scholarly journals 3-Hydroxy-8,14-secogammacera-7,14-dien-21-one: A New Onoceranoid Triterpenes from Lansium domesticum Corr. cv kokossan

Molbank ◽  
10.3390/m1157 ◽  
2020 ◽  
Vol 2020 (4) ◽  
pp. M1157
Author(s):  
Zulfikar ◽  
Nurul Putri ◽  
Sofa Fajriah ◽  
Muhammad Yusuf ◽  
Rani Maharani ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
2D Nmr ◽  
Breast Cancer Cell Lines ◽  
Spectroscopy Analysis ◽  
Weak Activity ◽  
Lansium Domesticum ◽  
High Resolution Mass Spectroscopy ◽  
Mass Spectroscopy Analysis ◽  
Resolution Mass ◽  
Mcf 7

A new onoceranoid triterpenes, namely 3-hydroxy-8,14-secogammacera-7,14-dien-21-one (1), has been isolated from the fruit peels of Lansium domesticum Corr. cv kokossan. The structure of 1 was determined on the basis of spectroscopic data including infrared, 1D and 2D-NMR, as well as high resolution mass spectroscopy analysis. Compound 1 showed a weak activity against MCF-7 breast cancer cell lines.

scholarly journals (22E,24S)-24-Propylcholest-5en-3α-acetate: A New Steroid from the Stembark Aglaia angustifolia (Miq.) (Meliaceae)

Molbank ◽  
10.3390/m1112 ◽  
2020 ◽  
Vol 2020 (1) ◽  
pp. M1112
Author(s):  
Ricson P. Hutagaol ◽  
Desi Harneti ◽  
Ace T. Hidayat ◽  
Nurlelasari Nurlelasari ◽  
Rani Maharani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Spectroscopic Data ◽  
Cancer Cell Line ◽  
2D Nmr ◽  
Spectroscopy Analysis ◽  
Weak Activity ◽  
High Resolution Mass Spectroscopy ◽  
Mass Spectroscopy Analysis ◽  
Resolution Mass ◽  
Mcf 7

A new propylcholesterol-type steroid, namely (22E,24S)-24-propylcholest-5en-3α-acetate (1), has been isolated from the stembark of Aglaia angustifolia (Miq.). The structure of 1 was determined on the basis of spectroscopic data including 1D- and 2D-NMR as well as high resolution mass spectroscopy analysis. Compound 1 showed weak activity against the MCF-7 breast cancer cell line.

scholarly journals Kokosanolide D: A New Tetranortriterpenoid from Fruit Peels of Lansium domesticum Corr. cv Kokossan

Molbank ◽  
10.3390/m1232 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1232
Author(s):  
Fawwaz M. Fauzi ◽  
Sylvia R. Meilanie ◽  
Zulfikar ◽  
Kindi Farabi ◽  
Tati Herlina ◽  
...  
Keyword(s):  
High Resolution ◽  
Mass Spectroscopy ◽  
Spectroscopic Data ◽  
2D Nmr ◽  
Spectroscopy Analysis ◽  
Related Compounds ◽  
Lansium Domesticum ◽  
High Resolution Mass Spectroscopy ◽  
Mass Spectroscopy Analysis ◽  
Resolution Mass

A novel tetranortriterpenoid named kokosanolide D has been isolated from fruit peels of Lansium domesticum. The structure of kokosanolide D was elucidated primarily on the basis of spectroscopic data including infrared, 1D and 2D-NMR, as well as high resolution mass spectroscopy analysis and comparison with related compounds previously reported.

scholarly journals 5,5′-Oxybis(1,3,7-trihydroxy-9H-xanthen-9-one): A New Xanthone from the Stem Bark of Garcinia porrecta (Clusiaceae)

Molbank ◽  
10.3390/m1153 ◽  
2020 ◽  
Vol 2020 (3) ◽  
pp. M1153
Author(s):  
Ayu N. Safitri ◽  
Nurlelasari ◽  
Tri Mayanti ◽  
Darwati ◽  
Unang Supratman
Keyword(s):  
High Resolution ◽  
Mass Spectroscopy ◽  
Spectroscopic Data ◽  
2D Nmr ◽  
Stem Bark ◽  
Spectroscopy Analysis ◽  
High Resolution Mass ◽  
High Resolution Mass Spectroscopy ◽  
Mass Spectroscopy Analysis ◽  
Resolution Mass

A new polyoxygenated dimer-type xanthone, namely 5,5′-oxybis(1,3,7-trihydroxy-9H-xanthen-9-one (1), has been isolated from the stem bark of Garcinia porrecta. The structure of 1 was determined based on spectroscopic data, including 1D and 2D-NMR as well as high resolution mass spectroscopy analysis.

scholarly journals Cytotoxic Sesquiterpenoids from the Stem Bark of Aglaia harmsiana (Meliaceae)

2020 ◽  
Vol 20 (6) ◽  
pp. 1448
Author(s):  
Hersa Milawati ◽  
Winda Sukmawati ◽  
Desi Harneti ◽  
Rani Maharani ◽  
Nurlelasari Nurlelasari ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Stem Bark ◽  
Hydroxyl Group ◽  
Breast Cancer Cell Lines ◽  
Spectroscopy Analysis ◽  
Chemical Structures ◽  
Ic50 Value ◽  
First Time ◽  
Mass Spectroscopy Analysis ◽  
Mcf 7

Three aromadendrane-type sesquiterpenoids, spathulenol (1), 4β,10α-dihydroxyaromadendrane (2), and 4α,10α-dihydroxyaromadendrane (3) were isolated from the stem bark of Aglaia harmsiana (Meliaceae). Compound 3 was isolated for the first time from Aglaia genus. The chemical structures of isolated compounds were elucidated by various spectroscopic methods, including one and two-dimensional NMR, as well as mass spectroscopy analysis. These sesquiterpenoids 1-3 were evaluated for their cytotoxic activity against MCF-7 breast cancer cell lines. The IC50 value of compound 1-3 were 31.65 ± 0.1, 8.41 ± 0.04 and 2.80 ± 0.02 µM, respectively. Among the aromadendrane-type sesquiterpenoids, compounds 2 and 3, which do not have a double bond, showed higher activity than compound 1. Whereas, compound 3 showed the strongest activity indicate that α configuration of hydroxyl group increases the cytotoxic activity.

scholarly journals Aerobic Decomposition of Trialkylquercetins: Structure Characterization and Antiproliferative Effect

2016 ◽  
Vol 11 (4) ◽  
pp. 1934578X1601100
Author(s):  
Sami M.R. Al-Jabban ◽  
Xiaojie Zhang ◽  
Guanglin Chen ◽  
Liva Harinantenaina Rakotondraibe ◽  
Qiao-Hong Chen
Keyword(s):  
Prostate Cancer ◽  
Spectroscopic Data ◽  
2D Nmr ◽  
Structure Characterization ◽  
Human Prostate Cancer ◽  
Proliferation Assay ◽  
Prostate Cancer Cells ◽  
Nmr Data ◽  
Aerobic Decomposition ◽  
Resolution Mass

The aerobic decomposition of 3,4′,7- O-trialkylquercetins was first reported in this paper. The structures of four new decomposed products were characterized by analyzing the 1D and 2D NMR data, as well as their high resolution mass spectroscopic data. Their antiproliferative activity toward human prostate cancer cells has been assessed through WST-1 cell proliferation assay. The decomposition mechanism was also proposed.

scholarly journals Cytotoxicity and Antibacterial Potential of Halogenated Chamigrenes from Malaysian Red Alga, Laurencia majuscula

2019 ◽  
Vol 6 (02) ◽  
pp. e36-e40
Author(s):  
Takashi Kamada ◽  
Chin-Soon Phan ◽  
Tatsufumi Okino ◽  
Charles Santhanaraju Vairappan
Keyword(s):  
Spectroscopic Data ◽  
2D Nmr ◽  
Red Alga ◽  
Antibiotic Resistant ◽  
North Borneo ◽  
Bioactive Secondary Metabolites ◽  
Laurencia Majuscula ◽  
Mcf 7 ◽  
Antibacterial Potential ◽  
New Metabolites

AbstractRed algae of the genus Laurencia have been known to produce a wide array of bioactive secondary metabolites. Here, we report the isolation of two new halogenated chamigrenes, lauremantanones A (1) and B (2), along with seven known compounds, dendroidiol (3), (+)-elatol (4), cartilagineol (5), obtusol (6), (+)-laurencenone B (7), 2-chloro-3-hydroxy-α-chamigren-9-one (8), and puertitol A (9), from a population of Laurencia majuscula (Harvey) Lucas from Mantanani Island (North Borneo). The structures of the two new metabolites were determined based on spectroscopic data (IR, 1D and 2D NMR, and MS). Compounds isolated from this alga exhibited potent cytotoxic (HeLa, MCF-7, P-388) and antibacterial (against antibiotic-resistant clinical bacteria) activities. The major metabolite of this population has significant importance in the geographical distribution of this species globally.

scholarly journals Chemical Constituents of the Aerial Parts ofDaucus carotasubsp.hispidusGrowing in Tunisia

2019 ◽  
Vol 14 (7) ◽  
pp. 1934578X1986351
Author(s):  
Saoussen Hammami ◽  
Abdelsamed I. Elshamy ◽  
Ridha El Mokni ◽  
Ali Snene ◽  
Kanako Iseki ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Squamous Carcinoma ◽  
2D Nmr ◽  
Spectroscopic Techniques ◽  
Aerial Parts ◽  
Weak Activity ◽  
Cervical Cells ◽  
Antimicrobial And Antioxidant Activity ◽  
First Time ◽  
High Resolution Mass Spectroscopy

Three known polyol menthane monoterpenoids, namely, (4 R)-1- p-menthen-6,8-diol (1), (4 R)-1- p-menthen-4,7-diol (2), and (1 R,2 R,4 R)- p-menthane-1,2,4-triol (3), and 6 known phenolics (4-9), in addition to β-sitosterol 3- O-glucoside (10), were isolated from the aerial parts of Daucus carota subsp. hispidus (Ball) Heywood (Family: Apiaceae) growing in Tunisia. The structures of the isolated compounds were established depending upon the spectroscopic techniques including one and two-dimensional nuclear magnetic resonance (1D, and 2D NMR) and high resolution mass spectroscopy (HRMS). The absolute configuration of the compounds 1 to 3 was determined using experimental circular dichroism (CD) for the first time. Compounds 1 to 3 were reported for the first time from this plant. Compounds 1 to 3 exhibited no antimicrobial and antioxidant activity using superoxide dismutase-like activities. Compounds 2 and 3 exhibited weak activity, while 1 showed negative cytotoxic activity against human mouth squamous carcinoma (HSC-2) and human cervical cells (HeLa) cancer cells.

scholarly journals Flavonoids from Twigs of Millettia pubinervis

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901
Author(s):  
Zhi Na ◽  
Qi-Shi Song ◽  
Hua-Bin Hu
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
Data Interpretation ◽  
2D Nmr ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Phytochemical Investigation ◽  
Mcf 7

A new flavone, 3-methoxy-5-hydroxy-[2”,3”:7,8] furanoflavone, pubinerone (1), was isolated from the twigs of Millettia pubinervis Kurz, together with ten known flavonoids, karanjin (2), kanjone (3), 3,6-dimethoxy-[2”,3”:7,8] furanoflavone (4), pongaglabrone (5), pongapin (6), pongaflavone (7), 3,6-dimethoxy-6”,6”-dimethylchromene-[2”,3”:7,8] flavone (8), pongachromene (9), 3,6-dimethoxy-3′,4′-methylenedioxy-6”,6”-dimethylchromene-[2”,3”:7,8] flavone (10) and demethoxykanugin (11). This is the first phytochemical investigation of this plant. The structure of compound 1 was elucidated on the basis of spectroscopic data interpretation, including 1D and 2D NMR and HREIMS analysis. The cytotoxicity of 1 against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7 and SW480, was evaluated, but it was inactive (IC50>40μM).

scholarly journals 10′-Deoxy-10′ α-hydroxyascochlorin, a New Cell Migration Inhibitor and Other Metabolites from Acremonium sp., a Fungal Endophyte in Ephedra trifurca

2013 ◽  
Vol 8 (5) ◽  
pp. 1934578X1300800
Author(s):  
W. M. Anoja P. Wanigesekara ◽  
E. M. Kithsiri Wijeratne ◽  
A. Elizabeth Arnold ◽  
A. A. Leslie Gunatilaka
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Metastatic Breast ◽  
Cancer Cell Line ◽  
2D Nmr ◽  
Fungal Endophyte ◽  
Lung Cancer Cell Line ◽  
Breast Cancer Cell Lines ◽  
Lung Cancer Cell ◽  
Mcf 7

A new ascochlorin, 10′-deoxy-10′ α-hydroxyascochlorin (1), together with ascofuranone (2), ascochlorin (3), and 4′,5′-dihydro-4′ β-hydroxyascochlorin (4) were isolated from Acremonium sp. LG0808, an endophytic fungal strain occurring in the stem tissue of the medicinal plant, Ephedra trifurca. The structure of 1 was elucidated on the basis of its high-resolution mass spectrometric, and 1D and 2D NMR spectroscopic data. Compounds 1 and 3 inhibited migration of metastatic prostate cancer cells, PC-3M. In addition, 3 exhibited moderately selective cytotoxicity against the NCI-H460 (non-small cell lung cancer) cell line, but its dimethyl ether (6) showed selective activity against PC-3M, MCF-7 (breast cancer), and MDA-MB-231 (metastatic breast cancer) cell lines.

scholarly journals Isolation and Structural Characterization of a New Minor Diterpene Glycoside from Stevia rebaudiana

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901 ◽  
Author(s):  
Venkata Sai Prakash Chaturvedula ◽  
Julian Zamora
Keyword(s):  
High Resolution ◽  
Structural Characterization ◽  
Spectroscopic Data ◽  
Stevia Rebaudiana ◽  
2D Nmr ◽  
Stevia Rebaudiana Bertoni ◽  
High Resolution Mass ◽  
Commercial Extract ◽  
Resolution Mass

From the commercial extract of the leaves of the sweet plant Stevia rebaudiana Bertoni obtained from Sinochem Qingdao Co. Ltd., a new diterpene glycoside having three β-D-glucopyranosyl units of which two of them were connected in a relatively rare linkage of 3-β-D-glucobiosyl substitution at C-19 position of the aglycone steviol. The structure of the new compound has been characterized as 13-β-D-glucopyranosyloxy ent-kaur-16-en-19-oic acid-[(3-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester (1) on the basis of extensive 1D (1H and 13C) and 2D NMR (TOCSY, HMQC, and HMBC), and High Resolution mass spectroscopic data as well as hydrolysis studies.

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