scholarly journals TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP

2020 ◽  
Vol 21 (22) ◽  
pp. 8859
Author(s):  
Maria Feoktistova ◽  
Roman Makarov ◽  
Martin Leverkus ◽  
Amir S. Yazdi ◽  
Diana Panayotova-Dimitrova
Keyword(s):  
Skin Disease ◽  
Regulatory Mechanism ◽  
Skin Diseases ◽  
Critical Factor ◽  
Skin Inflammation ◽  
Inflammatory Skin Diseases ◽  
Future Studies ◽  
Negative Regulatory Role ◽  
Loop Activation

cFLIP is required for epidermal integrity and skin inflammation silencing via protection from TNF-induced keratinocyte apoptosis. Here, we generated and analyzed cFLIP epidermal KO mice with additional TNF deficiency. Intriguingly, the ablation of TNF rescued the pathological phenotype of epidermal cFLIP KO from characteristic weight loss and increased mortality. Moreover, the lack of TNF in these animals strongly reduced and delayed the epidermal hyperkeratosis and the increased apoptosis in keratinocytes. Our data demonstrate that TNF signaling in cFLIP-deficient keratinocytes is the critical factor for the regulation of skin inflammation via modulated cytokine and chemokine expression and, thus, the attraction of immune cells. Our data suggest that autocrine TNF loop activation upon cFLIP deletion is dispensable for T cells, but is critical for neutrophil attraction. Our findings provide evidence for a negative regulatory role of cFLIP for TNF-dependent apoptosis and partially for epidermal inflammation. However, alternative signaling pathways may contribute to the development of the dramatic skin disease upon cFLIP deletion. Our data warrant future studies of the regulatory mechanism controlling the development of skin disease upon cFLIP deficiency and the role of cFLIP/TNF in a number of inflammatory skin diseases, including toxic epidermal necrolysis (TEN).

scholarly journals JNK1 Signaling Downstream of the EGFR Pathway Contributes to Aldara®-Induced Skin Inflammation

2021 ◽  
Vol 11 ◽  
Author(s):  
Aurore Le ◽  
Abdulkader Azouz ◽  
Séverine Thomas ◽  
Nicolas Istaces ◽  
Muriel Nguyen ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Skin Diseases ◽  
Myeloid Cells ◽  
Skin Inflammation ◽  
Inflammasome Activation ◽  
Inflammatory Skin Diseases ◽  
Egfr Signaling Pathway ◽  
Egfr Ligands

c-Jun N-terminal protein kinase 1 (JNK1) is involved in multiple biological processes but its implication in inflammatory skin diseases is still poorly defined. Herein, we studied the role of JNK1 in the context of Aldara®-induced skin inflammation. We observed that constitutive ablation of JNK1 reduced Aldara®-induced acanthosis and expression of inflammatory markers. Conditional deletion of JNK1 in myeloid cells led to reduced skin inflammation, a finding that was associated with impaired Aldara®-induced inflammasome activation in vitro. Next, we evaluated the specific role of JNK1 in epidermal cells. We observed reduced Aldara®-induced acanthosis despite similar levels of inflammatory markers. Transcriptomic and epigenomic analysis of keratinocytes revealed the potential involvement of JNK1 in the EGFR signaling pathway. Finally, we show that inhibition of the EGFR pathway reduced Aldara®-induced acanthosis. Taken together, these data indicate that JNK1 plays a dual role in the context of psoriasis by regulating the production of inflammatory cytokines by myeloid cells and the sensitivity of keratinocytes to EGFR ligands. These results suggest that JNK1 could represent a valuable therapeutic target in the context of psoriasis.

scholarly journals The role of IL-36γ/IL-1F9 in developing erythroderma in patients with psoriasis

2015 ◽  
Vol 96 (1) ◽  
pp. 80-84
Author(s):  
D V Zaslavskiy ◽  
I N Chuprov ◽  
A A Sydikov ◽  
K U Ibragimov ◽  
P Wolkenstein ◽  
...  
Keyword(s):  
Skin Disease ◽  
Skin Diseases ◽  
Drug Hypersensitivity ◽  
Hypersensitivity Syndrome ◽  
Specific Marker ◽  
Inflammatory Skin Disease ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin ◽  
Underlying Diseases

Erythroderma is the term used for naming any inflammatory skin disease affecting over 90% of cutaneous surface. Numerous etiologic factors may background erythroderma; however, this condition is most often associated with such underlying diseases as eczema, drug hypersensitivity syndrome, cutaneous epidermotropic lymphoma, photosensitization. Being the most severe clinical form of psoriasis, psoriatic erythroderma may be a life hazard in patients with psoriasis, requiring admission and systemic treatment. The paper reviews modern data on psoriasis and psoriatic erythroderma pathogenesis. The biological role of IL-36γ/IL-1F9 - novel specific marker of psoriasis - is described in detail. Data of researches of this marker in different forms of inflammatory skin disease are discussed. Unlike other earlier described markers of psoriasis, for example, S100 A7, A8, A9 proteins, IL-36γ was highly specific to psoriasis, and rarely found at other inflammatory skin diseases (atopic dermatitis, contact dermatitis). The role of IL-36γ in diagnosing erythroderma in patients with psoriasis is described. The most specific and promising marker for distinguishing psoriatic erythroderma from other forms of erythroderma, IL-36γ can be detected at early stages of the disease, allowing to administer early causative treatment, improving treatment effect and preventing complications.

scholarly journals PSYCHOGEOGRAPHICAL EXPERIENCE BETWEEN THE SELF AND THE PLACE

2022 ◽  
Vol 7 (1) ◽  
pp. 243-263
Author(s):  
Mohd Fadhli Shah Khaidzir ◽  
Ruzy Suliza Hashim ◽  
Noraini Md. Yusof
Keyword(s):  
Critical Role ◽  
Critical Factor ◽  
The Self ◽  
Future Research ◽  
Future Studies ◽  
Place Meaning ◽  
Solid Foundation ◽  
Self Discovery ◽  
Attachment Place

Background and Purpose: The absence of psychogeographical awareness is a critical factor contributing to the lackadaisical attitudes towards the place and its environment. As a result, it enables an individual to fully experience a location, both physically and intellectually, while also gaining a feeling of self-discovery and self-realisation.   Methodology: The purpose of this study was to examine the responses of a group of individuals who participated in a field observation. 40 participants from a Malaysian university's foundation level were brought to Malacca to experience the environment's geographical scenery at their own leisure. The survey data was then manually transcribed and analysed in accordance with the study's aim.   Findings: Interactions with individuals and observation of features in the countryside and urban surroundings enabled participants to go on a psychogeographical journey that influenced their way of thinking and behaving. All participants felt that the journey had influenced their experiences and perspectives on their thinking and behaviour, highlighting the critical role of this notion in establishing the connection between place and self.   Contributions:  The findings of this study provide a solid foundation for future research in the field of psychogeography. The data may be used as a baseline for future studies to determine whether a comparable impact exists in other locations, with or without significant features like those found in Malacca.   Keywords: Psychogeography, place attachment, place meaning, self-discovery, Malacca.   Cite as: Khaidzir, M. F. S., Hashim, R. S., & Md. Yusof, N. (2022). Psychogeographical experience between the self and the place.  Journal of Nusantara Studies, 7(1), 243-263. http://dx.doi.org/10.24200/jonus.vol7iss1pp243-263

scholarly journals Leptin System in Obese Dog Skin: A Pilot Study

Animals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2338
Author(s):  
Margherita Maranesi ◽  
Antonio Di Loria ◽  
Cecilia Dall’Aglio ◽  
Diego Piantedosi ◽  
Elvio Lepri ◽  
...  
Keyword(s):  
Immune System ◽  
Skin Diseases ◽  
Skin Inflammation ◽  
Normal Weight ◽  
Hair Follicles ◽  
Obese Group ◽  
System Control ◽  
System Composition ◽  
Skin Biology

Obesity predisposes to several health problems including skin diseases. However, information on the relationship between obesity and skin disorders in pets is very scarce. Leptin (LEP) is mainly produced by adipose tissue and has a prominent role in skin biology. This study evaluated the LEP system in the skin of obese dogs compared to normal-weight animals. The investigation was carried out on 10 obese (Obese group) and 10 normal-weight (Normal-weight group) dogs through Real-time PCR and immunohistochemistry. Cells of skin associated immune system were also evaluated. No differences were evidenced between the two groups as well as skin inflammation. LEP differences were no significant, while LEPR transcript appeared 10-fold higher in obesedogs than in normal-weight ones. Immunostaining for both molecules was observed in several skin structures such as the epidermis, hair follicles, and glands. No differences appeared in the skin associated immune system composition. This study is a preliminary report showing that LEP system changes in obese dog skin. The increased LEPR expression observed in the obese group suggests that the receptor plays a modulating role in the system control. However, the exact role of LEPin the skin under obesity conditions needs further elucidation.

Skin Disease Prediction

2020 ◽  
Vol 17 (8) ◽  
pp. 3458-3462
Author(s):  
S. L. Jany Shabu ◽  
Maram Sai Nithin ◽  
Medepalli Santhosh ◽  
M. S. Roobini ◽  
K. Mohana Prasad ◽  
...  
Keyword(s):  
Skin Disease ◽  
Skin Diseases ◽  
Skin Inflammation ◽  
Disease Prediction ◽  
Clinical Parameters

As of late, skin diseases are expanded in people. Skin illnesses are brought about by microscopic organisms or because of contaminations. A portion of the skin illnesses resemble ring worm, yeast disease, sensitivities and so on are increments and spread over skin step by step. So this sort of maladies ought to be distinguished in its previous stage to abstain from spreading. It tends to be distinguished utilizing a few variables like clinical parameters which are considered for recognizing the infection. The conceivable skin sicknesses in various ages are dermatitis in age 0–5 years, moles influences in 6–11 years age, and skin inflammation vulgaris in 12–16 years age. Dermatomyositis is a sort of skin illness that influences youngsters at age of 5–15 and grown-up at 40–60 age. Right now, objective is to give a device to help experts and buyers in finding and picking sickness. To accomplish this objective, we build up a methodology that permits a client to inquiry for disease that fulfil a lot of conditions dependent on sickness properties, for example, infection signs.

scholarly journals Nutritional Factors in the Prevention of Atopic Dermatitis in Children

2021 ◽  
Vol 8 ◽  
Author(s):  
Thulja Trikamjee ◽  
Pasquale Comberiati ◽  
Enza D'Auria ◽  
Diego Peroni ◽  
Gian Vincenzo Zuccotti
Keyword(s):  
Atopic Dermatitis ◽  
Life Stress ◽  
Skin Diseases ◽  
Maternal Diet ◽  
Skin Inflammation ◽  
Future Research ◽  
Skin Barrier Function ◽  
Nutritional Factors ◽  
Nutrition And Diet

Atopic dermatitis is one of the most frequent chronic skin diseases worldwide and often develops within the first few years of life. Recent advancements in our knowledge of its pathophysiology have brought to light the role of genetic predisposition and environmental triggers. With the increasing prevalence of allergic diseases, there is a strong need for a better understanding of the various modifiable eliciting factors of such conditions. The concomitant rise in food allergy and insights into the skin barrier function has highlighted the role of nutrition and diet in the prevention and modification of allergic disorders. Furthermore, the identification of the skin as an important route of sensitization, and the risk of progression to asthma later in life, stress the significance of optimizing our management of skin inflammation in the prevention of allergies. Many nutritional factors, including the type of maternal diet during pregnancy, the duration of breastfeeding, the epicutaneous exposure of allergenic food proteins in the first few years of life, the timing of the introduction of complementary foods, the supplementation of vitamins and probiotics/prebiotics during prenatal and early life, have been assessed as potential targets for the prevention of atopy and eczema. Here, we review the latest data addressing prenatal and perinatal nutritional and dietary interventions in the primary prevention of atopic dermatitis. Also, we define knowledge gaps and targets for future research in the prevention of atopic dermatitis.

scholarly journals IL-1 Family Antagonists in Mouse and Human Skin Inflammation

2021 ◽  
Vol 12 ◽  
Author(s):  
Praxedis Martin ◽  
Jérémie D. Goldstein ◽  
Loïc Mermoud ◽  
Alejandro Diaz-Barreiro ◽  
Gaby Palmer
Keyword(s):  
Skin Diseases ◽  
Inflammatory Responses ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Inflammatory Diseases ◽  
Skin Inflammation ◽  
Cell Type ◽  
Inflammatory Skin Diseases ◽  
Innate And Adaptive Immunity ◽  
Skin Biology

Interleukin (IL)-1 family cytokines initiate inflammatory responses, and shape innate and adaptive immunity. They play important roles in host defense, but excessive immune activation can also lead to the development of chronic inflammatory diseases. Dysregulated IL-1 family signaling is observed in a variety of skin disorders. In particular, IL-1 family cytokines have been linked to the pathogenesis of psoriasis and atopic dermatitis. The biological activity of pro-inflammatory IL-1 family agonists is controlled by the natural receptor antagonists IL-1Ra and IL-36Ra, as well as by the regulatory cytokines IL-37 and IL-38. These four anti-inflammatory IL-1 family members are constitutively and highly expressed at steady state in the epidermis, where keratinocytes are a major producing cell type. In this review, we provide an overview of the current knowledge concerning their regulatory roles in skin biology and inflammation and their therapeutic potential in human inflammatory skin diseases. We further highlight some common misunderstandings and less well-known observations, which persist in the field despite recent extensive interest for these cytokines.

The Role of Bioactive Compounds and other Metabolites from Mushrooms against Skin Disorders- A Systematic Review Assessing their Cosmeceutical and Nutricosmetic Outcomes

2020 ◽  
Vol 27 (41) ◽  
pp. 6926-6965
Author(s):  
Oludemi Taofiq ◽  
Maria Filomena Barreiro ◽  
Isabel C.F.R. Ferreira
Keyword(s):  
Systematic Review ◽  
Bioactive Compounds ◽  
Skin Diseases ◽  
Scientific Data ◽  
Inflammatory Skin Diseases ◽  
Toxicological Studies ◽  
Pros And Cons ◽  
Long Term Studies

Bioactive compounds derived from mushrooms have been shown to present promising potential as cosmeceutical or nutricosmetic ingredients. Scientific data reviewed herein showed that extracts prepared from medicinal and edible mushrooms and their individual metabolites presented antiinflammatory, antioxidant, photoprotective, antimicrobial, anti-tyrosinase, anti-elastase, and anticollagenase activities. These metabolites can be utilised as ingredients to suppress the severity of Inflammatory Skin Diseases, offer photoprotection to the skin, and correct Hyperpigmentation. However, studies regarding the molecular mechanism behind the mentioned bioactivities are still lacking. Challenges associated with the use of mushroom extracts and their associated metabolites as cosmeceutical and nutricosmetic ingredients include several steps from the fruiting bodies to the final product: extraction optimization, estimation of the efficacy and safety claims, the use of micro and nanocarriers to allow for controlled release and the pros and cons associated with the use of extracts vs individual compounds. This systematic review highlights that mushrooms contain diverse biomolecules that can be sustainably used in the development of nutricosmetic and cosmeceutical formulations. Reports regarding stability, compatibility, and safety assessment, but also toxicological studies are still needed to be considered. Furthermore, some of the constraints and limitations hindering the development of this type of ingredients still require long-term studies to achieve major breakthroughs.

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