scholarly journals Identification of Two New Phenanthrenes from Dendrobii Herba and Their Cytotoxicity towards Human Hypopharynx Squamous Carcinoma Cell (FaDu)

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2339 ◽  
Author(s):  
Bomi Nam ◽  
Seung Mok Ryu ◽  
Dongho Lee ◽  
Chan-Hun Jung ◽  
Chang Hyun Jin ◽  
...  
Keyword(s):  
Mass Spectra ◽  
Carcinoma Cell ◽  
Soluble Fraction ◽  
Spectroscopic Method ◽  
Squamous Carcinoma ◽  
2D Nmr ◽  
Ionization Mass ◽  
One Dimensional ◽  
Ic50 Values ◽  
Squamous Carcinoma Cell

Two new phenanthrenes, (1R,2R)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1H)-one (1) and 2,7-dihydroxy-phenanthrene-1,4-dione (2), were isolated from the ethyl acetate-soluble fraction of Dendrobii Herba, together with seven known phenanthrenes (3–9), two bibenzyls (10–12), and a lignan (13). Structures of 1 and 2 were elucidated by analyzing one-dimensional (1D) and two-dimensional (2D)-NMR and High-resolution electrospray ionization mass spectra (HR-ESI-MS) data. The absolute configuration of compound 1 was confirmed by the circular dichroism (CD) spectroscopic method. In cytotoxicity assay using FaDu human hypopharynx squamous carcinoma cell line, compounds 3–6, 8, 10, and 12 showed activities, with IC50 values that ranged from 2.55 to 17.70 μM.

A variant form of laminin is responsible for the neurite promoting activity in conditioned medium from a squamous carcinoma cell line

1991 ◽  
Vol 16 ◽  
pp. 82
Author(s):  
Hidehiko Yoshida ◽  
Shuji Hasegawa ◽  
Hiroshi Kuromi ◽  
Hideki Tanzawa ◽  
Kikuo Takahashi ◽  
...  
Keyword(s):  
Cell Line ◽  
Conditioned Medium ◽  
Carcinoma Cell ◽  
Squamous Carcinoma ◽  
Carcinoma Cell Line ◽  
Variant Form ◽  
Squamous Carcinoma Cell

scholarly journals Antiproliferative Illudalane Sesquiterpenes from the Marine Sediment Ascomycete Aspergillus oryzae

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 333
Author(s):  
Raha Orfali ◽  
Shagufta Perveen ◽  
Muhammad Farooq Khan ◽  
Atallah F. Ahmed ◽  
Mohammad A. Wadaan ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Aspergillus Oryzae ◽  
Marine Sediment ◽  
Zebrafish Embryo ◽  
Human Lung ◽  
Carcinoma Cell ◽  
2D Nmr ◽  
Carcinoma Cell Lines ◽  
Ic50 Values ◽  
Breast Carcinoma Cell Lines

The new asperorlactone (1), along with the known illudalane sesquiterpene echinolactone D (2), two known pyrones, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (3) and its acetate 4, and 4-hydroxybenzaldehyde (5), were isolated from a culture of Aspergillus oryzae, collected from Red Sea marine sediments. The structure of asperorlactone (1) was elucidated by HR-ESIMS, 1D, and 2D NMR, and a comparison between experimental and DFT calculated electronic circular dichroism (ECD) spectra. This is the first report of illudalane sesquiterpenoids from Aspergillus fungi and, more in general, from ascomycetes. Asperorlactone (1) exhibited antiproliferative activity against human lung, liver, and breast carcinoma cell lines, with IC50 values < 100 µM. All the isolated compounds were also evaluated for their toxicity using the zebrafish embryo model.

scholarly journals tert-Butylphenolic Derivatives from Paenibacillus odorifer—A Case of Bioconversion

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1951 ◽  
Author(s):  
Thi-Bach-Le Nguyen ◽  
Olivier Delalande ◽  
Isabelle Rouaud ◽  
Solenn Ferron ◽  
Laura Chaillot ◽  
...  
Keyword(s):  
Bacterial Strain ◽  
2D Nmr ◽  
One Dimensional ◽  
Spectroscopic Analyses ◽  
Human Keratinocyte ◽  
Rhizocarpon Geographicum ◽  
Ionisation Mass Spectrometry ◽  
Keratinocyte Cell ◽  
Ic50 Values ◽  
First Time

Two compounds (1) and (2) containing tert-butylphenol groups were, for the first time, produced during the culture of Paenibacillus odorifer, a bacterial strain associated with the crustose lichen, Rhizocarpon geographicum. Their entire structures were identified by one-dimensional (1D) and two-dimensional (2D) NMR and high-resolution electrospray ionisation mass spectrometry (HRESIMS) spectroscopic analyses. Among them, Compound 1 exhibited significant cytotoxicity against B16 murine melanoma and HaCaT human keratinocyte cell lines with micromolar half maximal inhibitory concentration (IC50) values. Furthermore, after supplementation studies, a putative biosynthesis pathway was proposed for Compound 1 throughout a bioconversion by this bacterial strain of butylated hydroxyanisole (BHA), an antioxidant polymer additive.

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