Copper-Catalyzed Ring-Opening Reactions of Alkyl Aziridines with B2pin2: Experimental and Computational Studies
Keyword(s):
The possibility to form new C–B bonds with aziridines using diboron derivatives continues to be a particularly challenging field in view of the direct preparation of functionalized β-aminoboronates, which are important compounds in drug discovery, being a bioisostere of β-aminoacids. We now report experimental and computational data that allows the individuation of the structural requisites and of reaction conditions necessary to open alkyl aziridines using bis(pinacolate)diboron (B2pin2) in a regioselective nucleophilic addition reaction under copper catalysis.
2014 ◽
Vol 70
(3)
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pp. o372-o373
2021 ◽
1986 ◽
Vol 108
(10)
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pp. 2517-2527
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Keyword(s):
1976 ◽
Vol 17
(36)
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pp. 3109-3112
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