scholarly journals Changes in Corneal Parameters after DMEK Surgery: A Swept-Source Imaging Analysis at 12-Month Follow-Up Time

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Anna Machalińska ◽  
Agnieszka Kuligowska ◽  
Karolina Kaleta ◽  
Monika Kuśmierz-Wojtasik ◽  
Krzysztof Safranow
Keyword(s):  
Time Course ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Source Imaging ◽  
Swept Source ◽  
Postoperative Changes ◽  
Course Changes ◽  
Topographic Parameters ◽  
Anterior Posterior

Purpose. To assess the time course changes in corneal topographic parameters during the one-year follow-up after Descemet membrane endothelial keratoplasty (DMEK) surgery. Materials and Methods. Twenty-one patients (24 eyes) who underwent DMEK surgery were evaluated. Best corrected visual acuity (BCVA), endothelial cell count (ECC), central corneal thickness (CCT), mean keratometry (MK), mean astigmatism (MA), astigmatism asymmetry (AA), and higher-order aberration (HOA) were assessed at baseline and 1, 3, 6 and 12 months after the surgery using CASIA2 anterior segment swept-source OCT (Tomey, Japan). Results. In patients who underwent DMEK surgery, BCVA improved gradually at the subsequent visits during the 12-month follow-up. A significant reduction in ECC and CCT at the 1st month was noted, which remained stable until the 6th month postoperatively. Anterior and total MK values remained unchanged, whereas changes in posterior keratometry were noticeable until the 6th month after surgery. A significant reduction in the anterior, posterior, and total astigmatism magnitude as well as astigmatism asymmetry was observed during the first 6 months after surgery. A gradual anterior, posterior, and total HOA decrease was documented until the 12th month after surgery. Negative correlations between baseline values of CCT, MK, MA, AA, and HOA and postoperative variations in those parameters at consecutive follow-up time points were observed. Accordingly, negative correlations between baseline CCT and postoperative changes in corneal topographic parameters after surgery were found. Conclusion. The stabilization of most corneal topographic parameters takes place within 6 months after the procedure, whereas HOA reduction and BCVA improvement gradually occur during the first year after surgery. Preoperative values of corneal topographic parameters strongly determine their changes detected after DMEK surgery, which may suggest that early therapeutic intervention results in better visual outcomes.

scholarly journals Effect of Pterygium Removal Combined with Conjunctival Autograft on Corneal Parameters in Swept-Source Imaging

2022 ◽  
Vol 11 (2) ◽  
pp. 329
Author(s):  
Marta P. Wiącek ◽  
Monika Kuśmierz-Wojtasik ◽  
Bogna Kowalska ◽  
Anna Machalińska
Keyword(s):  
Anterior Segment ◽  
Three Dimensional ◽  
Corneal Topography ◽  
Corneal Surface ◽  
Source Imaging ◽  
Swept Source ◽  
Eye Examination ◽  
Pterygium Excision ◽  
Oct Imaging

Background: Both pterygium ingrowth and excision determine alterations in corneal topography. The aim of this study was to evaluate the influence of pterygium removal combined with conjunctival autografts in addition to the use of human fibrin tissue glue on changes in corneal parameters as measured by 3-D swept-source anterior segment optical coherence tomography (AS-OCT) imaging. Methods: Sixteen eyes (16 patients) with pterygium that qualified for surgical treatment were enrolled in this study. Eye examination, slit lamp, and 3-D AS-OCT (CASIA 2) assessment were performed before the surgery and 7 days, 1 month, and 6 months after pterygium excision. Topographic parameters of both anterior and posterior surfaces of the cornea were analysed at each follow-up visit. Results: The gradual decrease in total astigmatism power from preoperative median 2.75 (6.15) D to 1.2 (1.1) D at 6-month follow-up (p = 0.034) was noted from the day 7 visit. Values were strongly influenced by variations of anterior cornea astigmatism. In contrast, a gradual total HOA reduction at the 1-month (from median 0.79 (1.3) D to 0.44 (0.27) D; p = 0.038) and at 6-month visits (0.25 (0.09); p = 0.001) was observed. Similarly, values were strongly influenced by variations of the anterior. Additionally, total average keratometry values increased from preoperative 44.05 (2.25) D to 44.6 (1.9) (p = 0.043) 1 month after the surgery. Conclusions: Significant steepening of the anterior cornea and a reduction in both astigmatism and HOA were observed after pterygium excision. The anterior corneal surface was an essential component of the total postoperative corneal topography values. Three-dimensional swept-source AS-OCT imaging seems to be a valuable tool for monitoring both the progression of the disease and postoperative effects in pterygium eyes.

scholarly journals Comparative Analysis of Corneal Parameters in Swept-Source Imaging between DMEK and UT-DSAEK Eyes

2021 ◽  
Vol 10 (21) ◽  
pp. 5119
Author(s):  
Anna Machalińska ◽  
Agnieszka Kuligowska ◽  
Bogna Kowalska ◽  
Krzysztof Safranow
Keyword(s):  
Comparative Analysis ◽  
Corneal Thickness ◽  
Bivariate Analysis ◽  
Endothelial Keratoplasty ◽  
Source Imaging ◽  
Swept Source ◽  
Post Operation ◽  
Baseline Values ◽  
Observation Period

Background: The need to provide a comparative analysis of corneal parameter changes compared to their preoperative values between Descemet membrane endothelial keratoplasty (DMEK) and ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) patients. Methods: The study included 24 eyes after UT-DSAEK and 24 eyes after DMEK. Visual acuity, endothelial cell count (ECC), central corneal thickness (CCT), mean keratometry (MK), mean astigmatism (MA), astigmatism asymmetry (AA) and higher-order aberrations (HOAs) were assessed at baseline and 1, 3, 6 and 12 months after the surgery. Results: From the 3rd month post operation, ECC was higher in the DMEK eyes than in the UT-DSAEK eyes (p = 0.01). In a bivariate analysis that was adjusted for age, DMEK was associated with a smaller decrease in posterior MK at the 1-month (β = −0.49, p = 0.002), 3-month (β = −0.50, p < 0.001), 6-month (β = −0.58, p < 0.001) and 12-month (β = −0.49, p < 0.001) follow-up visits. There were no significant differences in changes in anterior or combined surface MK throughout the observation period. Accordingly, no significant differences in changes in MA, AA or HOAs compared to the baseline values were identified between the eyes after DMEK and UT-DSAEK at any follow-up time point. Conclusions: UT-DSAEK seemed to be an easier and safer technique than DMEK while maintaining similar outcomes regarding irregular astigmatism and total keratometry values.

scholarly journals Comparison of Anterior Ocular Biometric Measurements Using Swept-Source and Time-Domain Optical Coherence Tomography

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Sisi Chen ◽  
Rongrong Gao ◽  
Colm McAlinden ◽  
Junming Ye ◽  
Yiran Wang ◽  
...  
Keyword(s):  
Time Domain ◽  
Corneal Thickness ◽  
Intraclass Correlation ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Correlation Coefficients ◽  
Random Order ◽  
Optical Coherence ◽  
Swept Source ◽  
Significant Difference

Purpose. To compare central corneal thickness (CCT), aqueous depth (AQD), and anterior chamber depth (ACD) measurements using the swept-source (CASIA SS-1000, Tomey, Japan) and time-domain (Visante, Carl Zeiss Meditec, USA) anterior segment optical coherence tomographers (OCT) in normal eyes. Methods. Sixty-eight eyes of 68 subjects were included. Three consecutive scans of each subject were obtained using both devices in a random order by one experienced operator. Standard deviation (Sw), coefficient of repeatability (CoR), coefficients of variation (CoV), and intraclass correlation coefficients (ICC) were used to evaluate the intraoperator repeatability. Agreement was assessed using the Bland–Altman plots and 95% limits of agreement (LoA). Results. All measurements of the swept-source OCT (SS-OCT) and time-domain OCT (TD-OCT) showed high repeatability with low CoR (CCT: 2.34 μm and 6.16 μm; AQD: 0.05 mm and 0.09 mm; ACD: 0.06 mm and 0.09 mm), low CoV (CCT: 0.16% and 0.42%; AQD: 0.61% and 0.97%; ACD: 0.53% and 0.83%), and high ICC (>0.98). The mean CCT with SS-OCT was slightly thicker than the results with TD-OCT (difference = 4.55 ± 2.62 μm, P<0.001). There was no statistically significant difference in AQD or ACD measurements between the two devices (0.01 ± 0.05 mm, P=0.111; 0.02 ± 0.05 mm, P=0.022, respectively). The 95% LoA between the SS-OCT and TD-OCT were −0.59 to 9.69 μm for CCT, −0.10 to 0.12 mm for AQD, and −0.09 to 0.12 mm for ACD. Conclusions. High levels of repeatability and agreement were found between the two devices for all three parameters, suggesting interchangeability. SS-OCT demonstrated superior repeatability compared with TD-OCT.

scholarly journals Impact of Rigid Gas Permeable Contact Lenses Removal on Anterior and Posterior Corneal Surfaces in Keratoconus Patients

2019 ◽  
Author(s):  
Motohiro Itoi ◽  
Koji Kitazawa ◽  
Hisayo Higashihara ◽  
Chie Sotozono
Keyword(s):  
Contact Lens ◽  
Contact Lenses ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Corneal Surface ◽  
Contact Lens Wear ◽  
Surface Areas ◽  
The Impact ◽  
Lens Wear ◽  
Anterior Posterior

AbstractPurposeTo evaluate the impact of removal of rigid gas-permeable (RGP) contact lenses on the anterior and posterior cornea surfaces of eyes with keratoconus.MethodsEight eyes of 8 patients with keratoconus (KC) (age 34.3 ± 15.3 years; range 19–60 years) were enrolled. Anterior segment optical coherence tomography (AS-OCT) was performed at 1, 5, 10, 20, and 60 minutes after the patients removed their RGP contact lenses. Measurements included anterior and posterior best-fit sphere (BFS); elevation values and corneal surface areas; corneal thickness at the thinnest point; and the anterior-posterior ratio of the corneal surface (As/Ps) between 1 minute and 60 minutes after RGP contact lens removal.ResultsAnterior and posterior elevation values and corneal surface areas showed significant increases, whereas anterior and posterior BFS and central corneal thickness decreased significantly (P < 0.01) between 1 minute and 60 minutes after RGP contact lens removal. No statistically significant differences were found in the As/Ps ratio during the first hour after suspending RGP contact lens wear.ConclusionsWe found that the patients with keratoconus experienced significant changes in both the anterior and posterior corneal shape for 60 minutes after removal of RGP contact lenses.

Corneal Thickness and Volume Measurements by Swept Source Anterior Segment Optical Coherence Tomography in Normal Subjects

2013 ◽  
Vol 38 (5) ◽  
pp. 531-536 ◽  
Author(s):  
Reina Fukuda ◽  
Tomohiko Usui ◽  
Takashi Miyai ◽  
Yosai Mori ◽  
Kazunori Miyata ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Normal Subjects ◽  
Optical Coherence ◽  
Swept Source ◽  
Volume Measurements

scholarly journals The CLASS Surgical Site Characteristics in a Clinical Grading Scale and Anterior Segment Optical Coherence Tomography: A One-Year Follow-Up

2018 ◽  
Vol 2018 ◽  
pp. 1-13
Author(s):  
Judyta Jankowska-Szmul ◽  
Edward Wylegala
Keyword(s):  
Anterior Segment ◽  
Early Postoperative Period ◽  
Swept Source ◽  
Pixel Intensity ◽  
Site Characteristics ◽  
Successful Group ◽  
Grading Scale ◽  
One Year ◽  
Clinical Grading

Purpose. We combined a clinical grading scale and swept source anterior segment OCT to describe the successful and failed CLASS. Material and Methods. 23 patients in the successful group and 17 patients in the failed group were compared in terms of the IBAGS grades and AS-OCT findings at one, three, and twelve months postoperatively. Results. The majority in the successful group presented shallow blebs (91%, 57%, and 52% at 1M, 3M, and 12M, resp.). 59% of the failed group presented no bleb (H0 E0) from the early postoperative period with the rate increasing to 88% at 3M and 100% at 12M. The scleral lake was detected in all the successful patients. The successful group showed significantly higher rates of TDM integrity (P<0.001), IF (P<0.001), and SCF (P<0.05), but there were no significant differences in the rates of microcysts between the groups (P>0.05). We found a significant decrease in the SL anteroposterior extent (P=0.003) and SL height (P<0.001) over time, with no significant correlation between the above parameters and IOP. Conclusions. The subconjunctival bleb may be a sign of the successful CLASS when it matches the AS-OCT findings of TDM integrity, maintained scleral lake, and intrascleral fluid. A validated OCT pixel intensity measurement is required to evaluate the bleb reflectivity.

scholarly journals Swept Source Optical Coherence Tomography Analysis of the Selected Eye’s Anterior Segment Parameters

2021 ◽  
Vol 10 (5) ◽  
pp. 1094
Author(s):  
Michał Dembski ◽  
Anna Nowińska ◽  
Klaudia Ulfik-Dembska ◽  
Edward Wylęgała
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Swept Source ◽  
Iridocorneal Angle ◽  
Glaucoma Diagnosis ◽  
Good Repeatability ◽  
Anterior Segment Parameters ◽  
Important Marker

Background: The present study determined the mean reference values of the anterior segment parameters of the selected eye using swept source optical coherence tomography (SS-OCT) in healthy Caucasian participants. Methods: A total of 166 volunteers (age 54–79 years), women (n = 92) and men (n = 74), were analyzed. One eye of each subject was randomly selected for anterior segment imaging. The anterior segment of the eye was scanned with CASIA2. The analyzed anterior segment parameters were divided into three groups, namely parameters of the cornea, lens, and angle. Results: The OCT (e.g., Ks, Kf, pKf, pKs, and central corneal thickness) and Fourier parameters of the cornea were significantly different between females and males. The iridocorneal angle was the smallest in the upper quadrant for all distance from the apex of the angle (250, 500, and 750 µm). Conclusions: Therefore, SS-OCT enables the analysis of parameters of the cornea, anterior chamber, lens, and iridocorneal angle, highlighting its clinical utility. Sex-specific differences in the analyzed parameters should be taken into account during the diagnosis of corneal diseases. The configuration of the filtration angle is an important marker during glaucoma diagnosis and drainage implant surgery. Measurements with CASIA 2is characterized by very good repeatability.

scholarly journals Role of anterior segment optical coherence tomography in the evaluation of microbial keratitis

2021 ◽  
Vol 7 (3) ◽  
pp. 548-553
Author(s):  
Isha Chaturvedi ◽  
Kamaljeet Singh ◽  
Jagriti Rana ◽  
Kshama Dwivedi ◽  
Reena Sachan
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Morphological Characteristics ◽  
Objective Evaluation ◽  
Response To Treatment ◽  
Optical Coherence ◽  
Microbial Keratitis ◽  
The Mean

Anterior segment optical coherence tomography (AS-OCT) is a newer technology that provides two-dimensional images of corneal infiltration. This study was undertaken to assess whether AS-OCT can aid objective evaluation and response to treatment in resolving microbial keratitis. This prospective study was performed on 17 patients of who underwent slit lamp and AS-OCT examination at presentation and follow up on days 3, 7, 14, 28 and 6 weeks. A standardized scanning protocol was used to measure the corneal thickness (CT) and infiltrate thickness (IT) using the caliper tool of a commercially available AS-OCT device. The mean CT in the infiltrated area and mean IT, both were thickest at presentation (710.88 um and 288.76 um respectively). The mean CT decreased to 665.12 µm, 650.24 µm, 584.35 µm, 549 µm, 507.47 µm on days 3, 7, 14, 28 and 6 weeks respectively. Similarly, the mean IT decreased to 287.24 µm, 244.41 µm, 197 µm, 174.59 µm and 154.82 µm. Paired t- test was used to calculate the statistical change in CT and IT, which was significant (p&#60;0.0001) at 6 weeks, at the rate of 0.67% and 1.01% per day. AS-OCT can show morphological characteristics of microbial keratitis and give quantitative assessment at every follow up.

scholarly journals Epithelial Remodelling After Epithelium-off Continuous Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus

2021 ◽  
Author(s):  
Junjie Piao ◽  
Ying Li ◽  
Meng Wang ◽  
Sun Joo Kim ◽  
Choun-Ki Joo ◽  
...  
Keyword(s):  
Corneal Thickness ◽  
Anterior Segment ◽  
Cross Linking ◽  
Ultraviolet A ◽  
Corneal Epithelial ◽  
Postoperative Changes ◽  
Uncorrected Distance Visual Acuity ◽  
Minimum Angle ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Abstract Background: To analyse regional corneal epithelial and stromal remodelling after epithelium-off (epi-off) continuous accelerated corneal collagen cross-linking (CXL) for keratoconus (KC).Methods: In this retrospective study, 20 patients (33 eyes) who were treated with epi-off continuous accelerated CXL (KXL system; Avedro, Inc., Waltham, MA, USA). All treatments were performed with ultraviolet-A (UVA) (energy, 7.2 J/cm2; irradiance, 30 mW/cm2), using continuous (4 min) illumination. The postoperative changes in corneal biometric and visual outcomes were compared. The corneal thickness changes were evaluated using anterior segment optical coherence tomography (Optovue). All patients were followed up for 12 months postoperatively.Results: Uncorrected distance visual acuity significantly improved from 1.06 ± 0.49 logarithm of the minimum angle resolution (logMAR) to 0.71 ± 0.37 logMAR at 3 months after epi-off continuous accelerated CXL (p<0.001). The corneal epithelial thickness changes were significant in the inner nasal at -1.48 ± 3.65 µm (p=0.024), -1.76 ± 4.21 µm in the inner superior-nasal (p=0.024), -1.52 ± 4.02 µm in the inner superior (p=0.046), -1.97 ± 4.57 µm in the inner superior-temporal (p=0.018), -2.12 ± 4.46 µm in the outer inferior (p=0.014), -2.15 ± 4.82 µm in the outer inferior-nasal (p=0.022), -1.73 ± 4.45 µm in the outer temporal (p=0.019) at 6 months after epi-off continuous accelerated CXL.Conclusions: Significant regional epithelial remodelling occurs after epi-off continuous accelerated CXL; a more regular corneal thickness profile and keratometric variations were observed after treatment.

scholarly journals Corneal thickness mapping by 3D swept-source anterior segment optical coherence tomography

2012 ◽  
Vol 90 (6) ◽  
pp. e452-e457 ◽  
Author(s):  
Alberto Neri ◽  
Marianna Malori ◽  
Patrizia Scaroni ◽  
Rosachiara Leaci ◽  
Elisabetta Delfini ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Swept Source
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