Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

With a fascinating complexity, governed by multiple physiological processes, the skin is considered a mantle with protective functions which during lifetime are frequently impaired, triggering dermatologic disorders. As one of the most prevalent dermatologic conditions worldwide, characterized by a complex pathogenesis and a high recurrence, acne can affect the patient’s quality of life. Smart topical vehicles represent a good option in the treatment of a versatile skin condition. By surpassing the stratum corneum known for diffusional resistance, a superior topical bioavailability can be obtained at the affected place. In this direction, the literature study presents microemulsions as a part of a condensed group of modern formulations. Microemulsions are appreciated for their superior profile in matters of drug delivery, especially for challenging substances with hydrophilic or lipophilic structures. Formulated as transparent and thermodynamically stable systems, using simplified methods of preparation, microemulsions have a simple and clear appearance. Their unique structures can be explained as a function of the formulation parameters which were found to be the mainstay of a targeted therapy.

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ISA247: Quality of Life Results from a Phase II, Randomized, Placebo-Controlled Study

Journal of Cutaneous Medicine and Surgery ◽

10.2310/7750.2008.07060 ◽

2008 ◽

Vol 12 (6) ◽

pp. 268-275 ◽

Cited By ~ 9

Author(s):

Aditya K. Gupta ◽

Richard G. Langley ◽

Charles Lynde ◽

Kirk Barber ◽

Wayne Gulliver ◽

...

Keyword(s):

Quality Of Life ◽

Phase Ii ◽

Life Quality ◽

Skin Condition ◽

Controlled Study ◽

Double Blind ◽

Plaque Type ◽

Psoriasis Disability Index ◽

Stable Plaque

Background: Psoriasis is a chronic skin condition that can negatively affect a patient's quality of life (QoL), often hindering social functioning. ISA247, a novel psoriatic agent, has shown clinical efficacy in moderate to severe psoriasis sufferers, but its effect on QoL is currently not reported. Objective: The objective of this study was to assess the effect of ISA247 on the QoL in patients with stable, plaque-type psoriasis. Methods: A phase II, randomized, double-blind, placebo-controlled, parallel-group, multicenter study assessed the effects of ISA247 doses of 0.5 mg/kg/d ( n = 77) or 1.5 mg/kg/d ( n = 83) compared with placebo ( n = 41) for 12 weeks. QoL was assessed using the Dermatology Life Quality Index (DLQI) and Psoriasis Disability Index (PDI) scales. Results: ISA247 treatment (pooled groups) significantly improved QoL scores as assessed by both the DLQI and the PDI compared with those receiving placebo ( p < .05). Treatment with the higher dose of 1.5 mg/kg/d demonstrated a significantly greater response to many of the QoL scales compared with the 0.5 mg/kg/d group ( p < .05). Conclusions: ISA247 appears to improve the QoL while also providing effective treatment for chronic, moderate to severe, plaque-type psoriasis.

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Manfaat Progressive Muscle Relaxation (PMR) sebagai intervensi keperawatan dalam meningkatkan Quality of Life (QOL) wanita kanker payudara yang menjalani kemoterapi

Indonesian Journal of Nursing Research (IJNR) ◽

10.35473/ijnr.v2i1.233 ◽

2019 ◽

Vol 2 (1) ◽

Author(s):

Anastasia Diah Larasati ◽

Anggorowati Anggorowati ◽

Andrew Johan

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Stress Reduction ◽

Muscle Relaxation ◽

Epidemiological Data ◽

Review Literature ◽

Progressive Muscle Relaxation ◽

Literature Study ◽

Patient Will

Based on epidemiological data, the incidence recorded globally by theInternational Agency for Research On Cancer (IARC) in 2012, as many as 43.3women had breast cancer. The patient will undergoing chemotherapy andexperience various disturbing symptoms. Various complaints can affect QOL.One of the therapies recommended by the journal Oncology Nursing is thetherapy of Progressive Muscle Relaxation (PMR).Objective: To find out the benefits of PMR as one of the nursing interventions indealing with the quality of life for women Ca. Mammae is undergoingchemotherapyThe method used in this paper is a review literature study. Databases used insource search are CINAHL, PubMed, Science Direct, and Medline. The criterionof inclusion in literature search is the year of article publishing starting in 2010until 2018, and the English full article. Search keywords are Progressive MuscleRelaxation, breast cancer, quality of life and chemotherapy. Literature analysisuses PICOT (Population, Intervention, Comparison, Outcome, and Time).Based on the analysis found 5 themes, namely the quality of life characteristicsof patients undergoing chemotherapy, PMR as a relaxation therapy, PMR as apsychological stress reduction intervention, PMR as an intervention to increasemuscle metabolism, and PMR as a pain reduction intervention.Patients who undergoing chemotherapy will experience a decrease in QOL. PMRis a recommended intervention to improve patient QOL.

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Combine therapy as a modern approach to treatment of allergic rhinitis

Terapevticheskii arkhiv ◽

10.26442/00403660.2021.08.200995 ◽

2021 ◽

Vol 93 (8) ◽

pp. 986-990

Author(s):

Alexander V. Emelyanov

Keyword(s):

Quality Of Life ◽

Clinical Trials ◽

Allergic Rhinitis ◽

Suboptimal Control ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Double Blind ◽

Modern Approach ◽

Dose Combination

Allergic rhinitis (AR) is one the most common allergic diseases affecting from 10 to 40% of the population in different countries, including Russia. AR is a risk factor of bronchial asthma, other upper airway disease and may decrease patient quality of life, their productivity, increase probability of occupational traumatism, depression and anxiety. AR also presents a substantial economic burden. The rationale to use fixed dose combination of intranasal steroids and topical H1 antihistamines includes suboptimal control of symptoms by monotherapy, its complementary pharmacologic activity and the results of clinical trials. This review focused on fixed dose combination of intranasal mometasone furoate and olopataine. Double blind placebo-controlled and open clinical trials have confirmed that this combination decreased severity of nasal and ocular symptoms of seasonal and perennial AR, improved patient quality of life and had a good tolerability. Its efficacy was higher than those of monotherapy. Fast onset of action and sustainable effect on symptoms (during 1 yr) may improve adherence patients to the treatment and control of symptoms of AR.

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SciaticNeuralgia an Agonising Encumbrance and its Modern Approach

COJ Nursing & Healthcare ◽

10.31031/cojnh.2018.03.000569 ◽

2018 ◽

Vol 3 (4) ◽

Author(s):

Avinash Shankar

Keyword(s):

Quality Of Life ◽

Clinical Response ◽

Medical Diagnosis ◽

Calcium Supplementation ◽

Modern Approach ◽

Excellent Quality ◽

Post Therapy

Sciatica not a medical diagnosis but is a symptom of an underlying vertebral condition i.e.,-lumbar herniation. dislocated disc, Spondylolisthesis and spinal stenosiswhere usually practiced medicine.Physicaltherapy, surgery and even alternative therapyfails to ensure cure but present regimea composite ofintravenous Calcium supplementation, cholecalciferoland bio neurogen composite achieved grade I clinical response in 93% cases without anywithdrawal. Drug adversity, hepatorenal alteration and recurrence in 5yrs of post therapy follow up with excellent quality of life

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External genital endometriosis: treatment and rehabilitation

Obstetrics Gynecology and Reproduction ◽

10.17749/2313-7347/ob.gyn.rep.2020.148 ◽

2020 ◽

Author(s):

A. G. Solopova ◽

E. E. Achkasov ◽

V. S. Moskvichyova ◽

E. Grigorevskaya ◽

D. M. Ampilogova

Keyword(s):

Quality Of Life ◽

Malignant Tumors ◽

Pathological Process ◽

Social Adaptation ◽

Cochrane Library ◽

Current View ◽

Comprehensive Treatment ◽

Modern Approach ◽

Rehabilitation Programs

Aim: to systematize data on rehabilitation methods and management tactics for women with external form of genital endometriosis.Materials and Methods. We searched for publications in international scientific databases: scientific electronic library eLibrary, Scholar, ScienceDirect, Cochrane Library, PubMed/MEDLINE for the last 5 years. The data on the modern approach to the therapy and rehabilitation of women with external genital endometriosis are presented. Search terms in Russian and English were used: “endometriosis”, “rehabilitation”, “gynecology”, “quality of life”.Results. Endometriosis is considered an independent risk factor for the development of malignant tumors not only of the reproductive system, but also of the large intestine, bladder, mammary glands. The review presents a current view of the treatment and rehabilitation of women with external genital endometriosis. Endometriosis is a polyetiological disease that can manifest itself as dysmenorrhea, dyspareunia, chronic pelvic pain, as well as dysuria and dyshesia when involving adjacent organs in the pathological process. Relapses, infertility, emotional and psychosexual disorders, problems with socialization are often detected in these patients.Conclusion. It is necessary not only to conduct comprehensive treatment, but also to develop personalized rehabilitation programs that can improve the quality of life, as well as create comfortable conditions for social adaptation in society.

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KUALITAS HIDUP LANJUT USIA YANG TINGGAL DI PANTI: STUDI LITERATUR

JURNAL KEPERAWATAN ◽

10.35790/jkp.v8i2.32322 ◽

2020 ◽

Vol 8 (2) ◽

pp. 58

Author(s):

Majesty Kowureng ◽

Kairupan Kairupan ◽

Ns. Kristamuliana

Keyword(s):

Quality Of Life ◽

Nursing Homes ◽

Elderly Population ◽

Critical Appraisal ◽

The Elderly ◽

Google Scholar ◽

Literature Study ◽

Physical Activity Interventions ◽

Elderly Living

Abstract : The increasing elderly population is a global phenomenon nowadays. Faced with this, the importance of ensuring the elderly is not only seen from a long life but also the quality of life of the elderly needs to be considered. Objective. The purpose of this literature study is to explain the quality of life and strategies to improve the quality of life of the elderly who live in nursing homes. Method. The method used to compile this literature study is by searching through an electronic database. Searching for articles is done by using the keywords Quality Of Life, Elderly, Nursing Homes, that are traced through Google Scholar, Pubmed, and Science Direct. The Joanna Briggs Institute (JBI) Critical Appraisal is used to assess and analyze the quality of the article methodology. Result. There were 723 articles published from 2015 to 2019 related to the quality of life of elderly living in nursing homes that were identified. However, of 723 articles, only 6 articles met with the review requirements. Six articles that meet the inclusion criteria are divided into two major themes, namely the quality of life of elderly living in nursing homes (4 studies) and interventions that affect improving the quality of life of elderly living in nursing homes (2 studies). Conclusion. This literature study concludes that the majority of elderly people living in nursing homes had a moderate quality of life and physical activity interventions and religious-spiritual interventions affected improving the quality of life in elderly nursing homes. Suggestion. The author suggests making modifications to the nursing care of the elderly who live in nursing homes that are adjusted to any changes that occur in the elderly needed to improve their quality of life.Keywords : Quality of Life, Elderly, Nursing Homes. Abstrak: Peningkatan populasi lanjut usia merupakan fenomena global saat ini. Menghadapi hal tersebut, pentingnya menjamin lanjut usia bukan hanya dilihat dari umur yang panjang, tetapi juga kualitas hidup lanjut usia perlu untuk diperhatikan. Tujuan penelitian ini untuk menjelaskan kualitas hidup dan strategi peningkatan kualitas hidup lanjut usia yang tinggal di panti. Metode yang digunakan untuk menyusun studi literatur ini adalah dengan mencari melalui database elektronik. Pencarian artikel dilakukan dengan menggunakan kata kunci Quality Of Life, Elderly, Nursing Homes, yang ditelusuri melalui Google Scholar, Pubmed, dan Science Direct. Menilai dan menganalisis kualitas metodologi dalam setiap studi menggunakan The Joanna Briggs Institute (JBI) Critical Appraisal. Hasil. Didapatkan 723 artikel terkait kualitas hidup lanjut usia yang tinggal di panti yang diidentifikasi dan dipublikasikan dari tahun 2015-2019. Dari 723 artikel hanya 6 artikel yang memenuhi syarat untuk dianalisis. Enam artikel yang memenuhi kriteria inklusi terbagi menjadi dua tema besar yaitu kualitas hidup lanjut usia yang tinggal di panti (4 studi) dan intervensi yang berpengaruh meningkatkan kualitas hidup lanjut usia yang tinggal di panti (2 studi). Kesimpulan. Dari studi literatur ini dapat disimpulkan bahwa sebagian besar lanjut usia yang tinggal di panti memiliki kualitas hidup pada tingkat sedang dan intervensi aktivitas fisik dan intervensi spiritual keagamaan berpengaruh pada peningkatan kualitas hidup lanjut usia yang tinggal di panti. Saran. Melakukan modifikasi pada asuhan keperawatan lanjut usia yang tinggal di panti yang disesuaikan dengan setiap perubahan yang terjadi pada lanjut usia sangat diperlukan demi meningkatkan kualitas hidup mereka.

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Poster 320: Improving Quality of Life with Intrathecal Targeted Drug Delivery: A Case Report

PM&R ◽

10.1016/j.pmrj.2018.08.332 ◽

2018 ◽

Vol 10 ◽

pp. S106-S106

Author(s):

Marissa L. Dombovy-Johnson ◽

William H. Fredericks ◽

Thomas P. Pittelkow

Keyword(s):

Quality Of Life ◽

Drug Delivery ◽

Case Report ◽

Targeted Drug Delivery ◽

Targeted Drug

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Nanocarriers for ocular drug delivery: current status and translational opportunity

RSC Advances ◽

10.1039/d0ra04971a ◽

2020 ◽

Vol 10 (46) ◽

pp. 27835-27855 ◽

Cited By ~ 3

Author(s):

Srividya Gorantla ◽

Vamshi Krishna Rapalli ◽

Tejashree Waghule ◽

Prem Prakash Singh ◽

Sunil Kumar Dubey ◽

...

Keyword(s):

Quality Of Life ◽

Drug Delivery ◽

Ocular Drug Delivery ◽

Current Status ◽

Ocular Diseases

Ocular diseases have a significant effect on vision and quality of life.

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Different Targeting Strategies for Treating Breast Cancer Bone Metastases

Current Pharmaceutical Design ◽

10.2174/1381612824666180619165728 ◽

2018 ◽

Vol 24 (28) ◽

pp. 3320-3331 ◽

Cited By ~ 4

Author(s):

Iram Irshad ◽

Pegah Varamini

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Bone Metastasis ◽

Treatment Options ◽

Tumor Burden ◽

Breast Cancer Patients ◽

Physiological Processes ◽

Metastatic Cells ◽

Skeletal Complications

Background: Breast cancer is the most frequently diagnosed malignancy in women worldwide. Breast cancer tends to metastasize to bone. Around 70% of the breast cancer patients eventually develop bone metastasis. After the bone invasion, metastatic cells disrupt the balance between osteoblastic and osteoclastic activities, leading to skeletal complications, characterized by pain and pathological fractures and hence worsening the patient's quality of life. Once tumor invades the bone, it is hard to treat it with, the so-far available treatments options (e.g. bisphosphonates and denosumab). Bone metastasis should be essentially controlled, in cancer treatment and there is a strong need to explore new, more efficient therapeutic targets. This review discusses the bone physiological processes and the recent advances in exploring different pathways involved in bone metastasis. Furthermore, some novel treatment options, which are under preclinical and clinical investigations, are highlighted. Conclusion: A deeper understanding of these metastatic pathways can provide oncology researchers with novel avenues for treating bone metastasis, one of the main challenges to cure breast cancer. The restoration of healthy bone environment will not only improve the patient's quality of life but also reduces the tumor burden.

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