scholarly journals Influence of Polymorphism on the NFkB1 Gene (rs28362491) on the Susceptibility to Sarcopenia in the Elderly of the Brazilian Amazon

2021 ◽  
Vol 11 (10) ◽  
pp. 1045
Author(s):  
Esdras E. B. Pereira ◽  
Darlen C. de Carvalho ◽  
Luciana P. C. Leitão ◽  
Juliana C. G. Rodrigues ◽  
Antônio A. C. Modesto ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Elderly People ◽  
Case Control Study ◽  
The Elderly ◽  
Population Substructure ◽  
Indel Polymorphism ◽  
Progressive Reduction ◽  
Fragment Analysis ◽  
Elderly Individuals ◽  
Control Study

Background: Sarcopenia is a disease characterized by progressive reduction in muscle mass and strength or function. Although it is known that sarcopenia may be associated with environmental factors, studies suggest the identification of genes related to skeletal muscle maintenance that explain the susceptibility to the disease. Objective: To analyze the influence of NFkB1 gene polymorphism on susceptibility to sarcopenia in the elderly. Methods: This is a case-control study, which included 219 elderly people, 74 elderly people with sarcopenia, and 145 without sarcopenia. Samples were analyzed for NFkB1 gene polymorphism (rs28362491), genotyped in PCR, and followed by fragment analysis. To avoid misinterpretation due to population substructure, we applied a previously developed set of 61 informative ancestral markers that were genotyped by multiplex PCR. We used logistic regression to identify differences in genotypic frequencies between elderly people with and without sarcopenia. Results: It was observed that the NFkB1 gene polymorphism presented frequencies of 24%, 50%, and 26% for the genotype DEL/DEL, DEL/INS, and INS/INS, respectively. Furthermore, elderly individuals with the INS/INS genotype had increased chances (p = 0.010; OR:2.943; 95%CI:1.301–6.654) for the development of sarcopenia. Conclusion: The INDEL polymorphism of the NFkB1 gene (rs28362491) may influence the susceptibility to sarcopenia in the elderly in elderly people in the Amazon.

Malnutrition Concerning Geriatric Depression and Associated Risk Factors: A Community-based Case-control Study in Rural Elderly of Bangladesh

2020 ◽  
Author(s):  
Md Ziaul Islam ◽  
Tasnim Disu ◽  
Shatmin Farjana ◽  
Mohammad Rahman
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
The Elderly ◽  
Case Control ◽  
Rural Elderly ◽  
Geriatric Depression ◽  
Elderly Individuals ◽  
Significant Difference ◽  
Associated Risk Factors ◽  
Control Study

Abstract Background: Malnutrition and depression are highly prevalent in the elderly and can lead to disparaging outcomes. Analytical studies on malnutrition concerning geriatric depression (GD) are very scarce in Bangladesh, although the size of the elderly population is increasing fast in the country. The current study aimed to assess the association between malnutrition and depression and associated risk factors in the rural elderly.Methods: A case-control study was conducted in 600 elderly residents (aged ≥60 years) of three rural communities of Bangladesh from January to October 2019. Three hundred depressed elderly people were enrolled as cases and 300 non-depressed elderly individuals were included as community controls by matching the age and living area of the cases. We used a semi-structured questionnaire based on the Geriatric Depression Scale-15 and the Bangla version of Mini-Nutritional Assessment-Short Form to collect data through face-to-face interviews. Measures included baseline and personal characteristics, malnutrition, GD, and associated risk factors. A binary logistic regression model was fitted to identify variables associated with the risk of GD.Results: The study found no significant difference in gender (male Vs. female) between cases (44.0% Vs. 56.0%) and controls (46.0% Vs. 54.0%). The study revealed that malnutrition was significantly (p<0.01) higher in cases (56.0%) than in controls (18.0%). The malnourished elderly had around three times AOR=3.155; 95% CI: 1.53-6.49, p=0.002) more (risk of having depression than the controls. The unemployed elderly (AOR=4.964; 95% CI: 2.361-10.440; p=0.0001) and the elderly of the lower and middle class (AOR=3.654; 95% CI: 2.266-7.767; p=0.001) were more likely to experience depression. The elderly having a poor diet were more likely to experience depression (AOR=3.384; 95% CI: 1.764-6.703; p=0.0001). The single elderly (AOR=2.368; 95% CI: 1.762-6.524; p=0.001) and the elderly tobacco users (AOR=2.332; 95% CI: 1.663-5.623; p=0.003) were more likely to experience depression.Conclusions: A significant association between malnutrition and depression is evident in the rural elderly individuals of Bangladesh. It will be a prolific initiative if policymakers merge malnutrition and the risk factors associated with geriatric depression in the provision of universal health care for better health and well-being of the rural elderly populations.

A Case Control Study of the Risks for Institutionalization of Elderly People in Nova Scotia

1994 ◽  
Vol 13 (1) ◽  
pp. 104-117 ◽  
Author(s):  
Katherine Glazebrook ◽  
Kenneth Rockwood ◽  
Paul Stolee ◽  
John Fisk ◽  
J. M. Gray
Keyword(s):  
Nova Scotia ◽  
Elderly People ◽  
Functional Impairment ◽  
Long Term Care ◽  
Case Control Study ◽  
The Elderly ◽  
Case Control ◽  
Term Care ◽  
Control Study

ABSTRACTFew studies of the risks of institutionalization of the elderly have had fully specified models using multivariate analysis, and several studies have examined highly selected populations, making their generalizability uncertain. We set out to examine the risks of institutionalization in elderly people in Nova Scotia. A case-control study, executed as part of the Canadian Study of Health and Aging examined 108 incident institutional cases and 533 community-dwelling elderly controls, using a standardized assessment interview conducted by trained interviewers. Multiple logistic regression analysis showed that advancing age, presence of dementia, functional impairment, poor self-rated health, recent hospital admission, and absence of a caregiver were important risks for entry into long term care. Institutions providing long-term care for the elderly need to be able to look after populations with a high prevalence of dementia and functional impairment.

scholarly journals Risk Factors for Falls among Elderly People: a Population-based Case-Control Study

2019 ◽  
Author(s):  
Vida Vakili ◽  
Ali Taghipour ◽  
Ehsan Mosa Farkhani ◽  
Hamid Reza Bahrami ◽  
Behnaz Beygi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Elderly People ◽  
Case Control Study ◽  
The Elderly ◽  
Case Control ◽  
Elderly Subjects ◽  
Old People ◽  
Gastrointestinal Problems ◽  
Risk Factors For Falls ◽  
Control Study

Introduction: Falling is one of the most common problems of the elderly people with a multi factorial nature and frequent cases. This study aimed to determine the risk factors of falls in old people covered by Mashhad University of Medical Sciences. Methods: This retrospective case-control study was conducted on 15,600 elderly participants. Data were extracted from Sina Electronic Health Record System (SinaEHR®, Iran). The obtained data were analyzed using STATA through odds ratio formula. Results: Risk factors of falls in the elderly subjects included age, fear of falling, higher body mass index, diabetes, anemia, gastrointestinal problems, hypothyroidism, use of sedatives, and smoking, after adjusting the potentially confounding effects of other variables. Conclusion: The current study provides evidence that patient-related factor such as diabetes, anemia, hypothyroidism and smoking are associated with falls in the elderly. The results of the present research can be used by health policy-makers to reduce fall-related costs of the old people by focusing on care services and high-risk individuals.

Methylenetetrahydrofolate Reductase (MTHFЮ Gene Polymorphism (677CT) and Increased Susceptibility to Migraine in Egyptian Population: A Case-Control Study

2019 ◽  
Vol 87 (12) ◽  
pp. 4165-4173
Author(s):  
DOAA M.A. ELZOGHBY, M.D.; MONA M. OSMAN, M.D. ◽  
RANDA M. AMIN, M.D.; HEBA H. ALY, M.D. ◽  
NEHAL E. MAHMOUD, M.D.; DALIA M. ELFAWY, M.D. ◽  
SOMIA ABDELHAMID BAWADY, M.Sc.
Keyword(s):  
Gene Polymorphism ◽  
Methylenetetrahydrofolate Reductase ◽  
Case Control Study ◽  
Case Control ◽  
Egyptian Population ◽  
Control Study ◽  
Increased Susceptibility

scholarly journals 744. Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine and Influenza Vaccine Against Pneumococcal Pneumonia Among Elderly Patients Aged 65 Years and Older in the Republic of Korea: A Case–Control Study

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S267-S267
Author(s):  
Jong Hun Kim ◽  
Byung Chul Chun ◽  
Joon Young Song ◽  
Hyo Youl Kim ◽  
In-Gyu Bae ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Elderly Population ◽  
Case Control Study ◽  
The Elderly ◽  
Case Control ◽  
Polysaccharide Vaccine ◽  
Vaccine Effectiveness ◽  
Pneumococcal Polysaccharide Vaccine ◽  
The Republic ◽  
Control Study

Abstract Background The national immunization program (NIP) of annual influenza vaccination to the elderly population (≥65 years of age) in the Republic of Korea (ROK) has been implemented since 1987. Recently, the 23-valent pneumococcal polysaccharide vaccine (PPV23) through the NIP has been provided to the elderly population in the ROK since May 2013. The aim of this study was to assess PPV23 and influenza vaccine (IV) effectiveness in preventing pneumococcal pneumonia (PP) among elderly patients ≥65 years of age. Methods A case–control study using a hospital-based cohort was conducted. Cases of PP including bacteremic PP and nonbacteremic PP were collected from 14 hospitals in the pneumococcal diseases surveillance program from March 2013 to October 2015. Controls matched by age and sex in the same hospital were selected. Demographic, clinical information, and vaccination histories were collected. Previous immunization was categorized into “vaccinated” if a patient had received vaccines as follows: PPV23 (4 weeks to 5 years) and IV (2 weeks to 6 months) prior to the diagnosis of PP for case patients and prior to the hospital admission for control patients. Adjusted odds ratio (OR) was calculated, controlling for underlying medical conditions. Vaccine effectiveness was defined as (1 – OR) × 100. Results During the study period, a total of 661 cases (104 bacteremic PP cases and 557 nonbacteremic PP cases) and 661 controls were enrolled for analyses. For overall patients ≥65 years of age, there was no significant vaccine effectiveness against PP. For young elderly patients with 65–74 years, IV alone (1.2%, [95% confidence interval (CI) −95.3% to 50.0%]) and PPV23 alone (21.9%, [95% CI −39.0% to 56.1%]) were not effective. However, significant vaccine effectiveness of PPV23 plus IV against PP was noted (54.4%, [95% CI 6.9–77.7%], P = 0.031). For older elderly patients ≥75 years of age, no significant vaccine effectiveness was observed. Conclusion Our study indicates that PPV23 plus IV may be effective in preventing PP among young elderly patients with 65–74 years, suggesting additive benefits of influenza plus PPV23 vaccination. Further studies are required to confirm the persistent additive protective effectiveness. Disclosures All authors: No reported disclosures.

Neuroleptic drug exposure and treatment of parkinsonism in the elderly: A case-control study

1995 ◽  
Vol 99 (1) ◽  
pp. 48-54 ◽  
Author(s):  
Jerry Avorn ◽  
Rhonda L. Bohn ◽  
Helen Mogun ◽  
Jerry H. Gurwitz ◽  
Mark Monane ◽  
...  
Keyword(s):  
Drug Exposure ◽  
Case Control Study ◽  
The Elderly ◽  
Case Control ◽  
Neuroleptic Drug ◽  
Control Study

scholarly journals Influence of Gender on Cardiac and Encephalic Inflammation in the Elderly with Cysticercosis: A Case Control Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Camila Lourencini Cavellani ◽  
Rosana Rosa Miranda Corrêa ◽  
Mara Lúcia Fonseca Ferraz ◽  
Laura Penna Rocha ◽  
Ana Carolina Guimarães Faleiros ◽  
...  
Keyword(s):  
Inflammatory Infiltrate ◽  
Case Control Study ◽  
The Elderly ◽  
Brain Parenchyma ◽  
Elderly Group ◽  
University Hospital ◽  
Evolutionary Stage ◽  
Age And Gender ◽  
And Gender ◽  
Control Study

Background. The present study explores the influence of the host’s age and gender upon the inflammatory infiltrate. We aimed to quantify the inflammatory infiltrate caused by cysticercosis, which is related to aging, in the heart and in the encephalon.Methods. 75 autopsy protocols with cysticercosis diagnosis from department of pathology at a university hospital from 1970 to 2008 were reviewed. Two groups were formed: elderly with cysticercosis and nonelderly with cysticercosis. We used KS-300 (Kontron-Zeiss) software for morphometric analysis of the inflammation.Results.The elderly had an average of3.1±2.5cysticerci, whereas the non-elderly had2.7±3.8parasites. The non-elderly group with cysticercosis had significantly more inflammation, both cardiac and encephalic, than the elderly group. The elderly females with cysticercosis had more cardiac and encephalic inflammation.Conclusions. In this study, we showed that the non-elderly had significantly more cardiac and encephalic inflammation than the elderly, and that such inflammatory infiltrate decreases with age and depends upon the evolutionary stage of the cysticercus. Furthermore, there are differences concerning gender in the intensity of the inflammatory response due to cysticerci in the heart and brain parenchyma during senescence. Even during this period, women continue to have a more intense response to the parasitosis.

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