scholarly journals Longitudinal Analysis of Cardiovascular Risk Factors in Active and Sedentary Kidney Transplant Recipients

Medicina ◽  
2020 ◽  
Vol 56 (4) ◽  
pp. 183
Author(s):  
Valentina Totti ◽  
Bo Fernhall ◽  
Rocco Di Michele ◽  
Paola Todeschini ◽  
Gaetano La Manna ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Renal Function ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Graft Function ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Over Time ◽  
Observation Period

Background: Despite the benefits of physical activity on cardiovascular risk in kidney transplant recipients (KTRs), the long-term effects of exercise have been poorly investigated. This is a three-year observational study comparing graft function and cardiovascular risk factors in active KTRs (AKTRs) vs. sedentary KTRs (SKTRs). Methods: KTRs with stable renal function were assigned to active or sedentary group in relation to the level of daily physical activity based on World Health Organization (WHO) recommendations (<150 or >150 minutes/week, respectively). Complete blood count, renal function indices, lipid profile, blood pressure and anthropometric measures were collected yearly for an observation period of three years. The comparisons between the two groups were performed by repeated measures analyses of covariance (ANCOVAs), with age as a covariate. Results: Fifty-four subjects were included in the study. Thirty of them were identified as AKTRs (M/F 26/4, aged 45 ± 12 years) and 24 as SKTRs (M/F 18/6, aged 51 ± 14 years). Baseline characteristics were similar between the groups except body mass index (BMI) that was significantly higher in SKTRs (p = 0.043). Furthermore, over the three-year observation period, BMI decreased in AKTRs and increased in SKTRs (p = 0.006). Graft function was stable in AKTRs, while it showed a decline over time in SKTRs, as indicated by the rise in serum creatinine levels (p = 0.006) and lower eGFR (p = 0.050). Proteinuria, glucose and uric acid levels displayed a decrease in AKTRs and an increase in SKTRs during the three-year period (p = 0.015, p = 0.004 and p = 0.013, respectively). Finally, concerning lipid profiles, AKTRs had a significant reduction over time of triglycerides levels, which conversely showed a clinically relevant increase in SKTRs (p = 0.014). Conclusions: Our findings indicate that regular weekly exercise training may counteract the increased cardiovascular risks and also prevent graft function decline in KTRs.

scholarly journals Waiting List and Kidney Transplant Vascular Risk: An Ongoing Unmet Concern

2019 ◽  
Vol 45 (1) ◽  
pp. 1-27 ◽  
Author(s):  
Domingo Hernández ◽  
Juana Alonso-Titos ◽  
Ana Maria Armas-Padrón ◽  
Veronica Lopez ◽  
Mercedes Cabello ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Kidney Transplant ◽  
Mineral Metabolism ◽  
Fibroblast Growth Factor 23 ◽  
Waiting List ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Pathogenic Mechanisms

Background: Chronic kidney disease (CKD) is an important independent risk factor for adverse cardiovascular events in patients waitlisted for kidney transplantation (KT). Although KT reduces cardiovascular risk, these patients still have a higher all-cause and cardiovascular mortality than the general population. This concerning situation is due to a high burden of traditional and nontraditional risk factors as well as uremia-related factors and transplant-specific factors, leading to 2 differentiated processes under the framework of CKD, atherosclerosis and arteriosclerosis. These can be initiated by insults to the vascular endothelial endothelium, leading to vascular calcification (VC) of the tunica media or the tunica intima, which may coexist. Several pathogenic mechanisms such as inflammation-related endothelial dysfunction, mineral metabolism disorders, activation of the renin-angiotensin system, reduction of nitric oxide, lipid disorders, and the fibroblast growth factor 23-klotho axis are involved in the pathogenesis of atherosclerosis and arteriosclerosis, including VC. Summary: This review focuses on the current understanding of atherosclerosis and arteriosclerosis, both in patients on the waiting list as well as in kidney transplant recipients, emphasizing the cardiovascular risk factors in both populations and the inflammation-related pathogenic mechanisms. Key Message: The importance of cardiovascular risk factors and the pathogenic mechanisms related to inflammation in patients waitlisted for KT and kidney transplant recipients.

scholarly journals Prospective characteristic of cardiovascular risk factors in renal transplant recipients

2020 ◽  
Vol 17 (2) ◽  
pp. 237-247
Author(s):  
M. V. Smaliakova ◽  
N. P. Mitkovskaya ◽  
A. V. Kalachik ◽  
E. A. Grigorenko
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Renal Transplantation ◽  
Cardiovascular Risk Factors ◽  
Postoperative Period ◽  
Complete Blood Count ◽  
Renal Transplant Recipients ◽  
Preoperative Period ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

The aim of the study is assess the dynamics of laboratory and instrumental parameters (these are cardiovascular risk factors) in patients with chronic kidney disease in the preoperative period and after renal transplantation.A single-center prospective cohort study included 43 kidney transplant recipients. Clinical examination, laboratory and instrumental studies were carried out in the preoperative period, in six months and in five years after transplantation. Laboratory tests included a complete blood count, coagulation, biochemical blood test and enzyme-linked immunosorbent assays. The dynamics of structural and functional heart parameters was studied by echocardiography in the preoperative period and in five years.It was found that the blood pressure, pulse rate, and hypotension episodes decreased after renal transplantation. Hyperaldosterone in the preoperative period was more common than after transplantation. It was observed that the blood level of total cholesterol, triglycerides, interleukin-6, tumor necrosis factor-α, and C-reactive protein decreased in the postoperative period. The hyperglycemia incidence significantly decreased by the end of the observation period. It was detected that the NT-proBNP level increased in all recipients in the preoperative period and decreased to normal values in 37.2 % (n = 16) recipients in the postoperative period. The number of red blood cells and the hemoglobin concentration increased and the hyperethropoietinemia incidence decreased in the postoperative period. The glomerular filtration rate was lower in six months after transplantation than in five years.

scholarly journals IMPROVEMENT OF CARDIOVASCULAR RISK FACTORS AND COSMETIC SIDE EFFECTS IN KIDNEY TRANSPLANT RECIPIENTS AFTER CONVERSION TO TACROLIMUS

2009 ◽  
Vol 153 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Josef Zadrazil ◽  
Pavel Horak ◽  
Jana Zahalkova ◽  
Pavel Strebl ◽  
Vladko Horcicka ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Side Effects ◽  
Cardiovascular Risk Factors ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Prevalence of Cardiovascular Risk Factors before Kidney Transplantation

2002 ◽  
Vol 12 (4) ◽  
pp. 299-304
Author(s):  
Muriel Rice ◽  
Judy Martin ◽  
Donna Hathaway ◽  
Elizabeth Tolley
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Kidney Transplant ◽  
Cardiovascular Events ◽  
African American Men ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cardiovascular Morbidity And Mortality ◽  
Personal Histories

Context Assessing the prevalence of cardiovascular risk factors is an essential step in developing risk profiles and individualizing interventions to reduce the cardiovascular morbidity and mortality of kidney transplant recipients. Objective To examine the prevalence of pretransplant modifiable, potentially modifiable, and nonmodifiable cardiovascular risk factors in patients who received kidney transplants between January 1, 1994, and December 31, 1996. Design An exploratory, retrospective nested case-control design was employed to assess pretransplant cardiovascular risk factors in kidney transplant recipients with documented posttransplant cardiovascular events (n=12) and kidney transplant recipients with no documented posttransplant cardiovascular events (n=66). Data were analyzed using frequencies, unpaired t tests, and χ2 analyses. Results Significantly higher means of body mass index values greater than 25 kg/m2 (32.3±5.8 kg/m2 vs 28.8±3.4 kg/m2) and serum total cholesterol levels greater than 200 mg/dL (254.5±5.7 mg/dL vs 242.3±39.3 mg/dL) were noted in patients with documented cardiovascular events compared to those with no documented cardiovascular events, respectively. Diabetes was more prevalent in patients with documented cardiovascular events (33%); these patients were also predominantly African American men who had a higher prevalence of family and personal histories of cardiovascular disease (17% and 33%).

Sign in / Sign up

Export Citation Format

Share Document