scholarly journals Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1936 ◽  
Author(s):  
Diego Stéfani T. Martinez ◽  
Gabriela H. Da Silva ◽  
Aline Maria Z. de Medeiros ◽  
Latif U. Khan ◽  
Anastasios G. Papadiamantis ◽  
...  

In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the Daphnia magna model and assessing acute toxicity determined as immobilisation. Cadmium (Cd2+) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd2+ adsorption capacity (ca. 4.5 times) in reconstituted water (Daphnia medium). The acute toxicity values (48 h-EC50) observed were 0.18 mg L−1 for Cd2+-only and 0.29 and 0.61 mg L−1 following co-exposure of Cd2+ with GO and BSA@GO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L−1. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd2+-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets.

1998 ◽  
Vol 33 (1) ◽  
pp. 95-110 ◽  
Author(s):  
W.R. Bennett ◽  
A.P. Farrell

Abstract The primary goal of this study was to investigate the possibility of using early life stages of white sturgeon (Acipenser transmontanus) (eggs, larvae and fry) as a species relevant to the Fraser River, B.C., for the acute and sublethal toxico-logical testing of forest industry effluents. Here we report the first successful acute toxicity tests for 8-day-old larvae and 42-day-old fry exposed to several chemicals known to be released into the Fraser River (i.e., 6 monochlorovanillin [6 MVAN], 4,5 dichloroguaiacol [4,5 DCG], 4,5 dichlorocatechol [4,5 DCAT], pentachlorophenol [PCP], and didecyldimethylammonium chloride [DDAC]). In most cases, white sturgeon fry were at the lower end of the range for acute toxicity values for chlorinated phenolic compounds, when compared with other juvenile fish species, and they were extremely sensitive to DDAC. The larval stage was usually more sensitive than the fry stage. Acute toxicity tests with fertilized eggs were unsuccessful. A postexposure growth study was inconclusive because neither control nor toxicant-exposed larvae and fry withstood the additional handling used for measuring body mass. At 62-days-old, fry were more tolerant of handling. This allowed measurement of their swimming performance. Although we have concerns about the reliability of using larvae for acute toxicity testing at this time, 60-day-old white sturgeon fry would appear to be both a sensitive and relevant species for assessing environmental impacts relevant to the Fraser River.


2008 ◽  
Vol 15 (5) ◽  
pp. 394-404 ◽  
Author(s):  
Stefan Scholz ◽  
Stephan Fischer ◽  
Ulrike Gündel ◽  
Eberhard Küster ◽  
Till Luckenbach ◽  
...  

2011 ◽  
Vol 103 (1-2) ◽  
pp. 38-45 ◽  
Author(s):  
Roman Ashauer ◽  
Anita Hintermeister ◽  
Eva Potthoff ◽  
Beate I. Escher

2021 ◽  
pp. 117213
Author(s):  
Binbin Sun ◽  
Yinqing Zhang ◽  
Ruixuan Li ◽  
Kunkun Wang ◽  
Bowen Xiao ◽  
...  

2016 ◽  
Vol 258 ◽  
pp. S66
Author(s):  
O. Olaru ◽  
G. Nitulescu ◽  
C. Spinu ◽  
I. Potolea ◽  
O. Pirvu ◽  
...  

2022 ◽  
Vol 45 ◽  
pp. 102485
Author(s):  
Carlos Eduardo Lach ◽  
Camila Schwarz Pauli ◽  
Aline Scheller Coan ◽  
Edesio Luiz Simionatto ◽  
Luciano André Deitos Koslowski

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