scholarly journals Prevalence and Determinants of Fatigue after COVID-19 in Non-Hospitalized Subjects: A Population-Based Study

2021 ◽  
Vol 18 (4) ◽  
pp. 2030
Author(s):  
Knut Stavem ◽  
Waleed Ghanima ◽  
Magnus K. Olsen ◽  
Hanne M. Gilboe ◽  
Gunnar Einvik
Keyword(s):  
Regression Analysis ◽  
Linear Regression Analysis ◽  
Population Based ◽  
Web Survey ◽  
Population Based Study ◽  
Symptom Load ◽  
Z Scores ◽  
The Mean ◽  
General Norm ◽  
Short Time

This study assessed the prevalence and determinants of fatigue in a population-based cohort of non-hospitalized subjects 1.5–6 months after COVID-19. It was a mixed postal/web survey of all non-hospitalized patients ≥18 years with a positive PCR for SARS-CoV-2 until 1 June 2020 in a geographically defined area. In total, 938 subjects received a questionnaire including the Chalder fatigue scale (CFQ-11) and the energy/fatigue scale of the RAND-36 questionnaire. We estimated z scores for comparison with general population norms. Determinants were analyzed using multivariable logistic and linear regression analysis. In total, 458 subjects (49%) responded to the survey at median 117.5 days after COVID-19 onset, and 46% reported fatigue. The mean z scores of the CFQ-11 total was 0.70 (95% CI 0.58 to 0.82), CFQ-11 physical 0.66 (0.55 to 0.78), CFQ-11 mental 0.47 (0.35 to 0.59) and RAND-36 energy/fatigue −0.20 (−0.31 to −0.1); all CFQ-11 scores differed from those of the norm population (p < 0.001). Female sex, single/divorced/widowed, short time since symptom debut, high symptom load, and confusion during acute COVID-19 were associated with higher multivariable odds of fatigue. In conclusion, the burden of post-viral fatigue following COVID-19 was high, and higher than in a general norm population. Symptoms of fatigue were most prevalent among women, those having a high symptom load, or confusion during the acute phase.

The impact of legs fat mass and legs lean fat mass on thigh circumference according cardiovascular risk: a population-based study

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
M Chlabicz ◽  
M Paniczko ◽  
J Jamolkowski ◽  
P Sowa ◽  
M Lapinska ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Regression Analysis ◽  
Linear Regression ◽  
Muscle Tissue ◽  
Fat Mass ◽  
Linear Regression Analysis ◽  
Population Based ◽  
Thigh Circumference ◽  
Tissue Model ◽  
The Mean

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Medical University of Bialystok, Poland Introduction A low thigh circumference is associated with an increased risk of high blood pressure, diabetes, cardiovascular diseases, and total mortality. Objectives The aim of the study was to investigate the relationship between the thigh circumference and cardiovascular (CV) risk classes, and to assess what type of tissue, adipose tissue or muscle tissue affects the thigh circumference. Methods The longitudinal, population-based, Polish study was conducted in 2017-2020. A total of 931 individuals aged 20-79 were analyzed. Pol-SCORE system was used to assess the 10-year risk of fatal CV based on the following risk factors: age, gender, smoking, systolic blood pressure, and total cholesterol for individuals aged 40-70.  Then, CV risk classes were assessed using the 2019 ESC/EAS guidelines. The measurement of thigh circumference were performed directly below the gluteal fold of the thigh. Both thighs were measured and the mean value was calculated as the final thigh circumference. Body composition was assessed using Dual Energy X-ray Absorptiometry (DEXA). Results The mean age was 49.1 ± 15.5 years and 43.2% male. The mean thigh circumference was 58.2 ± 5.9 cm, the mean legs fat mass was 7.7 ± 2.8kg, and the mean legs lean mass was 16.9 ± 4.0kg. Lower thigh circumference was associated with higher CV risk classes in univariate linear regression analysis (β -0.516, p = 0.002), as well adjusted by age and sex (β -0.839, p = 0.008), adjusted by age, sex, BMI (β -0.886, p &lt;0.001), and age, sex, WHR (β -0.988, p &lt;0.001). In linear regression analysis legs adipose tissue and muscle tissue were related to the thigh circumference independently of CV risk classes (Model 1) and Pol-SCORE value (Model 2). However, fatty tissue (Model 1: β 0.746, p &lt; 0.001; Model 2: β 0.749, p &lt; 0.001) affects the thigh circumference more than the muscle tissue (Model 1: β 0.479, p &lt; 0.001; Model 2: β 0.442, p &lt; 0.001) (Fig. 1). Conclusion Smaller thigh circumference was associated with higher CV risk classes. Thigh circumference was more influenced by adipose tissue than by muscle tissue, regardless of the Pol-SCORE  or CV risk classes. Table 1. Variable Model 1 Model 2 Beta p R2 Beta p R2 Legs fat mass 0.746 &lt;0.001 0.785 0.749 &lt;0.001 0.760 Legs lean mass 0.479 &lt;0.001 0.785 0.442 &lt;0.001 0.760 Model 1: adjusted for Cardiovascular risk classesModel 2: adjusted for Pol-SCOREResults of the linear regression analysis thigh circumference in the general population Abstract Figure 1.

scholarly journals The Relationship between Thyroid Function and Depressive Symptoms—the FIN-D2D Population-Based Study

2015 ◽  
Vol 8 ◽  
pp. CMED.S24111 ◽  
Author(s):  
Juha Saltevo ◽  
Hannu Kautiainen ◽  
Pekka Mäntyselkä ◽  
Antti Jula ◽  
Sirkka Keinänen-Kiukaanniemi ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Depressive Symptoms ◽  
Thyroid Function ◽  
Participation Rate ◽  
Population Based ◽  
Thyroid Stimulating Hormone ◽  
Free Triiodothyronine ◽  
Population Based Study ◽  
The Mean ◽  
The Relationship

The association between thyroid function and depression is controversial. Both conditions express many similar symptoms, but the studies done give conflicting results. This study draws on a random, population-based sample of 4500 subjects aged 45–75 years old from Finland. The basic clinical study was done in 2007 for 1396 men and 1500 women (64% participation rate). Thyroid stimulating hormone (TSH), free thyroxine (F-T4), and free triiodothyronine (F-T3) were measured in 2013 from frozen samples. The 21-item Beck Depression Inventory (BDI-21) was applied to assess depressive symptoms (score ≥10 points). The prevalence of depressive symptoms was 17.5% in women and 12.5% in men. In women, the mean levels of TSH, F-T4, and F-T3 without depressive symptoms vs. with the presence of depressive symptoms were 1.92/1.97 mU/L, 13.1/13.1 pmol/L, and 3.91/3.87 pmol/L (NS), respectively. In men, the levels were 1.87/1.94 mU/L, 13.5/13.7 pmol/L, and 4.18/4.12 pmol/L (NS), respectively. In multiple regression analysis, TSH had no relationship to BDI-21 total score. We found no association between depressive symptoms and thyroid values.

scholarly journals Visceral adiposity index is associated with lung function impairment: a population-based study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Sunyue He ◽  
Jie Yang ◽  
Xiaoyong Li ◽  
Hongxia Gu ◽  
Qing Su ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Lung Function ◽  
Linear Regression Analysis ◽  
Population Based ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Population Based Study ◽  
Adiposity Index ◽  
Function Impairment ◽  
Lung Function Impairment

Abstract Background The effects of visceral adiposity on decreased lung function have drawn much attention. Recently, the visceral adiposity index (VAI) has been proposed as a visceral fat distribution and dysfunction marker. However, the relationship between the VAI and lung function has not been investigated. The objective of the study was to analyze the association between the VAI and lung function and evaluate the potential of VAI as a predictor of lung function. Methods We collected data from a population-based study of 1786 subjects aged 40 years or older. All subjects completed a questionnaire and underwent anthropometric measurements and laboratory tests. Linear and logistic regression models were developed to assess the association between the VAI and lung function. Results The VAI was inversely related to FVC%predicted in men and negatively associated with both FVC%predicted and FEV1%predicted in women. In the linear regression analysis, the decrease in FVC%predicted associated with each 10% increase in the VAI was 1.127% in men and 1.943% in women; the decrease in FEV1%predicted associated with each 10%increase in the VAI was 0.663% in men and 1.738% in women. Further regression analysis revealed that the VAI was positively correlated with FVC and FEV1 impairment in women. Conclusions We were the first to show a clear correlation between the VAI and lung function impairment in the Chinese population. The VAI could be a simple and reliable approach in daily practice, and individuals, especially women with a high VAI, should receive additional screening and preventive interventions for respiratory disease.

scholarly journals Visceral adiposity index is associated with lung function impairment: A population-based study

2020 ◽  
Author(s):  
Sunyue He ◽  
Jie Yang ◽  
Xiaoyong Li ◽  
Hongxia Gu ◽  
Qing Su ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Lung Function ◽  
Linear Regression Analysis ◽  
Population Based ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Population Based Study ◽  
Adiposity Index ◽  
Function Impairment ◽  
Lung Function Impairment

Abstract Background: The effects of visceral adiposity on decreased lung function have drawn much attention. Recently, the visceral adiposity index (VAI) has been proposed as a visceral fat distribution and dysfunction marker. However, the relationship between the VAI and lung function has not been investigated. The objective of the study was to analyze the association between the VAI and lung function and evaluate the potential of VAI as a predictor of lung function.Methods: We enrolled data from a population-based study of 1786 subjects aged 40 years or older. All subjects completed a questionnaire and underwent anthropometric measurements and laboratory tests. Linear and logistic regression models were developed to assess the association between the VAI and lung function.Results: The VAI was inversely related to FVC%predicted in men and negatively associated with both FVC%predicted and FEV1%predicted in women. In the linear regression analysis, the decrease in FVC%predicted associated with a 1-SD increase in the VAI was 1.776% in men and 3.421% in women; the decrease in FEV1%predicted associated with a 1-SD increase in the VAI was 1.045% in men and 3.060% in women. Further regression analysis revealed that the VAI was positively correlated with FVC and FEV1 impairment in women.Conclusions: We were the first to show a clear correlation between VAI and lung function impairment in the Chinese population. The VAI could be a simple and reliable approach in daily practice, and individuals, especially women with a high VAI, should receive additional screening and preventive interventions for respiratory disease.

scholarly journals Refraining from Seeking Mental Healthcare and Poorer Mental Well-Being: A Longitudinal Population-Based study on Men in Sweden

2020 ◽  
Author(s):  
Sara Olsson ◽  
Bo Burström ◽  
Gunnel Hensing ◽  
Jesper Löve
Keyword(s):  
Regression Analysis ◽  
Linear Regression Analysis ◽  
Empirical Support ◽  
Mental Healthcare ◽  
Well Being ◽  
Population Based ◽  
Care Seeking ◽  
Population Based Study ◽  
Multivariable Linear Regression Analysis ◽  
Mental Well Being

Abstract Background: Depression and anxiety disorder contribute to a significant part of the disease burden among men, yet many men refrain from seeking care or receive insufficient care when they do seek it. This is plausibly detrimental to men’s mental well-being, but there is a lack of population-based research to confirm this. This study investigated 1) if men who had refrained from seeking mental healthcare had poorer mental well-being than those who sought care, 2) if those who sought care but perceived it as insufficient had poorer mental well-being than those who perceived care as sufficient, and 3) if these differences persisted over time. Methods: This longitudinal study used questionnaire data from a population-based sample of 1240 men, aged 19-64 years, in Sweden. Having refrained from seeking mental healthcare, or perceiving the care as insufficient, at any time in life, was assessed in a questionnaire, 2008. Current mental well-being was assessed in both 2008 and 2009 using mean scores on the WHO (Ten) Well-being Index, with a lower score indicating poorer mental well-being. Group differences were calculated using t-tests and multivariable linear regression analysis.Results: Of the men who had perceived a need for mental healthcare, 37% refrained from seeking such care. They had lower mental well-being scores in 2008, compared to those who sought care. Of those seeking care, 29 % perceived it as insufficient. They had lower mental well-being scores in 2008, compared to those who perceived the care as sufficient, but this was not statistically significant when controlling for potential confounders in the regression analysis. There were no differences in mental well-being scores based on care-seeking or perceived care-sufficiency in 2009. Conclusions: This population-based study provides some empirical support for the hypothesis that refraining from seeking mental healthcare, or perceiving the care as insufficient, is detrimental to men’s mental well-being. However, the lack of persistent differences contradicts this hypothesis. The results highlight the need for more research, using larger population-based samples of men, and longer follow-up periods. This should be combined with efforts to increase men’s mental healthcare-seeking and to provide mental healthcare that is perceived as sufficient.

scholarly journals Visceral adiposity index is associated with lung function impairment: A population-based study

2020 ◽  
Author(s):  
Sunyue He ◽  
Jie Yang ◽  
Xiaoyong Li ◽  
Hongxia Gu ◽  
Qing Su ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Lung Function ◽  
Linear Regression Analysis ◽  
Population Based ◽  
Visceral Adiposity ◽  
Visceral Adiposity Index ◽  
Population Based Study ◽  
Adiposity Index ◽  
Function Impairment ◽  
Lung Function Impairment

Abstract Background: The effects of visceral adiposity on decreased lung function have drawn much attention. Recently, the visceral adiposity index (VAI) has been proposed as a visceral fat distribution and dysfunction marker. However, the relationship between the VAI and lung function has not been investigated. The objective of the study was to analyze the association between the VAI and lung function and evaluate the potential of VAI as a predictor of lung function. Methods: We collected data from a population-based study of 1786 subjects aged 40 years or older. All subjects completed a questionnaire and underwent anthropometric measurements and laboratory tests. Linear and logistic regression models were developed to assess the association between the VAI and lung function. Results: The VAI was inversely related to FVC%predicted in men and negatively associated with both FVC%predicted and FEV1%predicted in women. In the linear regression analysis, the decrease in FVC%predicted associated with each 10% increase in the VAI was 1.127% in men and 1.943% in women; the decrease in FEV1%predicted associated with each 10% increase in the VAI was 0.663% in men and 1.738% in women. Further regression analysis revealed that the VAI was positively correlated with FVC and FEV1 impairment in women. Conclusions: We were the first to show a clear correlation between the VAI and lung function impairment in the Chinese population. The VAI could be a simple and reliable approach in daily practice, and individuals, especially women with a high VAI, should receive additional screening and preventive interventions for respiratory disease.

Reduced oxygenation but not fibrosis defined by functional magnetic resonance imaging predicts the long-term progression of chronic kidney disease

2018 ◽  
Vol 35 (6) ◽  
pp. 964-970 ◽  
Author(s):  
Kei Sugiyama ◽  
Tsutomu Inoue ◽  
Eito Kozawa ◽  
Masahiro Ishikawa ◽  
Akira Shimada ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Chronic Kidney Disease ◽  
Regression Analysis ◽  
Linear Regression Analysis ◽  
Resonance Imaging ◽  
Bold Mri ◽  
Adc Values ◽  
The Mean ◽  
Rate Of Decline ◽  
Observation Period

Abstract Background Although chronic hypoxia and fibrosis may be a key to the progression of chronic kidney disease (CKD), a noninvasive means of measuring these variables is not yet available. Here, using blood oxygen level–dependent (BOLD) and diffusion-weighted (DW) magnetic resonance imaging (MRI), we assessed changes in renal tissue oxygenation and fibrosis, respectively, and evaluated their correlation with prognosis for renal function. Methods The study was conducted under a single-center, longitudinal, retrospective observational design. We examined the prognostic significance of T2* values of BOLD-MRI and apparent diffusion coefficient (ADC) values on DW-MRI and other clinical parameters. The rate of decline in estimated glomerular filtration rate (eGFR) was calculated by linear regression analysis using changes in eGFR during the observation period. Results A total of 91 patients were enrolled, with a mean age of 55.8 ± 15.6 years. Among patients, 51 (56.0%) were males and 38 (41.8%) had diabetes mellitus. The mean eGFR was 49.2 ± 28.9 mL/min/1.73 m2 and the mean observation period was 5.13 years. ADC values of DW-MRI but not T2* values of BOLD-MRI were well correlated with eGFR at the initial time point. The mean annual rate of decline in eGFR during the 5-year observation period was −1.92 ± 3.00 mL/min/1.73 m2. On multiple linear regression analysis, the rate of decline in eGFR was significantly correlated with eGFR at the start point, period average amount of proteinuria and T2* values, but not with ADC values (t = 2.980, P = 0.004). Conclusions Reduced oxygenation as determined by low T2* values on BOLD-MRI is a clinically useful marker of CKD progression.

scholarly journals Mediterranean Lifestyle in Relation to Cognitive Health: Results from the HELIAD Study

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1557 ◽  
Author(s):  
Costas Anastasiou ◽  
Mary Yannakoulia ◽  
Meropi Kontogianni ◽  
Mary Kosmidis ◽  
Eirini Mamalaki ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Population Based ◽  
Lifestyle Factors ◽  
Cognitive Outcomes ◽  
Lifestyle Factor ◽  
Population Based Study ◽  
Cognitive Domains ◽  
Domain Specific ◽  
Z Scores ◽  
Lifestyle Pattern

Many lifestyle factors have been linked to cognitive function but little is known about their combined effect. An overall lifestyle pattern for people living in the Mediterranean basin has been proposed, including diet, but also physical activity, sleep and daily living activities with social/intellectual aspects. We aimed to examine the associations between a combination of these lifestyle factors and detailed cognitive performance. A total of 1716 participants from the Hellenic Longitudinal Investigation of Ageing and Diet (HELIAD), a population-based study of participants ≥65 years, were included in this analysis. Lifestyle factors were evaluated using standard, validated questionnaires and a Total Lifestyle Index (TLI) was constructed. Cognitive outcomes included mild cognitive impairment (MCI) diagnosis, a composite z-score (either continuous or with a threshold at the 25th percentile) and z-scores for five cognitive domains. A higher TLI was associated with 65% reduced odds for MCI in the non-demented individuals and 43% reduced odds for low global cognition when MCI participants were excluded, a risk reduction equivalent to 9 and 2.7 fewer years of ageing, respectively. Each lifestyle factor was differentially associated with domain-specific cognitive performance. Our results suggest that a TLI, more so than single lifestyle parameters, may be related to cognitive performance.

scholarly journals FACTORS LINKED TO THE PRACTICE OF PHYSICAL ACTIVITY AMONG THE ELDERLY IN SOUTHERN BRAZIL

2019 ◽  
Vol 25 (3) ◽  
pp. 216-219
Author(s):  
Alisson Padilha de Lima ◽  
Ezequiel Vitório Lini ◽  
Marilene Rodrigues Portella ◽  
Marlene Doring ◽  
Fabrício Bruno Cardoso
Keyword(s):  
Physical Activity ◽  
Urban Environment ◽  
Elderly People ◽  
The Elderly ◽  
Population Based ◽  
Level Of Evidence ◽  
Population Based Study ◽  
Multivariable Analyses ◽  
The Mean ◽  
The City

ABSTRACT Introduction The increase in chronic diseases and physical inactivity are major public health problems among elderly populations worldwide. Objective This article aimed to determine the prevalence and factors associated with the practice of physical activity (PA) among elderly people living in urban environment. Methods A cross-population-based study was conducted in 2014, with 196 elderly people aged ≥ 60 years of age living in urban environment in the city of Passo Fundo, in the State of Rio Grande do Sul. Gross and multivariable analyses were conducted using Poisson regression, estimating the ratios of gross and adjusted prevalence and calculating their respective 95% confidence intervals. Results The mean age was 71.3 (± 8.4). The gross prevalence for the practice of PA was 56.1%. After adjusted analysis, only the variable independent in activities of daily living (ADLs) remained significant (95% CI 1.05 to 4.83) (p = 0.037). Conclusions This research showed an association between the practice of PA and independence in ADLs. Level of Evidence II, Economic and decision analysis - Development of economic model or decision.

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