Deep-Learning-Based Polar-Body Detection for Automatic Cell Manipulation

Polar-body detection is an essential and crucial procedure in various automatic cell manipulations. The polar body can only be observed when it is located near the focal plane of the microscope, so we need to detect the polar body during cell rotation in cell manipulations. However, three-dimensional cell rotation by micropipette causes polar-body defocus and cell/polar-body deformation, which have not been discussed in existing image-level polar-body-detection approaches. Moreover, varying sizes of the polar bodies increase the difficulty of polar-body detection. In this paper, we propose a deep-learning-based framework to realize polar-body detection in cell rotation. The detection problem is interpreted as image segmentation, which separates the polar body from the background. Then, we improve U-net, which is a typical convolutional neural network (CNN) for medical-image segmentation, so that the network can be applied to polar-body detection, especially for the detection of defocused polar bodies and polar bodies of different sizes. For CNN training, we also designed a particular image-transformation method to simulate more cell-rotation situations, including cell- and polar-body deformation, so that the deformed polar body in cell rotation would be detected by the proposed method. Experiment results show that our method achieves high detection accuracy of 98.7% on a test dataset of 1000 images, and performs well in cell-rotation processes. This method can be applied to various automatic cell manipulations in the future.

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Efficient Medical Image Segmentation Of COVID-19 Chest CT Images Based on Deep Learning Techniques

2021 International Conference on Emerging Smart Computing and Informatics (ESCI) ◽

10.1109/esci50559.2021.9397043 ◽

2021 ◽

Author(s):

Sanika Walvekar ◽

Swati Shinde

Keyword(s):

Image Segmentation ◽

Deep Learning ◽

Medical Image ◽

Ct Images ◽

Medical Image Segmentation ◽

Chest Ct ◽

Learning Techniques

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Region-of-Interest-Based Cardiac Image Segmentation with Deep Learning

Applied Sciences ◽

10.3390/app11041965 ◽

2021 ◽

Vol 11 (4) ◽

pp. 1965

Author(s):

Raul-Ronald Galea ◽

Laura Diosan ◽

Anca Andreica ◽

Loredana Popa ◽

Simona Manole ◽

...

Keyword(s):

Image Segmentation ◽

Deep Learning ◽

Diagnostic System ◽

Region Of Interest ◽

General Purpose ◽

Medical Image Segmentation ◽

Dice Similarity Coefficient ◽

Learning Methods ◽

Study Results ◽

Whole Heart

Despite the promising results obtained by deep learning methods in the field of medical image segmentation, lack of sufficient data always hinders performance to a certain degree. In this work, we explore the feasibility of applying deep learning methods on a pilot dataset. We present a simple and practical approach to perform segmentation in a 2D, slice-by-slice manner, based on region of interest (ROI) localization, applying an optimized training regime to improve segmentation performance from regions of interest. We start from two popular segmentation networks, the preferred model for medical segmentation, U-Net, and a general-purpose model, DeepLabV3+. Furthermore, we show that ensembling of these two fundamentally different architectures brings constant benefits by testing our approach on two different datasets, the publicly available ACDC challenge, and the imATFIB dataset from our in-house conducted clinical study. Results on the imATFIB dataset show that the proposed approach performs well with the provided training volumes, achieving an average Dice Similarity Coefficient of the whole heart of 89.89% on the validation set. Moreover, our algorithm achieved a mean Dice value of 91.87% on the ACDC validation, being comparable to the second best-performing approach on the challenge. Our approach provides an opportunity to serve as a building block of a computer-aided diagnostic system in a clinical setting.

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ResBCDU-Net: A Deep Learning Framework for Lung CT Image Segmentation

Sensors ◽

10.3390/s21010268 ◽

2021 ◽

Vol 21 (1) ◽

pp. 268

Author(s):

Yeganeh Jalali ◽

Mansoor Fateh ◽

Mohsen Rezvani ◽

Vahid Abolghasemi ◽

Mohammad Hossein Anisi

Keyword(s):

Image Segmentation ◽

Deep Learning ◽

Ct Images ◽

Medical Image Segmentation ◽

Great Success ◽

Morphological Operations ◽

Ct Image ◽

Feature Maps ◽

Learning Framework ◽

Lung Ct

Lung CT image segmentation is a key process in many applications such as lung cancer detection. It is considered a challenging problem due to existing similar image densities in the pulmonary structures, different types of scanners, and scanning protocols. Most of the current semi-automatic segmentation methods rely on human factors therefore it might suffer from lack of accuracy. Another shortcoming of these methods is their high false-positive rate. In recent years, several approaches, based on a deep learning framework, have been effectively applied in medical image segmentation. Among existing deep neural networks, the U-Net has provided great success in this field. In this paper, we propose a deep neural network architecture to perform an automatic lung CT image segmentation process. In the proposed method, several extensive preprocessing techniques are applied to raw CT images. Then, ground truths corresponding to these images are extracted via some morphological operations and manual reforms. Finally, all the prepared images with the corresponding ground truth are fed into a modified U-Net in which the encoder is replaced with a pre-trained ResNet-34 network (referred to as Res BCDU-Net). In the architecture, we employ BConvLSTM (Bidirectional Convolutional Long Short-term Memory)as an advanced integrator module instead of simple traditional concatenators. This is to merge the extracted feature maps of the corresponding contracting path into the previous expansion of the up-convolutional layer. Finally, a densely connected convolutional layer is utilized for the contracting path. The results of our extensive experiments on lung CT images (LIDC-IDRI database) confirm the effectiveness of the proposed method where a dice coefficient index of 97.31% is achieved.

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Three-dimensional Medical Image Segmentation with SE-VNet Neural Networks

10.1145/3468945.3468948 ◽

2021 ◽

Author(s):

Sheng Lu ◽

Jungang Han ◽

Jiantao Li ◽

Liyang Zhu ◽

Jiewei Jiang ◽

...

Keyword(s):

Neural Networks ◽

Image Segmentation ◽

Medical Image ◽

Three Dimensional ◽

Medical Image Segmentation

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HPS-Net: Multi-Task Network for Medical Image Segmentation with Predictable Performance

Symmetry ◽

10.3390/sym13112107 ◽

2021 ◽

Vol 13 (11) ◽

pp. 2107

Author(s):

Xin Wei ◽

Huan Wan ◽

Fanghua Ye ◽

Weidong Min

Keyword(s):

Image Segmentation ◽

Deep Learning ◽

Loss Function ◽

Network Structure ◽

Medical Diagnosis ◽

Medical Image ◽

Medical Image Segmentation ◽

Training Mode ◽

Cooperative Training

In recent years, medical image segmentation (MIS) has made a huge breakthrough due to the success of deep learning. However, the existing MIS algorithms still suffer from two types of uncertainties: (1) the uncertainty of the plausible segmentation hypotheses and (2) the uncertainty of segmentation performance. These two types of uncertainties affect the effectiveness of the MIS algorithm and then affect the reliability of medical diagnosis. Many studies have been done on the former but ignore the latter. Therefore, we proposed the hierarchical predictable segmentation network (HPS-Net), which consists of a new network structure, a new loss function, and a cooperative training mode. According to our knowledge, HPS-Net is the first network in the MIS area that can generate both the diverse segmentation hypotheses to avoid the uncertainty of the plausible segmentation hypotheses and the measure predictions about these hypotheses to avoid the uncertainty of segmentation performance. Extensive experiments were conducted on the LIDC-IDRI dataset and the ISIC2018 dataset. The results show that HPS-Net has the highest Dice score compared with the benchmark methods, which means it has the best segmentation performance. The results also confirmed that the proposed HPS-Net can effectively predict TNR and TPR.

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Region-to-boundary deep learning model with multi-scale feature fusion for medical image segmentation

Biomedical Signal Processing and Control ◽

10.1016/j.bspc.2021.103165 ◽

2022 ◽

Vol 71 ◽

pp. 103165

Author(s):

Xiaowei Liu ◽

Lei Yang ◽

Jianguo Chen ◽

Siyang Yu ◽

Keqin Li

Keyword(s):

Image Segmentation ◽

Deep Learning ◽

Medical Image ◽

Feature Fusion ◽

Learning Model ◽

Medical Image Segmentation ◽

Scale Feature ◽

Multi Scale ◽

Deep Learning Model

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Ensemble-based deep meta learning for medical image segmentation

Journal of Intelligent & Fuzzy Systems ◽

10.3233/jifs-219221 ◽

2021 ◽

pp. 1-7

Author(s):

Usman Ahmed ◽

Jerry Chun-Wei Lin ◽

Gautam Srivastava

Keyword(s):

Image Segmentation ◽

Deep Learning ◽

Learning Algorithm ◽

State Of The Art ◽

Medical Image Segmentation ◽

The State ◽

Data Set ◽

Deep Learning Algorithm ◽

Meta Learning ◽

Small Set

Deep learning methods have led to a state of the art medical applications, such as image classification and segmentation. The data-driven deep learning application can help stakeholders to collaborate. However, limited labelled data set limits the deep learning algorithm to generalize for one domain into another. To handle the problem, meta-learning helps to learn from a small set of data. We proposed a meta learning-based image segmentation model that combines the learning of the state-of-the-art model and then used it to achieve domain adoption and high accuracy. Also, we proposed a prepossessing algorithm to increase the usability of the segments part and remove noise from the new test image. The proposed model can achieve 0.94 precision and 0.92 recall. The ability to increase 3.3% among the state-of-the-art algorithms.

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