scholarly journals Short-Chain Fatty Acids Inhibit Growth Hormone and Prolactin Gene Transcription via cAMP/PKA/CREB Signaling Pathway in Dairy Cow Anterior Pituitary Cells

2013 ◽  
Vol 14 (11) ◽  
pp. 21474-21488 ◽  
Author(s):  
Jian-Fa Wang ◽  
Shou-Peng Fu ◽  
Su-Nan Li ◽  
Zhong-Ming Hu ◽  
Wen-Jing Xue ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Signaling Pathway ◽  
Gene Transcription ◽  
Dairy Cow ◽  
Anterior Pituitary ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Pituitary Cells ◽  
Prolactin Gene

Short-chain fatty acids and thyroid hormone interact in regulating enterocyte gene transcription

Surgery ◽  
1999 ◽  
Vol 126 (2) ◽  
pp. 293-298 ◽  
Author(s):  
Shufen Meng ◽  
James T. Wu ◽  
Sonia Y. Archer ◽  
Richard A. Hodin
Keyword(s):  
Fatty Acids ◽  
Thyroid Hormone ◽  
Gene Transcription ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

Short chain fatty acids reduces OPCs loss by inhibiting activation of astrocytes via SGK1/IL-6 signaling pathway

2021 ◽  
Author(s):  
Yanmin Gao ◽  
Di Xie ◽  
Yang Wang ◽  
Lei Niu ◽  
Hua Jiang
Keyword(s):  
Fatty Acids ◽  
Signaling Pathway ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Ischemic Brain ◽  
Proliferation And Apoptosis ◽  
Oligodendrocyte Precursor ◽  
Related Pathway ◽  
Chain Fatty Acids

Abstract Short chain fatty acids (SCFAs) are known to be actively involved in neurological disease, but their roles in hypoxic-ischemic brain injury (HIBI) is unclear. This study established a rat model of HIBI, then measured the changes in IL-6 and NLRP3, proliferation and apoptosis indicators of oligodendrocyte precursor cells (OPCs). The mechanism of SCFAs on astrocytes were also investigated. To further explore the mechanism, astrocytes were treated with hypoxia in vitro and OPCs were treated with IL-6. The results showed that SCFAs significantly alleviated the activation of astrocyte and loss of OPCs induced by HIBI. SCFAs pretreatment was associated with the following: (1) downregulation of NLRP3, IL-6, CCL2, and IP-10; (2) was no effect on proliferation of OPCs; (3) amelioration of the abnormal expression of Bax and Bcl-2; and (4) regulation of IL-6 expression via SGK1 related pathway in astrocytes. Our findings revealed that SCFAs alleviated loss of OPCs through regulating the astrocytes activation by SGK1/IL-6 signaling pathway.

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