scholarly journals New Indications for Liver Transplantation

2021 ◽  
Vol 10 (17) ◽  
pp. 3867
Author(s):  
Alberto Zanetto ◽  
Sarah Shalaby ◽  
Martina Gambato ◽  
Giacomo Germani ◽  
Marco Senzolo ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Transplant Patient ◽  
Patient Survival ◽  
Therapeutic Option ◽  
Chronic Liver Failure ◽  
Exclusion Criteria ◽  
Cancer Metastases ◽  
Colorectal Cancer Metastases ◽  
Clinical Conditions

Liver transplantation (LT) is an important therapeutic option for the treatment of several liver diseases. Modern LT is characterized by remarkable improvements in post-transplant patient survival, graft survival, and quality of life. Thanks to these great improvements, indications for LT are expanding. Nowadays, clinical conditions historically considered exclusion criteria for LT, have been considered new indications for LT, showing survival advantages for patients. In this review, we provide an updated overview of the principal newer indications for LT, with particular attention to alcoholic hepatitis, acute-on-chronic liver failure (ACLF), cholangiocarcinoma and colorectal cancer metastases.

scholarly journals Liver transplantation for metastatic colorectal cancer (case report)

2019 ◽  
Vol 23 (4) ◽  
pp. 54-67
Author(s):  
I. A. Porshennikov ◽  
A. V. Sokolov ◽  
E. E. Shchekina ◽  
A. Yu. Chubukov ◽  
T. A. Tretyakova ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Transplantation ◽  
Metastatic Colorectal Cancer ◽  
Short Review ◽  
Cancer Case ◽  
Current State ◽  
Cancer Metastases ◽  
Colorectal Cancer Case ◽  
Unresectable Liver Metastases ◽  
Colorectal Cancer Metastases

Liver transplantation is currently controversial for colorectal cancer metastases and not recommended in clinical guidelines. We report the first Russian case of liver transplantation from cadaveric donor in a patient with multiple bilobar unresectable liver metastases of colon cancer. We observe no recurrences within 10 months on everolimus-based immunosuppression and adjuvant treatment. The current state of the problem and the place of liver transplantation in metastatic colorectal cancer treatment are discussed in a short review.

Comparison of Quality of Life Between Two Clinical Conditions With Immunosuppressive Therapy: Liver Transplantation and Multiple Sclerosis

2012 ◽  
Vol 44 (9) ◽  
pp. 2609-2611 ◽  
Author(s):  
E. Fernández-Jiménez ◽  
M.A. Pérez-San-Gregorio ◽  
A. Martín-Rodríguez ◽  
E. Domínguez-Cabello ◽  
G. Navarro-Mascarell ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Liver Transplantation ◽  
Immunosuppressive Therapy ◽  
Clinical Conditions

scholarly journals Medical Image of the Month: COVID-19-Associated Pulmonary Aspergillosis in a Post-Liver Transplant Patient

2021 ◽  
Vol 23 (4) ◽  
pp. 98-99
Author(s):  
Anandajith P ◽  
◽  
Zubair Mohamed ◽  
Dinesh Balakrishnan ◽  
S Sudhindran
Keyword(s):  
Liver Transplantation ◽  
Bronchoalveolar Lavage ◽  
Medical Image ◽  
Transplant Patient ◽  
Invasive Ventilation ◽  
Chronic Liver Failure ◽  
Liver Transplant Patient ◽  
Pulmonary Aspergillosis ◽  
Admission Screening ◽  
Autoimmune Etiology

No abstract available. Article truncated after first 150 words. A previously healthy, 48-year-old woman, admitted with a working diagnosis of acute-on-chronic liver failure (Grade III) secondary to an autoimmune etiology, was found to be SARS COV-2 RTPCR positive on routine admission screening. She was initially managed with standard medical care for COVID, including steroids. She required invasive ventilation for worsening encephalopathy and when her antigen test was negative 10 days later, she underwent an urgent liver transplantation. Her preoperative infection screen (culture of blood, bronchoalveolar lavage, urine) was negative and computerized tomography (CT) of the chest was normal (Figure 1). She was extubated on day 3 after liver transplantation. Her recovery was uneventful until the 10th postoperative day when she developed cough and desaturation. A repeat CT chest showed multiple multilobular consolidatory nodules with central breakdown involving both lung (Figure 2). Her bronchoalveolar lavage culture grew Aspergillus fumigatus (azole sensitive) which fulfilled criteria for proven COVID-19 Associated pulmonary aspergillosis …

scholarly journals Cytoglobin as a Biomarker in Cancer: Potential Perspective for Diagnosis and Management

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Tatsha C. Bholah ◽  
Vidushi S. Neergheen-Bhujun ◽  
Nikolas J. Hodges ◽  
Sabrina D. Dyall ◽  
Theeshan Bahorun
Keyword(s):  
Cancer Detection ◽  
Functional Role ◽  
Early Detection Of Cancer ◽  
Patient Survival ◽  
Early Cancer ◽  
Therapeutic Option ◽  
Early Cancer Detection ◽  
Research Initiatives

The search for biomarkers to detect the earliest glimpse of cancer has been one of the primary objectives of cancer research initiatives. These endeavours, in spite of constant clinical challenges, are now more focused as early cancer detection provides increased opportunities for different interventions and therapies, with higher potential for improving patient survival and quality of life. With the progress of the omics technologies, proteomics and metabolomics are currently being used for identification of biomarkers. In this line, cytoglobin (Cygb), a ubiquitously found protein, has been actively reviewed for its functional role. Cytoglobin is dynamically responsive to a number of insults, namely, fibrosis, oxidative stress, and hypoxia. Recently, it has been reported that Cygb is downregulated in a number of malignancies and that an induced overexpression reduces the proliferative characteristics of cancer cells. Thus, the upregulation of cytoglobin can be indicative of a tumour suppressor ability. Nevertheless, without a comprehensive outlook of the molecular and functional role of the globin, it will be most unlikely to consider cytoglobin as a biomarker for early detection of cancer or as a therapeutic option. This review provides an overview of the proposed role of cytoglobin and explores its potential functional role as a biomarker for cancer and other diseases.

scholarly journals Anaesthesia for Live Related Liver Transplantation: Experience at a Teaching Hospital in Abroad

1970 ◽  
Vol 39 (3) ◽  
Author(s):  
K Sadar ◽  
MA Hannan ◽  
S Aneja
Keyword(s):  
Liver Transplantation ◽  
Therapeutic Option ◽  
Service Availability ◽  
Invasive Monitoring ◽  
Blood Products ◽  
Chronic Liver Failure ◽  
Laboratory Service ◽  
Non Invasive ◽  
Apollo Hospital ◽  
Liver Transplantations

ordinary, challenging and very much special for anaesthesiologists. The liver transplantation programme at Indraprastha Apollo Hospital, Delhi, India has been running since 1998. Both live related and cadveric liver transplantations are performed and it is about 100 to 120 per year. In this prospective study, the anaesthetic aspects of 10 live related liver transplantations are reviewed. Here we focused on anaesthetic technique used; indications for liver transplantation and type of graft transplanted; survival rate; duration of anaesthesia and cost; intra-operativeLive related liver transplantation is no longer experimental. It is the therapeutic option for patients with chronic liver failure. Adequate logistic and prompt laboratory service, availability of blood products, maximum invasive and non invasive monitoring is mandatory for better outcome.BMJ 2010; 39(3)

Hospitalization and Life Support before Liver Transplantation – Easily available Predictors for Post-Transplant Patient Survival

2018 ◽  
Vol 102 ◽  
pp. S273
Author(s):  
Leke Wiering ◽  
Paul Ritschl ◽  
Michael Hippler-Benscheidt ◽  
Felix Aigner ◽  
Matthias Biebl ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Transplant Patient ◽  
Life Support ◽  
Patient Survival ◽  
Post Transplant

Predictors of Liver Transplant Patient Survival

2016 ◽  
Vol 27 (1) ◽  
pp. 98-106 ◽  
Author(s):  
Lisiane Pruinelli ◽  
Karen A. Monsen ◽  
Cynthia R. Gross ◽  
David M. Radosevich ◽  
György J. Simon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Large Scale ◽  
Transplant Patient ◽  
Patient Survival ◽  
The United States ◽  
Liver Transplant Patient ◽  
Holistic View ◽  
Donor Liver Transplantation

Objective: Liver transplantation is a costly and risky procedure, representing 25 050 procedures worldwide in 2013, with 6729 procedures performed in the United States in 2014. Considering the scarcity of organs and uncertainty regarding prognosis, limited studies address the variety of risk factors before transplantation that might contribute to predicting patient’s survival and therefore developing better models that address a holistic view of transplant patients. This critical review aimed to identify predictors of liver transplant patient survival included in large-scale studies and assess the gap in risk factors from a holistic approach using the Wellbeing Model and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement. Data Source: Search of the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline, and PubMed from the 1980s to July 2014. Study Selection: Original longitudinal large-scale studies, of 500 or more subjects, published in English, Spanish, or Portuguese, which described predictors of patient survival after deceased donor liver transplantation. Data Extraction: Predictors were extracted from 26 studies that met the inclusion criteria. Data Synthesis: Each article was reviewed and predictors were categorized using a holistic framework, the Wellbeing Model (health, community, environment, relationship, purpose, and security dimensions). Conclusions: The majority (69.7%) of the predictors represented the Wellbeing Model Health dimension. There were no predictors representing the Wellbeing Dimensions for purpose and relationship nor emotional, mental, and spiritual health. This review showed that there is rigorously conducted research of predictors of liver transplant survival; however, the reported significant results were inconsistent across studies, and further research is needed to examine liver transplantation from a whole-person perspective.

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