Biocompatibility of Nanoscale Hydroxyapatite Coating on TiO2 Nanotubes

In this study, a highly-ordered TiO2 nanotube array was successfully fabricated on the surface of a pure titanium foil using the anodization method, and a hydroxyapatite (HA) layer was electrochemically deposited on the vertically aligned titania (TiO2) nanotube array. The TiO2 nanotubes exhibited an inner diameter ranging from 44.5 to 136.8 nm, a wall thickness of 9.8 to 20 nm and a length of 1.25 to 3.94 µm, depending on the applied potential, and the anodization time and temperature. The TiO2 nanotubes provided a high number of nucleation sites for the HA precipitation during electrochemical deposition, resulting in the formation of a nanoscale HA layer with a particle size of about 50 nm. The bond strength between the HA coating and the nanotubular layer with an inner diameter of 136.8 nm was over 28.7 MPa, and the interlocking between the nanoscale HA and the TiO2 nanotubes may have been responsible for the high bond strength. The biocompatibility assessment was conducted on Ti foil with a composite coat of nanoscale HA and the TiO2 nanotube array by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) array with mesenchymal stem cells (MSCs). The mesenchymal stem cells adhered to and spread onto the nanoscale HA layer with plenty of extending filopodia, indicating excellent biocompatibility of the HA coat, the composite coat of nanoscale HA and the TiO2 nanotube array. The findings suggest that the nanoscale HA coating on the TiO2 nanotube array might be a promising way to improve the bond strength and the compatibility of the HA layer.

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Preparation of TiO2 Nanotube Array on the Pure Titanium Surface by Anodization Method and Its Hydrophilicity

Scanning ◽

10.1155/2021/2717921 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Jianguo Lin ◽

Wenhao Cai ◽

Qing Peng ◽

Fanbin Meng ◽

Dechuang Zhang

Keyword(s):

Applied Voltage ◽

Tio2 Nanotubes ◽

Pure Titanium ◽

Angle Measurement ◽

Anatase Tio2 ◽

Tio2 Nanotube ◽

Tio2 Nanotube Array ◽

Water Contact ◽

Nanotube Array ◽

Anodization Time

In this work, a highly ordered TiO2 nanotube array on pure titanium (Ti) was prepared by anodization. The effects of the applied voltage and anodization time on the microstructure of the TiO2 nanotube arrays were investigated, and their hydrophilicity was evaluated by the water contact angle measurement. It was found that a highly ordered array of TiO2 nanotubes can be formed on the surface of pure Ti by anodized under the applied voltage of 20 V and the anodization time in the range of 6-12 h, and the nanotube diameter and length can be regulated by anodization time. The as-prepared TiO2 nanotubes were in an amorphous structure. After annealing at 550°C for 3 h, the amorphous TiO2 can be transformed to the anatase TiO2 through crystallization. The anatase TiO2 array exhibited a greatly improved hydrophilicity, depending on the order degree of the array and the diameter of the nanotubes. The sample anodized at 20 V for 12 h and then annealed at 550°C for 3 h exhibited a superhydrophilicity due to its highly ordered anatase TiO2 nanotube array with a tube diameter of 103.5 nm.

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Zinc-Doped TiO2 Nanotube Arrays

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.434-435.446 ◽

2010 ◽

Vol 434-435 ◽

pp. 446-447 ◽

Cited By ~ 7

Author(s):

Yang Yang ◽

Xiao Hui Wang ◽

Long Tu Li

Keyword(s):

Tio2 Nanotubes ◽

Tio2 Nanotube Arrays ◽

Tio2 Nanotube ◽

Nanotube Arrays ◽

Tio2 Nanotube Array ◽

Tem Analysis ◽

Nanotube Array ◽

Doped Tio2 ◽

Main Technique ◽

Valence Structure

Zinc-doped TiO2 nanotube arrays were fabricated by immersing TiO2 nanotube arrays in zinc-containing solution for hours. And subsequent heat-treatment was crucial for Zn2+ coming into the crystal lattice of TiO2 nanotubes. TEM analysis was used as main technique to investigate the structure of zinc-doped TiO2 nanotubes, and found that the Zn2+ ions only combine into the lattice of TiO2 nanotubes. This kind of doping can change the valence structure in the surface of TiO2 nanotube array. The obtained zinc-doped TiO2 nanotube arrays have potential application in photocatalysis.

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In Vitro Assessment of Hydroxyapatite Coating on the Surface of Additive Manufactured Ti6Al4V Scaffolds

Materials Science Forum ◽

10.4028/www.scientific.net/msf.879.2444 ◽

2016 ◽

Vol 879 ◽

pp. 2444-2449 ◽

Cited By ~ 1

Author(s):

Ekaterina Chudinova ◽

Maria Surmeneva ◽

Andrey Koptioug ◽

Irina V. Savintseva ◽

Irina Selezneva ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Human Mesenchymal Stem Cells ◽

Nanocrystalline Structure ◽

X Ray Diffraction ◽

Ha Coating ◽

Magnetron Sputter Deposition ◽

In Vitro Assessment ◽

Average Size

Custom orthopedic and dental implants may be fabricated by additive manufacturing (AM), for example using electron beam melting technology. This study is focused on the modification of the surface of Ti6Al4V alloy coin-like scaffolds fabricated via AM technology (EBM®) by radio frequency (RF) magnetron sputter deposition of hydroxyapatite (HA) coating. The scaffolds with HA coating were characterized by Scanning Electron microscopy, X-ray diffraction. HA coating showed a nanocrystalline structure with the crystallites of an average size of 32±9 nm. The ability of the surface to support adhesion and the proliferation of human mesenchymal stem cells was studied using biological short-term tests in vitro. In according to in vitro assessment, thin HA coating stimulated the attachment and proliferation of cells. Human mesenchymal stem cells cultured on the HA-coated scaffold also formed mineralized nodules.

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Correction: 3D Au-decorated Bi2MoO6 nanosheet/TiO2 nanotube array heterostructure with enhanced UV and visible-light photocatalytic activity

Journal of Materials Chemistry A ◽

10.1039/c7ta90152f ◽

2017 ◽

Vol 5 (31) ◽

pp. 16422-16422 ◽

Cited By ~ 4

Author(s):

Jingsheng Cai ◽

Jianying Huang ◽

Yuekun Lai

Keyword(s):

Photocatalytic Activity ◽

Visible Light ◽

Tio2 Nanotube ◽

Tio2 Nanotube Array ◽

Nanotube Array ◽

Visible Light Photocatalytic Activity ◽

Visible Light Photocatalytic

Correction for ‘3D Au-decorated Bi2MoO6 nanosheet/TiO2 nanotube array heterostructure with enhanced UV and visible-light photocatalytic activity’ by Jingsheng Cai et al., J. Mater. Chem. A, 2017, DOI: 10.1039/c7ta02077e.

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