Blood Plasma’s Protective Ability against the Degradation of S-Nitrosoglutathione under the Influence of Air-Pollution-Derived Metal Ions in Patients with Exacerbation of Heart Failure and Coronary Artery Disease

One of the consequences of long-term exposure to air pollutants is increased mortality and deterioration of life parameters, especially among people diagnosed with cardiovascular diseases (CVD) or impaired respiratory system. Aqueous soluble inorganic components of airborne particulate matter containing redox-active transition metal ions affect the stability of S-nitrosothiols and disrupt the balance in the homeostasis of nitric oxide. Blood plasma’s protective ability against the decomposition of S-nitrosoglutathione (GSNO) under the influence of aqueous PM extract among patients with exacerbation of heart failure and coronary artery disease was studied and compared with a group of healthy volunteers. In the environment of CVD patients’ plasma, NO release from GSNO was facilitated compared to the plasma of healthy controls, and the addition of ascorbic acid boosted this process. Model studies with albumin revealed that the amount of free thiol groups is one of the crucial factors in GSNO decomposition. The correlation between the concentration of NO released and -SH level in blood plasma supports this conclusion. Complementary studies on gamma-glutamyltranspeptidase activity and ICP-MS multielement analysis of CVD patients’ plasma samples in comparison to a healthy control group provide broader insights into the mechanism of cardiovascular risk development induced by air pollution.

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Effects of caspase 8 gene polymorphism on the risks for development/course of chronic heart failure

Patologiya krovoobrashcheniya i kardiokhirurgiya ◽

10.21688/1681-3472-2013-4-45-49 ◽

2015 ◽

Vol 17 (2) ◽

pp. 45

Author(s):

Ye. N. Berezikova ◽

M. G. Pustovetova ◽

S. N. Shilov ◽

A. V. Yefremov ◽

A. T. Teplyakov ◽

...

Keyword(s):

Heart Failure ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Chronic Heart Failure ◽

Gene Polymorphism ◽

Polymorphic Locus ◽

Control Group ◽

Caspase 8 ◽

Polymorphic Loci ◽

Artery Disease

The aim of the study was to identify genetic determinants of increased risks for heart failure severity. Clinical and genetic aspects of the effects of gene polymorphism caspase 8 (polymorphic loci -652(6N)I/D and D302H) on the risks for development and severity of chronic heart failure (CHF) in patients with coronary artery disease were investigated. 277 patients with CHF were studied (182 males and 95 females aged 45 to 65 years (mean age 59.27.7 years). Genotypes were identified by using RFLP analysis of PCR products. The control group included 136 people (mean age 53.64.8 years) who had no symptoms of cardiovascular disorders. The presence of del allele and genotype del/del polymorphic locus -652(6N)I/D gene caspase 8 was associated with an increased risk for heart failure, while the allele ins and genotype ins/ins were found to serve as protective factors. Allele ins and genotype ins/ins polymorphic locus -652(6N)I/D gene caspase 8 proved to be associated with protective effects on the course of CHF in patients with coronary artery disease, while allele del and genotype del/del could be considered as predictors of an unfavorable course of the disease. The analysis revealed no significant differences in the frequency distribution of genotypes and alleles of polymorphic loci D302H gene caspase 8 in patients with chronic heart failure and in the control group, as well as in the dependence on the functional class of heart failure. The definition of polymorphism -652(6N)I/D gene caspase 8 can be recommended for early prediction of risks and severity of heart failure.

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Statin administration is associated with higher IGF-1 levels in patients without diabetes mellitus

Problems of Endocrinology ◽

10.14341/probl8759 ◽

2018 ◽

Vol 64 (4) ◽

pp. 200-207

Author(s):

Olga V. Shpagina ◽

Irina Z. Bondarenko ◽

Galina S. Kolesnikova

Keyword(s):

Heart Failure ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Chronic Heart Failure ◽

Total Cholesterol ◽

Statin Therapy ◽

Left Ventricular ◽

Control Group ◽

Artery Disease ◽

Group 1

Background: Research makes it clear that the IGF-1 level correlates with cardiovascular disease, chronic heart failure, and mortality. Yet, little is known about the effect of statins on IGF-1. Aims: to evaluate the effect of statin treatment on IGF-1 and its association with a cardiovascular risk. Material and methods: The study included 115 patients (mean age, 55.8±6.1 years) who either were overweight or had mild obesity (body mass index 28.6±3.8 kg/m2) without diabetes. Group 1 consisted of 70 patients with verified coronary artery disease receiving statin therapy; group 2 included 45 healthy subjects. Coronary angiography and treadmill test were used to diagnose coronary artery disease. Impaired glucose tolerance and total cholesterol, triglycerides, LPHD, LPLD, fibrinogen, and IGF-1 levels were evaluated in all the subjects. Heart chamber geometry was assessed by echocardiography. Results: The IGF-1 level was significantly higher in group 1 compared to the control group (196 and 167 ng/ml, respectively; р=0.014). Serum levels of IGF-1 were associated with duration of statin therapy (R=0.311; p=0.000), stage of hypertension (R=0.187; p=0.04), fibrinogen (R=0.274; p=0.033), TG (R=0.316; p=0.006), total cholesterol (R=–0.213; p=0.016), LPLD (R=–0.184; p=0.038), smoking (R=0.3; p=0.009), ejection fraction (R=0.298; p=0.041), end-diastolic volume (R=0.422; p=0.036), end-systolic volume (R=0.407; p=0.042), end-diastolic dimension (R=0.27; p=0.014), interventricular septal thickness (R=0.247; p=0.02), and left ventricular posterior wall thickness (R=0.258; p=0.019). Rosuvastatin dose positively correlated with the IGF-1 level (R=0.521; p=0.028). Conclusions: Statin administration is associated with higher IGF-1 levels in patients without diabetes. High IGF-1 level correlates with the risk factors of coronary artery disease: hypertension, lipid profile, and fibrinogen level and has an adverse effect on chronic heart failure by altering the cardiac remodeling.

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Hypertension But Not Heart Failure or Coronary Artery Disease is Associated with Mental Disorders

10.21203/rs.3.rs-39513/v1 ◽

2020 ◽

Author(s):

Hossein Namdar ◽

Fatemeh Jamshidi ◽

Davoud Ezzati ◽

raana Zakeri ◽

Seyyed-Reza Sadat-Ebrahimi

Keyword(s):

Heart Failure ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Psychological Disorders ◽

Study Groups ◽

Cross Sectional Study ◽

Control Group ◽

Depression Anxiety Stress Scale ◽

Cross Sectional ◽

Artery Disease

Abstract Background: Previous studies have emphasized the significant association between depression, anxiety, and stress and hypertension (HTN), heart failure (HF), and coronary artery disease (CAD). However, among included patients with HF or CAD in those studies, there were considerable proportions of patients with concomitant HTN and vice versa leading to some possible bias in final estimations. Therefore, we aimed to exclude those patients with concomitant diseases and reassess the association between these three prevalent cardiovascular diseases with three important psychological disorders. Methods: In this cross-sectional study, 300 patients were evaluated, including 100 with HTN (without a history or concomitant HF or CAD), 100 with HF (without HTN or CAD), and 100 with CAD (without HTN or HF). Moreover, 100 healthy volunteers were considered as the control group. Depression Anxiety Stress Scale 21 was used to measure the magnitude of depression, anxiety, and stress. Result: The average scores of 4.6, 9.1, 3.7, and 4.4 for depression, 3.9, 11.1, 4.1, and 3.6 for anxiety and 6.5, 13.6, 5.2, and 5.4 for stress were detected in control, HTN, CAD, and HF groups, respectively. The depression, anxiety, and stress scores of HTN group were significantly higher than the control (p<0.05), CAD (p<0.05) and HF (p<0.05) groups; this is while these scores were not significantly different between other study groups (p>0.05).Conclusion: Our study demonstrated a significantly higher magnitude of psychological disorders in patients with HTN. However, their magnitude in patients with HF and CAD without concomitant HTN were similar to those in healthy participants.

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Hypertension but Not Heart Failure or Coronary Artery Disease is Associated With Mental Disorders

10.21203/rs.3.rs-33844/v1 ◽

2020 ◽

Author(s):

Hossein Namdar ◽

Fatemeh Jamshidi ◽

Davoud Ezzati ◽

raana Zakeri ◽

Seyyed-Reza Sadat-Ebrahimi

Keyword(s):

Heart Failure ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Psychological Disorders ◽

Study Groups ◽

Cross Sectional Study ◽

Control Group ◽

Depression Anxiety Stress Scale ◽

Cross Sectional ◽

Artery Disease

Abstract Background Previous studies have emphasized the significant association between depression, anxiety, and stress and hypertension (HTN), heart failure (HF), and coronary artery disease (CAD). However, among included patients with HF or CAD in those studies, there were considerable proportions of patients with concomitant HTN and vice versa leading to some possible bias in final estimations. Therefore, we aimed to exclude those patients with concomitant diseases and reassess the association between these three prevalent cardiovascular diseases with three important psychological disorders. Methods In this cross-sectional study, 300 patients were evaluated, including 100 with HTN (without a history or concomitant HF or CAD), 100 with HF (without HTN or CAD), and 100 with CAD (without HTN or HF). Moreover, 100 healthy volunteers were considered as the control group. Depression Anxiety Stress Scale 21 was used to measure the magnitude of depression, anxiety, and stress. Result The average scores of 4.6, 9.1, 3.7, and 4.4 for depression, 3.9, 11.1, 4.1, and 3.6 for anxiety and 6.5, 13.6, 5.2, and 5.4 for stress were detected in control, HTN, CAD, and HF groups, respectively. The depression, anxiety, and stress scores of HTN group were significantly higher than the control (p < 0.05), CAD (p < 0.05) and HF (p < 0.05) groups; this is while these scores were not significantly different between other study groups (p > 0.05). Conclusion Our study demonstrated a significantly higher magnitude of psychological disorders in patients with HTN. However, their magnitude in patients with HF and CAD without concomitant HTN were similar to those in healthy participants.

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