scholarly journals The Efficacy of a New AMCOP® Elastodontic Protocol for Orthodontic Interceptive Treatment: A Case Series and Literature Overview

2022 ◽  
Vol 19 (2) ◽  
pp. 988
Author(s):  
Alessio Danilo Inchingolo ◽  
Assunta Patano ◽  
Giovanni Coloccia ◽  
Sabino Ceci ◽  
Angelo Michele Inchingolo ◽  
...  
Keyword(s):  
Treatment Period ◽  
Orthodontic Treatment ◽  
Case Series ◽  
Clinical Effectiveness ◽  
Adaptation Capacity ◽  
Literature Overview ◽  
Developmental Age ◽  
Functional Appliances ◽  
First Time ◽  
Clinical Cases

Background: Elastodontics is a specific interceptive orthodontic treatment that uses removable elastomeric appliances. They are functional appliances that produce neuromuscular, orthopedic and dental effects. Thus, these devices are useful in the developmental age, when skeletal structures are characterized by important plasticity and adaptation capacity, allowing to remove factors responsible for malocclusions. Elastomeric devices are generally well tolerated by patients requiring simple collaboration and management. This work can be useful to update all orthodontists already adopting these appliances or for those who want to approach them for the first time. This study aimed to describe four cases treated with new elastomeric devices called AMCOP Bio-Activators and to provide an overview of elastodontics, its evolution, indications and limits. Methods: A total of four clinical cases were presented after a treatment period of 16–20 months to evaluate the clinical and radiological effects of the elastodontic therapy. Results: The effectiveness of Bio-Activators on clinical cases was evidenced with a significant improvement in skeletal and dentoalveolar relationship, and malocclusion correction in a limited treatment period (16–20 months). Conclusions: The Bio-Activators showed clinical effectiveness to achieve therapeutic targets according to a low impact on the patient’s compliance.

scholarly journals Steering the Mandible in the Right Direction : Forsus Case Series

2021 ◽  
pp. 030157422110054
Author(s):  
Prachi Gohil ◽  
Sonali Mahadevi ◽  
Bhavya Trivedi ◽  
Neha Assudani ◽  
Arth Patel ◽  
...  
Keyword(s):  
Orthodontic Treatment ◽  
Case Series ◽  
Treatment Compliance ◽  
Class Ii ◽  
Skeletal Class ◽  
Skeletal Class Ii ◽  
Technological Advances ◽  
Functional Appliances ◽  
The Right ◽  
Mandibular Retrognathia

We are in the process of discovery of new vistas for technological advances in terms of various appliances with a vision of making orthodontic treatment compliance free as well as successful. Due to improved technology, the enigma of treating the Class II syndrome is palliated. “Out of the box” thinking has become a norm to treat certain situations that were not corrected in noncompliant patients. Fixed functional appliances are valuable tools introduced to assist the correction of skeletal Class II malocclusion with mandibular retrognathia at the deceleration stage of growth for achieving stable results. In this direction a case series is reported of patients having the above conditions and undergoing orthodontic treatment using a Forsus FFA. Joining hands with technology is a win-win situation for both the patient and the orthodontist.

scholarly journals Profiling the expression of pro-metastatic genes in association with the clinicopathological features of primary breast cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Seyed-Mohammad Mazloomi ◽  
Mitra Foroutan-Ghaznavi ◽  
Vahid Montazeri ◽  
Gholamreza Tavoosidana ◽  
Ashraf Fakhrjou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Target Genes ◽  
Case Series ◽  
Clinicopathological Features ◽  
Cell Junctions ◽  
Homologous Gene ◽  
Axillary Lymph ◽  
Luminal A ◽  
Transcriptional Profiles ◽  
First Time

Abstract Background Metastasis accounts for ninety percent of breast cancer (BrCa) mortality. Cortactin, Ras homologous gene family member A (RhoA), and Rho-associated kinase (ROCK) raise cellular motility in favor of metastasis. Claudins (CLDN) belong to tight junction integrity and are dysregulated in BrCa. Thus far, epidemiologic evidence regarding the association of different pro-metastatic genes with pathological phenotypes of BrCa is largely inconsistent. This study aimed to determine the possible transcriptional models of pro-metastatic genes incorporate in holding the integrity of epithelial cell–cell junctions (CTTN, RhoA, ROCK, CLDN-1, CLDN-2, and CLDN-4), for the first time, in association with clinicopathological features of primary BrCa. Methods In a consecutive case-series design, 206 newly diagnosed non-metastatic eligible BrCa patients with histopathological confirmation (30–65 years) were recruited in Tabriz, Iran (2015–2017). Real-time RT-PCR was used. Then fold changes in the expression of target genes were measured. Results ROCK amplification was associated with the involvement of axillary lymph node metastasis (ALNM; ORadj. = 3.05, 95%CI 1.01–9.18). Consistently, inter-correlations of CTTN-ROCK (β = 0.226, P < 0.05) and RhoA-ROCK (β = 0.311, P < 0.01) were determined among patients diagnosed with ALNM+ BrCa. In addition, the overexpression of CLDN-4 was frequently observed in tumors identified by ALNM+ or grade III (P < 0.05). The overexpression of CTTN, CLDN-1, and CLDN-4 genes was correlated positively with the extent of tumor size. CTTN overexpression was associated with the increased chance of luminal-A positivity vs. non-luminal-A (ORadj. = 1.96, 95%CI 1.02–3.77). ROCK was also expressed in luminal-B BrCa tumors (P < 0.05). The estrogen receptor-dependent transcriptions were extended to the inter-correlations of RhoA-ROCK (β = 0.280, P < 0.01), ROCK-CLDN-2 (β = 0.267, P < 0.05), and CLDN-1-CLDN-4 (β = 0.451, P < 0.001). Conclusions For the first time, our findings suggested that the inter-correlations of CTTN-ROCK and RhoA-ROCK were significant transcriptional profiles determined in association with ALNM involvement; therefore the overexpression of ROCK may serve as a potential molecular marker for lymphatic metastasis. The provided binary transcriptional profiles need more approvals in different clinical features of BrCa metastasis.

Electrophysiological effects and clinical utility of propafenone in children

2021 ◽  
pp. 1-5
Author(s):  
Manavotam Singh ◽  
Keore McKenzie ◽  
Mark L. Hudak ◽  
Anil K. Gehi ◽  
Sunita J. Ferns
Keyword(s):  
Case Series ◽  
Clinical Effectiveness ◽  
Retrospective Case ◽  
Cardiac Side Effects ◽  
Cardiac Depression ◽  
Case Series Study ◽  
Baseline Characteristics ◽  
Antiarrhythmic Medication ◽  
Electrophysiological Effects ◽  
Series Study

Abstract Aim: This retrospective case series study sought to describe the safety and clinical effectiveness of propafenone for the control of arrhythmias in children with and without CHD or cardiomyopathy. Methods: We reviewed baseline characteristics and subsequent outcomes in a group of 63 children treated with propafenone at 2 sites over a 15-year period Therapy was considered effective if no clinically apparent breakthrough episodes of arrhythmias were noted on the medication. Results: Sixty-three patients (29 males) were initiated on propafenone at a median age of 2.3 years. CHD or cardiomyopathy was noted in 21/63 (33%). There were no significant differences between demographics, clinical backgrounds, antiarrhythmic details, side effect profiles, and outcomes between children with normal hearts and children with CHD or cardiomyopathy. Cardiac depression at the initiation of propafenone was more common amongst children with CHD or cardiomyopathy compared to children with normal hearts. Systemic ventricular function was diminished in 15/63 patients (24%) prior to starting propafenone and improved in 8/15 (53%) of patients once better rhythm control was achieved. Other than one child in whom medication was stopped due to gastroesophageal reflux, no other child experienced significant systemic or cardiac side effects during treatment with propafenone. Propafenone achieved nearly equal success in controlling arrhythmias in both children with normal hearts and children with congenital heart disease or cardiomyopathy (90% versus 86%, p = 0.88). Conclusion: Propafenone is a safe and effective antiarrhythmic medication in children.

scholarly journals Current Advances in Robotics for Head and Neck Surgery—A Systematic Review

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1398
Author(s):  
Felix Boehm ◽  
Rene Graesslin ◽  
Marie-Nicole Theodoraki ◽  
Leon Schild ◽  
Jens Greve ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Large Scale ◽  
Case Series ◽  
Clinical Effectiveness ◽  
Neck Surgery ◽  
Head And Neck Surgery ◽  
Daily Routine ◽  
Surgical Robots ◽  
Standard Procedures

Background. In the past few years, surgical robots have recently entered the medical field, particularly in urology, gynecology, and general surgery. However, the clinical effectiveness and safety of robot-assisted surgery (RAS) in the field of head and neck surgery has not been clearly established. In this review, we evaluate to what extent RAS can potentially be applied in head and neck surgery, in which fields it is already daily routine and what advantages can be seen in comparison to conventional surgery. Data sources. For this purpose, we conducted a systematic review of trials published between 2000 and 2021, as well as currently ongoing trials registered in clinicaltrials.gov. The results were structured according to anatomical regions, for the topics “Costs,” “current clinical trials,” and “robotic research” we added separate sections for the sake of clarity. Results. Our findings show a lack of large-scale systematic randomized trials on the use of robots in head and neck surgery. Most studies include small case series or lack a control arm which enables a comparison with established standard procedures. Conclusion. The question of financial reimbursement is still not answered and the systems on the market still require some specific improvements for the use in head and neck surgery.

scholarly journals Corticotomy-assisted orthodontic treatment. A systematic review of the biological basis and clinical effectiveness

2015 ◽  
Vol 36 (7) ◽  
pp. 794-801 ◽  
Author(s):  
Ali Hassan ◽  
Samar Al-Saeed ◽  
Basma Al-Maghlouth ◽  
Maha Bahammam ◽  
Amal Linjawi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Orthodontic Treatment ◽  
Clinical Effectiveness ◽  
Biological Basis

scholarly journals Use of Cantilever Mechanics for Impacted Teeth: Case Series

2013 ◽  
Vol 7 (1) ◽  
pp. 186-197 ◽  
Author(s):  
Sergio Paduano ◽  
Gianrico Spagnuolo ◽  
Gerardo Franzese ◽  
Gioacchino Pellegrino ◽  
Rosa Valletta ◽  
...  
Keyword(s):  
Orthodontic Treatment ◽  
Case Series ◽  
Permanent Teeth ◽  
Impacted Teeth ◽  
Adolescents And Adults ◽  
Fixed Appliances

This paper describes the orthodontic treatment, and the biomechanics of cantilevers for the impaction of permanent teeth in youngs, adolescents, and adults. In these case series, multibracket straightwire fixed appliances, together with cantilever mechanics, were used to treat the impaired occlusion.

scholarly journals Clinical and histopathological features of a lingual mucosal horn: First time described clinical case series

2019 ◽  
Vol 5 (3) ◽  
Author(s):  
Frédérick Gaultier ◽  
Anne-Laure Ejeil ◽  
Francois Lepelletier ◽  
Bruno Gogly ◽  
Hafida Cherifi ◽  
...  
Keyword(s):  
Clinical Case ◽  
Case Series ◽  
Histopathological Features ◽  
First Time

scholarly journals Optimal Use of a Panoramic Radiograph as a Screening Tool for Condylar Resorption in Patients Undergoing Active Orthodontic Treatment: A Case Series

2020 ◽  
Vol 10 ◽  
pp. 65
Author(s):  
Shaima Malik ◽  
Shilpa Singh ◽  
Robby T. George ◽  
Mayank Kakkar ◽  
Nikhilesh R. Vaid
Keyword(s):  
Orthodontic Treatment ◽  
Behavioral Therapy ◽  
Mandibular Condyle ◽  
Case Series ◽  
Panoramic Radiograph ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Initial Examination ◽  
Panoramic Radiographs ◽  
Specific Medication

Condylar resorption of temporomandibular joint findings in the panoramic radiographs is an indication of bone resorption suggesting possible degenerative joint disease that warrants early screen and subsequent referral to a dedicated specialist. This case series reports three patients that underwent the active orthodontic treatment for the duration of approximately 24–36 months. The patients were asymptomatic at the initial examination. The clinical examination was negative for clicking; the range of motion on opening, lateral excursion, and protrusion was normal. Neither of these patients had a history of rheumatic disease or bruxism. During the later stages of orthodontic treatment, two of the three patients reported mild pain and clicking during mastication, which was also confirmed chairside on clinical evaluation. Patients were referred to the orofacial pain specialist, were they were prescribed specific medication for the symptoms, along with cognitive behavioral therapy, and were further evaluated for splint therapy. Panoramic radiographs taken before the start of the treatment, during the treatment and at the completion of the orthodontic treatments indicate the progression in the resorption of mandibular condyle in all three patients suggesting possible degeneration that warrants further investigation and therapy.

Orthodontic Conundrums Part 2: Finishing Cases to a Class III Molar Relationship

2021 ◽  
Vol 14 (1) ◽  
pp. 27-31
Author(s):  
Naeem I Adam ◽  
Adam Jowett ◽  
Trevor Hodge
Keyword(s):  
Clinical Relevance ◽  
Orthodontic Treatment ◽  
Class I ◽  
Patient Harm ◽  
Class Iii ◽  
Facial Profile ◽  
Clinical Cases

This is the second article in a series on conundrums in orthodontics. A Class I molar relationship is a frequent aim of orthodontic treatment. There are, however, examples where intentionally finishing to a Class III molar relationship is the more pragmatic and preferable option. Pursuing this approach in the appropriate circumstances may, for example, prevent deleterious consequences to the facial profile or avoid the need for further dental extractions. This article explores the indications for finishing cases to a Class III molar relationship with illustrated clinical cases. CPD/Clinical Relevance: Dogmatic attempts to deliver Class I molar relationships, in all cases, without consideration of the consequences, have the potential to cause the patient harm. The orthodontist must then consider all possible options available, including those resulting in a Class III molar relationship.

Erosive pustulöse Dermatose der Kopfhaut: häufig übersehen und selten diagnostiziert

2020 ◽  
Vol 8 (1) ◽  
pp. 21-22
Author(s):  
Markus Braun-Falco
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Actinic Keratosis ◽  
Diagnostic Delay ◽  
Case Series ◽  
Older Men ◽  
Uncommon Disease ◽  
First Time

Erosive pustular dermatosis of the scalp (EPDS) is an uncommon disease and primarily affects older men who have photodamaged bald scalp, as was confirmed by our case series. EPDS is probably an overlooked disease, whose diagnosis is often missed because of a higher incidence of other cutaneous diseases affecting the same area and usually secondary to chronic actinic damage, such as actinic keratosis, basal cell carcinoma, and squamous cell carcinoma. For the first time, we report a case series of misdiagnosed EPDS with the aim of understanding why a diagnosis of EPDS was initially missed and try to give some tips to avoid future diagnostic delay.

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