Smoking and Radiolucent Periapical Lesions in Root Filled Teeth: Systematic Review and Meta-Analysis

Aim: This systematic review and meta-analysis aimed to investigate the association between smoking habits and the prevalence of radiolucent periapical lesions (RPLs) in root-filled teeth (RFT). Methods: The Population, Intervention, Comparison, and Outcome (PICO) question was: in adult patients who have RFT, does the absence or presence of a smoking habit affect the prevalence of RPLs associated with RFT? Systematic MEDLINE/PubMed, Wiley Online Database, Web of Science, Scopus, and PRISMA protocol were used to evaluate and present the results. Studies comparing smokers with control non-smoker subjects, including RFT, and providing data on the prevalence of RFT with RPLs, were included. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system was used for certainty in the evidence. The risk of bias was assessed according to Cochrane Collaboration common scheme for bias and ROBINS-I tool. Cumulative meta-analysis was performed with a random effects model. PROSPERO registration code: CRD42020165279. Results: Four studies reported data on inclusion criteria, representing data from 9257 root-filled teeth—4465 from non-smokers and 4792 from smoker patients. The meta-analysis provided an odds ratio indicating a significant association between smoking and higher prevalence of root filled teeth with radiolucent periapical lesions (OR = 1.16; 95% CI = 1.07–1.26; p = 0.0004). The certainty of the literature assessment was moderate per GRADE. The ROBINS-I tool classified three studies as low risk of bias, and the fourth as moderate risk of bias. Conclusions: Moderate, quality scientific evidence indicates a weak but significant relationship between smoking and the prevalence of RPLs in RFT. Smoking can be considered a negative prognostic factor for the outcome of root canal treatment. Endodontic providers should be aware of the relationship between smoking and persistent apical periodontitis, assessed as RPLs, in RFT.

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Cigarette Smoking and Root Filled Teeth Extraction: Systematic Review and Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm9103179 ◽

2020 ◽

Vol 9 (10) ◽

pp. 3179 ◽

Cited By ~ 1

Author(s):

Daniel Cabanillas-Balsera ◽

Juan J. Segura-Egea ◽

María C. Jiménez-Sánchez ◽

Victoria Areal-Quecuty ◽

Benito Sánchez-Domínguez ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Cochrane Collaboration ◽

Risk Of Bias ◽

Smoking Habits ◽

Assessment Development ◽

Negative Prognostic Factor ◽

Reported Data ◽

Teeth Extraction

Aim: The aim of this systematic review and meta-analysis was to investigate the possible association between smoking habits and the occurrence of root-filled teeth (RFT) extraction. Material and Methods: The Population, Intervention, Comparison, and Outcome (PICO) question was in adult patients who had RFT, does the absence or presence of smoking habits affect the prevalence of extracted RFT? Systematic MEDLINE/PubMed, Wiley Online Database, Web of Science, and PRISMA protocol was used to evaluate and present the results. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system was used for certainty in the evidence. The risk of bias was assessed according to Cochrane Collaboration common scheme for bias and ROBINS-I tool. Cumulative meta-analysis was performed with a random effects model. PROSPERO registration code: CRD42020165279. Results: After search strategy, 571 articles were recovered, seven were selected for full-text analysis, and two reported data on inclusion criteria, including 516 RFT, 351 in non-smokers, and 165 in smoker subjects. The meta-analysis provided an odds ratio indicating significant association between smoking and the prevalence of extracted RFT (OR = 3.43, 95% CI = 1.17–10.05, p = 0.02, I² = 64%). The certainty of the literature assessment was low per GRADE. Both studies were considered as moderate risk of bias. Conclusions: Tobacco smoking should be considered a negative prognostic factor for the outcome of root canal treatment, although the quality of the evidence is low. RFT of smoking patients are three times more likely to be extracted. Continuing to smoke after endodontic treatment may increase the risk of treatment failure. However, the overall strength of evidence is low. This must be considered a limitation of the present study and the conclusion should be valued with caution.

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Use of trolamine to prevent and treat acute radiation dermatitis: a systematic review and meta-analysis

Revista Latino-Americana de Enfermagem ◽

10.1590/1518-8345.2035.2929 ◽

2018 ◽

Vol 26 (0) ◽

Cited By ~ 4

Author(s):

Amanda Gomes de Menêses ◽

Paula Elaine Diniz dos Reis ◽

Eliete Neves Silva Guerra ◽

Graziela De Luca Canto ◽

Elaine Barros Ferreira

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Grey Literature ◽

Cochrane Collaboration ◽

Risk Of Bias ◽

Radiation Dermatitis ◽

Cochrane Library ◽

Assessment Development ◽

Manual Search ◽

The Cochrane Collaboration

ABSTRACT Objective: to evaluate the effects of trolamine in the prevention or treatment of radiation dermatitis. Method: systematic review and meta-analysis. Detailed individual search strategies for Cinahl, Cochrane Library Central, LILACS, PubMed, and Web of Science were developed in January 2016. A manual search was also performed to find additional references. A grey literature search was executed by using Google Scholar. Two researchers independently read the titles and abstracts from every cross-reference. The risk of bias of the included studies was analyzed by the Cochrane Collaboration Risk of Bias Tool. The quality of evidence and grading of strength of recommendations was assessed using Grades of Recommendation, Assessment, Development and Evaluation (GRADE). Results: seven controlled clinical trials were identified. The controls used were calendula, placebo, institutional preference / usual care, Aquaphor®, RadiaCare™, and Lipiderm™. The studies were pooled using frequency of events and risk ratio with 95% confidence intervals, in subgroups according to radiation dermatitis graduation. Conclusion: based on the studies included in this review, trolamine cannot be considered as a standardized product to prevent or treat radiation dermatitis in patients with breast and head and neck cancer.

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Association between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0251241 ◽

2021 ◽

Vol 16 (5) ◽

pp. e0251241

Author(s):

Flávia Ramos Kazan Oliveira ◽

Ana Flora Silva e Gustavo ◽

Renan Braga Gonçalves ◽

Fernanda Bolfi ◽

Adriana Lúcia Mendes ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Risk Of Bias ◽

Age At Menarche ◽

Random Effects Model ◽

Voice Change ◽

Assessment Development ◽

Infant Diet ◽

Age Range ◽

Menarche Age

The objective of this systematic review was to evaluate the association between a soy-based infant diet and the onset of puberty. We included studies in which children were fed a soy-based diet, and we compared them with those who were not. The primary outcomes were the onset of puberty in girls (thelarche, pubarche, and menarche age), boys (pubarche, voice change, testicular and penis enlargement age), and both (risk of delayed and precocious puberty [PP]). Search strategies were performed in PubMed, Embase, LILACS, and CENTRAL databases. Two reviewers selected eligible studies, assessed the risk of bias, and extracted data from the included studies. The odds ratio (OR) and mean difference (MD) were calculated with a 95% confidence interval (CI) as a measure of the association between soy consumption and outcomes. We used a random-effects model to pool results across studies and the Grading of Recommendations Assessment, Development, and Evaluation to evaluate the certainty of evidence. We included eight studies in which 598 children consumed a soy-based diet but 2957 did not. The primary outcomes that could be plotted in the meta-analysis were the risk of PP and age at menarche. There was no statistical difference between groups for PP (OR: 0.51, 95% CI: 0.09 to 2.94, 3 studies, 206 participants, low certainty of evidence). No between-group difference was observed in menarche age (MD 0.14 years, 95% CI -0.16 to 0.45, 3 studies, 605 children, low certainty of evidence). One study presented this outcome in terms of median and interquartile range, and although the onset of menarche was marginally increased in girls who received a soy-based diet, the reported age was within the normal age range for menarche. We did not find any association between a soy-based infant diet and the onset of puberty in boys or girls. Trial Registration: PROSPERO registration: CRD42018088902.

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Use of convalescent plasma in patients with coronavirus disease (Covid-19): Systematic review and meta-analysis

10.1101/2021.02.14.20246454 ◽

2021 ◽

Author(s):

Fernando Tortosa ◽

Gabriela Carrasco ◽

Martin Ragusa ◽

Pedro Haluska ◽

Ariel Izcovich

Keyword(s):

Systematic Review ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Invasive Mechanical Ventilation ◽

Standard Of Care ◽

Risk Of Bias ◽

Current Evidence ◽

Assessment Development ◽

Treatment Standard ◽

Study Selection

AbstractObjetivesTo assess the effects of convalescent plasma treatment in patients with coronavirus disease (COVID-19).Study designSystematic review and Meta-analysisData sourcesA systematic search was carried out on the L · OVE (Living OVerview of Evidence) platform for COVID-19 until October 31, 2020Study selectionRandomized clinical trials in which people with probable or confirmed COVID-19 were randomized to drug treatment, standard care, or placebo. Pairs of reviewers independently screened potentially eligible articles.MethodsThe PRISMA guidelines were followed for conducting a systematic review and meta-analysis. The risk of bias of the included studies was assessed using the Cochrane risk of bias tool 2.0, and the certainty of the evidence using the recommendation assessment, development and evaluation (GRADE) approach. For each outcome, the interventions were classified into groups, from most to least beneficial or harmful.ResultsWe identified 10 RCTs (randomized controlled trials) involving 11854 patients in which convalescent plasma was compared with standard of care or other treatments. The results of five RCTs that evaluated the use of convalescent plasma in patients with COVID-19 did not show significant differences in the effect on mortality and the need for invasive mechanical ventilation.ConclusionsCurrent evidence is insufficient to recommend the use of convalescent plasma in the treatment of moderate or severe COVID-19.Contribution of the authors

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Effectiveness of multicomponent treatment in patients with fibromyalgia: Protocol for a systematic review and meta-analysis

10.21203/rs.3.rs-127742/v1 ◽

2020 ◽

Author(s):

Felipe Araya-Quintanilla ◽

Hector Gutierrez-Espinoza ◽

Jorge Fuentes ◽

Fernanda Prieto-Lafrentz ◽

Leonardo Pavez ◽

...

Keyword(s):

Systematic Review ◽

Fixed Effects ◽

Pain Catastrophizing ◽

Meta Analysis ◽

Cochrane Collaboration ◽

Mean Difference ◽

Assessment Development ◽

Grade Scale ◽

Registration Number ◽

The Cochrane Collaboration

Abstract Background The purpose of this protocol is to provide new and clear data on the systematic review with meta-analysis with the current Cochrane methodology to compare the effectiveness of multicomponent treatment versus other interventions for patients with fibromyalgia. Methods This protocol conforms to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) and the recommendations of the Cochrane Collaboration Handbook. An electronic search will be conducted in MEDLINE, EMBASE, Web of Science, Cochrane CENTRAL, LILACS, CINAHL, and PEDro, from the inception until January 2021. There will be no language restrictions. The Cochrane Collaboration tool for assessing the risk of bias (RoB2) will be used. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) scale will be used to evaluate the strength of the evidence. The DerSimonian and Laird random effects of Mantel-Haenszel fixed effects methods will be used, depending on the heterogeneity. To compute a pooled estimate of mean difference (MD) or standardized mean difference (SMD), and respective 95% confidence intervals (CI) for pain intensity, physical function, pain catastrophizing, kinesiophobia, quality of life, sleep quality, and level of depression. Discussion This systematic review will synthesize evidence on the effectiveness of multicomponent treatment in patients with fibromyalgia. This systematic review could add important evidence in the treatment of FM that could improve the clinical practice and the making of decisions and actions in this field. The novel statistical analysis will try to show the effects of multicomponent treatment by type and dose of exercise in patients with FM. The results will be disseminated by publication in a peer-reviewed journal. Ethics approval will not be needed because the data used for this systematic review will be obtained from individual trials and there will be no concerns about privacy. PROSPERO systematic review registration number: CRD42020142082

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Safety and Efficacy of Pilocarpine, Cevimeline and Diquafosol Compared to Artificial Tears for the Treatment of Dry Eye: Protocol for a Systematic Review.

10.21203/rs.3.rs-133476/v1 ◽

2020 ◽

Author(s):

José Gerardo Serrano-Robles ◽

Ana Karen Pérez-Vázquez ◽

Alejandro Navas-Pérez ◽

Enrique O Graue-Hernandez ◽

Arturo Ramirez-Miranda ◽

...

Keyword(s):

Systematic Review ◽

Dry Eye ◽

Ocular Surface ◽

Data Extraction ◽

Meta Analysis ◽

Cochrane Collaboration ◽

Risk Of Bias ◽

Review Author ◽

Artificial Tears ◽

Ocular Surface Disease Index

Abstract Background: Dry eye disease (DED) is a condition that affects the ocular surface and affects millions of people around the world. In recent years a stepped scheme has been proposed for the treatment of DED, with the use of an artificial tear being the mainstay of treatment. In this scheme, the use of secretagogues is suggested as part of the treatment for patients with moderate to severe affectation. With this systematic review we aim to evaluate the effectiveness and safety of secretagogues for DED.Methods: Electronic databases will be searched; we will include randomized controlled trials that compare secretagogues and artificial tears. Study inclusion will not be restricted on the basis of language or publication status. We will use Google Translate to assess studies written in languages other than English and Spanish. Identification, evaluation, data extraction and assessment of risk of bias will be conducted by two authors of the review, a third review author will resolve any disagreement. The outcomes will be the ocular surface disease index score, osmolarity and tear film break-up time. We will use the Cochrane Collaboration Risk of Bias (RoB) tool for assessing the risk of bias of the included studies. Based on the heterogeneity of the included studies, we will combine the findings in a meta-analysis using a random versus a fixed effect model. If we deem meta-analysis as inappropriate, we will document the reasons and report findings from the individual studies narratively.Discussion: Based on the evidence obtained we will evaluate the effect of Pilocarpine, Cevimeline and Diquafosol and compare it to artificial tears on multiple outcome measures.This systematic review aims to determine the efficacy and safety of the secretagogues pilocarpine, cevimeline and diquafosol to help clinicians in the decision-making process.Registration: PROSPERO CRD42020218407

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Parent–Infant Interventions to Promote Parental Sensitivity During NICU Hospitalization: Systematic Review and Meta-Analysis

Journal of Early Intervention ◽

10.1177/1053815121991928 ◽

2021 ◽

pp. 105381512199192

Author(s):

Andréane Lavallée ◽

Gwenaëlle De Clifford-Faugère ◽

Ariane Ballard ◽

Marilyn Aita

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Standard Care ◽

Assessment Tool ◽

Meta Analysis ◽

Risk Of Bias ◽

Parental Sensitivity ◽

Assessment Development ◽

Implementation Failure ◽

Meta Analyses

This systematic review and meta-analysis examined the effectiveness of parent–infant interventions for parents of preterm infants on parental sensitivity compared to standard care or active comparators. This review follows the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and was prospectively registered in the International Prospective Register of Systematic Reviews (PROSPERO; registration ID: CRD42016047083). Database searches were performed from inception to 2020 to identify eligible randomized controlled trials. Two review authors independently selected studies, extracted data, and assessed the risk of bias using the Cochrane risk of bias assessment tool and quality of evidence using the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) guidelines. A total of 19 studies ( n = 2,111 participants) were included and 14 were suitable to be pooled in our primary outcome meta-analysis. Results show no significant effect of parent–infant interventions over standard care or basic educational programs, on parental sensitivity. Results may not necessarily be due to the ineffectiveness of the interventions but rather due to implementation failure or high risk of bias of included studies.

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Effectiveness of pharmacological treatments in Duchenne muscular dystrophy: a protocol for a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2019-029341 ◽

2019 ◽

Vol 9 (9) ◽

pp. e029341 ◽

Cited By ~ 4

Author(s):

Carlos Pascual Morena ◽

Vicente Martinez-Vizcaino ◽

Celia Álvarez-Bueno ◽

Ruben Fernández Rodríguez ◽

Estela Jiménez López ◽

...

Keyword(s):

Systematic Review ◽

Duchenne Muscular Dystrophy ◽

Muscular Dystrophy ◽

Meta Analysis ◽

Cochrane Collaboration ◽

Risk Of Bias ◽

Walking Distance ◽

Pharmacological Treatments ◽

Registration Number ◽

The Cochrane Collaboration

IntroductionIn recent years, important advances have been made in the treatment of Duchenne muscular dystrophy (DMD). This protocol proposes a methodology for carrying out a systematic review and meta-analysis that aims to: (1) improve the evidence of the benefits of different pharmacological treatments in boys with DMD, and (2) compare the benefit of treatments specifically aimed at delaying the progression of disease in the functional outcomes.Methods and analysisThis protocol is guided by the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) and by the Cochrane Collaboration Handbook. A thorough selection of the literature will be done through the MEDLINE, EMBASE and Web of Science databases. The search will be conducted in English and Spanish. The Risk of Bias 2.0 tool from the Cochrane Collaboration will be used to assess the risk of bias. A narrative synthesis of the data will be performed. Meta-analysis will be conducted for effect of treatment on the 6 min walking distance (6MWD), North Star Ambulatory Assessment and Timed Functional Tests. Subgroup analyses will be performed by age or baseline values of the 6MWD, and overall bias.Ethics and disseminationThe approval of an ethical committee is not required. All the included trials will comply with the current ethical standards and the Declaration of Helsinki. The results of this proposed systematic review and meta-analysis will provide a general overview and evidence concerning the effectiveness of pharmacological treatments in Duchenne muscular dystrophy. Findings will be disseminated to academic audiences through peer-reviewed publications, as well as to clinical audiences, patients’ associations and policy makers, and may influence guideline developers in order to improve outcomes for these patients.PROSPERO registration numberCRD42018102207

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Insomnia Interventions in the Workplace: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17176401 ◽

2020 ◽

Vol 17 (17) ◽

pp. 6401

Author(s):

Juan Vega-Escaño ◽

Ana María Porcel-Gálvez ◽

Rocío de Diego-Cordero ◽

José Manuel Romero-Sánchez ◽

Manuel Romero-Saldaña ◽

...

Keyword(s):

Systematic Review ◽

Randomized Clinical Trials ◽

Behavioral Therapy ◽

Meta Analysis ◽

Sleep Onset ◽

Cochrane Collaboration ◽

Risk Of Bias ◽

Publication Date ◽

The Impact

The aim of this systematic review and meta-analysis was to identify and evaluate the impact of interventions to improve or reduce insomnia in the workforce through randomized clinical trials. Following the recommendations of the PRISMA and MARS statement, a systematic literature search was carried out on the PubMed, Web of Science, CINHAL, and PsycINFO databases, with no restrictions on the language or publication date. For the meta-analysis, a random-effects model and the Insomnia Severity Index were used as outcome measures. To assess the risk of bias and the quality of evidence, the Cochrane Collaboration tool and the GRADE method were used, respectively. Twenty-two studies were included in the systematic review and 12 studies in the meta-analysis, making a total of 14 intervention groups with a sample of 827 workers. Cognitive behavioral therapy was the most widely used intervention. According to the estimated difference between the means, a moderate effect for the reduction of insomnia symptoms after the intervention (MD −2.08, CI 95%: [−2.68, −1.47]) and a non-significant degree of heterogeneity were obtained (p = 0.64; I2 = 0%). The quality of the evidence and the risk of bias were moderate. The results suggest that interventions on insomnia in the workplace are effective for improving workers’ health, and that improvements in the quality of sleep and a decrease in the symptoms of insomnia are produced, thanks to an increase in weekly sleeping hours and a reduction in latency at sleep onset. As regards work, they also led to improvements in productivity, presenteeism, and job burnout.

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Association between vision impairment and mortality: protocol for a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2020-037556 ◽

2020 ◽

Vol 10 (6) ◽

pp. e037556

Author(s):

Joshua R Ehrlich ◽

Jacqueline Ramke ◽

David Macleod ◽

Bonnielin K Swenor ◽

Helen Burn ◽

...

Keyword(s):

Systematic Review ◽

Global Health ◽

Data Extraction ◽

Meta Analysis ◽

Risk Of Bias ◽

Vision Impairment ◽

Published Data ◽

Assessment Development ◽

Evaluation Approach ◽

Meta Analyses

IntroductionDue to growth and ageing of the world’s population, the number of individuals worldwide with vision impairment (VI) and blindness is projected to increase rapidly over the coming decades. VI and blindness are an important cause of years lived with disability. However, the association of VI and blindness with mortality, including the risk of bias in published studies and certainty of the evidence, has not been adequately studied in an up-to-date systematic review and meta-analysis.Methods and analysisThe planned systematic review and meta-analysis will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Databases, including MEDLINE Ovid, Embase Ovid and Global Health, will be searched for relevant studies. Two reviewers will then screen studies and review full texts to identify studies for inclusion. Data extraction will be performed, and for included studies, the risk of bias and certainty of the evidence will be assessed using the Grades of Recommendation, Assessment, Development and Evaluation approach. The prognostic factor in this study is visual function, which must have been measured using a standard objective ophthalmic clinical or research instrument. We will use standard criteria from WHO to categorise VI and blindness. All-cause mortality may be assessed by any method one or more years after baseline assessment of vision. Results from included studies will be meta-analysed according to relevant sections of the Meta-analysis Of Observational Studies in Epidemiology checklist.Ethics and disseminationThis review will only include published data; therefore, ethics approval will not be sought. The findings of this review and meta-analysis will be published in an open-access, peer-reviewed journal and will be included in the ongoing Lancet Global Health Commission on Global Eye Health.

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