Pregabalin Failed to Prevent Dry Eye Symptoms after Laser-Assisted in Situ Keratomileusis (LASIK) in a Randomized Pilot Study

Purpose: Perioperative pregabalin administration has been found to reduce the risk of persistent pain after a variety of surgical procedures. However, this approach has not been tested in relation to eye surgery. As such, the purpose of this study was to evaluate whether perioperative pregabalin can reduce the presence of dry eye (DE) symptoms, including eye pain, six months after laser-assisted in situ keratomileusis (LASIK). Methods: Prospective, masked, randomized single-center pilot study. Patients were treated with either pregabalin (oral solution of pregabalin 150 mg twice daily, first dose prior to surgery, continued for a total of 28 doses over 14 days) or placebo solution. The primary outcome was dry eye symptoms as measured by the Dry Eye Questionnaire 5 (DEQ-5). Secondary outcome measures included pain-related eye symptoms. Results: In total, 43 individuals were enrolled in the study and randomized to pregabalin (n = 21) or placebo (n = 22). Of those, 42 individuals completed the final visit after six months of follow-up. Some differences were noted between the two groups at baseline, including a higher frequency of females in the pregabalin group. At 6-months, there were no significant differences in the percentage of patients with DE symptoms (DEQ5 ≥ 6, 57% vs. 33%, p = 0.14), DE symptom severity (DEQ5, 6.6 ± 5.0 vs. 4.5 ± 4.2, p = 0.14), ocular pain intensity (numerical rating scale, 1.10 ± 1.48 vs. 0.38 ± 0.97, p = 0.08), or neuropathic pain complaints (Neuropathic Pain Symptom Inventory-Eye, 2.81 ± 4.07 vs. 3.14 ± 5.85, p = 0.83) between the pregabalin and control groups. Ocular signs were likewise similar between the groups, and of note, did not correlate with DE symptoms. The strongest predictor of DE symptoms six months post-surgery was the presence of DE symptoms prior to surgery. Conclusions: Perioperative pregabalin did not reduce the frequency or severity of DE symptoms at a six month follow-up after LASIK in this small pilot study.

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Dry eye symptoms and plasma hormone levels - A pilot study

Contact Lens and Anterior Eye ◽

10.1016/j.clae.2013.08.031 ◽

2013 ◽

Vol 36 ◽

pp. e7-e8

Author(s):

Fiona Stapleton ◽

Ulrike Hampel ◽

Noor Badarudin ◽

Isabelle Jalbert ◽

Michele Madigan ◽

...

Keyword(s):

Pilot Study ◽

Dry Eye ◽

Hormone Levels ◽

Eye Symptoms ◽

Plasma Hormone ◽

Dry Eye Symptoms

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Prevalence of dry eye in college students at Uparwara community in Raipur

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20193967 ◽

2019 ◽

Vol 6 (9) ◽

pp. 3768

Author(s):

Andrea Kolla ◽

Devesh Dahariya ◽

Male Shiva Ram ◽

Varaprasad Kolla

Keyword(s):

College Students ◽

Risk Factor ◽

Pilot Study ◽

Dry Eye ◽

Electronic Devices ◽

Questionnaire Study ◽

Age Group ◽

Declaration Of Helsinki ◽

Eye Symptoms ◽

Dry Eye Symptoms

Background: The study aims to investigate the prevalence of dry eye in college students in the Uparwara community.Methods: This pilot study was conducted tenure to declaration of Helsinki rules with n=240 (males 200 and females 40) with in the age group of 18-25 years, OSDI questionnaire was used to assess the prevalence among the college students of Uparwara community at Raipur.Results: Data from 240 subjects were analyzed with a mean age group of 19.41±0.70 mean±SD. This OSDI questionnaire study with subscales for dry eye symptoms were measured in both the genders males 213 (89%), females 27 (11%). The percentage distributions among the subjects showed that 116 (48.3%) participants reported dry eye symptoms and 124 (51.6%) was normal.Conclusions: This study emphasized on the prolonged usage of VDT and electronic devices i.e., >4 hours as a compliance factor for dry eye, our data suggest that VDT usage less than 4 hours also can be a risk factor for dry eye since all our 116 participants with dry eye symptoms are VDT users and interestingly 78% (90) of them are <4 hours VDT users but still have dry eye symptoms.

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3494 Naltrexone as a Diagnostic Tool in Ocular Neuropathic Pain

Journal of Clinical and Translational Science ◽

10.1017/cts.2019.41 ◽

2019 ◽

Vol 3 (s1) ◽

pp. 16-17

Author(s):

Nicholas Fowler ◽

Romulo Albuquerque ◽

Jooyoung Cho ◽

Nicholas Bell ◽

Paras Vora ◽

...

Keyword(s):

Neuropathic Pain ◽

Cohort Studies ◽

Dry Eye ◽

Tear Film ◽

Scleral Buckle ◽

Corneal Sensitivity ◽

Retrospective Cohort Studies ◽

Study Population ◽

Eye Symptoms ◽

Dry Eye Symptoms

OBJECTIVES/SPECIFIC AIMS: The study aims to track and correlate ocular neuropathic symptoms, corneal sensitivity and dry-eye like pain, after scleral buckle and posterior vitrectomy surgeries. The goal is to identify a population of patients that receive these retinal surgeries that experience ocular neuropathic pain. METHODS/STUDY POPULATION: Methods - Prospective and Retrospective cohort studies were designed with the follow cohorts: scleral buckle, posterior vitrectomy, and control. Typical follow up for SB/PV surgeries are: 1 day, 1 week, 1, 3, 6, 12 months post surgery. CS and DELP metrics are measured at each visit. For study interventions, all subjects (from both arms) will undergo the same series of tests, in the same sequence at each visit. Phase 1 of the visit focuses on CS and phase 2 on DELP. These interventions are as follows: first, subjects will receive Drop A; Drop A will be administered in a randomized, double-blinded manner at each visit to either balanced salt solution (control) or Muro 128 5% hypertonic saline (experimental). Drop A will be administered to both eyes. After receiving the drops, subjects will complete a visual analog scale questionnaire to grade their corneal sensitivity. Next, subjects will undergo a five minute washout. After the washout, subjects will receive Drop B; Drop B will be whichever drop was not administered in the Drop A phase. After Drop B is given, subjects will complete the visual analog scale. To begin phase 2, subjects will be given the Ocular Surface Disease Index to record dry eye signs and symptoms. Finally, tear film parameters will be collected using Schirmer’s tear production test and tear film breakup time. Study Population. - Inclusion criteria: For retrospective cohort studies, subjects who have undergone unilateral SB or PV in the past year. For prospective cohort studies, subjects who will undergo unilateral SB or PV in the near future, and age-matched controls. Exclusion criteria: For both retrospective and prospective arms, the same exclusion criteria apply. They include: a previous diagnosis of dry eye; current use of neuropathic pharmacotherapies (including gabapentin, pregabalin, TCAs, SNRIs, carbamazepine, and opioids). RESULTS/ANTICIPATED RESULTS: As of 11/15/18, only the scleral buckle retrospective study arm had enough subjects for any meaningful preliminary report; the arm currently has 8 subjects. Of these 8 subjects, 5/8 subjects report increased surgical-eye corneal sensitivity and 6/8 show discordant dry eye symptoms and tearfilm parameters. Our power analysis showed that N=16 subjects in a group are required to detect a statistical significant difference in corneal sensitivity response. We expect to see a relapsing and remitting pattern of pain (as measured by corneal sensitivity and dry eye questionnaire), as is typical of neuropathic pain. Regarding dry eye symptoms, we anticipate subjects will have prominent dry eye symptoms (as measured by a validated questionnarie), but show no abnormalities in tearfilm parameters. DISCUSSION/SIGNIFICANCE OF IMPACT: To our knowledge, this is the first observational study of neuropathic pain symptoms of corneal sensitivity and dry-eye like pain, in post retinal surgery patients. We recognize the challenge of diagnosing neuropathic pain; currently the gold standard is clinical. However, symptoms of neuropathic pain are non-specific and subtle. Identification of a population suffering from post-retinal surgery ocular neuropathic pain will provide a foundation to test topical naltrexone as a diagnostic tool. If our hypothesis is correct, topical naltrexone could serve as a cheap, easy, and quick diagnostic test for ocular neuropathic pain. We envision this diagnostic test would allow many misdiagnosed and mistreated post-surgical patients to be treated with appropriate therapies aimed at neuropathic etiologies.

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In vivo detection of clinically non-apparent ocular surface inflammation in patients with meibomian gland dysfunction-associated refractory dry eye symptoms: a pilot study

Eye ◽

10.1038/eye.2015.103 ◽

2015 ◽

Vol 29 (8) ◽

pp. 1099-1110 ◽

Cited By ~ 15

Author(s):

Y Qazi ◽

A Kheirkhah ◽

C Blackie ◽

A Cruzat ◽

M Trinidad ◽

...

Keyword(s):

Pilot Study ◽

Dry Eye ◽

Ocular Surface ◽

Meibomian Gland ◽

In Vivo Detection ◽

Eye Symptoms ◽

Surface Inflammation ◽

Ocular Surface Inflammation ◽

Dry Eye Symptoms

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Dry Eye Post-Laser-Assisted In Situ Keratomileusis: Major Review and Latest Updates

Journal of Ophthalmology ◽

10.1155/2018/4903831 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Eyal Cohen ◽

Oriel Spierer

Keyword(s):

Risk Factors ◽

Dry Eye ◽

Preoperative Assessment ◽

Visual Outcome ◽

Preoperative Screening ◽

Short Term ◽

Eye Symptoms ◽

Major Review ◽

Dry Eye Symptoms

Dry eye is one of the most common complications occurring after laser-assisted in situ keratomileusis (LASIK), with virtually all patients experiencing some degree of postoperative dry eye symptoms. Enhanced understanding of the pathophysiology and mechanism of dry eye development in addition to preoperative screening of patients who are prone to dry eye is essential for better patient satisfaction and for improving short-term visual outcome postoperatively. This article reviews the latest studies published on LASIK-associated dry eye, including epidemiology, pathophysiology, risk factors, preoperative assessment, and management.

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Patient satisfaction and self-reported dry eye symptoms in hyperopic patients treated with femtosecond laser in situ keratomileusis

Clinical Ophthalmology ◽

10.2147/opth.s195991 ◽

2019 ◽

Vol Volume 13 ◽

pp. 741-754

Author(s):

Petri Mäkinen ◽

Anne Huhtala ◽

Juhani Pietilä ◽

Janika Nättinen ◽

Teppo Rajala ◽

...

Keyword(s):

Patient Satisfaction ◽

Femtosecond Laser ◽

Dry Eye ◽

Laser In Situ Keratomileusis ◽

Eye Symptoms ◽

Dry Eye Symptoms

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Assessment Of Dry Eye Symptoms And Quality Of Sleep In Engineering Students During The Covid-19 Pandemic

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.3593 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 1202-1207

Author(s):

Pavithra S ◽

Dheepak Sundar M

Keyword(s):

Sleep Quality ◽

Dry Eye ◽

Screen Time ◽

Engineering Students ◽

Statistical Tests ◽

Quality Of Sleep ◽

Cross Sectional ◽

Eye Symptoms ◽

Dry Eye Symptoms

To assess dry eye symptoms (DES) and quality of sleep in engineering students during the Covid19 pandemic lockdown and also to assess the association between DES and sleep quality. A cross-sectional questionnaire-based study was carried out among 396 engineering students studying in Saveetha engineering college. The study tool used was a semi-structured google form questionnaire designed for assessing digital device usage, symptoms of dry eye disease and sleep pattern. Responses were analyzed using appropriate statistical tests. Overall 64.1% attained a score of more than 10, indicating the presence of DES. 70.2% of the study population used digital screens for more than 13 hours. A statistically significant association was found between increased screen time and presence of DES(p<0.05). 64.9% had a score of >18 indicating reduced sleep quality. About 77.1% of the students with DES had reduced sleep quality, and a significant association (p<0.01) was observed between the two. During the Covid19 pandemic lockdown, there appears to be rising prevalence of DES in student population, one of the reasons being increased screen time. The sleep quality was also found to be reduced, and a significant association was found between DES and sleep quality.

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