scholarly journals Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 6123
Author(s):  
Chia Wei Cheah ◽  
Nisreen Mohammed Al-Namnam ◽  
May Nak Lau ◽  
Ghee Seong Lim ◽  
Renukanth Raman ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Randomized Clinical Trials ◽  
Calcium Phosphates ◽  
Bone Substitutes ◽  
Calcium Sulphate ◽  
Dental Tissue ◽  
Socket Preservation ◽  
Skeletal Defects ◽  
Recent Developments ◽  
Biological Performance

Alloplasts are synthetic, inorganic, biocompatible bone substitutes that function as defect fillers to repair skeletal defects. The acceptance of these substitutes by host tissues is determined by the pore diameter and the porosity and inter-connectivity. This narrative review appraises recent developments, characterization, and biological performance of different synthetic materials for bone, periodontal, and dental tissue regeneration. They include calcium phosphate cements and their variants β-tricalcium phosphate (β-TCP) ceramics and biphasic calcium phosphates (hydroxyapatite (HA) and β-TCP ceramics), calcium sulfate, bioactive glasses and polymer-based bone substitutes which include variants of polycaprolactone. In summary, the search for synthetic bone substitutes remains elusive with calcium compounds providing the best synthetic substitute. The combination of calcium sulphate and β-TCP provides improved handling of the materials, dispensing with the need for a traditional membrane in guided bone regeneration. Evidence is supportive of improved angiogenesis at the recipient sites. One such product, (EthOss® Regeneration, Silesden UK) has won numerous awards internationally as a commercial success. Bioglasses and polymers, which have been used as medical devices, are still in the experimental stage for dental application. Polycaprolactone-TCP, one of the products in this category is currently undergoing further randomized clinical trials as a 3D socket preservation filler. These aforementioned products may have vast potential for substituting human/animal-based bone grafts.

Developing Bio-Stable and Biodegradable Composites for Tissue Replacement and Tissue Regeneration

2002 ◽  
Vol 724 ◽  
Author(s):  
Min Wang
Keyword(s):  
Tissue Regeneration ◽  
Polymer Matrix Composites ◽  
Calcium Phosphates ◽  
Bone Matrix ◽  
Bone Substitutes ◽  
The Body ◽  
Volume Percentage ◽  
Matrix Polymer ◽  
Tissue Replacement ◽  
The Matrix

AbstractBone is the substantial unit of human skeletal system, which supports the body and its movement. At the ultra-structure level, the bone matrix is a composite material consisting of bone mineral particles, which are mainly substituted, calcium-deficient hydroxyapatite, and collagen, which is a natural polymer. Bone serves as the template for developing bone replacement materials. Research on biomaterials analogous to bone was started in the early 1980s by incorporating bioactive particles into biocompatible polymers so as to produce bone substitutes. Over the last two decades, a variety of bioactive polymer matrix composites have been developed for tissue substitution and tissue regeneration. The bioactive phases in these composites are normally one of the calcium phosphates, especially synthetic hydroxyapatite (HA, Ca10(PO4)6(OH)2) which closely resembles bone apatite and exhibits osteoconductivity. If enhanced bioactivity is required, bioceramics having higher bioactivity such as Bioglass® and A-W glass-ceramic can be used as the bioactive phase in the composites. For tissue replacement, bio-stable polymers such as polyethylene (PE) and polysulfone (PSU) are used as the matrix polymer. For tissue regeneration, natural, biodegradable polymers such as polyhydroxybutyrate (PHB) and chitin are used as matrices. Furthermore, mechanical as well as biological performance of a particular composite can be controlled by varying the amount of the bioactive phase in the composite, thus meeting specific clinical requirements. For bioactive ceramic-polymer composites, major influencing factors such as shape, size and size distribution of bioactive particles, mechanical properties and volume percentage of the bioactive phase, properties of the matrix polymer, distribution of bioactive particles in the matrix and the particle-matrix interfacial state should be controlled in order to obtain materials of desirable properties. Various techniques are used to evaluate the composites.

scholarly journals Cyclodextrin-Based Supramolecular Complexes of Osteoinductive Agents for Dental Tissue Regeneration

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 136
Author(s):  
Masahiko Terauchi ◽  
Atsushi Tamura ◽  
Yoshinori Arisaka ◽  
Hiroki Masuda ◽  
Tetsuya Yoda ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Formation ◽  
Small Molecule ◽  
Tissue Regeneration ◽  
Alveolar Bone ◽  
Inclusion Complexation ◽  
Dental Tissue ◽  
Polyelectrolyte Complexes ◽  
Small Molecule Drugs

Oral tissue regeneration has received growing attention for improving the quality of life of patients. Regeneration of oral tissues such as alveolar bone and widely defected bone has been extensively investigated, including regenerative treatment of oral tissues using therapeutic cells and growth factors. Additionally, small-molecule drugs that promote bone formation have been identified and tested as new regenerative treatment. However, treatments need to progress to realize successful regeneration of oral functions. In this review, we describe recent progress in development of regenerative treatment of oral tissues. In particular, we focus on cyclodextrin (CD)-based pharmaceutics and polyelectrolyte complexation of growth factors to enhance their solubility, stability, and bioactivity. CDs can encapsulate hydrophobic small-molecule drugs into their cavities, resulting in inclusion complexes. The inclusion complexation of osteoinductive small-molecule drugs improves solubility of the drugs in aqueous solutions and increases in vitro osteogenic differentiation efficiency. Additionally, various anionic polymers such as heparin and its mimetic polymers have been developed to improve stability and bioactivity of growth factors. These polymers protect growth factors from deactivation and degradation by complex formation through electrostatic interaction, leading to potentiation of bone formation ability. These approaches using an inclusion complex and polyelectrolyte complexes have great potential in the regeneration of oral tissues.

Engineering 3D printed bioactive composite scaffolds based on the combination of aliphatic polyester and calcium phosphates for bone tissue regeneration

2021 ◽  
Vol 122 ◽  
pp. 111928
Author(s):  
Eduardo H. Backes ◽  
Emanuel M. Fernandes ◽  
Gabriela S. Diogo ◽  
Catarina F. Marques ◽  
Tiago H. Silva ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Phosphates ◽  
Bone Tissue Regeneration ◽  
Aliphatic Polyester ◽  
Composite Scaffolds ◽  
3D Printed

scholarly journals Surgical Treatment of Periodontal Intrabony Defects with Calcium Sulphate in Combination with Beta Tricalcium Phosphate – A 12-Month Retrospective Clinical Evaluation

2010 ◽  
Vol 53 (4) ◽  
pp. 229-234 ◽  
Author(s):  
Sujith Sukumar ◽  
Ivo Dřízhal ◽  
Josef Bukač ◽  
Vladimíra Paulusová ◽  
Shriharsha Pilathadka
Keyword(s):  
Tissue Regeneration ◽  
Tricalcium Phosphate ◽  
Gingival Recession ◽  
Calcium Sulphate ◽  
Intrabony Defects ◽  
Clinical Attachment Level ◽  
Beta Tricalcium Phosphate ◽  
Probing Depth ◽  
One Year ◽  
Attachment Level

Alloplastic bone graft materials are widely been used in combination with barrier membranes to achieve guided tissue regeneration in the treatment of periodontal intrabony defects. This study was designed to evaluate the clinical outcome of a composite material, beta tricalcium phosphate in combination with calcium sulphate in the treatment of periodontal intrabony defects. The combination of these materials is believed to aid in guided tissue regeneration owing to their properties. Thirty nine intrabony defects in 21 patients were treated with Fortoss® Vital (Biocomposites, Staffordshire, UK). Clinical parameters were evaluated including changes in probing depth, clinical attachment level/loss and gingival recession at baseline and one year postoperatively. The mean differences in measurements between the baseline and one year postoperatively are a reduction of 1.98±1.16 mm (p=0.000) in case of probing depth and a gain of 1.68±1.12 mm (p=0.000) in clinical attachment level and an increase of 0.31±0.67 mm (p=0.009) in gingival recession measurements. The study results show that the treatment with a combination of beta tricalcium phosphate and calcium sulphate led to a significantly favorable clinical improvement in periodontal intrabony defects one year postoperatively.

scholarly journals Virus-Based Nanomaterials and Nanostructures

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 567
Author(s):  
Jin-Woo Oh ◽  
Dong-Wook Han
Keyword(s):  
Energy Harvesting ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Special Issue ◽  
Future Directions ◽  
Biomimetic Materials ◽  
Recent Developments ◽  
Energy Harvesting Devices

This Special Issue highlights the recent developments and future directions of virus-based nanomaterials and nanostructures in energy and biomedical applications. The virus-based biomimetic materials formulated using innovative ideas presented herein are characterized for the applications of biosensors and nanocarriers. The research contributions and trends based on virus-based materials, covering energy-harvesting devices to tissue regeneration over the last two decades, are described and discussed.

scholarly journals Injectable Highly Tunable Oligomeric Collagen Matrices for Dental Tissue Regeneration

2020 ◽  
Vol 3 (2) ◽  
pp. 859-868 ◽  
Author(s):  
Divya Pankajakshan ◽  
Sherry L. Voytik-Harbin ◽  
Jacques E. Nör ◽  
Marco C. Bottino
Keyword(s):  
Tissue Regeneration ◽  
Dental Tissue ◽  
Collagen Matrices

scholarly journals iPSC for Dental Tissue Regeneration

2014 ◽  
Vol 1 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Kim Hynes ◽  
Stan Gronthos ◽  
P. Mark Bartold
Keyword(s):  
Tissue Regeneration ◽  
Dental Tissue

scholarly journals Titanium-containing bioactive phosphate glasses

2012 ◽  
Vol 370 (1963) ◽  
pp. 1352-1375 ◽  
Author(s):  
A. Kiani ◽  
N. J. Lakhkar ◽  
V. Salih ◽  
M. E. Smith ◽  
J. V. Hanna ◽  
...  
Keyword(s):  
Physical Properties ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Review Paper ◽  
Phosphate Glasses ◽  
Bone Substitute Material ◽  
Soft Tissue Regeneration ◽  
Recent Developments ◽  
Titanium Incorporation ◽  
Biomedical Field

The use of biomaterials has revolutionized the biomedical field and has received substantial attention in the last two decades. Among the various types of biomaterials, phosphate glasses have generated great interest on account of their remarkable bioactivity and favourable physical properties for various biomedical applications relating to both hard and soft tissue regeneration. This review paper focuses mainly on the development of titanium-containing phosphate-based glasses and presents an overview of the structural and physical properties. The effect of titanium incorporation on the glassy network is to introduce favourable properties. The biocompatibility of these glasses is described along with recent developments in processing methodologies, and the potential of Ti-containing phosphate-based glasses as a bone substitute material is explored.

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