scholarly journals MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension

2020 ◽  
Vol 21 (9) ◽  
pp. 3253 ◽  
Author(s):  
Susana Carregal-Romero ◽  
Lucía Fadón ◽  
Edurne Berra ◽  
Jesús Ruíz-Cabello
Keyword(s):  
Pulmonary Hypertension ◽  
Side Effects ◽  
Lung Diseases ◽  
Clinical Applications ◽  
Local Administration ◽  
Future Role ◽  
Lung Targeting ◽  
Chemically Modified ◽  
Enhanced Stability

In this review, the potential future role of microRNA-based therapies and their specific application in lung diseases is reported with special attention to pulmonary hypertension. Current limitations of these therapies will be pointed out in order to address the challenges that they need to face to reach clinical applications. In this context, the encapsulation of microRNA-based therapies in nanovectors has shown improvements as compared to chemically modified microRNAs toward enhanced stability, efficacy, reduced side effects, and local administration. All these concepts will contextualize in this review the recent achievements and expectations reported for the treatment of pulmonary hypertension.

scholarly journals Serotonin Receptors – From Molecular Biology to Clinical Applications

2011 ◽  
pp. 15-25 ◽  
Author(s):  
M. PYTLIAK ◽  
V. VARGOVÁ ◽  
V. MECHÍROVÁ ◽  
M. FELŠÖCI
Keyword(s):  
Pulmonary Hypertension ◽  
Serotonin Receptors ◽  
Clinical Applications ◽  
Panic Disorders ◽  
The Past ◽  
Complex Processes ◽  
Selective Agents ◽  
Different Populations ◽  
Irritable Bowel

Serotonin (5-hydroxytryptamine) is an ubiquitary monoamine acting as one of the neurotransmitters at synapses of nerve cells. Serotonin acts through several receptor types and subtypes. The profusion of 5-HT receptors should eventually allow a better understanding of the different and complex processes in which serotonin is involved. Its role is expected in the etiology of several diseases, including depression, schizophrenia, anxiety and panic disorders, migraine, hypertension, pulmonary hypertension, eating disorders, vomiting and irritable bowel syndromes. In the past 20 years, seven distinct families of 5-HT receptors have been identified and various subpopulations have been described for several of them. Increasing number of 5-HT receptors has made it difficult to unravel the role of 5-HT receptor subpopulations due to the lack of suitable selective agents. The present review describes the different populations and nomenclature of recently discovered 5-HT receptors and their pharmacological relevance.

Identifying pulmonary hypertension in newly recognized interstitial lung diseases – a role of new scoring system

2020 ◽  
Author(s):  
Małgorzata Sobiecka ◽  
Katarzyna Lewandowska ◽  
Jarosław Kober ◽  
Monika Franczuk ◽  
Agnieszka Skoczylas ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Scoring System ◽  
Lung Diseases ◽  
Interstitial Lung Diseases ◽  
New Scoring

scholarly journals Protective role of myelocytic nitric oxide synthases in pulmonary hypertension due to lung diseases and/or hypoxia

2020 ◽  
Vol 155 (2) ◽  
pp. 69-73
Author(s):  
Takaaki Ogoshi ◽  
Masato Tsutsui ◽  
Kazuhiro Yatera ◽  
Hiroshi Mukae
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Lung Diseases ◽  
Protective Role ◽  
Nitric Oxide Synthases

CASSINI and AVERT – future role of NOACs for VTE prevention in cancer patients?

VASA ◽  
2020 ◽  
Vol 49 (3) ◽  
pp. 247-248
Author(s):  
Leonie Kühnemund ◽  
Eva Freisinger
Keyword(s):  
Cancer Patients ◽  
Future Role

Man am I Stoned, I think! The role of experience and side effects in the perception of drug effects

1972 ◽  
Author(s):  
Cornelis Bakker ◽  
Albert S. Carlin ◽  
Robert Heaton ◽  
Reese T. Jones ◽  
Theodore X. Barber
Keyword(s):  
Side Effects ◽  
Drug Effects

The future role of the psychiatrist in Europe – a UEMS perspective

2014 ◽  
Vol 11 (01) ◽  
pp. 35-42
Author(s):  
M. Hermans
Keyword(s):  
Mental Health ◽  
Mental Health Professionals ◽  
Health Professionals ◽  
General Interest ◽  
Future Role ◽  
Personal Opinion ◽  
The Future ◽  
The Subject ◽  
The Many

SummaryThe author presents his personal opinion inviting to discussion on the possible future role of psychiatrists. His view is based upon the many contacts with psychiatrists all over Europe, academicians and everyday professionals, as well as the familiarity with the literature. The list of papers referred to is based upon (1) the general interest concerning the subject when representing ideas also worded elsewhere, (2) the accessibility to psychiatrists and mental health professionals in Germany, (3) being costless downloadable for non-subscribers and (4) for some geographic aspects (e.g. Belgium, Spain, Sweden) and the latest scientific issues, addressing some authors directly.

ROLE OF rhBMP-2 AND rhBMP-7 IN THE METABOLISM AND DIFFERENTIATION OF OSTEOBLAST-LIKE CELLS CULTURED ON CHEMICALLY MODIFIED TITANIUM SURFACES

2012 ◽  
pp. 141208072802005
Author(s):  
Fabiano Ribeiro Cirano ◽  
ADRIANE TOGASHI ◽  
MARCIA MARQUES ◽  
FRANCISCO PUSTIGLIONI ◽  
LUIZ LIMA
Keyword(s):  
Chemically Modified ◽  
Titanium Surfaces ◽  
Cells Cultured
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