scholarly journals Total Tear IgE Levels Correlate with Allergenic and Irritating Environmental Exposures in Individuals with Dry Eye

2019 ◽  
Vol 8 (10) ◽  
pp. 1627 ◽  
Author(s):  
Dermer ◽  
Theotoka ◽  
Lee ◽  
Chhadva ◽  
Hackam ◽  
...  
Keyword(s):  
Dry Eye ◽  
Immunoglobulin E ◽  
Environmental Exposures ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
The Us ◽  
Eye Symptoms ◽  
Logistic Regressions ◽  
Dry Eye Symptoms

Dry eye (DE) and allergic conjunctivitis may present similarly, and it remains unclear whether some individuals have an underlying allergic component to their DE. To better understand this relationship, we performed a cross-sectional study in 75 individuals with DE symptoms and/or signs. Immunoglobulin E (IgE) levels in tear samples were quantified and home environmental exposures assessed via standardized survey. Tears were collected by Schirmer strip, and total tear IgE levels were quantified using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using descriptive statistics and linear and logistic regressions. The main outcome measures were total tear IgE levels and their association with environmental exposures. The mean age of the subjects was 66.2 ± 7.8 years. Sixty-two individuals had dry eye symptoms (Dry Eye Questionnaire-5 ≥ 6), and 75 had one or more signs of DE. Detectable total tear IgE levels were observed in 76% of subjects, and 17.3% had high levels (>1 ng/mL). Individuals with exposure to pet(s) (odds ratio (OR) 11.5, p = 0.002) and smoke (OR 38.6, p = 0.008) at home were more likely to have high IgE levels compared to those not exposed. Individuals with tears collected during spring or summer were 3.9 times (p = 0.028) more likely to have high IgE compared to those sampled at other times of year. Subjects born in the US were 3.45 times (p = 0.010) more likely to have high IgE compared to individuals born outside the US. To conclude, a majority of individuals with DE symptoms and/or signs had detectable IgE levels in their tears. High tear IgE levels were correlated with allergy season and exposures in the home linked with allergy.

scholarly journals Prevalence and pattern of dry eye symptoms among “okada” riders in Southwest Nigeria using the ocular surface disease index: A cross sectional study

2021 ◽  
Vol 18 (2) ◽  
pp. 81
Author(s):  
AdetunjiOlusesan Adenekan ◽  
OlubankeTheodora Ilo ◽  
AdegboyegaSunday Alabi ◽  
OlufisayoTemitayo Aribaba ◽  
FolasadeBolanle Akinsola
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Cross Sectional Study ◽  
Disease Index ◽  
Sectional Study ◽  
Ocular Surface Disease Index ◽  
Cross Sectional ◽  
Southwest Nigeria ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

scholarly journals Case finding of dry eye disease in Norwegian optometric practice: a cross-sectional study

2021 ◽  
Vol 14 (1) ◽  
pp. 1-6
Author(s):  
Ann Elisabeth Ystenæs ◽  
Ingeborg Sand ◽  
Vibeke Sundling
Keyword(s):  
Dry Eye ◽  
Contact Lens ◽  
Cross Sectional Study ◽  
Case Finding ◽  
Eye Disease ◽  
Cross Sectional ◽  
Eye Symptoms ◽  
The Mean ◽  
Breakup Time ◽  
Dry Eye Symptoms

Optometrists are primary eye care providers, and it is essential that they efficiently identify patients who will benefit from dry eye management. The aim of the study was to explore case finding of dry eye disease (DED) in optometric practice. A cross-sectional study examining dry eye symptoms and signs in 186 patients (18–70 years of age) attending a routine eye examination, with DED defined according to the criteria of the Tear Film and Ocular Surface Society Dry Eye Workshop II. Standard statistical tests were used, and clinical diagnostics were explored using sensitivity, specificity, and receiveroperating curve (ROC) statistics. Fifty-six patients were contact lens wearers, and they were significantly younger than the non-contact lens wearers (mean age 35 (SD = 1) versus 48 (± 2) years). The mean best corrected visual acuity (BCVA) in the better eye was 1.0 (± 0.1) (decimal acuity). There was no difference in BCVA between contact lens wearers and non-contact lens wearers. The mean Ocular Surface Disease Index (OSDI) score was 22 (± 19), and 138 patients had at least one positive homeostasis marker. Eighty-six had DED, 52 had signs without symptoms, and 23 had symptoms without signs of DED. The sensitivity and specificity of OSDI in detecting any positive homeostasis marker were 62% and 54%, respectively. In all, 106 patients had meibomian gland dysfunction (MGD), of which 49 were asymptomatic. In a ROC analysis, an OSDI ≥ 13 showed a diagnostic ability to differentiate between patients with a fluorescein breakup time (FBUT) < 10 seconds and a fluorescein breakup time ≥ 10 seconds, but not between patients with and without staining or MGD. The majority of patients had dry eye signs and/or dry eye symptoms. Routine assessment of FBUT and meibomian glands may enable case finding of DED in optometric practice.

Assessment Of Dry Eye Symptoms And Quality Of Sleep In Engineering Students During The Covid-19 Pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1202-1207
Author(s):  
Pavithra S ◽  
Dheepak Sundar M
Keyword(s):  
Sleep Quality ◽  
Dry Eye ◽  
Screen Time ◽  
Engineering Students ◽  
Statistical Tests ◽  
Quality Of Sleep ◽  
Cross Sectional ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

To assess dry eye symptoms (DES) and quality of sleep in engineering students during the Covid19 pandemic lockdown and also to assess the association between DES and sleep quality. A cross-sectional questionnaire-based study was carried out among 396 engineering students studying in Saveetha engineering college. The study tool used was a semi-structured google form questionnaire designed for assessing digital device usage, symptoms of dry eye disease and sleep pattern. Responses were analyzed using appropriate statistical tests. Overall 64.1% attained a score of more than 10, indicating the presence of DES. 70.2% of the study population used digital screens for more than 13 hours. A statistically significant association was found between increased screen time and presence of DES(p<0.05). 64.9% had a score of >18 indicating reduced sleep quality. About 77.1% of the students with DES had reduced sleep quality, and a significant association (p<0.01) was observed between the two. During the Covid19 pandemic lockdown, there appears to be rising prevalence of DES in student population, one of the reasons being increased screen time. The sleep quality was also found to be reduced, and a significant association was found between DES and sleep quality.

scholarly journals Smartphone-based digital phenotyping for dry eye toward P4 medicine: a crowdsourced cross-sectional study

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Takenori Inomata ◽  
Masahiro Nakamura ◽  
Jaemyoung Sung ◽  
Akie Midorikawa-Inomata ◽  
Masao Iwagami ◽  
...  
Keyword(s):  
Dry Eye ◽  
Cross Sectional Study ◽  
Multidimensional Analysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
P4 Medicine ◽  
Symptom Profiles ◽  
Digital Phenotyping ◽  
Logistic Regressions ◽  
Participatory Medicine

AbstractMultidimensional integrative data analysis of digital phenotyping is crucial for elucidating the pathologies of multifactorial and heterogeneous diseases, such as the dry eye (DE). This crowdsourced cross-sectional study explored a novel smartphone-based digital phenotyping strategy to stratify and visualize the heterogenous DE symptoms into distinct subgroups. Multidimensional integrative data were collected from 3,593 participants between November 2016 and September 2019. Dimension reduction via Uniform Manifold Approximation and Projection stratified the collected data into seven clusters of symptomatic DE. Symptom profiles and risk factors in each cluster were identified by hierarchical heatmaps and multivariate logistic regressions. Stratified DE subgroups were visualized by chord diagrams, co-occurrence networks, and Circos plot analyses to improve interpretability. Maximum blink interval was reduced in clusters 1, 2, and 5 compared to non-symptomatic DE. Clusters 1 and 5 had severe DE symptoms. A data-driven multidimensional analysis with digital phenotyping may establish predictive, preventive, personalized, and participatory medicine.

scholarly journals Symptoms of ocular surface disease in construction workers: comparative study with office workers.

2020 ◽  
Author(s):  
Sergio Hernandez-Llamas ◽  
Ana Karen Paz-Ramos ◽  
Patricio Marcos-González ◽  
Francisco Amparo ◽  
Manuel Garza
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Construction Workers ◽  
Office Workers ◽  
Cross Sectional ◽  
Office Environment ◽  
Degree Of Confidence ◽  
Eye Symptoms ◽  
Associated Risk Factors ◽  
Dry Eye Symptoms

Abstract Purpose To investigate and contrast the prevalence of dry eye symptoms in construction workers and office workers using the OSDI questionnaire. Methods A cross-sectional, observational study was conducted using the OSDI questionnaire to evaluate dry eye symptoms and associated risk factors. Sampled size calculation with a power of 80% and a 95% degree of confidence suggested the inclusion of 298 participants. Results We studied 304 subjects (149 construction workers and 155 office workers). More than half (55%) of the participants presented dry eye symptoms (OSDI > 12). The average OSDI score was 21.30 ± 22.20 points, being lower in the group of construction workers (12.45±17.50) than in-office workers (28.51±22.99) (p <0.001). Considering participants who had moderate and severe symptoms (23 to 100 points in OSDI), office workers presented dry eye symptoms 4.15 times more frequent than construction workers (OR 4.15, 95% CI 2.52, 6.85). Women presented statistical evidence of higher OSDI scores than men (32.47 ± 23.72 vs. 14.87 ± 18.48, respectively). Conclusions Construction workers have four times less risk of presenting dry eye symptoms than people working in the average office space highlighting the pernicious effects of some of the conditions in the office environment to the ocular surface. .

scholarly journals Evaluation of Strip Meniscometry and Association with Clinical and Demographic Variables in a Community Eye Study (in Bangladesh)

2020 ◽  
Vol 9 (10) ◽  
pp. 3366
Author(s):  
Mamunur A.K.M. Rashid ◽  
Zhang Zhe Thia ◽  
Calesta Hui Yi Teo ◽  
Sumaiya Mamun ◽  
Hon Shing Ong ◽  
...  
Keyword(s):  
Dry Eye ◽  
Multivariable Analysis ◽  
Cross Sectional Study ◽  
Meibomian Gland ◽  
Demographic Variables ◽  
Clinical Test ◽  
Ocular Surface Disease Index ◽  
Cross Sectional ◽  
Garment Workers ◽  
Eye Symptoms

Strip meniscometry (SM) is a relatively new technique for evaluating inferior tear meniscus. We described SM in an epidemiology study and its potential associations with clinical and tear parameters. This cross-sectional study involved 1050 factory garment workers in Gazipur, Bangladesh. The Ocular Surface Disease Index (OSDI) questionnaire and a standard examination for dry eye and meibomian gland dysfunction (MGD), including the five-second SM, were performed by a single ophthalmologist. The participants’ ages were 35.56 ± 12.12 years (range 18–59), with 53.8% women. The overall SM was 7.7 ± 3.6 mm, with skewness of 0.126 and kurtosis of 1.84 in frequency distribution. SM values were significantly lower in men than women, and significantly correlated with schirmers (r = 0.71) and tear break up time (TBUT) (r = 0.89). A lower SM value was associated with higher OSDI, lower Schirmer test, increased MG severity and lower TBUT. In multivariable analysis, when adjusted by age, SM values remained associated with schirmers and TBUT, and inversely associated with OSDI. In a separate regression model, higher SM was associated with increasing age, reduced severity of MGD grading, and increased TBUT. To conclude, SM is a rapid clinical test associated with dry eye symptoms and signs, with findings affected by both tear secretion and tear stability.

scholarly journals Symptoms of ocular surface disease in construction workers: comparative study with office workers

2020 ◽  
Author(s):  
Sergio Hernandez-Llamas ◽  
Ana Karen Paz-Ramos ◽  
Patricio Marcos-González ◽  
Francisco Amparo ◽  
Manuel Garza-Leon
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Significant Risk ◽  
Construction Workers ◽  
Office Workers ◽  
Cross Sectional ◽  
Degree Of Confidence ◽  
Eye Symptoms ◽  
Associated Risk Factors ◽  
Dry Eye Symptoms

Abstract Background: To investigate and contrast the prevalence of dry eye symptoms in construction workers and office workers using the OSDI questionnaire.Methods: A cross-sectional, observational study was conducted using the OSDI questionnaire to evaluate dry eye symptoms and associated risk factors. Sampled size calculation with a power of 80% and a 95% degree of confidence suggested the inclusion of 298 participants. Results: We studied 304 subjects (149 construction workers and 155 office workers). More than half (55%) of the participants presented dry eye symptoms (OSDI > 12). The average OSDI score was 21.30 ± 22.20 points, being lower in the group of construction workers (12.45±17.50) than in-office workers (28.51±22.99) (p <0.001). Considering participants who had moderate and severe symptoms (23 to 100 points in OSDI), office workers presented dry eye symptoms 4.15 times more frequently than construction workers (OR 4.15, 95% CI 2.52, 6.85). Women presented statistical evidence of higher OSDI scores than men (32.47 ± 23.72 vs. 14.87 ± 18.48, respectively). Conclusions: construction workers have four times less risk of presenting dry eye symptoms than people working in the average office space. This highlights the pernicious effects on the ocular surface of the office environment, which poses a significant risk for the development or worsening of dry eye symptoms.

scholarly journals Symptoms of ocular surface disease in construction workers: comparative study with office workers.

2020 ◽  
Author(s):  
Sergio Hernandez-Llamas ◽  
Ana Karen Paz-Ramos ◽  
Patricio Marcos-González ◽  
Francisco Amparo ◽  
Manuel Garza-Leon
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Significant Risk ◽  
Construction Workers ◽  
Office Workers ◽  
Cross Sectional ◽  
Degree Of Confidence ◽  
Eye Symptoms ◽  
Associated Risk Factors ◽  
Dry Eye Symptoms

Abstract Background: To investigate and contrast the prevalence of dry eye symptoms in construction workers and office workers using the OSDI questionnaire.Methods: A cross-sectional, observational study was conducted using the OSDI questionnaire to evaluate dry eye symptoms and associated risk factors. Sampled size calculation with a power of 80% and a 95% degree of confidence suggested the inclusion of 298 participants. Results: We studied 304 subjects (149 construction workers and 155 office workers). More than half (55%) of the participants presented dry eye symptoms (OSDI > 12). The average OSDI score was 21.30 ± 22.20 points, being lower in the group of construction workers (12.45±17.50) than in-office workers (28.51±22.99) (p <0.001). Considering participants who had moderate and severe symptoms (23 to 100 points in OSDI), office workers presented dry eye symptoms 4.15 times more frequently than construction workers (OR 4.15, 95% CI 2.52, 6.85). Women presented statistical evidence of higher OSDI scores than men (32.47 ± 23.72 vs. 14.87 ± 18.48, respectively). Conclusions: construction workers have four times less risk of presenting dry eye symptoms than people working in the average office space. This highlights the pernicious effects on the ocular surface of the office environment, which poses a significant risk for the development or worsening of dry eye symptoms.

scholarly journals Prevalence and Risk Factors of Severe Dry Eye in Bangladesh-Based Factory Garment Workers

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 634 ◽  
Author(s):  
Mamunur AKM Rashid ◽  
Calesta Hui Yi Teo ◽  
Sumaiya Mamun ◽  
Hon Shing Ong ◽  
Louis Tong
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Age Groups ◽  
Meibomian Gland ◽  
Ocular Surface Disease Index ◽  
Cross Sectional ◽  
Garment Workers ◽  
Severity Grading ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

This study sought to evaluate the prevalence of dry eye and meibomian gland dysfunction (MGD) and the associated factors of severe dry eye symptoms (SDES) among garments worker of Gazipur, Bangladesh. We prospectively collected cross-sectional data for 1050 garments workers of a factory (70% response). All participants had an evaluation of the Ocular Surface Disease Index (OSDI), and a detailed ophthalmic examination including tear breakup time (TBUT), ocular surface fluorescein staining, and Schirmer’s I test. MGD grading was based on the viscosity/color and ease of manual expression of meibum. Mean age of participants was 35.5 ± 12.1 years; 53.8% were women. The prevalence of dry eye (OSDI > 12) was 64.2% (95% CI 61.2–67.1%). OSDI was not significantly different between sex or age-groups but associated with increasing MGD grade (p < 0.001), reduced TBUT (<5 s) [p < 0.001], and reduced Schirmer’s test (<5 mm) [p < 0.001]. Thirty-five percent had SDES (OSDI > 32). Using univariate logistic regressions, SDES was associated with older age (Odds Ratio (OR) 1.01, 95% Confidence Interval [1.005–1.03] per year increase) and male sex (OR 1.76, 95% CI: 1.36–2.27). When adjusted for age and sex, SDES were strongly associated with increase in MGD severity grading (OR 188, 95% CI: 91–390). However, in multivariate regression, TBUT, but not MGD severity, became the only significant determinant of SDES (OR 13.0, 95% CI: 6.3–27.0, for every 1 s decrease in TBUT). MGD is common in garments workers, contributing to dry eye symptoms in addition to other tear parameters. Reduced tear stability is associated with SDES.

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