scholarly journals Exposure to Dichlorodiphenyldichloroethylene (DDE) and Metallothionein Levels in Rats Fed with Normocaloric or High-Fat Diet: A Review

2020 ◽  
Vol 21 (5) ◽  
pp. 1903 ◽  
Author(s):  
Vincenzo Migliaccio ◽  
Lillà Lionetti ◽  
Rosalba Putti ◽  
Rosaria Scudiero
Keyword(s):  
Heavy Metals ◽  
Trace Metals ◽  
Metal Binding ◽  
High Fat Diet ◽  
Endocrine Disrupting Chemicals ◽  
Stress Factors ◽  
High Fat ◽  
Main Metabolite ◽  
Endocrine Disrupting ◽  
Mammalian Tissues

The growing number of studies on metallothioneins (MTs), cysteine-rich metal-binding proteins, have been disclosing new functions of these proteins. Thanks to their inducibility, they were considered to play a pivotal role in regulating trace metals homeostasis and in detoxification from heavy metals; nowadays, it is known that they are involved in various physiological and pathological processes, such as regulation of apoptosis, elimination of free radicals, and protection of nucleic acids against toxic insults. MT induction has been demonstrated following stress factors other than heavy metals, such as endocrine-disrupting chemicals, insecticides, and herbicides. However, retrieved data are often controversial: in some cases, xenobiotics elicit MT expression and synthesis; under different conditions, they lead to a decrease in cellular MT content. This review describes the MT response to dichlorodiphenyltrichloroethane (DDT) contamination in mammalian tissues. In particular, attention focuses on changes in MT expression, synthesis, and localization in rat liver, kidneys, and testes following oral administration of dichlorodiphenyldichloroethylene (DDE), the main metabolite of DDT, under normal dietary conditions or in combination with a high fat diet potentially able to increase the cellular uptake of this lipophilic pesticide. The potential connection between MT expression and synthesis, lipophilic substances and trace metals availability is also discussed.

scholarly journals Chemical mixtures and neurobehavior: a review of epidemiologic findings and future directions

2020 ◽  
Vol 35 (3) ◽  
pp. 245-256
Author(s):  
Ann M. Vuong ◽  
Kimberly Yolton ◽  
Joseph M. Braun ◽  
Bruce P. Lanphear ◽  
Aimin Chen
Keyword(s):  
Heavy Metals ◽  
Endocrine Disrupting Chemicals ◽  
Epidemiological Studies ◽  
Interactive Effects ◽  
Chemical Mixtures ◽  
Future Directions ◽  
The Public ◽  
Chemical Models ◽  
Endocrine Disrupting ◽  
The Impact

AbstractBackgroundEpidemiological studies have historically focused on single toxicants, or toxic chemicals, and neurodevelopment, even though the interactions of chemicals and nutrients may result in additive, synergistic, antagonistic, or potentiating effects on neurological endpoints. Investigating the impact of environmentally-relevant chemical mixtures, including heavy metals and endocrine disrupting chemicals (EDCs), is more reflective of human exposures and may result in more refined environmental policies to protect the public.ObjectiveIn this review, we provide a summary of epidemiological studies that have analyzed chemical mixtures of heavy metals and EDCs and neurobehavior utilizing multi-chemical models, including frequentist and Bayesian methods.ContentStudies investigating chemicals and neurobehavior have the opportunity to not only examine the impact of chemical mixtures, but they can also identify chemicals from a mixture that may play a key role in neurotoxicity, investigate interactive effects, estimate non-linear dose response, and identify potential windows of susceptibility. The examination of neurobehavioral domains is particularly challenging given that traits emerge and change over time and subclinical nuances of neurobehavior are often unrecognized. To date, only a handful of epidemiological studies examining neurodevelopment have utilized multi-pollutant models in the investigation of heavy metals and EDCs. However, these studies were successful in identifying contaminants of importance from the exposure mixtures.Summary and OutlookInvestigators are encouraged to broaden their focus to include more environmentally relevant mixtures of chemicals using advanced statistical approaches, particularly to aid in identifying potential mechanisms underlying associations.

Effects of green tea polyphenols on trace metals level of rats on food restriction and high-fat diet

2019 ◽  
Vol 51 ◽  
pp. 91-97
Author(s):  
Nannan Wu ◽  
Guangyu Yang ◽  
Chong Tian ◽  
Weijie Yi ◽  
Shuiqing He ◽  
...  
Keyword(s):  
Trace Metals ◽  
Green Tea ◽  
High Fat Diet ◽  
Food Restriction ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
High Fat

scholarly journals Epidemiological trends of hormone-related cancers in Slovenia

2016 ◽  
Vol 67 (2) ◽  
pp. 83-92 ◽  
Author(s):  
Vesna Zadnik ◽  
Mateja Krajc
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Heavy Metals ◽  
Endocrine Disrupting Chemicals ◽  
Hormone Balance ◽  
Endocrine Disrupting ◽  
Cancer Types ◽  
Breast And Prostate Cancer ◽  
Epidemiological Trends ◽  
Developed World

AbstractThe incidence of hormone-related cancers tends to be higher in the developed world than in other countries. In Slovenia, six hormone-related cancers (breast, ovarian, endometrial, prostate, testicular, and thyroid) account for a quarter of all cancers. Their incidence goes up each year, breast and prostate cancer in particular. The age at diagnosis is not decreasing for any of the analysed cancer types. The risk of breast cancer is higher in the western part of the country, but no differences in geographical distribution have been observed for other hormone-related cancers. Furthermore, areas polluted with endocrine-disrupting chemicals that affect hormone balance such as PCBs, dioxins, heavy metals, and pesticides, do not seem to involve a greater cancer risk. We know little about how many cancers can be associated with endocrine disruptors, as there are too few reliable exposure studies to support an association.

scholarly journals Interactions between benzophenone-3 and dietary fat in mammary tumorigenesis

2020 ◽  
Author(s):  
Anastasia Kariagina ◽  
Olena Morozova ◽  
Reyhane Hoshyar ◽  
Mark D. Aupperlee ◽  
Mitchell A. Borin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cell ◽  
Endocrine Disrupting Chemicals ◽  
Mammary Tumorigenesis ◽  
Protective Effects ◽  
High Fat ◽  
Low Fat ◽  
Low Fat Diet ◽  
Endocrine Disrupting ◽  
Fat Diets

Abstract Background Benzophenone-3 is a putative endocrine disrupting chemical and common active ingredient in sunscreens and personal care products. The potential of endocrine disrupting chemicals to act as agonists or antagonists in critical hormonally regulated processes, such as mammary gland development and mammary tumorigenesis, demands evaluation of their potential in promoting breast cancer. We previously demonstrated promotion of mammary tumorigenesis by a diet high in saturated animal fat. This study examines the activity of benzophenone-3 in a dietary context to provide insight into its potential role in promoting breast cancer, and how diet might influence this. Methods Mammary tumorigenesis was studied in a BALB/c mouse Trp53-null transplantation model. Three-week-old mice were fed low-fat or high-fat diets, and at ten weeks of age were switched to high-fat or low-fat diets, respectively, while other mice were maintained continuously on low-fat diet. Mice additionally were treated continuously with or without benzophenone-3. The level of benzophenone-3 exposure yielded levels in urine similar to that observed in humans subjected to heavy topical exposure of benzophenone-3-containing commercial sunscreen. Results Benzophenone-3 had complex effects that were dependent upon diet and tumor histopathology. Benzophenone-3 was protective in regard to epithelial tumorigenesis in mice fed low-fat diet and was promotional for epithelial tumorigenesis in mice fed high-fat diet restricted to adulthood. It increased tumor cell proliferation, decreased tumor cell apoptosis, and increased tumor vascularity in a manner dependent on specific dietary regimen and tumor histopathology. Protective effects were not always concordant with a decrease in properties associated with tumor progression. Notably, although benzophenone-3 seemed protective for tumorigenesis in mice fed low-fat diet, spindle cell tumors that arose in these mice showed increased proliferation and decreased apoptosis. Conclusions Benzophenone-3 elicits promotional and protective effects on mammary tumorigenesis dependent upon diet and tumor histopathology. However, even in instances of an ostensibly protective effect, other parameters suggest potential for greater risk. This points to a need for further studies of benzophenone-3 in both animal models and humans as a potential breast cancer risk factor, as well as a more general need to evaluate endocrine disrupting chemicals in the context of varying diets.

Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones

2019 ◽  
Vol 89 (1-2) ◽  
pp. 45-54
Author(s):  
Akemi Suzuki ◽  
André Manoel Correia-Santos ◽  
Gabriela Câmara Vicente ◽  
Luiz Guillermo Coca Velarde ◽  
Gilson Teles Boaventura
Keyword(s):  
Thyroid Hormones ◽  
High Fat Diet ◽  
Female Offspring ◽  
Flaxseed Oil ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Flour ◽  
Maternal Consumption

Abstract. Objective: This study aimed to evaluate the effect of maternal consumption of flaxseed flour and oil on serum concentrations of glucose, insulin, and thyroid hormones of the adult female offspring of diabetic rats. Methods: Wistar rats were induced to diabetes by a high-fat diet (60%) and streptozotocin (35 mg/kg). Rats were mated and once pregnancy was confirmed, were divided into the following groups: Control Group (CG): casein-based diet; High-fat Group (HG): high-fat diet (49%); High-fat Flaxseed Group (HFG): high-fat diet supplemented with 25% flaxseed flour; High-fat Flaxseed Oil group (HOG): high-fat diet, where soya oil was replaced with flaxseed oil. After weaning, female pups (n = 6) from each group were separated, received a commercial rat diet and were sacrificed after 180 days. Serum insulin concentrations were determined by ELISA, the levels of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined by chemiluminescence. Results: There was a significant reduction in body weight at weaning in HG (−31%), HFG (−33%) and HOG (44%) compared to CG (p = 0.002), which became similar by the end of 180 days. Blood glucose levels were reduced in HFG (−10%, p = 0.044) when compared to CG, and there was no significant difference between groups in relation to insulin, T3, T4, and TSH after 180 days. Conclusions: Maternal severe hyperglycemia during pregnancy and lactation resulted in a microsomal offspring. Maternal consumption of flaxseed reduces blood glucose levels in adult offspring without significant effects on insulin levels and thyroid hormones.

Topical Application of Capsaicin Reduces Visceral Adipose Fat by Affecting Adipokine Levels in High-Fat Diet-Induced Obese Mice

Obesity ◽  
2012 ◽  
Author(s):  
Gong-Rak Lee ◽  
Mi Kyung Shin ◽  
Dong-Joon Yoon ◽  
Ah-Ram Kim ◽  
Rina Yu ◽  
...  
Keyword(s):  
Topical Application ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Visceral Adipose
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