The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet

Artesunate was well known as an antimalarial drug. Our previous research found that it has hypolipidemia effects in rabbits fed with a high-fat diet, especially combined with ursolic acid. In this study, we reconfirmed the lipid-lowering effect of artesunate and ursolic acid in hamsters and analyzed the metabolic changes using gas chromatography time-of-flight mass spectrometry (GC/TOF MS). Compared with the model group, a variety of different metabolites of artesunate and ursolic acid, alone or in combination, were found and confirmed. These differential metabolites, including fatty acids, lipids, and amino acids, were involved in lipid metabolism, energy metabolism, and amino acid metabolism. It indicated that two agents of artesunate and ursolic acid could attenuate or normalize the metabolic transformation on these metabolic pathways.

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Anti-hyperlipidemic effect of rice bran polysaccharide and its potential mechanism in high-fat diet mice

Food & Function ◽

10.1039/c7fo00654c ◽

2017 ◽

Vol 8 (11) ◽

pp. 4028-4041 ◽

Cited By ~ 17

Author(s):

Ying Nie ◽

Feijun Luo ◽

Long Wang ◽

Tao Yang ◽

Limin Shi ◽

...

Keyword(s):

Lipid Metabolism ◽

Rice Bran ◽

High Fat Diet ◽

Lipid Lowering ◽

Potential Mechanism ◽

High Fat ◽

Lowering Effect ◽

Lipid Lowering Effect

The evaluation of the lipid-lowering effect of rice bran polysaccharides (RBP) and identification of the related genes of lipid metabolism. RBP, rice bran polysaccharide; HFD, high fat diet.

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Transcriptome and translatome analyses reveal the regulatory role of betaine in high fat diet (HFD)-induced hepatic steatosis

10.21203/rs.3.rs-461586/v1 ◽

2021 ◽

Author(s):

Tengda Huang ◽

Jingsu Yu ◽

Zupeng Luo ◽

Lin Yu ◽

Siqi Liu ◽

...

Keyword(s):

High Fat Diet ◽

Translational Regulation ◽

Mrna Translation ◽

Lipid Lowering ◽

Common Disease ◽

High Fat ◽

Alcoholic Fatty Liver ◽

Lowering Effect ◽

Lipid Lowering Effect ◽

Translational Level

Abstract Non-alcoholic fatty liver disease (NAFLD) is a common disease with a multitude of complications. Increasing evidence shows that the dietary supplement with betaine, a natural chemical molecule, can effectively reduce the fat accumulation in the liver. Translational regulation is considered to play a vital role in gene expression, but whether betaine functions through the regulation of gene translational level is still unclear. To this end, RNC-seq (ribosome-nascent chain complex bound mRNA sequencing) and RNA-seq co-analyses were performed to identify betaine target genes by using the liver samples from high-fat diet + betaine treated and high-fat diet treated mice. The results showed that betaine does play a lipid-lowering role by regulating the expression of gene translation levels; some NAFLD- and lipid metabolism- associated genes were differentially expressed at translational level, for example. And the mRNA translation ratio (TR) of gene significantly increased after betaine treatment. Besides, it is found that the regulation of some genes at transcriptional level is opposite to that at translational level, which indicates that transcriptional regulation and translational regulation may be independent from each other. Finally, we identified several candidate genes, especially Gpc1 , which may mediate the lipid-lowering effect of betaine in the liver. To sum up, this study depicted the molecular portrait of mice liver with or without betaine treatment from the angel of translatome and transcriptome, giving insights into the molecular mechanism of betaine-mediated lipid-lowering effect and also providing new clues for understanding and prevention of NAFLD.

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The gut microbiota confers the lipid-lowering effect of bitter melon (Momordica charantia L.) In high-fat diet (HFD)-Induced hyperlipidemic mice

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2020.110667 ◽

2020 ◽

Vol 131 ◽

pp. 110667

Author(s):

Fang Zhang ◽

Xiaopo Zhang ◽

Jiaqi Yu ◽

Yinfeng Tan ◽

Peng Guo ◽

...

Keyword(s):

Gut Microbiota ◽

High Fat Diet ◽

Momordica Charantia ◽

Lipid Lowering ◽

Bitter Melon ◽

High Fat ◽

Lowering Effect ◽

Lipid Lowering Effect

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The metabolic change of serum lysophosphatidylcholines involved in the lipid lowering effect of triterpenes from Alismatis rhizoma on high-fat diet induced hyperlipidemia mice

Journal of Ethnopharmacology ◽

10.1016/j.jep.2015.11.017 ◽

2016 ◽

Vol 177 ◽

pp. 10-18 ◽

Cited By ~ 32

Author(s):

Sen Li ◽

Shuna Jin ◽

Chengwu Song ◽

Chang Chen ◽

Yang Zhang ◽

...

Keyword(s):

High Fat Diet ◽

Metabolic Change ◽

Lipid Lowering ◽

High Fat ◽

Lowering Effect ◽

Alismatis Rhizoma ◽

Lipid Lowering Effect

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Hypolipidemic Effects of Three Purgative Decoctions

Evidence-based Complementary and Alternative Medicine ◽

10.1093/ecam/nep178 ◽

2011 ◽

Vol 2011 ◽

pp. 1-10 ◽

Cited By ~ 6

Author(s):

Sung-Hui Tseng ◽

Ting-Yi Chien ◽

Jiun-Rong Chen ◽

I-Hsin Lin ◽

Ching-Chiung Wang

Keyword(s):

High Fat Diet ◽

Weight Control ◽

Internal Heat ◽

Serum Triglyceride ◽

Hepatic Function ◽

The Body ◽

Lipid Lowering ◽

High Fat ◽

Beneficial Effects ◽

Lipid Lowering Effect

In traditional Chinese medicine (TCM), purgation is indicated when a person suffers an illness due to the accumulation of evil internal heat. Obese individuals with a large belly, red face, thick and yellow tongue fur, constipation, and avoidance of heat are thought accumulates of evil internal heat, and they are also treated with purgatives such asTa-Cheng-Chi-Tang(TCCT),Xiao-Chen-Chi-Tang(XCCT), andTiao-Wei-Chen-Chi-Tang(TWCCT) by TCM doctors. In previous studies, our group found that TCCT has potent anti-inflammatory activity, and that XCCT is an effective antioxidant. Since rhubarb is the principle herb in these three prescriptions, we will first present a thorough review of the literature on the demonstrated effect (or lack of effect) of rhubarb and rhubarb-containing polyherbal preparations on lipid and weight control. We will then continue our research with an investigation of the anti-obesity and lipid-lowering effect of TCCT, XCCT, TWCCT, and rhubarb extracts using two animal models. TWCCT lowered the serum triglyceride concentration as much as fenofibrate in Triton WR-1339-treated mice. Daily supplementation with XCCT and TWCCT significantly attenuated the high-fat-diet-induced hypercholesterolemia in rats. In addition, TWCCT also significantly lowered the high-fat-diet-induced hypertriglycemia. Although feeding high-fat diet rats with these extracts did not cause loose stools or diarrhea or other deleterious effects on renal or hepatic function. None of these extracts lowered the body weight of rats fed on high-fat diet. In conclusion, the results suggest that XCCT and TWCCT might exert beneficial effects in the treatment of hyperlipidemia.

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Lipid-lowering effect of molluscan (Katelysia opima) glycosaminoglycan (GAG) in hypercholesterolemic induced rats

Biological Chemistry ◽

10.1515/hsz-2013-0214 ◽

2014 ◽

Vol 395 (3) ◽

pp. 355-364 ◽

Cited By ~ 1

Author(s):

Vijayabaskar Pandian ◽

Natarajan Aravindan ◽

Sethupathy Subramanian ◽

Somasundaram T. Somasundaran

Keyword(s):

High Fat Diet ◽

Low Density Lipoprotein ◽

Cholesterol Acyltransferase ◽

Density Lipoprotein ◽

Lipid Lowering ◽

Low Density ◽

High Fat ◽

Lecithin Cholesterol Acyltransferase ◽

Baseline Levels ◽

Lipid Lowering Effect

Abstract Identifying pharmacologically safe lipid-lowering ‘deliverables’ could potentiate therapeutic outcome for diet-induced atherogenesis. Accordingly, we investigated the potential of molluscan (Katelysia opima) glycosaminoglycan (GAG) in modulating the early lipid changes in atherogenesis. Wistar rats were fed a diet with (n=24) or without (n=6) hypercholesterolemic atherogenic CCT (rat chow supplemented with 4% cholesterol, 1% cholic acid, and 0.5% thiouracil) for 17 days. CCT-fed rates were (i) treated with isolated molluscan GAG (40 mg/kg/day, s.c.) for 10 days after the introduction of CCT diet, (ii) cotreated with GAG (40 mg/kg/day, s.c.) for 17 days, or (iii) treated with heparin (200 units/kg/day, s.c.) for 10 days after the introduction of CCT. The increases induced by CCT diet in the plasma levels of cholesterol, triglycerides, high-density lipoprotein, very-low-density lipoprotein, and low-density lipoprotein were completely attenuated with GAG treatment. Consistently, alterations induced by CCT diet in the levels of plasma lecithin cholesterol acyltransferase and lipoprotein lipase activities were restored to baseline levels with GAG treatment. Coherently, histology revealed a decrease associated with GAG treatment in the CCT-diet-induced foam cells (in aorta), tubular damages (kidney), and lipid accumulations (liver). Together, these results suggest that GAG may exert antiatherogenesis potential by significantly attenuating lipid modulations derived by a high-fat diet. Further, the data imply that the GAG extracts may comprehensively prevent hypercholesterolemia-associated tissue damage and could thus serve as a therapeutic deliverable for hypercholesterolemia.

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Rosmarinic Acid Exhibits a Lipid-Lowering Effect by Modulating the Expression of Reverse Cholesterol Transporters and Lipid Metabolism in High-Fat Diet-Fed Mice

Biomolecules ◽

10.3390/biom11101470 ◽

2021 ◽

Vol 11 (10) ◽

pp. 1470

Author(s):

Jean Baptiste Nyandwi ◽

Young Shin Ko ◽

Hana Jin ◽

Seung Pil Yun ◽

Sang Won Park ◽

...

Keyword(s):

Lipid Metabolism ◽

Cardiovascular Diseases ◽

High Fat Diet ◽

Rosmarinic Acid ◽

Acid Treatment ◽

Lipid Lowering ◽

High Fat ◽

Lowering Effect ◽

Lipid Lowering Effect ◽

Liver Tissues

Hyperlipidemia is a potent risk factor for the development of cardiovascular diseases. The reverse cholesterol transport (RCT) process has been shown to alleviate hyperlipidemia and protect against cardiovascular diseases. Recently, rosmarinic acid was reported to exhibit lipid-lowering effects. However, the underlying mechanism is still unclear. This study aims to investigate whether rosmarinic acid lowers lipids by modulating the RCT process in high-fat diet (HFD)-induced hyperlipidemic C57BL/6J mice. Our results indicated that rosmarinic acid treatment significantly decreased body weight, blood glucose, and plasma total cholesterol and triglyceride levels in HFD-fed mice. Rosmarinic acid increased the expression levels of cholesterol uptake-associated receptors in liver tissues, including scavenger receptor B type 1 (SR-B1) and low-density lipoprotein receptor (LDL-R). Furthermore, rosmarinic acid treatment notably increased the expression of cholesterol excretion molecules, ATP-binding cassette G5 (ABCG5) and G8 (ABCG8) transporters, and cholesterol 7 alpha-hydroxylase A1 (CYP7A1) as well as markedly reduced cholesterol and triglyceride levels in liver tissues. In addition, rosmarinic acid facilitated fatty acid oxidation through AMP-activated protein kinase (AMPK)-mediated carnitine palmitoyltransferase 1A (CPT1A) induction. In conclusion, rosmarinic acid exhibited a lipid-lowering effect by modulating the expression of RCT-related proteins and lipid metabolism-associated molecules, confirming its potential for the prevention or treatment of hyperlipidemia-derived diseases.

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