scholarly journals Silk-Based Materials for Hard Tissue Engineering

Materials ◽  
2021 ◽  
Vol 14 (3) ◽  
pp. 674
Author(s):  
Vanessa J. Neubauer ◽  
Annika Döbl ◽  
Thomas Scheibel
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Bone Tissue Regeneration ◽  
Mineralized Tissue ◽  
Hard Tissue ◽  
Material Stiffness ◽  
Physico Chemical ◽  
Natural Tissue ◽  
Hard Tissue Engineering

Hard tissues, e.g., bone, are mechanically stiff and, most typically, mineralized. To design scaffolds for hard tissue regeneration, mechanical, physico-chemical and biological cues must align with those found in the natural tissue. Combining these aspects poses challenges for material and construct design. Silk-based materials are promising for bone tissue regeneration as they fulfill several of such necessary requirements, and they are non-toxic and biodegradable. They can be processed into a variety of morphologies such as hydrogels, particles and fibers and can be mineralized. Therefore, silk-based materials are versatile candidates for biomedical applications in the field of hard tissue engineering. This review summarizes silk-based approaches for mineralized tissue replacements, and how to find the balance between sufficient material stiffness upon mineralization and cell survival upon attachment as well as nutrient supply.

scholarly journals Electrospinning of Nanofibers for Tissue Engineering Applications

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Haifeng Liu ◽  
Xili Ding ◽  
Gang Zhou ◽  
Ping Li ◽  
Xing Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Fiber Morphology ◽  
Hard Tissue ◽  
Nanoscale Material ◽  
Considerable Potential ◽  
Recent Interest ◽  
Material Fabrication

Electrospinning is a method in which materials in solution are formed into nano- and micro-sized continuous fibers. Recent interest in this technique stems from both the topical nature of nanoscale material fabrication and the considerable potential for use of these nanoscale fibres in a range of applications including, amongst others, a range of biomedical applications processes such as drug delivery and the use of scaffolds to provide a framework for tissue regeneration in both soft and hard tissue applications systems. The objectives of this review are to describe the theory behind the technique, examine the effect of changing the process parameters on fiber morphology, and discuss the application and impact of electrospinning on the fields of vascular, neural, bone, cartilage, and tendon/ligament tissue engineering.

scholarly journals Fabrication of Novel Silk Fibroin - LDHs Composite Arhitectures for Potential Bone Tissue Engineering

2017 ◽  
Vol 54 (4) ◽  
pp. 659-665
Author(s):  
Bianca Galateanu ◽  
Ionut Cristian Radu ◽  
Eugenia Vasile ◽  
Ariana Hudita ◽  
Mirela Violeta Serban ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Biomedical Applications ◽  
Nanocomposite Materials ◽  
Hard Tissue ◽  
Hard Tissue Engineering ◽  
Hydrogel Nanocomposite ◽  
Hydroxyapatite Formation

Nanocomposite materials have attracted a high interest for biomedical applications because their special properties related with structure and composition. In this paper we synthesized novel hydrogel nanocomposite materials special designed for hard tissue engineering. The nanocomposite materials are able to promote hydroxyapatite formation by alternating soaking mineralization demanded for increasing of cells biocompatibility and adhesion.

Scaffolds for Hard Tissue Engineering by Ionotropic Gelation of Alginate?Influence of Selected Preparation Parameters

2007 ◽  
Vol 90 (6) ◽  
pp. 1703-1708 ◽  
Author(s):  
R. Dittrich ◽  
G. Tomandl ◽  
F. Despang ◽  
A. Bernhardt ◽  
Th. Hanke ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hard Tissue ◽  
Ionotropic Gelation ◽  
Hard Tissue Engineering

Development of a novel biomaterial with an important osteoinductive capacity for hard tissue engineering

2018 ◽  
Vol 52 ◽  
pp. 101-107 ◽  
Author(s):  
Meda-Romana Simu ◽  
Emoke Pall ◽  
Teodora Radu ◽  
Maria Miclaus ◽  
Bogdan Culic ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hard Tissue ◽  
Hard Tissue Engineering

Preparation and performance evaluation of electrospun poly(3-hydroxybutyrate) composite scaffolds as a potential hard tissue engineering application

2019 ◽  
Vol 34 (4-5) ◽  
pp. 386-400 ◽  
Author(s):  
Moein Zarei ◽  
Nader Tanideh ◽  
Shahrokh Zare ◽  
Fatemeh Sari Aslani ◽  
Omid Koohi-Hosseinabadi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Carbon Nanotube ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Hydroxyapatite Nanoparticles ◽  
Hard Tissue ◽  
Composite Scaffolds ◽  
Tissue Reactions ◽  
Hard Tissue Engineering

In the present study, poly(3-hydroxybutyrate)-based composite scaffolds were prepared with multi-walled carbon nanotubes and hydroxyapatite nanoparticles for hard tissue engineering applications by electrospinning. All the prepared scaffolds showed connective porous structure, which were suitable for cell proliferation and migration. The mechanical properties of the poly(3-hydroxybutyrate) scaffold were improved by 0.5% of carbon nanotube addition, whereas the addition of hydroxyapatite nanoparticles up to 10% had an insignificant effect in tensile strength. However, scanning electron microscopy and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay results suggested that the mesenchymal stem cells attachment and their metabolic activities on the surface of the poly(3-hydroxybutyrate) scaffolds with hydroxyapatite were enhanced compared to poly(3-hydroxybutyrate) scaffolds. In addition, after 6 weeks of in vivo biocompatibility results in a model of rat indicated better tissue reactions for the scaffolds that contained hydroxyapatite. Overall, poly(3-hydroxybutyrate) composite scaffolds with 10% hydroxyapatite and 0.5% carbon nanotube showed optimal performances for the potential scaffold for hard tissue engineering application.

PCL and PCL/PLA Scaffolds for Bone Tissue Regeneration

2013 ◽  
Vol 683 ◽  
pp. 168-171 ◽  
Author(s):  
Tatiana Patrício ◽  
Antonio Gloria ◽  
Paulo J. Bártolo
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Cell Attachment ◽  
Bone Tissue Regeneration ◽  
Engineering Applications ◽  
Printing System

This paper investigates the use of PCL and PCL/PLA scaffolds, produced using a novel additive biomanufacturing system called BioCell Printing, for bone tissue engineering applications. Results show that the BioCell Printing system produces scaffolds with regular and reproducible architecture, presenting no toxicity and enhancing cell attachment and proliferation. It was also possible to observe that the addition of PLA to PCL scaffolds strongly improves the biomechanical performance of the constructs.

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