scholarly journals One-Year Hemodynamic Performance of Three Cardiac Aortic Bioprostheses: A Randomized Comparative Clinical Trial

2021 ◽  
Vol 10 (22) ◽  
pp. 5340
Author(s):  
Lourdes Montero-Cruces ◽  
Manuel Carnero-Alcázar ◽  
Fernando José Reguillo-Lacruz ◽  
Francisco Javier Cobiella-Carnicer ◽  
Daniel Pérez-Camargo ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Maximum Velocity ◽  
Aortic Annulus ◽  
Pairwise Comparisons ◽  
Comparative Clinical Trial ◽  
The Mean ◽  
Hemodynamic Performance ◽  
One Year

Background: We aimed to compare 1 year the hemodynamic in-vivo performance of three biological aortic prostheses (Carpentier Perimount Magna EaseTM, Crown PRTTM, and TrifectaTM). Methods: The sample used in this study comes from the “BEST-VALVE” clinical trial, which is a phase IV single-blinded randomized clinical trial with the three above-mentioned prostheses. Results: 154 patients were included. Carpentier Perimount Magna EaseTM (n = 48, 31.2%), Crown PRTTM (n = 51, 32.1%) and TrifectaTM (n = 55, 35.7%). One year after the surgery, the mean aortic gradient and the peak aortic velocity was 17.5 (IQR 11.3–26) and 227.1 (IQR 202.0–268.8) for Carpentier Perimount Magna EaseTM, 21.4 (IQR 14.5–26.7) and 237.8 (IQR 195.9–261.9) for Crown PRTTM, and 13 (IQR 9.6–17.8) and 209.7 (IQR 176.5–241.4) for TrifectaTM, respectively. Pairwise comparisons demonstrated improved mean gradients and maximum velocity of TrifectaTM as compared to Crown PRTTM. Among patients with nominal prosthesis sizes ≤21, the mean and peak aortic gradient was higher for Crown PRTTM compared with TrifectaTM, and in patients with an aortic annulus measured with metric Hegar dilators less than or equal to 22 mm. Conclusions: One year after surgery, the three prostheses presented a different hemodynamic performance, being TrifectaTM superior to Crown PRTTM.

scholarly journals Immediate Post-Operative Outcomesof Stapled and Hand Sewn Techniques during Oesophagogastrostomy: A Randomized Clinical Trial

2020 ◽  
Vol 6 (1) ◽  
pp. 43-47
Author(s):  
Mohammad Zakir Hossain Bhuiyan ◽  
Syed Aminul Haque ◽  
Mohammad Ahtashamul Haque ◽  
Farhana Tarannum
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Single Centre ◽  
Anastomotic Complications ◽  
Operative Outcomes ◽  
Group A ◽  
Cardia Carcinoma ◽  
The Mean ◽  
One Year ◽  
Group B

Background: Oesophagogastrostomy is a very crucial surgical management. Objective:The purpose of the present study was to observe the immediate post-operative outcomes of stapled and hand sewn techniques during oesophagogastrostomy. Methodology: This single centre, parallel randomized clinical trial was conducted in the Department of Thoracic Surgery at National institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh from January 2011 to December 2011 for a period of one year. Prior to commencement of this study the study protocol was approved by the thesis committee of NIDCH. Patients were purposefully selected from different surgery ward of NIDCH irrespective of age and sex of patients for the study.Patients were divided into two groups designated as group A and B.Stapled oesophagogastric anastomosis was performed in group A and hand sewn anastomosis was done in group B.Immediate post-operative complication were recorded. Result: A total of 60 patients of oesophageal or gastric cardia carcinoma were recruited for this study. Of them 32 cases were assigned to Stapler method and 28 cases to Hand-sewn method of oesophagogastrostomy. The mean age of the patients of group A and group B were 56.1±12.7 years and 55.3±8.3 years respectively. Regarding blood loss during operation, the table shows that in group A mean + SD were 430.4±63.2 ml and in group B mean + SD were 529.6 +86.9 ml. In one stage operation in group A it was mean + SD i.e. 362.2±38.3 ml and in group B it was mean + SD 529.6±86.9 ml. In two stage operation in group A it was mean 466.2±39.7 ml and in group B it was mean±SD 585.6±62.2 ml. Respiratory complication developed in 9.4% of the patients in group A and 17.9% patients in group B. Cardiac complication developed in 3.1 % of the patients in group A and 7.1 % of patients in group B. Wound infection developed in 12.5% of the patients in group A and 10.7% of the patients in group B. Conclusion: In conclusion most of the immediate anastomotic complications are less in stapled anastomotic technique than hand sewn technique Journal of National Institute of Neurosciences Bangladesh, 2020;6(1): 43-47

Comparision of two fluoride varnishes for controlling white spot lesions. Randomized clinical trial

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Jesús Alberto Luengo - Fereira
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
White Spot ◽  
Controlled Clinical Trial ◽  
White Spot Lesions ◽  
Randomized Controlled Clinical Trial ◽  
Chi Square ◽  
Randomized Controlled ◽  
Anterior Teeth ◽  
The Mean

Objective: To compare two fluorinated varnishes for the control of white spot lesions.Material and Methods: A randomized controlled clinical trial was conducted. A total of 103 active whitespot lesions on permanent upper anterior teeth from 24 patients, aged 7 to 9 years were randomly assigned totwo groups, G1: Duraphat® (n=52) and G2: DuraShield® (n=51). Weekly applications were perform for fourconsecutive weeks. Fifth week the dimension, regression and activity of the lesions were evaluated. Student’sT test, Wilcoxon Ranks and Chi square were used at 5% significance. Results: At the end of the study, the lesion reduction was observed in 69.7%, finding significant differences(p<0.05) in the mean of the initial and final dimensions in general (2.74 mm to 1.91 mm) and in each group, G1(2.84 mm to 2.03 mm), G2 (2.64 mm to 1.78 mm). In the activity of the lesions, it was found in the G1, 12 active and6 inactive lesions; while in G2, there were 14 active and 29 inactive; these differences were significant (p<0.05). Conclusions: The two evaluated products showed similar clinical efficacy in the remineralization of activewhite spot lesions after 4 weeks of therapy.

scholarly journals Accuracy, Labor-Time and Patient-Reported Outcomes with Partially versus Fully Digital Workflow for Flapless Guided Dental Implants Insertion—A Randomized Clinical Trial with One-Year Follow-Up

2021 ◽  
Vol 10 (5) ◽  
pp. 1102
Author(s):  
Corina Marilena Cristache ◽  
Mihai Burlibasa ◽  
Ioana Tudor ◽  
Eugenia Eftimie Totu ◽  
Fabrizio Di Francesco ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Dental Implants ◽  
Entry Point ◽  
Angular Deviation ◽  
Digital Workflow ◽  
Position Information ◽  
Patient Reported ◽  
The Mean ◽  
Edentulous Patients

(1) Background: Prosthetically-driven implant positioning is a prerequisite for long-term successful treatment. Transferring the planned implant position information to the clinical setting could be done using either static or dynamic guided techniques. The 3D model of the bone and surrounding structures is obtained via cone beam computed tomography (CBCT) and the patient’s oral condition can be acquired conventionally and then digitalized using a desktop scanner, partially digital workflow (PDW) or digitally with the aid of an intraoral scanner (FDW). The aim of the present randomized clinical trial (RCT) was to compare the accuracy of flapless dental implants insertion in partially edentulous patients with a static surgical template obtained through PDW and FDW. Patient outcome and time spent from data collection to template manufacturing were also compared. (2) Methods: 66 partially edentulous sites (at 49 patients) were randomly assigned to a PDW or FDW for guided implant insertion. Planned and placed implants position were compared by assessing four deviation parameters: 3D error at the entry point, 3D error at the apex, angular deviation, and vertical deviation at entry point. (3) Results: A total of 111 implants were inserted. No implant loss during osseointegration or mechanical and technical complications occurred during the first-year post-implants loading. The mean error at the entry point was 0.44 mm (FDW) and 0.85 (PDW), p ≤ 0.00; at implant apex, 1.03 (FDW) and 1.48 (PDW), p ≤ 0.00; the mean angular deviation, 2.12° (FDW) and 2.48° (PDW), p = 0.03 and the mean depth deviation, 0.45 mm (FDW) and 0.68 mm (PDW), p ≤ 0.00; (4) Conclusions: Despite the statistically significant differences between the groups, and in the limits of the present study, full digital workflow as well as partially digital workflow are predictable methods for accurate prosthetically driven guided implants insertion.

scholarly journals Effect of Acupressure on Stress and Anxiety of Patients with Multiple Sclerosis: A Sham-controlled Randomized Clinical Trial

2020 ◽  
Vol 10 (3) ◽  
pp. 270-283
Author(s):  
Mohammad Ali Nahayati ◽  
◽  
Seyed Abolfazl Vaghar Seyyedin ◽  
Hamid Reza Bahrami-Taghanki ◽  
Zahra Rezaee ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Test Scores ◽  
Sham Group ◽  
Applied Pressure ◽  
Intervention Group ◽  
T Test ◽  
Significant Difference ◽  
The Mean

Objective: Stress and anxiety are common in patients with Multiple Sclerosis (MS). These complications exacerbate the symptoms of MS. This study aims to evaluate the effect of acupressure on stress and anxiety of MS patients. Methods: In this randomized clinical trial, participants were 106 MS Patients referred to Multiple Sclerosis Society in Mashhad, Iran. After signing an informed consent form, they completed a demographic form and stress, and the Depression Anxiety Stress Scale - 42 items (DASS-42). Then, they were randomly assigned into intervention and sham groups by tossing a coin. Participants in the intervention group were asked apply a pressure on the Shenmen and Yin Tang acupoints for one month (once per day for 15 minutes), while the sham group applied pressure 2.5 cm below the Shenmen acupoint and 3 cm above the Yin Tang acupoint. Participants in each group were then completed the DASS-42 again one hour after the final session. Data were analyzed using chi-square test, Kolmogorov-Smirnov test, independent t-test, and Paired t-test. Results: In the intervention and sham groups, there was no statistically significant difference between the mean pre-test scores of stress (34.73±5.80 vs. 33.06±6.42) and anxiety (27.09±6.99 vs. 25.31±6.88), and neither between the mean post-test scores of stress (29.20±6.21 vs. 33.73±9.44) and anxiety (22.79±5.68 vs. 25.21±6.72) (P>0.05). However, comparison of DASS-42 scores between groups showed that the mean scores of stress and anxiety in the intervention group were significantly lower than in the sham group (P< 0.05). Conclusion: It seems that acupressure can be used along with other therapeutic and pharmacological interventions to reduce stress and anxiety in patients with MS.

Early Intervention Options for Acute Low Back Pain Patients: A Randomized Clinical Trial with One-Year Follow-Up Outcomes

2010 ◽  
Vol 20 (2) ◽  
pp. 256-263 ◽  
Author(s):  
Travis Whitfill ◽  
Robbie Haggard ◽  
Samuel M. Bierner ◽  
Glenn Pransky ◽  
Robert G. Hassett ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Low Back Pain ◽  
Back Pain ◽  
Early Intervention ◽  
Randomized Clinical Trial ◽  
Low Back ◽  
Acute Low Back Pain ◽  
One Year ◽  
Pain Patients
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