scholarly journals The Rise of the OM-LoC: Opto-Microfluidic Enabled Lab-on-Chip

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1467
Author(s):  
Harry Dawson ◽  
Jinane Elias ◽  
Pascal Etienne ◽  
Sylvie Calas-Etienne
Keyword(s):  
Low Cost ◽  
Optical Components ◽  
New Era ◽  
Lab On Chip ◽  
Highly Sensitive ◽  
Multiple Challenges ◽  
On Chip ◽  
Optical Circuits ◽  
Made In

The integration of optical circuits with microfluidic lab-on-chip (LoC) devices has resulted in a new era of potential in terms of both sample manipulation and detection at the micro-scale. On-chip optical components increase both control and analytical capabilities while reducing reliance on expensive laboratory photonic equipment that has limited microfluidic development. Notably, in-situ LoC devices for bio-chemical applications such as diagnostics and environmental monitoring could provide great value as low-cost, portable and highly sensitive systems. Multiple challenges remain however due to the complexity involved with combining photonics with micro-fabricated systems. Here, we aim to highlight the progress that optical on-chip systems have made in recent years regarding the main LoC applications: (1) sample manipulation and (2) detection. At the same time, we aim to address the constraints that limit industrial scaling of this technology. Through evaluating various fabrication methods, material choices and novel approaches of optic and fluidic integration, we aim to illustrate how optic-enabled LoC approaches are providing new possibilities for both sample analysis and manipulation.

Low cost optical particle detection for lab on chip systems based on DVD technology

2007 ◽  
Author(s):  
Andrew L. Clow ◽  
Rainer Künnemeyer ◽  
Paul Gaynor ◽  
John C. Sharpe
Keyword(s):  
Low Cost ◽  
Particle Detection ◽  
Lab On Chip ◽  
On Chip

An autonomous lab-on-chip sensor for in situ measurements of seawater total alkalinity

2021 ◽  
Author(s):  
Allison Schaap ◽  
Stathys Papadimitriou ◽  
Socratis Loucaides ◽  
Matthew Mowlem
Keyword(s):  
In Situ Measurements ◽  
Total Alkalinity ◽  
Lab On Chip ◽  
On Chip

Point-of-Care Systems for Rapid DNA Quantification in Oncology

2008 ◽  
Vol 94 (2) ◽  
pp. 216-225 ◽  
Author(s):  
Marco Bianchessi ◽  
Sarah Burgarella ◽  
Marco Cereda
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Semiconductor Industry ◽  
Point Of Care Testing ◽  
Lab On Chip ◽  
Diagnostic Assays ◽  
Care Systems ◽  
Point Of Care Systems ◽  
The Common ◽  
On Chip

The development of new powerful applications and the improvement in fabrication techniques are promising an explosive growth in lab-on-chip use in the upcoming future. As the demand reaches significant levels, the semiconductor industry may enter in the field, bringing its capability to produce complex devices in large volumes, high quality and low cost. The lab-on-chip concept, when applied to medicine, leads to the point-of-care concept, where simple, compact and cheap instruments allow diagnostic assays to be performed quickly by untrained personnel directly at the patient's side. In this paper, some practical and economical considerations are made to support the advantages of point-of-care testing. A series of promising technologies developed by STMicroelectronics on lab-on-chips is also presented, mature enough to enter in the common medical practice. The possible use of these techniques for cancer research, diagnosis and treatment are illustrated together with the benefits offered by their implementation in point-of-care testing.

A low-cost, label-free DNA detection method in lab-on-chip format based on electrohydrodynamic instabilities, with application to long-range PCR

Lab on a Chip ◽  
2012 ◽  
Vol 12 (22) ◽  
pp. 4738 ◽  
Author(s):  
Mohamed Lemine Youba Diakité ◽  
Jerôme Champ ◽  
Stephanie Descroix ◽  
Laurent Malaquin ◽  
François Amblard ◽  
...  
Keyword(s):  
Long Range ◽  
Detection Method ◽  
Dna Detection ◽  
Low Cost ◽  
Label Free ◽  
Lab On Chip ◽  
Free Dna ◽  
Chip Format ◽  
Long Range Pcr ◽  
On Chip

scholarly journals Subwavelength Grating Double Slot Waveguide Racetrack Ring Resonator for Refractive Index Sensing Application

Sensors ◽  
2020 ◽  
Vol 20 (12) ◽  
pp. 3416 ◽  
Author(s):  
Nikolay Lvovich Kazanskiy ◽  
Svetlana Nikolaevna Khonina ◽  
Muhammad Ali Butt
Keyword(s):  
Ring Resonator ◽  
Numerical Study ◽  
Slot Waveguide ◽  
Lab On Chip ◽  
Subwavelength Grating ◽  
Resonator Design ◽  
Highly Sensitive ◽  
Light Matter Interaction ◽  
On Chip ◽  
The One

In this paper, a racetrack ring resonator design based on a subwavelength grating double slot waveguide is presented. The proposed waveguide scheme is capable of confining the transverse electric field in the slots and the gaps between the grating segments. This configuration facilitates a large light–matter interaction which elevates the sensitivity of the device approximately 2.5 times higher than the one that can be obtained via a standard slot waveguide resonator. The best sensitivity of the design is obtained at 1000 nm/RIU by utilizing a subwavelength grating double slot waveguide of period 300 nm. The numerical study is conducted via 2D and 3D finite element methods. We believe that the proposed sensor design can play an important role in the realization of highly sensitive lab-on-chip sensors.

scholarly journals An Intelligent Low-Power Low-Cost Mobile Lab-On-Chip Yeast Cell Culture Platform

IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 70733-70745
Author(s):  
Yumin Liao ◽  
Ningmei Yu ◽  
Dian Tian ◽  
Chen Wang ◽  
Shuaijun Li ◽  
...  
Keyword(s):  
Cell Culture ◽  
Low Power ◽  
Yeast Cell ◽  
Low Cost ◽  
Lab On Chip ◽  
On Chip

Microfluidic Control Using Vapor Based Valves

2007 ◽  
Author(s):  
Wei Xu ◽  
Hong Xue ◽  
Mark Bachman ◽  
G. P. Li
Keyword(s):  
Temperature Gradient ◽  
Low Cost ◽  
Constant Flow ◽  
Lab On Chip ◽  
Air Pocket ◽  
Valve Function ◽  
Air Valve ◽  
On Chip ◽  
Silicon Based ◽  
At Will

Microflow valving and regulating are two important functions for microfluidic systems for applications such as Lab-on-Chip. Although silicon based counterparts have been studied extensively, few good technologies exist for polymer based microvalves and regulators. In this paper, we present designs and methods for microvalve and microflow regulators that are readily integrated into polymer microfluidic devices. The technologies utilize “air-pocket” structures built into the sidewalls of the microchannels. When liquid is filled in such a channel, air is trapped in “air pocket” structures due to the hydrophobicity of the polymer. By creating a small thermal gradient between the fluid in the channel and the air in the pockets, one can controllably evaporate fluid into the air pocket where it condenses. This displaces air out of the pocket into the flow channel, increasing the resistance to flow. The air valve retreats to its original pocket when the temperature gradient is removed, thus allowing one to increase or decrease fluid flow at will. If the temperature gradient is maintained long enough, the air will completely block the channel, forming an irreversible valving of the flow. Therefore, the same device can be used as either a valve or flow-regulating device. Microfluidic prototypes were built and tested using this technology. The results show successful constant flow delivery as well as valve function. This novel vapor based microflow valve and regulator has advantages of low cost, simple design, and both ease of fabrication and integration.

scholarly journals An Optical Fiber Chemical Sensor for the Detection of Copper(II) in Drinking Water

Sensors ◽  
2019 ◽  
Vol 19 (23) ◽  
pp. 5246 ◽  
Author(s):  
Pesavento ◽  
Profumo ◽  
Merli ◽  
Cucca ◽  
Zeni ◽  
...  
Keyword(s):  
Drinking Water ◽  
Optical Fiber ◽  
Optical Fibers ◽  
Chemical Sensor ◽  
Low Cost ◽  
Self Assembled Monolayer ◽  
Ph Values ◽  
Highly Sensitive ◽  
Selective Sensor

Highly sensitive plasmonic optical fiber platforms combined with receptors have been recently used to obtain selective sensors. A low-cost configuration can be obtained exploiting a D-shaped plastic optical fiber covered with a multilayer sensing surface. The multilayer consists of a gold film, functionalized with a specific receptor, where the surface plasmon resonance (SPR) occurs. The signal is produced by the refractive index variation occurring as a consequence of the receptor-to analyte binding. In this work, a selective sensor for copper(II) detection in drinking water, exploiting a self-assembled monolayer (SAM) of d,l-penicillamine as the sensing layer, has been developed and tested. Different concentrations of copper(II) in NaCl 0.1 M solutions at different pH values and in a real matrix (drinking water) have been considered. The results show that the sensor is able to sense copper(II) at concentrations ranging from 4 × 10-6 M to 2 × 10-4 M. The use of this optical chemical sensor is a very attractive perspective for fast, in situ and low-cost detection of Cu(II) in drinking water for human health concerns. Furthermore, the possibility of remote control is feasible as well, because optical fibers are employed.

Development of highly sensitive polysilicon nanogap with APTES/GOx based lab-on-chip biosensor to determine low levels of salivary glucose

2014 ◽  
Vol 220 ◽  
pp. 101-111 ◽  
Author(s):  
Sharma Rao Balakrishnan ◽  
U. Hashim ◽  
G.R. Letchumanan ◽  
M. Kashif ◽  
A.R. Ruslinda ◽  
...  
Keyword(s):  
Lab On Chip ◽  
Highly Sensitive ◽  
Low Levels ◽  
On Chip
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