scholarly journals Inhibition of Lipid Accumulation and Adipokine Levels in Maturing Adipocytes by Bauhinia rufescens (Lam.) Stem Bark Extract Loaded Titanium Oxide Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7238
Author(s):  
Ghedeir M. Alshammari ◽  
Abu ElGasim A. Yagoub ◽  
Pandurangan Subash-Babu ◽  
Amro B. Hassan ◽  
Doha M. Al-Nouri ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Stem Bark ◽  
Lipid Lowering ◽  
Bark Extract ◽  
Related Gene ◽  
Gene Expressions ◽  
Gene Markers ◽  
Tio2 Nps ◽  
Ft Ir ◽  
Stem Bark Extract

The present study reports a cost-effective, environmentally friendly method to increase the bioavailability and bio-efficacy of B. rufescens stem bark extract in the biological system via functional modification as B. rufescens stem bark nanoparticles (BR-TO2-NPs). The biosynthesis of BR- -NPs was confirmed by UV-visible (UV-vis) and Fourier-transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), and X-ray diffraction analyses. The shifts in FT-IR stretching vibrations of carboxylic and nitro groups (1615 cm−1), the O–H of phenolics or carboxylic acids (3405 cm−1), alkanes, and alkyne groups (2925 and 2224 cm−1) of the plant extract and lattice (455) indicated successful biosynthesis of BR- -NPs. Compared with the stem bark extract, 40 ng/dL dose of BR- -NPs led to a reduction in adipogenesis and an increase in mitochondrial biogenesis-related gene expressions, adiponectin-R1, PPARγC1α, UCP-1, and PRDM16, in maturing-adipocytes. This confirmed the intracellular uptake, bioavailability, and bio-efficiency of BR-TiO2-NPs. The lipid-lowering capacity of BR-TiO2-NPs effectively inhibited the metabolic inflammation-related gene markers, IL-6, TNF-α, LTB4-R, and Nf-κb. Further, BR-TiO2-NPs stimulating mitochondrial thermogenesis capacity was proven by the significantly enhanced CREB-1 and AMPK protein levels in adipocytes. In conclusion, BR-TiO2-NPs effectively inhibited lipid accumulation and proinflammatory adipokine levels in maturing adipocytes; it may help to overcome obesity-associated comorbidities.

scholarly journals Isolation and Characterization of Secondary Metabolite from the Stem Bark Extract of Allophylus africanus Beauv (Sapindaceae)

2021 ◽  
Vol 46 (2) ◽  
Author(s):  
C.G. Kwekowe ◽  
E.O. Johnbull ◽  
I.E. Otuokere
Keyword(s):  
1H Nmr ◽  
Stem Bark ◽  
Spectroscopic Studies ◽  
Wide Distribution ◽  
Solvent Mixture ◽  
Bark Extract ◽  
Spectra Analysis ◽  
Isolation And Characterization ◽  
Ft Ir ◽  
Stem Bark Extract

Isolation of secondary metabolites from the stem bark of Allophylus africanus Beauv (Sapindaceae) was carried out. The plant has a wide distribution in West Africa, with Nigeria (Mambila Plateau, Calabar) inclusive. It has been used in communities for both its medicinal and economic importance. The stem bark of A. africanus was extracted by percolation using chloroform as solvent and concentrated by evaporation at room temperature. Single spot with an Rf value of 0.87 was obtained at a solvent mixture of hexane: chloroform at ratio 2:8 from finger column chromatography . Characterization using spectra analysis which include FT-IR, 1H-NMR, 13C-NMR, H-H COSY, H-C COSY, 135 DEPT and mass spectroscopy.  Spectroscopic  studies  of  A. Africanus stem bark extract led to the elucidation of the structure of the compound.  FT-IR spectrum indicates  that the compound is an aromatic derivative. Aromatic protons where seen at the 1H-NMR chemical shift values of 7.25 ppm. Olefinic protons at 5.124,  5.146  and  6.162  ppm  appeared  as  doublets  of  doublets  of  doublets. The  compound  1-((E)- 7(((1E,5E)-6-((2,3-dimethyl-4-(((E)-3,4,5,6-tetramethyldeca-7,9-dien-2-yl)oxy)pentyl)oxy)-3,4- dimethylhexa-1,5-dien-1-yl)oxy)hept-4-en-1-yl)-4-propylbenzene was isolated.

Sequestered uptake of chromium(VI) by Irvingia gabonensis stem bark extract anchored silica gel

2021 ◽  
Author(s):  
James F. Amaku ◽  
Segun A. Ogundare ◽  
Kovo G. Akpomie ◽  
Comfort M. Ngwu ◽  
Jeanet Conradie
Keyword(s):  
Silica Gel ◽  
Stem Bark ◽  
Bark Extract ◽  
Chromium Vi ◽  
Irvingia Gabonensis ◽  
Stem Bark Extract

scholarly journals Carbohydrate digestive enzymes are inhibited by Poincianella pluviosa stem bark extract: relevance on type 2 diabetes treatment

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Camila Gabriel Kato-Schwartz ◽  
Anacharis Babeto de Sá-Nakanishi ◽  
Ana Carolina Guidi ◽  
Geferson de Almeida Gonçalves ◽  
Fernanda Giacomini Bueno ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Digestive Enzymes ◽  
Stem Bark ◽  
Bark Extract ◽  
Diabetes Treatment ◽  
Type 2 Diabetes Treatment ◽  
Stem Bark Extract

scholarly journals Effect of Carica papaya L. Stem Bark Extracts on Cholesterol Concentration in Rats Induced with Streptosozin

2020 ◽  
Vol 151 ◽  
pp. 01011
Author(s):  
Safrida Safrida ◽  
Mustafa Sabri
Keyword(s):  
Body Weight ◽  
Carica Papaya ◽  
Stem Bark ◽  
Negative Control ◽  
Diabetic Rats ◽  
Cholesterol Concentration ◽  
Bark Extract ◽  
Treatment Groups ◽  
Randomized Design ◽  
Stem Bark Extract

This study was designed to determine the effect of Carica papaya L. stem bark extracts on cholesterol concentration in rats induced with glibenclamide. A completely randomized design was used for the experiment which consisted of 6 treatment groups, each group consisted of four rats, as follows:1) KN (negative control, non-diabetic rats); KP, diabetic rats given glibenclamide 10 mg/kg body weight; EP 1, diabetic rats given 0 mg/kg body weight/day extract; EP2, diabetic rats given 100 mg/kg body weight/day extract; and EP3, diabetic rats given 200 mg/kg body weight/day extract, EP4, diabetic rats given 300 mg/kg body weight/day extract for 28 day. The results showed that C. papaya L. stem bark extract decreased (P<0.05) cholesterol levels in diabetic rats. It was concluded that C. papaya L. stem bark extract had potential as anti-hypercholesterolemic in diabetic rats.

Sub-chronic Study of Aqueous Stem Bark Extract of Senna siamea in Rats

2012 ◽  
Vol 5 (6) ◽  
pp. 314-321 ◽  
Author(s):  
A. Mohammed ◽  
S.B. Mada ◽  
H.M. Yakasai
Keyword(s):  
Stem Bark ◽  
Bark Extract ◽  
Senna Siamea ◽  
Chronic Study ◽  
Stem Bark Extract
Sign in / Sign up

Export Citation Format

Share Document