scholarly journals Long Non-coding RNAs as Important Biomarkers in Laryngeal Cancer and Other Head and Neck Tumours

2019 ◽  
Vol 20 (14) ◽  
pp. 3444 ◽  
Author(s):  
Alessia Maria Cossu ◽  
Laura Mosca ◽  
Silvia Zappavigna ◽  
Gabriella Misso ◽  
Marco Bocchetti ◽  
...  
Keyword(s):  
Head And Neck ◽  
Laryngeal Cancer ◽  
Neck Region ◽  
Head And Neck Carcinoma ◽  
Molecular Signatures ◽  
Head And Neck Tumours ◽  
Head And Neck Region ◽  
Neck Carcinoma ◽  
Non Coding Rnas ◽  
Pharmacological Application

Head and neck carcinoma (HNC) is a heterogeneous disease encompassing a variety of tumors according to the origin. Laryngeal cancer (LC) represents one of the most frequent tumors in the head and neck region. Despite clinical studies and advance in treatment, satisfactory curative strategy has not yet been reached. Therefore, there is an urgent need for the identification of specific molecular signatures that better predict the clinical outcomes and markers that serve as suitable therapeutic targets. Long non-coding RNAs (lncRNA) are reported as important regulators of gene expression and represent an innovative pharmacological application as molecular biomarkers in cancer. The purpose of this review is to discuss the most relevant epigenetic and histological prognostic biomarkers in HNC, with particular focus on LC. We summarize the emerging roles of long non-coding RNAs in HNC and LC development and their possible use in early diagnosis.

Elevated Serum Secretory Immunoglobulin a Levels in Patients with Head and Neck Carcinoma

1983 ◽  
Vol 91 (2) ◽  
pp. 136-142 ◽  
Author(s):  
Tsuneo Watanabe ◽  
J. Dirk Iglehart ◽  
Dani P. Bolognesi ◽  
Edwin B. Cox ◽  
Anna Vaughn ◽  
...  
Keyword(s):  
Head And Neck ◽  
Immunoglobulin A ◽  
Elevated Serum ◽  
Neck Region ◽  
Head And Neck Carcinoma ◽  
Secretory Immunoglobulin A ◽  
Diagnostic Significance ◽  
Head And Neck Region ◽  
Neck Carcinoma ◽  
Secretory Immunoglobulin

Secretory immunoglobulin A (SlgA) is a major component of the secretory immune system and has been demonstrated in the sera of patients with various pathologic conditions. Current studies were undertaken to quantitate secretory components (SC) in sera of patients with squamous cell carcinoma in the head and neck region by means of a sensitive double-antibody radioimmunoassay. Patients with head and neck carcinoma were found to have threefold higher levels of SC (1.54 ± 0.74 mg/ml) compared to normal controls (0.51 ± 0.22mg/ml, P < .0001). Of interest was that the sera of patients who had successfully been treated 2 to 6 months prior to the study demonstrated statistically lower levels than those of patients with untreated carcinoma or recurrent disease. SC in sera appears to be in the form of SlgA. The origin and diagnostic significance of SC are briefly discussed.

scholarly journals SAFE TRACHEOSTOMY IN HEAD AND NECK CARCINOMA PATIENTS DURING COVID ERA: METHOD AND DEMOGRAPHICS

2020 ◽  
pp. 42-43
Author(s):  
Bonny A Joseph ◽  
Sandeep Ghosh ◽  
Sanjay M Desai
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Head And Neck Carcinoma ◽  
Surgical Oncology ◽  
Head And Neck Malignancy ◽  
Safety Measures ◽  
Head And Neck Region ◽  
Neck Malignancy ◽  
Neck Carcinoma

Introduction: Tracheostomy is inevitable in the management of many head and neck malignancy. The indications vary from supportive to palliative. During Covid-19 era, ensuring surgeon safety while performing tracheostomy is of utmost importance as tracheostomy is considered an aerosol generating procedure. Materials and methods: All the patients who underwent tracheostomy as part of the management of carcinoma of head and neck region in the department of Surgical Oncology from March till October 2020 Conclusion: Following proper safety measures while doing tracheostomy will ensure safety of the surgeon.

scholarly journals A rare clinical case: schwannoma of tongue

2019 ◽  
Vol 5 (3) ◽  
pp. 789
Author(s):  
Chandra Veer Singh ◽  
Sheetal Radia ◽  
Saalim Sheikh ◽  
Vijay Haribhakti
Keyword(s):  
Head And Neck ◽  
Rare Case ◽  
Neck Region ◽  
Surgical Excision ◽  
Imaging Studies ◽  
Head And Neck Tumours ◽  
Head And Neck Region ◽  
Complete Surgical Excision ◽  
Slow Growing ◽  
Rule Out

<p class="abstract">Schwannoma are slow growing tumours, which can arise from any peripheral nerve. 10% of schwannomas that occur in the head and neck region mostly originate from the vagus or sympathetic nervous system. Extracranial schwannomas in the head and neck region are rare neoplasm. Intraoral schwannoma are only 1% of the all head and neck tumours. Diagnosis is established by imaging studies such as magnetic resonance imaging or computed tomography, while FNAC is used to rule out other conditions. We report a rare case of lingual schwannomas generally present as a painless lump schwannoma of the tongue in a 27-year-old male complaining of asymptomatic swelling over a posterolateral surface of the tongue, treated by complete surgical excision. The diagnosis was established on the basis of clinical, histopathological, and immunohistochemical examination. We report a rare case of schwannoma over the posterolateral surface of tongue. Prognosis is good for the patient when this condition is correctly diagnosed as the condition rarely recurs after complete resection.</p>

scholarly journals Prevalence of head and neck tumours in Calabar, South Eastern Nigeria

2016 ◽  
Vol 7 (3) ◽  
pp. 123-126 ◽  
Author(s):  
Okezie Obasi Kanu ◽  
Martin A. Nnoli ◽  
Chinyere A. Asoegwu
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
The Body ◽  
Slight Variation ◽  
Head And Neck Tumours ◽  
Female Ratio ◽  
Tumor Registry ◽  
Head And Neck Region ◽  
Head And Neck Malignancies ◽  
South Eastern

Background: Malignancies in the head and neck region though relatively rare, compared to other regions of the body, they contribute significantly to morbidity and mortality in affected patients. In Nigeria, the burden of managing head and Neck malignancies is enormous and there is yet to be a unified record of nation-wide incidence of malignancies involving the head and neck region despite the fact the head and neck malignancies have been diagnosed and documented since the 1960’s. The histological pattern and frequency however seems to have some slight variation depending on the region and the identified aetiological risk factors.Aims and Objectives: The aim of this study was to determine the pattern of head and neck tumours seen in the region and the commonest malignancies in the cohort. By comparing the relative prevalence of the lesions with other centers in the country and international published literature we hope to make a case for proper tumour registry and move for nation-wide studies.Materials and Methods: The authors reviewed the histopathological data of the tumor registry at the University of Calabar Teaching Hospital, a major referral Center in South-Eastern Nigeria between 2005 and 2012. All cases of head and Neck tumours with histological diagnosis were included for analysis, their demographic data were obtained and analyzed using SPSSv16.Results: Two hundred and twenty-five specimens from the head and neck region were analyzed during this 6 year period giving an average of 34 cases per year. The Male: Female ratio was 1.2:1.The age range was from 2 years to 76 years with overall mean of 32.7 years. One hundred and forty-five cases (63.3%) were benign while 84 malignant cases (36.7%) were recorded for the study period. The average number of new malignant cases seen was 14 per year. Malignancies were commoner in those less than 50 years of age and were mostly those of epithelial origin.Conclusion: Variations in the regional demographics of head and neck tumors in the country could be accounted for by the differences in data collection methods and certain aetiological factors that may be unique to those regions. A proper tumor registry in each region, harmonized with a national cancer registry may resolve some of these discrepancies.Asian Journal of Medical Sciences Vol. 7(3) 2016 123-126

Tumours metastasizing to the head and neck – a report of seven cases

1993 ◽  
Vol 107 (12) ◽  
pp. 1171-1173 ◽  
Author(s):  
Izumi Mochimatsu ◽  
Mamoru Tsukuda ◽  
Shigeru Furukawa ◽  
Shuji Sawaki
Keyword(s):  
Hepatocellular Carcinoma ◽  
Renal Cell Carcinoma ◽  
Head And Neck ◽  
Neck Region ◽  
Primary Site ◽  
Primary Hepatocellular Carcinoma ◽  
Head And Neck Tumours ◽  
Head And Neck Region ◽  
The Past ◽  
Primary Renal Cell Carcinoma

Metastatic tumours involving the head and neck region are rare. Over the past 18 years, seven such cases were treated at our clinic. Of those, four were in one of the paranasal sinuses, three had arisen from a primary hepatocellular carcinoma and one from an osteogenic fibrosarcoma of the leg. In the remaining three cases, metastases to the larynx, the tonsil, and the parotid gland arose from a primary renal cell carcinoma, a thyroid carcinoma, and a breast carcinoma, respectively. In metastatic tumours, the primary site can often be identified by the histopathological features. Accordingly, when malignant head and neck tumours are suspected of being metastatic in character, it is important to search carefully for the primary site.

Bronchoscopy in the Staging and Evaluation of Head and Neck Carcinoma

1983 ◽  
Vol 92 (4) ◽  
pp. 373-376 ◽  
Author(s):  
Bruce Leipzig
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Neck Region ◽  
Head And Neck Carcinoma ◽  
Tracheobronchial Tree ◽  
Squamous Cell Carcinomas ◽  
Chest Radiographs ◽  
Upper Aerodigestive Tract ◽  
Neck Carcinoma ◽  
The Face

There is no consensus of opinion regarding the use of routine bronchoscopy, either rigid or flexible, to evaluate patients with primary squamous cell carcinomas of the upper aerodigestive tract for the possibility of second synchronous primary cancers. Whereas there is certainty of the effectiveness of this endoscopy in patients with questionable lesions or masses on chest radiographs, the value of this procedure in the face of a normal, unequivocal chest radiograph remains questionable. Six patients with primary carcinomas in the upper head and neck region and normal chest radiographs were among 98 patients evaluated within the past 6 months by triple endoscopy. In three instances, a small (less than 2 cm) lesion was discovered in the tracheobronchial tree, utilizing rigid diagnostic bronchoscopy. In three other patients with positive cytology from bronchial washings, a lung primary carcinoma has not been discovered. These presumed false-positive findings add a watchword of warning. The observation of these patients provides evidence to support the routine panendoscopic evaluation of all patients with squamous cell carcinomas of the head and neck. A valid study to identify subgroups at risk to develop these cancers should be encouraged.

scholarly journals Radiation-induced Fibrosarcoma of the Larynx: a Case Report and Review of Literature

2021 ◽  
Author(s):  
Wei Gong ◽  
Donghai Huang
Keyword(s):  
Head And Neck ◽  
Surgical Resection ◽  
Rare Complication ◽  
Neck Region ◽  
Head And Neck Carcinoma ◽  
Malignant Tumour ◽  
Primary Treatment ◽  
Head And Neck Region ◽  
Complete Surgical Resection ◽  
Radiation Induced

Abstract Background: Radiation-induced sarcoma (RIS) is a rare complication following radiotherapy of head and neck carcinoma. It occurs mostly within the limits of the irradiated area and always suggests a poor prognosis. Case summary: Herein, we reported one case of a 61-year-old male with laryngeal squamous cell carcinoma (SCC), who had a history of surgery and radiotherapy. In 2014, this patient was admitted in our hospital for increasing hoarseness five years after surgery and radiotherapy. Finally, the patient was diagnosed as fibrosarcoma and was given total laryngectomy, the patient was died in August 2019 within following up. In addition, the clinical and pathological characteristics of similar cases and their probable tumorgenesis were also reviewed. Conclusion: RIS is increasingly important. They usually occur mostly within the limits of the irradiated area. SCC is the most common malignant tumour in the head and neck region, and radiotherapy is a primary adjuvant therapy method. For patients receiving radiotherapy, physicians should follow up more carefully for early detection the RISs. For sarcomas occurring in head and neck region, especially RIS, complete surgical resection is the primary treatment. The choice of radiotherapy and chemotherapy should be more cautious. The prognosis of primary sarcomas or RISs is still controversial. No matter primary sarcomas or RISs, we believe that complete surgical resection should be considered as a top priority in surgery.

Implantation metastasis following percutaneous endoscopic gastrostomy

1993 ◽  
Vol 107 (10) ◽  
pp. 946-949 ◽  
Author(s):  
Ollivier Laccourreye ◽  
Eric Chabardes ◽  
Agnés Mérite-Drancy ◽  
Françoise Carnot ◽  
Philippe Renard ◽  
...  
Keyword(s):  
Head And Neck ◽  
Percutaneous Endoscopic Gastrostomy ◽  
Head And Neck Carcinoma ◽  
Head And Neck Tumours ◽  
Endoscopic Gastrostomy ◽  
Valuable Adjunct ◽  
Neck Carcinoma ◽  
Tumour Implantation ◽  
The Face ◽  
Implantation Metastasis

AbstractSince it was first described, the original percutaneous endoscopic gastrostomy (PEG) technique has proved to be a valuable adjunct in patients with head and neck tumours. This procedure is being increasingly utilized in the face of swallowing impairment related to head and neck carcinoma. Although generally well tolerated, it may be associated with complications. In this report, we document tumour implantation at the percutaneous endoscopic gastric site and review the report cases. It appears that implantation metastasis does alter prognosis.

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