Epstein-Barr Virus and Human Adenovirus Viremia in Renal Tumors Is Associated with Histological Features of Malignancy

Background: There is growing evidence that viral infections may impact the risk and clinical course of malignancies, including solid tumors. The aim of this study was to assess the possible association of selected chronic/latent viral infections with the clinical course of renal cell carcinoma (RCC). Methods: In this prospective study we enrolled 27 patients undergoing partial or radical nephrectomy due to the histologically confirmed RCC and followed them up for one year post-operation. Isolation of the nucleic acids was performed using the NucleoSpin Tissue Kit (Macherey-Nagel, Düren, Germany) from tumor tissue and using the EZ1 Virus Mini Kit v2.0 from plasma. The number of viral copies of human adenovirus (ADV), herpes simplex virus HSV-1 and HSV-2, Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK virus (BKV) and John Cunningham virus (JCV) in the tissue and plasma was assessed with real-time PCR. Results: Viral infections were diagnosed in ten patients (37.0%), including three ADV cases (11.1%) and eight EBV cases (29.6%). Infected patients tended to be significantly older (71.3 vs. 57.6 years, p < 0.05), more commonly presented with chronic renal disease (OR 2.4, p < 0.05), diabetes (OR 4.2, p < 0.05) and overweight (OR 2.0, p < 0.05). Regarding oncological data, infected patients were found to have a higher rate of high-grade cancers (OR 5.0, p < 0.05) and a higher rate of papillary RCCs (OR 8.3, p < 0.05). Status of viral infections had no influence on the clinical cancer stage, surgical procedure or survival. Conclusions: EBV and ADV infections are common in renal cancer patients and increase the risk of high-grade RCC presence. While there is no significant impact on short term survival, further studies are needed to assess the relevance of these findings in a long run.

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Epstein-Barr virus and human adenovirus viremia in renal tumors is associated with histological features of kidney cancer

10.21203/rs.3.rs-23595/v1 ◽

2020 ◽

Author(s):

Piotr Kryst ◽

Sławomir Poletajew ◽

Aleksandra Wyczałkowska-Tomasik ◽

Stefan Gonczar ◽

Maciej Wysocki ◽

...

Keyword(s):

Epstein Barr Virus ◽

Viral Infections ◽

Clinical Course ◽

Human Adenovirus ◽

Bk Virus ◽

Renal Tumors ◽

High Grade ◽

Term Survival ◽

Barr Virus ◽

Epstein Barr

Abstract Background. There is a growing evidence that viral infections may impact the risk and clinical course of malignancies, including solid tumors. The aim of this study was to assess the possible association of selected chronic / latent viral infections with the clinical course of renal cell carcinoma (RCC).Methods. In this prospective study we enrolled 27 patients undergoing partial or radical nephrectomy due to the histologically confirmed RCC and followed them up for one year post-operation. Isolation of the nucleic acids of human adenovirus (ADV), herpes simplex virus HSV-1 and HSV-2, Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK virus (BKV) and John Cunningham virus (JCV) from tumor tissue was performed using the NucleoSpin Tissue Kit (Macherey-Nagel, Düren, Germany) or EZ1 Virus Mini Kit (Qiagen, Hilden, Germany). The number of viral copies in the tissue was assessed with the real-time PCR.Results. Viral infections were diagnosed in ten patients (37.0%), including three ADV cases (11.1%) and eight EBV cases (29.6%). Infected patients tended to be significantly older (71.3 vs. 57.6 years, p < 0.05), more commonly presented with chronic renal disease (OR 2.4, p < 0.05), diabetes (OR 4.2, p < 0.05) and overweight (OR 2.0, p < 0.05). Regarding oncological data, infected patients were found to have a higher rate of high-grade cancers (OR 5.0, p < 0.05) and a higher rate of papillary RCCs (OR 8.3, p < 0.05). Status of viral infections had no influence on the clinical cancer stage, surgical procedure or survival.Conclusions. EBV and ADV infections are common in renal cancer patients and increase the risk of high-grade RCC presence. While there is no significant impact on short term survival, further studies are needed to assess the relevance of these findings in a long run.Trial registration. Medical University of Warsaw KB/37/2017

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Epstein-Barr virus, human cytomegalovirus, human herpesvirus 6 and 7, human adenovirus, John Cunningham virus, and BK virus are not associated with gliomas in humans

Polish Annals of Medicine ◽

10.29089/2021.21.00202 ◽

2021 ◽

Author(s):

Bożena Czarkowska-Pączek ◽

Rafal Górski ◽

Aleksandra Wyczałkowska-Tomasik ◽

Maciej Bujko ◽

Leszek Pączek

Keyword(s):

Epstein Barr Virus ◽

Human Herpesvirus ◽

Human Adenovirus ◽

Bk Virus ◽

John Cunningham Virus ◽

Barr Virus ◽

Risk Of Death ◽

Course Material ◽

Epstein Barr

Introduction: The literature points to several viruses associated with brain carcinogenesis, including gliomas. Aim: The aim of this study was to assess the presence of several viruses in gliomas and plasma from patients with brain tumor and the possible association of viral positivity with the clinical course. Material and methods: The study group consisted of 37 patients with gliomas who were subjected to surgery. Mean patient age was 54.59 (SD 15.85) years. The presence of viral DNA was assessed using real-time polymerase chain reaction. Results and discussion: We did not confirm any BK virus, John Cunningham virus, or human adenovirus-positive gliomas. The percentage of patients with gliomas positive for Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpesvirus (HHV) 6 and 7 was 18.9%, 8.1%, 2.7%, and 10.8%, respectively. We did not confirm the co-occurrence of glioma and plasma viral positivity. Fisher’s test did not reveal the influence of viral infection on the risk of death. We did not detect any differences regarding sex, WHO classification of gliomas, or the functional impairment evaluated by the Karnofsky scale index at admission to the hospital in the group of patients positive or negative for EBV, CMV, or HHV6. Conclusions: We cannot confirm an association of the investigated viruses with gliomas.

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Epstein-Barr Virus Versus Novel Coronavirus-Induced Hemophagocytic Lymphohistocytosis: The Uncharted Waters

Journal of Investigative Medicine High Impact Case Reports ◽

10.1177/2324709620950107 ◽

2020 ◽

Vol 8 ◽

pp. 232470962095010 ◽

Cited By ~ 1

Author(s):

Rawan Amir ◽

Asim Kichloo ◽

Jagmeet Singh ◽

Ravinder Bhanot ◽

Michael Aljadah ◽

...

Keyword(s):

Bacterial Infections ◽

Epstein Barr Virus ◽

Genetic Mutations ◽

High Grade ◽

The Novel ◽

Barr Virus ◽

First Case ◽

Epstein Barr ◽

Virus Versus ◽

Novel Coronavirus

Hemophagocytic lymphohistocytosis (HLH) is a hyperinflammatory syndrome characterized by fever, hepatosplenomegaly, and pancytopenia. It may be associated with genetic mutations or viral/bacterial infections, most commonly Epstein-Barr virus (EBV) and cytomegalovirus. As for the novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), also known as COVID-19 (coronavirus disease-2019), the cytokine storm it triggers can theoretically lead to syndromes similar to HLH. In this article, we report a case of a 28-year-old female who presented with high-grade fevers, found to have both SARS-CoV-2 and EBV infections, and eventually began to show signs of early HLH. To our knowledge, this is the first case reported in literature that raises the possibility of SARS-CoV-2–related HLH development.

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Cytomegalovirus-Associated Hemophagocytic Syndrome

PEDIATRICS ◽

10.1542/peds.75.2.280 ◽

1985 ◽

Vol 75 (2) ◽

pp. 280-283

Author(s):

ELIZABETH H. DANISH ◽

BEVERLY B. DAHMS ◽

MARY L. KUMAR

Keyword(s):

Viral Infection ◽

Epstein Barr Virus ◽

Hemophagocytic Syndrome ◽

Clinical Course ◽

Underlying Disease ◽

Barr Virus ◽

Pathologic Findings ◽

Immunosuppressed Patients ◽

Epstein Barr ◽

Herpes Group

Virus-associated hemophagocytic syndrome, first described by Risdall and co-workers in 1979,1 is a rare histiocytic proliferative syndrome characterzed by fever, hepatosplenomegaly, pancytopenia, and erythrophagocytosis by histiocytes that appear benign by histologic criteria. The clinical course and pathologic findings may be identical with another histiocytic disorder, familial erythrophagocytic lymphohistiocytosis, which occurs predominantly in infants. Diagnosis of virus-associated hemophagocytic syndrome depends entirely on evidence of concurrent viral infection, usually of the herpes group. Epstein-Barr virus has been associated with this syndrome in the few cases reported in children without underlying disease, whereas cytomegalovirus (CMV) has been implicated in immunosuppressed patients. We report a case of fatal CMV-associated hemophagocytic syndrome which occurred in a previously healthy infant.

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Acute Pharyngitis: Etiology and Diagnosis

PEDIATRICS ◽

10.1542/peds.97.6.949 ◽

1996 ◽

Vol 97 (6) ◽

pp. 949-954

Author(s):

Alan L. Bisno

Keyword(s):

Herpes Simplex ◽

Influenza A ◽

Epstein Barr Virus ◽

Viral Infections ◽

Clinical Manifestations ◽

Acute Pharyngitis ◽

Herpesvirus Type ◽

Barr Virus ◽

Epstein Barr

Acute pharyngitis may be caused by a wide variety of microbial agents (Table 1). The relative importance of each of these agents varies greatly depending on a number of epidemiologic factors, including age of the patient, season of the year, and geographic locale. Viruses Most cases of acute pharyngitis are viral in etiology and involve the pharynx as well as other portions of the respiratory tract as manifestations of the common cold, influenza, or croup. Examples include the rhinoviruses, coronaviruses, influenza A and B, and the parainfluenza viruses. Certain viral infections causing sore throat may exhibit clinical manifestations that are rather distinctive. Examples include enteroviruses (herpangina due to Coxsackie A), Epstein-Barr virus (infectious mononucleosis), cytomegalovirus (cytomegalovirus mononucleosis), adenovirus (pharyngoconjunctival fever, acute respiratory disease of military recruits), and herpes simplex virus (pharyngitis, gingivitis, and stomatitis). In many instances, however, the illnesses caused by these agents may overlap so broadly with that of streptococcal pharyngitis as to be clinically indistinguishable. Thus, Epstein-Barr virus, adenovirus, and herpes virus may all cause fever, exudative pharyngitis, and cervical adenitis. Several studies have documented the role of primary herpesvirus type 1 infection as a cause of acute pharyngitis in college students.1-4 Herpesvirus type 2 can occasionally cause a similar illness as a consequence of oral-genital sexual contact.5 Although herpesvirus infections may involve the anterior oral cavity (vesicular or ulcerative gingivostomatitis) as well as the posterior pharynx, they do not routinely do so. Only about one-fourth of students with culturally and serologically proven primary herpes simplex type 1 pharyngitis studied by Glezen et al,2 for example, had gingivostomatitis.

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Pancytopenia Secondary to SARS-CoV 2 Infection-A Case Reprt

10.21203/rs.3.rs-657352/v1 ◽

2021 ◽

Author(s):

Neeraj Sharma ◽

Rajat Shukla ◽

Rachna Warrier ◽

Kunal Kumar ◽

Nalin Singh ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Blood Cells ◽

Epstein Barr Virus ◽

Viral Infections ◽

Parvovirus B19 ◽

Rare Complication ◽

Elderly Male ◽

Barr Virus ◽

Immunodeficiency Virus ◽

Epstein Barr

Abstract Pancytopenia is a condition when person has low count of all three types of blood cells causing a triage of anemia, leukopenia and thrombocytopenia. It should not be considered as a disease in itself but rather the sign of a disease that needs to be further evaluated. Among the various causes, viral infections like Human Immunodeficiency Virus, Cytomegalovirus, Epstein-Barr virus and Parvovirus B19 have been implicated. Pancytopenia is a rare complication and not commonly seen in patients with COVID 19 disease. Here, we report a case of pancytopenia in previously immunocompetent elderly male patient with SARS-CoV2 infection.

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Profound CD4+ T lymphocytopenia in human immunodeficiency virus negative individuals, improved with anti-human herpes virus treatment

Colombia Medica ◽

10.25100/cm.v43i4.1159 ◽

2012 ◽

pp. 305-311 ◽

Cited By ~ 3

Author(s):

María Lilia Diaz Betancourth ◽

Julio Cesar Klinger ◽

Victoria Eugenia Niño

Keyword(s):

Human Immunodeficiency Virus ◽

Epstein Barr Virus ◽

Herpes Virus ◽

Viral Infections ◽

Human Herpes ◽

Barr Virus ◽

Human Herpes Virus ◽

Immunodeficiency Virus ◽

Epstein Barr ◽

Herpès Virus

Lymphocytopenia and CD4+ T lymphocytopenia can be associated with many bacterial, fungal, parasite and viral infections. They can also be found in autoimmune and neoplastic diseases, common variable immunodeficiency syndrome, physical, psychological and traumatic stress, malnutrition and immunosuppressive therapy. Besides, they can also be brought into relation, without a known cause, with idiopathic CD4+ T lymphocytopenia. Among viral infections, the Retrovirus, specially the human immunodeficiency virus, is the most frequently cause. However, many acute viral infections, including cytomegalovirus and Epstein Barr virus can be associated with transient lymphocytopenia and CD4+ T lymphocytopenia. As is well known, transient lymphocytopenia and CD4+ T lymphocytopenia are temporary and overcome when the disease improves. Nonetheless, severe CD4+ T Lymphocytopenia associated with chronic infections by human herpes virus has not been reported. We describe 6 cases of human immunodeficiency virus negative patients, with chronic cytomegalovirus and Epstein Barr virus infections and profound lymphocytopenia with clinical symptoms of cellular immunodeficiency. These patients improved rapidly with ganciclovir or valganciclovir treatment. We claim here that it is important to consider the chronic human herpes virus infection in the differential diagnosis of profoundly CD4+ T lymphocytopenia etiology, when human immunodeficiency virus is absent, in order to start effective treatment and to determine, in future studies, the impact of chronic human herpes virus infection in human beings’ health.

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