale aux États-Unis. Nos résultats préliminaires indiquent que ces associations motivent les citoyens à s’impliquer quand elles offrent des programmes et des activités qui : 1) intéressent les bénévoles et les donateurs; 2) rassemblent directement ou indirectement les membres de la communauté; 3) collaborent avec d’autres associations tant au sein de la communauté qu’au-delà de celle-ci; et 4) encouragent l’éducation et la conscientisation communautaires. Ces constats aident à établir un modèle pour mieux comprendre la présence civique des associations à but non lucratif dans les communautés et indiquent une piste à suivre pour des recherches futures qui examineraient l’influence de ces associations sur le niveau de participation civique.

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