scholarly journals Effect of Pterygium Removal Combined with Conjunctival Autograft on Corneal Parameters in Swept-Source Imaging

2022 ◽  
Vol 11 (2) ◽  
pp. 329
Author(s):  
Marta P. Wiącek ◽  
Monika Kuśmierz-Wojtasik ◽  
Bogna Kowalska ◽  
Anna Machalińska
Keyword(s):  
Anterior Segment ◽  
Three Dimensional ◽  
Corneal Topography ◽  
Corneal Surface ◽  
Source Imaging ◽  
Swept Source ◽  
Eye Examination ◽  
Pterygium Excision ◽  
Oct Imaging

Background: Both pterygium ingrowth and excision determine alterations in corneal topography. The aim of this study was to evaluate the influence of pterygium removal combined with conjunctival autografts in addition to the use of human fibrin tissue glue on changes in corneal parameters as measured by 3-D swept-source anterior segment optical coherence tomography (AS-OCT) imaging. Methods: Sixteen eyes (16 patients) with pterygium that qualified for surgical treatment were enrolled in this study. Eye examination, slit lamp, and 3-D AS-OCT (CASIA 2) assessment were performed before the surgery and 7 days, 1 month, and 6 months after pterygium excision. Topographic parameters of both anterior and posterior surfaces of the cornea were analysed at each follow-up visit. Results: The gradual decrease in total astigmatism power from preoperative median 2.75 (6.15) D to 1.2 (1.1) D at 6-month follow-up (p = 0.034) was noted from the day 7 visit. Values were strongly influenced by variations of anterior cornea astigmatism. In contrast, a gradual total HOA reduction at the 1-month (from median 0.79 (1.3) D to 0.44 (0.27) D; p = 0.038) and at 6-month visits (0.25 (0.09); p = 0.001) was observed. Similarly, values were strongly influenced by variations of the anterior. Additionally, total average keratometry values increased from preoperative 44.05 (2.25) D to 44.6 (1.9) (p = 0.043) 1 month after the surgery. Conclusions: Significant steepening of the anterior cornea and a reduction in both astigmatism and HOA were observed after pterygium excision. The anterior corneal surface was an essential component of the total postoperative corneal topography values. Three-dimensional swept-source AS-OCT imaging seems to be a valuable tool for monitoring both the progression of the disease and postoperative effects in pterygium eyes.

scholarly journals Changes in Corneal Parameters after DMEK Surgery: A Swept-Source Imaging Analysis at 12-Month Follow-Up Time

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Anna Machalińska ◽  
Agnieszka Kuligowska ◽  
Karolina Kaleta ◽  
Monika Kuśmierz-Wojtasik ◽  
Krzysztof Safranow
Keyword(s):  
Time Course ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Source Imaging ◽  
Swept Source ◽  
Postoperative Changes ◽  
Course Changes ◽  
Topographic Parameters ◽  
Anterior Posterior

Purpose. To assess the time course changes in corneal topographic parameters during the one-year follow-up after Descemet membrane endothelial keratoplasty (DMEK) surgery. Materials and Methods. Twenty-one patients (24 eyes) who underwent DMEK surgery were evaluated. Best corrected visual acuity (BCVA), endothelial cell count (ECC), central corneal thickness (CCT), mean keratometry (MK), mean astigmatism (MA), astigmatism asymmetry (AA), and higher-order aberration (HOA) were assessed at baseline and 1, 3, 6 and 12 months after the surgery using CASIA2 anterior segment swept-source OCT (Tomey, Japan). Results. In patients who underwent DMEK surgery, BCVA improved gradually at the subsequent visits during the 12-month follow-up. A significant reduction in ECC and CCT at the 1st month was noted, which remained stable until the 6th month postoperatively. Anterior and total MK values remained unchanged, whereas changes in posterior keratometry were noticeable until the 6th month after surgery. A significant reduction in the anterior, posterior, and total astigmatism magnitude as well as astigmatism asymmetry was observed during the first 6 months after surgery. A gradual anterior, posterior, and total HOA decrease was documented until the 12th month after surgery. Negative correlations between baseline values of CCT, MK, MA, AA, and HOA and postoperative variations in those parameters at consecutive follow-up time points were observed. Accordingly, negative correlations between baseline CCT and postoperative changes in corneal topographic parameters after surgery were found. Conclusion. The stabilization of most corneal topographic parameters takes place within 6 months after the procedure, whereas HOA reduction and BCVA improvement gradually occur during the first year after surgery. Preoperative values of corneal topographic parameters strongly determine their changes detected after DMEK surgery, which may suggest that early therapeutic intervention results in better visual outcomes.

scholarly journals The CLASS Surgical Site Characteristics in a Clinical Grading Scale and Anterior Segment Optical Coherence Tomography: A One-Year Follow-Up

2018 ◽  
Vol 2018 ◽  
pp. 1-13
Author(s):  
Judyta Jankowska-Szmul ◽  
Edward Wylegala
Keyword(s):  
Anterior Segment ◽  
Early Postoperative Period ◽  
Swept Source ◽  
Pixel Intensity ◽  
Site Characteristics ◽  
Successful Group ◽  
Grading Scale ◽  
One Year ◽  
Clinical Grading

Purpose. We combined a clinical grading scale and swept source anterior segment OCT to describe the successful and failed CLASS. Material and Methods. 23 patients in the successful group and 17 patients in the failed group were compared in terms of the IBAGS grades and AS-OCT findings at one, three, and twelve months postoperatively. Results. The majority in the successful group presented shallow blebs (91%, 57%, and 52% at 1M, 3M, and 12M, resp.). 59% of the failed group presented no bleb (H0 E0) from the early postoperative period with the rate increasing to 88% at 3M and 100% at 12M. The scleral lake was detected in all the successful patients. The successful group showed significantly higher rates of TDM integrity (P<0.001), IF (P<0.001), and SCF (P<0.05), but there were no significant differences in the rates of microcysts between the groups (P>0.05). We found a significant decrease in the SL anteroposterior extent (P=0.003) and SL height (P<0.001) over time, with no significant correlation between the above parameters and IOP. Conclusions. The subconjunctival bleb may be a sign of the successful CLASS when it matches the AS-OCT findings of TDM integrity, maintained scleral lake, and intrascleral fluid. A validated OCT pixel intensity measurement is required to evaluate the bleb reflectivity.

scholarly journals Rationale and protocol for the 7- and 8-year longitudinal assessments of eye health in a cohort of young adults in the Raine Study

BMJ Open ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. e033440
Author(s):  
Samantha Sze-Yee Lee ◽  
Gareth Lingham ◽  
Seyhan Yazar ◽  
Paul G Sanfilippo ◽  
Jason Charng ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Anterior Segment ◽  
Sun Exposure ◽  
Longitudinal Change ◽  
Raine Study ◽  
Human Research Ethics ◽  
Registration Number ◽  
Eye Examination ◽  
Clinical Trials Registry

IntroductionEye diseases and visual impairment more commonly affect elderly adults, thus, the majority of ophthalmic cohort studies have focused on older adults. Cohort studies on the ocular health of younger adults, on the other hand, have been few. The Raine Study is a longitudinal study that has been following a cohort since their birth in 1989–1991. As part of the 20-year follow-up of the Raine Study, participants underwent a comprehensive eye examination. As part of the 27- and 28-year follow-ups, eye assessments are being conducted and the data collected will be compared with those of the 20-year follow-up. This will provide an estimate of population incidence and updated prevalence of ocular conditions such as myopia and keratoconus, as well as longitudinal change in ocular parameters in young Australian adults. Additionally, the data will allow exploration of the environmental, health and genetic factors underlying inter-subject differential long-term ocular changes.Methods and analysisParticipants are being contacted via telephone, email and/or social media and invited to participate in the eye examination. At the 27-year follow-up, participants completed a follow-up eye screening, which assessed visual acuity, autorefraction, ocular biometry and ocular sun exposure. Currently, at the 28-year follow-up, a comprehensive eye examination is being conducted which, in addition to all the eye tests performed at the 27-year follow-up visit, includes tonometry, optical coherence tomography, funduscopy and anterior segment topography, among others. Outcome measures include the incidence of refractive error and pterygium, an updated prevalence of these conditions, and the 8-year change in ocular parameters.Ethics and disseminationThe Raine Study is registered in the Australian New Zealand Clinical Trials Registry. The Gen2 20-year, 27-year and 28-year follow-ups are approved by the Human Research Ethics Committee of the University of Western Australia. Findings resulting from the study will be published in health or medical journals and presented at conferences.Trial registration numberACTRN12617001599369; Active, not recruiting.

Corneal tomographic changes during corneal rigid gas-permeable contact lens wear in keratoconic eyes

2020 ◽  
pp. bjophthalmol-2020-317057
Author(s):  
Shizuka Koh ◽  
Ryota Inoue ◽  
Naoyuki Maeda ◽  
Yoshinori Oie ◽  
Vishal Jhanji ◽  
...  
Keyword(s):  
Contact Lenses ◽  
Amplitude Ratio ◽  
Anterior Segment ◽  
Three Dimensional ◽  
Biomechanical Properties ◽  
Corneal Surface ◽  
Surface Flattening ◽  
Contact Lens Wear ◽  
Fourier Harmonic ◽  
The Difference

Background/AimsWe aimed to investigate the refractive changes in the posterior corneal surface in keratoconus (KC) associated with wearing spherical corneal rigid gas-permeable contact lenses (corneal GPs) with apical touch or three-point touch fitting and the effect of spherical corneal GPs on corneal biomechanics.MethodsPatients with KC wearing corneal GPs every day without facing complications were enrolled as a single group. Corneal tomographic data were obtained using a three-dimensional anterior segment optical coherence tomography from the same eye with and without corneal GPs. Dioptric data from the central 3-mm zone of the posterior corneal surface were decomposed into spherical, regular astigmatism, asymmetry and higher-order irregularity components using Fourier harmonic analysis. The corneal biomechanical indices were deformation amplitude ratio within 2 mm, integrated radius, stiffness parameter at first applanation and linear Corvis Biomechanical Index. Correlations between the difference in Fourier indices with and without corneal GPs and the corneal biomechanical parameters were analysed.ResultsThirty-two eyes of 32 patients with KC were enrolled. Spherical, regular astigmatism and asymmetry components were significantly smaller with corneal GP wear than without the wear (all p<0.001). All biomechanical indices were significantly correlated with the difference in the spherical components with and without corneal GPs.ConclusionCorneal biomechanical properties of KC were correlated with posterior corneal surface flattening induced by wearing corneal GPs on the spherical components. This effect is greater in biomechanically weaker corneas.

scholarly journals Topical Azithromycin 1% in acute management of inflammatory pterygium

2011 ◽  
Vol 1 (1) ◽  
pp. 2 ◽  
Author(s):  
Len V Hua ◽  
Ami Halvorson ◽  
Blair Lonsberry ◽  
Fraser Horn
Keyword(s):  
Anterior Segment ◽  
Signs And Symptoms ◽  
Severe Case ◽  
Ocular Inflammation ◽  
Topical Steroids ◽  
Acute Management ◽  
Interventional Study ◽  
Small Pilot Study ◽  
Eye Examination

The purpose of the article is to investigate the effects of topical azithromycin 1% (Azasite) in treating acute ocular inflammation related to long standing pterygium. A prospective interventional study of 8 consecutive cases with pterygium presenting to our University Eye Clinics over the period of one month with acute symptoms of red eye(s) and irritation. After patient education and receipt of consent to the study, patients were treated with topical azithromycin 1% (Azasite) twice a day for the first two days and once a day for the next 12 days. Anterior segment photo was taken before treatment and 3-day and/or 7-day after treatment in addition to eye examination. Six out of the eight cases reported of significant improvement or resolution of signs and symptoms on the follow up visits. One severe case did not respond as well after a week of treatment and was successfully managed by topical prednisolone. Another case did not comply with the study protocol. In this small pilot study, Azasite was effective in management of acute mild to moderate ocular inflammation triggered by ocular surface disease, including pterygium. Severe ocular inflammation may require more potent anti-inflammatory therapy like topical steroids.

Corneal and Conjunctival Calcification in a Dialysis Patient Reversed by Parathyroidectomy

2020 ◽  
pp. 1-3
Author(s):  
Maria Beatriz C.N. Pessoa ◽  
Ruth Miyuki Santo ◽  
Aline A. De Deus ◽  
Eduardo Jorge Duque ◽  
Carlos Eduardo Rochitte ◽  
...  
Keyword(s):  
End Stage Renal Disease ◽  
Dialysis Patient ◽  
Anterior Segment ◽  
Maintenance Hemodialysis ◽  
Short Term ◽  
Before And After ◽  
Eye Examination ◽  
Stage Renal Disease ◽  
End Stage

Mineral and bone metabolism disorders are relatively common among patients with end-stage renal disease on maintenance hemodialysis. Corneal and conjunctival calcification is the main extravascular site for calcification. Recently, this form of calcification has been linked to vascular calcification. Secondary hyperparathyroidism can lead to high levels of calcium and phosphorus and increase the risk of calcification. Here, we report a case of a 38-year-old female with severe hyperparathyroidism who underwent eye examination before and after parathyroidectomy. Anterior segment optical coherence tomography showed an improvement in the number and size of ocular calcifications 6 months after surgery. This case calls attention to the importance of eye examination in patients on dialysis and brings the possibility of recovery of calcification in a short-term follow-up.

scholarly journals Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range

2009 ◽  
Vol 17 (17) ◽  
pp. 14880 ◽  
Author(s):  
Michalina Gora ◽  
Karol Karnowski ◽  
Maciej Szkulmowski ◽  
Bartlomiej J. Kaluzny ◽  
Robert Huber ◽  
...  
Keyword(s):  
High Speed ◽  
Anterior Segment ◽  
Swept Source ◽  
Human Eye ◽  
Ultra High Speed ◽  
Swept Source Oct ◽  
Oct Imaging

Isolated keratinising corneal ocular surface squamous neoplasia with multifocal recurrence

2021 ◽  
Vol 14 (7) ◽  
pp. e243925
Author(s):  
Swati Singh ◽  
Saumya Jakati ◽  
Anand Pasari ◽  
Sayan Basu
Keyword(s):  
Visual Acuity ◽  
Ocular Surface ◽  
Anterior Segment ◽  
Surgical Excision ◽  
Ocular Surface Squamous Neoplasia ◽  
Corneal Surface ◽  
Stratified Squamous Epithelium ◽  
The Right ◽  
Multifocal Recurrence

Corneal ocular surface squamous neoplasia usually begins at the limbus and presents as an avascular translucent sheet over the corneal surface. This case report describes a 67-year-old man with an unusual isolated, keratinous nodular corneal lesion. Slit-lamp examination showed an elevated, avascular, whitish plaque-like lesion at the central cornea surrounded by a normal corneal epithelium, with reduced visual acuity of 20/200 in the right eye. Anterior segment optical coherence tomography displayed a hyper-reflective, thickened epithelium with back shadowing. Histopathology showed keratinising hyperplastic stratified squamous epithelium with parakeratosis and moderate nuclear pleomorphism in lower second/third of epithelium suggestive of moderate dysplasia. His visual acuity returned to 20/20 after surgical excision but he developed multifocal corneal recurrences 6 weeks later, which were successfully managed with seven cycles of topical interferon immunotherapy. There are no recurrences observed at 6 months of follow-up.

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