scholarly journals Cardiac Telocytes 16 Years on—What Have We Learned So Far, and How Close Are We to Routine Application of the Knowledge in Cardiovascular Regenerative Medicine?

2021 ◽  
Vol 22 (20) ◽  
pp. 10942
Author(s):  
Martin Klein ◽  
Mária Csöbönyeiová ◽  
Stanislav Žiaran ◽  
Ľuboš Danišovič ◽  
Ivan Varga
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Cell Therapy ◽  
Human Subjects ◽  
Research Area ◽  
Future Research ◽  
Ongoing Research ◽  
Routine Application ◽  
Cardiovascular Regeneration ◽  
A Cell

The regeneration of a diseased heart is one of the principal challenges of modern cardiovascular medicine. There has been ongoing research on stem-cell-based therapeutic approaches. A cell population called telocytes (TCs) described only 16 years ago largely contributed to the research area of cardiovascular regeneration. TCs are cells with small bodies and extremely long cytoplasmic projections called telopodes, described in all layers of the heart wall. Their functions include cell-to-cell signaling, stem-cell nursing, mechanical support, and immunoregulation, to name but a few. The functional derangement or quantitative loss of TCs has been implicated in the pathogenesis of myocardial infarction, heart failure, arrhythmias, and many other conditions. The exact pathomechanisms are still unknown, but the loss of regulative, integrative, and nursing functions of TCs may provide important clues. Therefore, a viable avenue in the future modern management of these conditions is TC-based cell therapy. TCs have been previously transplanted into a mouse model of myocardial infarction with promising results. Tandem transplantation with stem cells may provide additional benefit; however, many underresearched areas need to be addressed in future research before routine application of TC-based cell therapy in human subjects. These include the standardization of protocols for isolation, cultivation, and transplantation, quantitative optimization of TC transplants, cost-effectivity analysis, and many others.

ST-elevation myocardial infarction complicated by cardiac arrest in a young patient with familiar dyslipidemia

2021 ◽  
Vol 148 (12) ◽  
pp. 141-145
Author(s):  
Pham Minh Tuan ◽  
Doan Tuan Vu
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Arrest ◽  
Stem Cell ◽  
Cell Therapy ◽  
Young Patient ◽  
Stem Cell Therapy ◽  
St Elevation Myocardial Infarction ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
St Elevation

Coronary heart disease in young patients always poses great challenges for every healthcare system with differences in clinical manifestations, etiology, epidemiology, angiographic characteristics and prognosis. The objective of this study was to describe a case of ST-elevation myocardial infarction complicated by cardiac arrest in a young patient with familial dyslipidemia. A 30-year-old male visited our hospital with typical angina. During the examination, he suffered a sudden loss of consciousness, the monitor showed ventricular fibrillation. After successful resuscitation of cardiac arrest, electrocardiography showed apparent ST-elevation from V2 to V6 leads consistent with the diagnosis of anterolateral infarction. Emergency coronary angiogram showed severe three-vessel lesions including complete occlusion of the LAD artery and 80 - 90% stenosis of the other two coronary branches. Our patient’s coronary arteries were revascularized using drug-eluting stents in LAD artery and subsequently RCA artery, stem cell therapy was applied during the interventional process. Routine laboratory test results showed dyslipidemia and his family records suggested familiar (hereditary) dyslipidemia which affected his mother and sister. 1-month follow-up echocardiography showed a drastic improvement of LVEF by roughly 15%. The combination of revascularization, stem cell therapy, and lipid-lowering therapy has shown a good therapeutic effect.

Optimizing Stem Cell Therapy for Cardiac Repair Following a Myocardial Infarction

2013 ◽  
pp. 513-524
Author(s):  
Kaustabh Singh ◽  
Keith R. Brunt ◽  
Richard D. Weisel ◽  
Ren-Ke Li
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cardiac Repair

scholarly journals Mesenchymal Stem Cell Therapy of Pulmonary Fibrosis

2018 ◽  
Vol 27 (11) ◽  
pp. 1581-1587 ◽  
Author(s):  
Hong-Meng Chuang ◽  
Tina Emily Shih ◽  
Kang-Yun Lu ◽  
Sheng-Feng Tsai ◽  
Horng-Jyh Harn ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Pulmonary Fibrosis ◽  
Cell Therapy ◽  
Clinical Application ◽  
Stem Cell Therapy ◽  
Drug Application ◽  
New Drugs ◽  
Future Research ◽  
Pharmaceutical Therapy

Although the clinical application of new drugs has been shown to be effective in slowing disease progression and improving the quality of life in patients with pulmonary fibrosis, the damaged lung tissue does not recover with these drugs. Thus, there is an urgent need to establish regenerative therapy, such as stem cell therapy or tissue engineering. Moreover, the clinical application of mesenchymal stem cell (MSC) therapy has been shown to be safe in humans with idiopathic pulmonary fibrosis (IPF). It seems that a combination of MSC transplantation and pharmaceutical therapy might have additional benefits; however, the experimental design for its efficacy is still lacking. In this review, we provide an overview of the mechanisms that were identified when IPF was treated with MSC transplantation or new drugs. To maximize the therapeutic effect, we suggest that MSC transplantation is combined with drug application for synergistic effects. This review provides clinicians and scientists with the most efficient medical options, in the hope that this will spur on future research and lead to an eventual cure for this disease.

scholarly journals Therapeutic effect of mesenchymal stem cell therapy in the LVEF, LVEDV, and LVESV after myocardial infarction

2021 ◽  
Vol 122 (11) ◽  
pp. 785-792
Author(s):  
M. M. Rabiei ◽  
K. S. Khoramgah ◽  
I. A. Darazam ◽  
S. Vafaei-Nezhad ◽  
S. Dargahi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Therapeutic Effect ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy

Theories of Meaning in Schema Matching

2009 ◽  
pp. 282-308
Author(s):  
Joerg Evermann
Keyword(s):  
Theoretical Basis ◽  
Research Area ◽  
Schema Matching ◽  
Future Research ◽  
Database Integration ◽  
Ongoing Research ◽  
Matching Methods ◽  
The Past ◽  
Theories Of Meaning

Schema matching is the identification of database elements with similar meaning as preparation for subsequent database integration. Over the past 20 years, different schema-matching methods have been proposed and have been shown to be successful to various degrees. However, schema matching is an ongoing research area and the problem is not yet considered to be solved. This article reviews existing schema-matching methods from the perspective of theories of meanings drawn from philosophy and psychology. It positions existing methods, raises questions for future research based on these theories, and shows how these theories can form a firm theoretical basis as well as guide future schema-matching research.

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