scholarly journals The Effect of Lactobacillus acidophilus YT1 (MENOLACTO) on Improving Menopausal Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

2020 ◽  
Vol 9 (7) ◽  
pp. 2173
Author(s):  
Eun Yeong Lim ◽  
So-Young Lee ◽  
Hee Soon Shin ◽  
Jaekwang Lee ◽  
Young-Do Nam ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Lactobacillus Acidophilus ◽  
Menopausal Symptoms ◽  
Controlled Clinical Trial ◽  
Life Questionnaire ◽  
Sexual Symptoms ◽  
Significant Difference ◽  
Double Blinded

This study evaluated the efficacy of Lactobacillus acidophilus YT1 (MENOLACTO) for alleviating menopausal symptoms. This study was a multi-center, randomized, double-blinded, placebo-controlled clinical trial involving female subjects (ages: 40–60 years) with menopausal symptoms and a Kupperman index (KMI) score ≥ 20. Subjects were administered 1 × 108 CFU/day MENOLACTO or placebo, with the primary endpoint being total KMI score, and the effect of secondary endpoints on alleviating menopausal symptoms according to individual categories of the modified KMI, as well as a quality of life questionnaire (MENQOL questionnaire). After 12 weeks, total KMI scores decreased significantly, demonstrating improved menopausal symptoms relative to placebo along with improved modified KMI scores. Additionally, quality of life, according to the MENQOL questionnaire, significantly improved in all four symptoms—physical, psychosocial, vasomotor, and sexual symptoms. Moreover, we observed no significant difference between the two groups or significant changes in blood follicle-stimulating hormone and estradiol levels or endometrial thickness. These results demonstrated that MENOLACTO alleviated menopausal symptoms without notable side effects and improved quality of life, suggesting its efficacy as an alternative supplement to alleviate menopausal symptoms in women ineligible for hormonal therapy.

Improvement in Migraine-Specific Quality of Life in A Clinical Trial of Rizatriptan

Cephalalgia ◽  
1997 ◽  
Vol 17 (8) ◽  
pp. 867-872 ◽  
Author(s):  
NC Santanello ◽  
AB Polis ◽  
SL Hartmaier ◽  
MS Kramer ◽  
GA Block ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Functional Disability ◽  
Controlled Clinical Trial ◽  
Life Questionnaire ◽  
Test Statistic ◽  
Related Quality ◽  
Health Related ◽  
The Impact

A validated migraine-specific questionnaire (24-h Migraine Quality of Life Questionnaire1: 24-h MQoLQ) was used to assess the impact of migraine and migraine therapy on health related quality of life during an acute migraine attack. Male and female migraineurs aged 18-55 years were randomized to placebo ( n = 41), rizatriptan 2.5 mg ( n = 47), 5 mg ( n = 74), or 10 mg ( n = 85) in a triple-blind, placebo-controlled clinical trial. Rizatriptan 5 mg and 10 mg were significantly more efficacious than placebo on pain relief and functional disability. After accounting, for multiple comparisons to placebo, rizatriptan 10 mg showed significantly better responses compared to placebo on three of five domains of 24-h MQoLQ (social functioning, migraine symptoms, and feelings/concerns). The O'Brien's Rank Sum Test statistic showed a statistically significant overall difference on the 24-h MQoLQ between the 10 mg rizatriptan and placebo groups ( p = 0.005) and for the overall close trend ( p 0.001).

scholarly journals The Effect of Positive Thinking Training on Different Dimensions of Quality of Life of Hemodialysis Patients: A Randomized Controlled Clinical Trial

2020 ◽  
Vol 12 (3) ◽  
Author(s):  
Mahmoudreza Peyravi ◽  
Mehdi Amirkhani ◽  
Faeze Abadi ◽  
Ali Abbasijahromi ◽  
Shima Sheidaie ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Emotional Health ◽  
Intervention Group ◽  
Hemodialysis Patients ◽  
Controlled Clinical Trial ◽  
Life Questionnaire ◽  
Positive Thinking ◽  
Different Dimensions

Background: Nowadays, the quality of life of hemodialysis patients has decreased, which doubled the need for educational interventions. Objectives: The current study investigated the effect of positive thinking training on different dimensions of quality of life of hemodialysis patients. Methods: This is a controlled clinical trial study conducted on 70 hemodialysis patients in Fasa, Fars province, in 2019. The patients were selected using the simple sampling method. Then, they were divided into two groups of intervention (n = 35) and control (n = 35). After obtaining informed consent, the researchers asked the participants to complete the SF-36 Quality of Life Questionnaire. The intervention group was trained positive thinking skills in 8 workshop sessions; each lasted for 90 minutes. Data were analyzed using SPSS version 20. To analyze the data, statistical tests such as chi-square, Kolmogorov-Smirnov, independent, and t-test were used. Results: The mean and standard deviation of the patients’ quality of life in the intervention group increased from 35.95 ± 10.07 to 55.98 ± 11.71 (P < 0.001). The changes in patients’ quality of life before and after the intervention were also assessed in 8 dimensions, which showed that the quality of life of the patients did not change significantly in terms of physical function (P = 0.42) and physical pain (P = 0.62), but for other dimensions, it was significantly increased (P < 0.001). Conclusions: Positive thinking training improved the quality of life of hemodialysis patients, particularly in the dimensions of the emotional role, emotional health, energy and vitality, social performance, and general health is recommended.

The Effectiveness of Combination of Viola odorata L., Rosa damascena Mill. and Coriandrum sativum L. on Quality of Life of Patients with Migraine Headaches: A Randomized, Double Blinded, Placebo - Controlled Clinical Trial

2019 ◽  
Author(s):  
Mohadese Kamali ◽  
Haleh Tajadini ◽  
Rostam Seifadini ◽  
Mitra Mehrabani ◽  
Yunes Jahani ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Coriandrum Sativum ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Rosa Damascena ◽  
Viola Odorata ◽  
Migraine Headaches ◽  
Double Blinded

Headache is one of the most common public health problems in the world, which causes patients to see a doctor. Migraine is the second most common cause of headaches after tension headaches. This study is a randomized, double blinded, placebo - controlled clinical trial, using SF36 questionnaire, to evaluate the effect of combination of Viola odorata L., Rosa damascena Mill. and Coriandrum sativum L. on the quality of life, in patients with migraine after 4 weeks. In all domains of the SF36 questionnaire, the scores after intervention in the drug group were significantly higher than the control group after 4 weeks. This study showed that, combination of V. odorata, R. damascena and C. sativum, improves the quality of life of patients with migraine.

scholarly journals Comparison of the efficacy and tolerability of an oral dosage form made from Fumaria vaillantii versus cetirizinein management of chronic urticaria: A single-blind, randomized, clinical trial

2018 ◽  
Vol 5 (6) ◽  
Author(s):  
Fatemeh Eghbalian ◽  
Nafiseh Esmaili ◽  
Mehrdad Karimi ◽  
Fahimeh Mohajerani ◽  
Roja Rahimi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Adverse Events ◽  
Chronic Urticaria ◽  
Fumaric Acid ◽  
Oral Dosage ◽  
Inflammatory Factor ◽  
Life Questionnaire ◽  
Significant Difference

BACKGROUND: Chronic urticaria (CU) is one of the common allergic diseases whose conventional treatments have failed to desirably manage it. Fumariavaillantii is used in Persian medicine to treat CU. The anti-inflammatory and anti-histaminic effects of chemical components of Fumaria such as fumaric acid and caffeic acid were confirmed. Dimethyl fumarate reduces the pro- inflammatory contribution and monomethyl fumarate can increase IL-4, an antiinflammatory interleukin, or can decrease IFN- , an inflammatory factor. The current study assesses the efficacy and tolerability of Fumaria vaillantii versus cetirizine in the management of CU. METHODS: The formulation and standardization of Fumaria syrup were done in Tehran University of Medical Sciences. Patients were randomized to twice- daily treatment with Fumaria syrup or cetirizine syrup (n=39 in each group) for four weeks. The efficacy assessment included Urticaria Activity Score (UAS) and Chronic Urticaria Quality of Life Questionnaire (CUQ2oL) and the safety evaluations included Common Terminology Criteria for Adverse Events Questionnaire. RESULTS: The fumaric acid content in 5 ml of Fumaria syrup was calculated to be 0.12 mg. The results of clinical trial showed that UAS was significantly higher in the Fumaria group than in the cetirizine group, after the first week of follow-up (p<0.001), but no significant difference was demonstrated between the two groups on week 4 (p=0.57). One month after the research was finished, the UAS score of the cetirizine group was significantly higher than that of the Fumaria group (p<0.001). After finishing the interventions, difference of CU-Q2oL was not significant between the two groups; however, the QOL score was significantly lower in the Fumaria group (p<0.001) at 8th week. About adverse events, the incidence of somnolence in the Fumaria group was significantly lower than in the cetirizine group (p<0.001). CONCLUSIONS: Fumaria vaillantii demonstrated its effects on CU later than cetirizine, but led to more permanent effects, better quality of life, and lower incidence of adverse events as compared to cetirizine. More clinical trials with higher populations are needed to achieve more conclusive results.

scholarly journals Effects of Linear and Non-periodized Combined Training on Health-related Quality of Life of Adults With Obesity: a Randomized Clinical Trial

2021 ◽  
Author(s):  
Willen Remon Tozetto ◽  
Larissa dos Santos Leonel ◽  
Tiago Turnes ◽  
Giovani Firpo Del Duca
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Health Related Quality ◽  
Combined Training ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related

Abstract Background: Health-related quality of life (HRQoL) is impaired by obesity and can be improved by combined training, even the effects of training periodization on HRQoL are not clear. The study aimed to compare combined training with the non-periodized and the linear periodization on HRQoL of obese adults. Methods: This is a blinded, controlled clinical trial involving adults with obesity (BMI ≥ 30 kg/m²), randomized into control (CG), non-periodized (NG) and linear periodization (PG) group. Three times a week for 16 weeks, NG and PG performed combined training for 60 minutes. The NG performed aerobic exercises between 50-59% of the reserve heart rate (HRres) and strength at 10-12 maximum repetitions (MR). The PG started with 40-49% of HRres and 12-14 MRs and progressively increased the intensity (50-59% and 10-12 MRs; 60-69% and 8-10 MRs) with total volume equalized with NG. HRQoL was investigated through the SF-36 questionnaire, according to its components and domains. In statistics, Generalized Estimation Equations and mean differences (∆) were used. Results: Of the 69 participants (23 in each group), 36 completed the intervention (CG=13, NG=9 and PG=14). A significant difference was observed in time of physical function, with superiority in training groups (CG:∆=1.2 vs NG and PG, respectively: ∆=10.0). The mental component and mental health domain showed a significant difference for NG (∆=30.2 and ∆=23.1, respectively). Conclusion: The combined training was able to bring benefits to the physical functioning of adults with obesity and, specifically, the non-periodized training improved mental health indicators effectively.Clinical Trial Registry: RBR-3c7rt3 Date of Registration: 07/02/2018

scholarly journals Osteopathic Manipulative Treatment Effect on Pain Relief and Quality of Life in Oncology Geriatric Patients: A Nonrandomized Controlled Clinical Trial

2018 ◽  
Vol 17 (4) ◽  
pp. 1163-1171 ◽  
Author(s):  
Chiara Arienti ◽  
Teresa Bosisio ◽  
Silvia Ratti ◽  
Rossella Miglioli ◽  
Stefano Negrini
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Pain Relief ◽  
Pain Intensity ◽  
Geriatric Patients ◽  
Controlled Clinical Trial ◽  
Osteopathic Manipulative Treatment ◽  
Oncology Patients ◽  
Significant Difference

Purpose: The aim of present study was to study the effect of osteopathic manipulation on pain relief and quality of life improvement in hospitalized oncology geriatric patients. Methods: A nonrandomized controlled clinical trial was performed in the Oncology Rehabilitation Unit, Milan, Italy, from September 2015 to March 2016. Twenty-three older cancer patients were enrolled and allocated in 2 experimental groups: the study group (OMT group, N = 12) underwent osteopathic manipulative treatment in addition to physiotherapy, and the control group (PT group, N = 12) underwent only physiotherapy. At enrollment (T0), 24 recruited oncology patients completed the sociodemographic forms and were evaluated for pain intensity and quality of life by an external examiner. All patients were revaluated every week (T1, T2, T3, and T4) for pain intensity and at the end of the study treatment (T4) for quality of life. A standard level of significance was set at α < .05. Results: The 2 groups did not significantly differ in age ( P = .682), body mass index ( P = .413), or gender ( P = 1). The osteopathic manipulative treatment added to physiotherapy produced a significant reduction in Numeric Rating Scale (NRS) scores both at T2 ( P = .004) and T4 ( P = .002). The difference in quality of life improvements between T0 and T4 was not statistically significant. NRS improved in the PT group at T4. Between-group analysis of NRS and quality of life with the Mann-Whitney test did not show any significant difference between the 2 treatments. Conclusions: Our study showed a significant improvement in pain relief and a nonsignificant improvement in quality of life in hospitalized geriatric oncology patients during osteopathic manipulative treatment. Trial Registration: Protocol registered on Clinicaltrials.gov (NCT03142386).

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